scholarly journals Efficacy of Antioxidants in Amelioration the Toxic Effect of Oxidative Stress Induced By COVID- 19 Infection

2021 ◽  
Vol 6 (2) ◽  
pp. 21-27
Author(s):  
Said Said Elshama
Keyword(s):  
Oxidative Stress ◽  
Toxic Effect

scholarly journals Modulatory effect of Syzygium aromaticum and Pelargonium graveolens on oxidative stress and inflammation

2018 ◽  
Author(s):  
Ilias Marmouzi ◽  
El Mostafa Karym ◽  
Rachid Alami ◽  
Meryem El Jemli ◽  
Mourad Kharbach ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Essential Oils ◽  
Toxic Effect ◽  
Tetrahymena Pyriformis ◽  
Syzygium Aromaticum ◽  
Minimal Risk ◽  
Pelargonium Graveolens ◽  
Anti Inflammatory

AbstractBackgroundTherapy combination is defined as disease treatment with two or more medication to acheive efficacy with lower doses or lower toxicity. Regarding its reported toxicities and efficacy, the Essential Oils (EOs) from Syzygium aromaticum (SA) and Pelargonium graveolens (PG) were combined for in vitro and in vivo assays and toxicities.MethodsThe Essential Oils and mixture were tested for in vivo/in vitro antioxidant and anti-inflammatory activities. The assays included the animal model of acute inflammation (carrageenan model), the protective effect on H2O2/Sodium nitroprissude induced stress in Tetrahymena pyriformis, and the in vitro antioxidant assays.ResultsThe chemical analysis of the investigated Oils has lead to the identification of Eugenol (74.06%), Caryophyllene (11.52%) and Carvacrol acetate (7.82%) as the major element in SA; while PG was much higher in Citronellol (30.77%), 10-epi-γ-Eudesmol (22.59%), and Geraniol (13.95%). In our pharmacological screening of samples, both Oils demonstrated good antioxidant effects. In vivo investigation of the antioxidant activity in the protozoa model (T. pyriformis) demonstrated a lesser toxic effect of EOs mixture with no significant differences when oxidative stress markers and antioxidant enzymes (MDA, SOD and CAT) were evaluated. On the other hand the in vivo model of inflammatory response to carrageenan demonstrated a good inhibitory potential of both EOs. The EOs Mixture demonstrated equivalent bioactivity with lower toxic effect and minimal risk for each compound.ConclusionsThe results from this study indicate that EOs mixture from SA and PG demonstrated promising modulatory antioxidant/anti-inflammatory effect, which suggest an efficient association for therapy.

scholarly journals Pharmacoprophylaxis of liver diseases: creating a new hepatoprotector

2020 ◽  
Vol 17 ◽  
pp. 00061
Author(s):  
Svetlana Zykova ◽  
Sergey Shurov ◽  
Aleksey Savinkov ◽  
Nino Gugushvili ◽  
Vladimir Talismanov
Keyword(s):  
Oxidative Stress ◽  
Carbon Tetrachloride ◽  
Toxic Effect ◽  
Alanine Aminotransferase ◽  
Liver Diseases ◽  
Hepatoprotective Activity ◽  
Control Group ◽  
Biochemical Indicators ◽  
Intact Group ◽  
Biochemical Studies

The article presents a study of the hepatoprotective activity of a tricyclic heterocycle, which refers to 5, 6, 7, 8-tetrahydroquinolines. The effect of 8, 8-dimethyl-5-p-tolyl-8, 9-dihydro-2H-pyrido [4, 3, 2-de] cinnolin-3 (7H) was studied on rats under the influence of the model of toxic hepatosis induced by carbon tetrachloride to find out the indicators of peroxidation and biochemical indicators. Biochemical studies have shown that modelling toxic fat hepatosis caused by the inception of carbon tetrachloride to rats increased the activity of alanine aminotransferase by 2.5 times more compared with the intact group, indicating the development of oxidative stress induced by the treatment of pyrido [4, 3, 2] Cinnol I that reduced the toxic effect of CTC by 79.9 %. Mexidol had a less pronounced hepatoprotective effect: the activity of Alanine aminotransferase on animals of the second group was lower by 29.2 % than on rats from the control group. Thus, a new compound with hepatoprotective activity has been developed and studied.

scholarly journals Vitamin C attenuates the toxic effect of aristolochic acid on renal tubular cells via decreasing oxidative stress-mediated cell death pathways

2015 ◽  
Vol 12 (4) ◽  
pp. 6086-6092 ◽  
Author(s):  
TSAI-KUN WU ◽  
CHYOU-WEI WEI ◽  
YING-RU PAN ◽  
SHUR-HUEIH CHERNG ◽  
WEI-JUNG CHANG ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Vitamin C ◽  
Toxic Effect ◽  
Aristolochic Acid ◽  
Tubular Cells ◽  
Renal Tubular Cells ◽  
Cell Death Pathways ◽  
Renal Tubular

Toxic effect of organophosphate compounds on the kidneys

2020 ◽  
Vol 22 (3) ◽  
pp. 199-205
Author(s):  
M. O. Sokolova ◽  
V. E. Sobolev ◽  
D. A. Reshetkina ◽  
O. A. Nagibovich
Keyword(s):  
Oxidative Stress ◽  
Toxic Effect ◽  
Kidney Injury ◽  
Pathological Process ◽  
Ultrastructural Changes ◽  
Systemic Hemodynamic ◽  
Organophosphate Compounds ◽  
Disease Epidemiology ◽  
Organophosphate Intoxication ◽  
Toxic Damage

Abstract. The study describes: the toxic effect of organophosphate intoxication compounds on the human and animal organism, the contribution of organophosphate to the chronic kidney disease epidemiology and the acute kidney poisoning pathophysiology caused by organophosphate compounds. The study shows oxidative stress and systemic hemodynamic disturbance in the pathogenesis of organophosphate-induced kidney injury. We summarized effects of organophosphate substances on the structural and functional kidneys tissue characteristics in humans and animals. Biomarkers useful for early diagnosis of kidneys toxic damage are shown. In study we considered microscopic and ultrastructural changes in the anatomical and histological kidney structures caused by acute and chronic organophosphate intoxication. The organophosphate compounds are highly toxic, easily overcome the epithelial integument, are able to penetrate cell membranes and the blood-brain barrier. These compounds are involved in the disruption of several key biological processes the acetylcholinesterase irreversible inhibition and the oxidative stress induction in the excretory organs cells. The kidneys are not the first target in the toxic effect of organophosphate compounds in the human body, but are actively involved in the pathological process. It was established that kidneys tissue damage by organophosphate compounds can manifest itself differently depending on the duration of exposure, type and concentration of the toxic compound. It was shown that the kidney injury pathogenesis during acute and chronic intoxication by organophosphate compounds remains not fully understood. Nephron dysfunction patterns depending from various doses and toxic agents exposure duration have not been identified.

scholarly journals Effect of sea buckthorn meal extract in alleviating the toxic effect of ochratoxin A and zearalenone in porcine peripheral blood mononuclear cells

2021 ◽  
Vol 24 (1) ◽  
pp. 84-92
Author(s):  
Daniela Eliza Marin ◽  
Gina Cecilia Pistol
Keyword(s):  
Oxidative Stress ◽  
Toxic Effect ◽  
Ochratoxin A ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Sea Buckthorn ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells ◽  
Vitro Effect

Abstract The mycotoxins ochratoxin A (OTA) and zearalenone (ZEA) are frequent contaminants of cereals responsible for important toxic effects in human and animals. The aim of this study was to investigate the in vitro effect of the sea buckthorn meal extract in alleviating the toxic effect of ochratoxin A and zearalenone on oxidative stress and inflammation using porcine peripheral blood mononuclear cells. Our results have shown that both zearalenone and ochratoxin causes oxidative damage and alter the inflammatory response. The use of the sea buckthorn meal extract can improve some markers of the oxidative stress (total antioxidant status) and inflammation (pro-inflammatory cytokines IL-1β, TNF-α, IL-8, IL-6) altered by exposure to the mycotoxins ZEA and OTA and our results indicate that this waste represents a promising biological method that can be used for the alleviation of the mycotoxins negative effects.

Adaptations to oxidative stress in Zea mays roots under short-term Pb2+ exposure

Biologia ◽  
2015 ◽  
Vol 70 (2) ◽  
Author(s):  
Gurpreet Kaur ◽  
Harminder Pal Singh ◽  
Daizy Rani Batish ◽  
Ravinder Kumar Kohli
Keyword(s):  
Oxidative Stress ◽  
Zea Mays ◽  
Toxic Effect ◽  
Contaminated Soils ◽  
Sharp Decrease ◽  
Crop Productivity ◽  
Animal Life ◽  
Short Term

AbstractLead (Pb), a widespread contaminant in terrestrial landscape, is highly detrimental to plant and animal life. Specifically, Pb-contaminated soils cause a sharp decrease in crop productivity, thereby posing a serious risk to agriculture. A study was planned to investigate the toxic effect of Pb

scholarly journals Effects of Quercetin-Loaded Nanoparticles on MCF-7 Human Breast Cancer Cells

Medicina ◽  
2019 ◽  
Vol 55 (4) ◽  
pp. 114 ◽  
Author(s):  
Firoozeh Niazvand ◽  
Mahmoud Orazizadeh ◽  
Layasadat Khorsandi ◽  
Mohammadreza Abbaspour ◽  
Esrafil Mansouri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Toxic Effect ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cell Line Cell ◽  
Mcf 7

Background and objectives: Previous studies have shown anti-tumor activity of quercetin (QT). However, the low bioavailability of QT has restricted its use. This study aimed to assess the toxic effect of QT encapsulated in solid lipid nanoparticles (QT-SLNs) on the growth of MCF-7 human breast cancer cells. Materials and Methods: MCF-7 and MCF-10A (non-tumorigenic cell line) cell lines treated with 25 µmol/mL of QT or QT-SLNs for 48 h. Cell viability, colony formation, oxidative stress, and apoptosis were evaluated to determine the toxic effects of the QT-SLNs. Results: The QT-SLNs with appropriate characteristics (particle size of 85.5 nm, a zeta potential of −22.5 and encapsulation efficiency of 97.6%) were prepared. The QT-SLNs showed sustained QT release until 48 h. Cytotoxicity assessments indicated that QT-SLNs inhibited MCF-7 cells growth with a low IC50 (50% inhibitory concentration) value, compared to the free QT. QT-SLNs induced a significant decrease in the viability and proliferation of MCF-7 cells, compared to the free QT. QT-SLN significantly increased reactive oxygen species (ROS) level and MDA contents and significantly decreased antioxidant enzyme activity in the MCF-7 cells. Following QT-SLNs treatment, the expression of the Bcl-2 protein significantly decreased, whereas Bx expression showed a significant increase in comparison with free QT-treated cells. Furthermore, The QT-SLNs significantly increased apoptotic and necrotic indexes in MCF-7 cells. Viability, proliferation, oxidative stress and apoptosis of MCF-10A cells were not affected by QT or QT-SLNs. Conclusions: According to the results of this study, SLN significantly enhanced the toxic effect of QT against human breast cancer cells.

scholarly journals Toxic effect comparison of three typical sterilization nanoparticles on oxidative stress and immune inflammation response in rats

2015 ◽  
Vol 4 (2) ◽  
pp. 486-493 ◽  
Author(s):  
Huan-Liang Liu ◽  
Hong-Lian Yang ◽  
Ben-Cheng Lin ◽  
Wei Zhang ◽  
Lei Tian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Toxic Effect ◽  
Inflammation Response ◽  
Immune Inflammation

Three typical sterilization nanoparticles can cause oxidative stress and immune inflammation response to rats, and their toxicities showed significant differences.

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