scholarly journals ISOLATION AND INVESTIGATION OF PHYTOCHEMICALS AND PHARMACOLOGICAL SCREENING OF TAGETES ERECTA L. LEAVES EXTRACT

2018 ◽  
Vol 6 (4) ◽  
pp. 39-44
Author(s):  
Thorat Kranti Jayavant
Keyword(s):  
Drug Development ◽  
Development Process ◽  
Cancer Cell Line ◽  
Extraction Process ◽  
Herbal Drugs ◽  
Synthetic Drugs ◽  
Muscular Pain ◽  
Plant Constituents ◽  
Tagetes Erecta L ◽  
Pharmacological Screening

Extraction and isolation of plant constituents plays an important role as a therapeutic remedy. Isolation of active plant constituents helps in developing lead molecule in drug development process. Aim of present study is to extract, isolate plant constituents and spectral and pharmacological investigation. The major advantage of herbal drugs to synthetic drugs is that they produce more therapeutic effect and fewer side effects. Herbal drugs also have potential in drug development by generating a lead molecule which helps in designing of synthetic drugs. Tagetes species belonging to family Asteraceae, are most common in plant kingdom, which is used in different areas like cosmetic preparation, medicines as well as it is most commonly used as ornamentals. Flowers are mainly used for all these purposes by using extraction process. Tagetes species contains mainly lutien such as carotenoids or xanthophylls containing two cyclic end groups and basic C-40 isoprene unit. The leaves are reported to possess wound healing, antiulcer, muscular pain relief activities10. The basic criteria of present work are to isolate the active plant constituents from these plants and to avail about its anticancer activity on cancer cell line

scholarly journals Cytotoxic and Gene Expression Research on Kras Gene in Lung Cancer Cell Line of A549 Treated with Tinospora Coridifolia Extract

2019 ◽  
Vol 8 (9S2) ◽  
pp. 295-297
Keyword(s):  
Low Cost ◽  
Herbal Medicines ◽  
Cancer Cell Line ◽  
Modern Medicine ◽  
Lung Cancer Cell Line ◽  
Herbal Drugs ◽  
Human Beings ◽  
Kras Gene ◽  
Modern Times ◽  
Synthetic Drugs

There has been global resurgence of interest in herbal drugs in the recent past. Though herbal medicines are effective in the treatment of various ailments very often these drugs are unscientifically exploited or improperly used. Therefore, these herbal drugs deserve detailed studies in the light of modern medicine. In spite of synthetic drugs, herbal drugs have their place in therapy. Their effectiveness, low-cost and comparative freedom from serious toxic effects makes these medicines not only popular but also an acceptable mode of treating diseases even in modern times. Medicinal plants are those plants that are used in treating and preventing specific and human has been using herbs for generations around the world, due to charm needed to cure the disease, many people have come to the conclusion that even chemical drugs their answers may already be sick of these medications may be harmful for health them in the future. Still, the use of plants as a source of medicine is very much important for human beings. Identify medicinal and how to use them is so important.

An ayurvedic tablet formulation for ulcer protection

2020 ◽  
Vol 10 (4) ◽  
pp. 35-38
Author(s):  
Shiva Kumar K ◽  
Purushothaman M ◽  
Soujanya H ◽  
Jagadeeshwari S
Keyword(s):  
Pharmacological Activity ◽  
The Body ◽  
Gastric Ulcers ◽  
Antiulcer Activity ◽  
Herbal Drugs ◽  
Human Beings ◽  
Synthetic Drugs ◽  
Scientific Investigations ◽  
System A ◽  
The World

Gastric ulcers or the peptic ulcer is the primary disease that affects the gastrointestinal system. A large extent of the population in the world are suffering from the disease, and the age group of people those who suffer from ulcers are 20-55years. Herbs are known to the human beings that are useful in the treatment of diseases, and there are a lot of scientific investigations that prove the pharmacological activity of herbal drugs. Practitioners have been using the herbal material to treat the ulcers successfully, and the same had been reported scientifically. Numerous publications have been made that proves the antiulcer activity of the plants around the world. The tablets were investigated for the antiulcer activity in two doses 200 and 400mg/kg in albino Wistar rats in the artificial ulcer those are induced by the ethanol. The prepared tablets showed a better activity compared to the standard synthetic drug and the marketed ayurvedic formulation. The tablets showed a dose-dependent activity in ulcer prevention and treatment. Many synthetic drugs are available for the ulcer treatment, and the drugs pose the other problems in the body by showing the side effects and some other reactions. This limits the use of synthetic drugs to treat ulcers effectively. Herbs are known to the human beings that are useful in the treatment of diseases, and there are a lot of scientific investigations that prove the pharmacological activity of herbal drugs.

Intelligent Drug Development

2014 ◽  
Author(s):  
Michael Tansey
Keyword(s):  
Clinical Trials ◽  
Cost Effectiveness ◽  
Drug Development ◽  
Clinical Research ◽  
Development Process ◽  
Drug Development Process ◽  
Individual Trial ◽  
Specific Technology

Clinical research is heavily regulated and involves coordination of numerous pharmaceutical-related disciplines. Each individual trial involves contractual, regulatory, and ethics approval at each site and in each country. Clinical trials have become so complex and government requirements so stringent that researchers often approach trials too cautiously, convinced that the process is bound to be insurmountably complicated and riddled with roadblocks. A step back is needed, an objective examination of the drug development process as a whole, and recommendations made for streamlining the process at all stages. With Intelligent Drug Development, Michael Tansey systematically addresses the key elements that affect the quality, timeliness, and cost-effectiveness of the drug-development process, and identifies steps that can be adjusted and made more efficient. Tansey uses his own experiences conducting clinical trials to create a guide that provides flexible, adaptable ways of implementing the necessary processes of development. Moreover, the processes described in the book are not dependent either on a particular company structure or on any specific technology; thus, Tansey's approach can be implemented at any company, regardless of size. The book includes specific examples that illustrate some of the ways in which the principles can be applied, as well as suggestions for providing a better context in which the changes can be implemented. The protocols for drug development and clinical research have grown increasingly complex in recent years, making Intelligent Drug Development a needed examination of the pharmaceutical process.

scholarly journals Bayesian meta-analytical methods to incorporate multiple surrogate endpoints in drug development process

2015 ◽  
Vol 35 (7) ◽  
pp. 1063-1089 ◽  
Author(s):  
Sylwia Bujkiewicz ◽  
John R. Thompson ◽  
Richard D. Riley ◽  
Keith R. Abrams
Keyword(s):  
Drug Development ◽  
Analytical Methods ◽  
Development Process ◽  
Surrogate Endpoints ◽  
Drug Development Process

scholarly journals Precision Medicine: From “Omics” to Economics towards Data-Driven Healthcare - Time for European Transformation

2017 ◽  
Vol 2 (Suppl. 1) ◽  
pp. 1-10 ◽  
Author(s):  
Denis Lacombe ◽  
Lifang Liu ◽  
Françoise Meunier ◽  
Vassilis Golfinopoulos
Keyword(s):  
Drug Development ◽  
Development Process ◽  
Precision Oncology ◽  
Drug Development Process ◽  
Cancer Treatments ◽  
True Value ◽  
Efficient Access ◽  
Funding Agencies ◽  
Anti Cancer

There is room for improvement for optimally bringing the latest science to the patient while taking into account patient priorities such as quality of life. Too often, regulatory agencies, governments, and funding agencies do not stimulate the integration of research into care and vice versa. Re-engineering the drug development process is a priority, and healthcare systems are long due for transformation. On one hand, patients need efficient access to treatments, but despite precision oncology approaches, efficiently shared screening platforms for sorting patients based on the biology of their tumour for trial access are lacking and, on the other hand, the true value of cancer care is poorly addressed as central questions such as dose, scheduling, duration, and combination are not or sub-optimally addressed by registration trials. Solid evidence on those parameters could potentially lead to a rational and wiser use of anti-cancer treatments. Together, optimally targeting patient population and robust comparative effectiveness data could lead to more affordable and economically sound approaches. The drug development process and healthcare models need to be interconnected through redesigned systems taking into account the full math from drug development into affordable care.

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