scholarly journals Cytotoxic and Gene Expression Research on Kras Gene in Lung Cancer Cell Line of A549 Treated with Tinospora Coridifolia Extract

2019 ◽  
Vol 8 (9S2) ◽  
pp. 295-297
Keyword(s):  
Low Cost ◽  
Herbal Medicines ◽  
Cancer Cell Line ◽  
Modern Medicine ◽  
Lung Cancer Cell Line ◽  
Herbal Drugs ◽  
Human Beings ◽  
Kras Gene ◽  
Modern Times ◽  
Synthetic Drugs

There has been global resurgence of interest in herbal drugs in the recent past. Though herbal medicines are effective in the treatment of various ailments very often these drugs are unscientifically exploited or improperly used. Therefore, these herbal drugs deserve detailed studies in the light of modern medicine. In spite of synthetic drugs, herbal drugs have their place in therapy. Their effectiveness, low-cost and comparative freedom from serious toxic effects makes these medicines not only popular but also an acceptable mode of treating diseases even in modern times. Medicinal plants are those plants that are used in treating and preventing specific and human has been using herbs for generations around the world, due to charm needed to cure the disease, many people have come to the conclusion that even chemical drugs their answers may already be sick of these medications may be harmful for health them in the future. Still, the use of plants as a source of medicine is very much important for human beings. Identify medicinal and how to use them is so important.

scholarly journals Analysis of Cytotoxic and Gene Expression of KRAS Gene in Lung Cancer Cell Line of A549 Treated with Tinospora Coridifolia Extract

2019 ◽  
Vol 8 (9S3) ◽  
pp. 1149-1152
Keyword(s):  
Herbal Medicines ◽  
Cancer Cell Line ◽  
Modern Medicine ◽  
Lung Cancer Cell Line ◽  
Herbal Drugs ◽  
Human Beings ◽  
Recent Past ◽  
Lung Cancer Cell ◽  
Kras Gene ◽  
Medicinal Properties

There has been global resurgence of interest in herbal drugs in the recent past. Although herbal medicines are very often efficient in treating different ailments, these medications are either unscientifically utilized or misused. Thus, in the light of modern medicine, these herbal drugs deserve thorough research. Medicinal properties consist of those plants that are used in treating and preventing specific and human has been using herbs for generations around the world, due to charm needed to cure the disease, many people have come to the conclusion that even chemical drugs their answers may already be sick of these medications may be harmful for health them in the future. Still, the use of plants as a source of medicine is very much important for human beings. Identify medicinal and how to use them is so important.

scholarly journals An Efficient Feature Specific Neural Network for Multi Class Classification

2019 ◽  
Vol 8 (2S3) ◽  
pp. 1223-1226
Keyword(s):  
Low Cost ◽  
Herbal Medicines ◽  
Modern Medicine ◽  
Herbal Drugs ◽  
Human Beings ◽  
Recent Past ◽  
Modern Times ◽  
Synthetic Drugs ◽  
The World ◽  
Multi Class Classification

There has been global resurgence of interest in herbal drugs in the recent past. Though herbal medicines are effective in the treatment of various ailments very often these drugs are unscientifically exploited or improperly used. Therefore, these herbal drugs deserve detailed studies in the light of modern medicine. In spite of synthetic drugs, herbal drugs have their place in therapy. Their effectiveness, low-cost and comparative freedom from serious toxic effects makes these medicines not only popular but also an acceptable mode of treating diseases even in modern times. Medicinal plants are those plants that are used in treating and preventing specific and human has been using herbs for generations around the world, due to charm needed to cure the disease, many people have come to the conclusion that even chemical drugs their answers may already be sick of these medications may be harmful for health them in the future. Still, the use of plants as a source of medicine is very much important for human beings. Identify medicinal and how to use them is so important.

An ayurvedic tablet formulation for ulcer protection

2020 ◽  
Vol 10 (4) ◽  
pp. 35-38
Author(s):  
Shiva Kumar K ◽  
Purushothaman M ◽  
Soujanya H ◽  
Jagadeeshwari S
Keyword(s):  
Pharmacological Activity ◽  
The Body ◽  
Gastric Ulcers ◽  
Antiulcer Activity ◽  
Herbal Drugs ◽  
Human Beings ◽  
Synthetic Drugs ◽  
Scientific Investigations ◽  
System A ◽  
The World

Gastric ulcers or the peptic ulcer is the primary disease that affects the gastrointestinal system. A large extent of the population in the world are suffering from the disease, and the age group of people those who suffer from ulcers are 20-55years. Herbs are known to the human beings that are useful in the treatment of diseases, and there are a lot of scientific investigations that prove the pharmacological activity of herbal drugs. Practitioners have been using the herbal material to treat the ulcers successfully, and the same had been reported scientifically. Numerous publications have been made that proves the antiulcer activity of the plants around the world. The tablets were investigated for the antiulcer activity in two doses 200 and 400mg/kg in albino Wistar rats in the artificial ulcer those are induced by the ethanol. The prepared tablets showed a better activity compared to the standard synthetic drug and the marketed ayurvedic formulation. The tablets showed a dose-dependent activity in ulcer prevention and treatment. Many synthetic drugs are available for the ulcer treatment, and the drugs pose the other problems in the body by showing the side effects and some other reactions. This limits the use of synthetic drugs to treat ulcers effectively. Herbs are known to the human beings that are useful in the treatment of diseases, and there are a lot of scientific investigations that prove the pharmacological activity of herbal drugs.

Nano Phytomedicine Based Delivery System for CNS Disease

2020 ◽  
Vol 21 (9) ◽  
pp. 661-673 ◽  
Author(s):  
Mohammed Asadullah Jahangir ◽  
Chettupalli Anand ◽  
Abdul Muheem ◽  
Sadaf Jamal Gilani ◽  
Mohamad Taleuzzaman ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Low Cost ◽  
Herbal Medicines ◽  
Herbal Drugs ◽  
Widespread Acceptance ◽  
The Central Nervous System ◽  
Low Toxicity ◽  
Ancient Times ◽  
Plant Sources ◽  
Herbal Formulations

Herbal medicines are being used since ancient times and are an important part of the alternative and traditional medicinal system. In recent decades, scientists are embracing herbal medicines based on the fact that a number of drugs that are currently in use are derived directly or indirectly from plant sources. Moreover, herbal drugs have lesser side effects, albeit are potentially strong therapeutic agents. The herbal medicine market is estimated to be around US $62 billion globally. Herbal medicine has gained widespread acceptance due to its low toxicity, low cost, ease of accessibility and efficacy in treating difficult diseases. Safety and efficacy are another important factors in the commercialization process of herbal medicines. Nanotechnology has been shown to be potentially effective in improving the bioactivity and bioavailability of herbal medicines. Development of nano-phytomedicines (or by reducing the size of phytomedicine), attaching polymers with phytomedicines and modifying the surface properties of herbal drugs, have increased the solubility, permeability and eventually the bioavailability of herbal formulations. Novel formulations such as niosomes, liposomes, nanospheres, phytosomes etc., can be exploited in this area. This article reviews herbal medicines, which have prominent activity in the Central Nervous System (CNS) disorders and reported nano-phytomedicines based delivery systems.

scholarly journals AN EXHAUSTIVE REVIEW ON HERBS USED IN THE MANAGEMENT OF DIABETES MELLITUS TYPE 2

2019 ◽  
pp. 5-11
Author(s):  
Salman Mau ◽  
Shakir Saleem ◽  
Vishwadeepak Kimothi ◽  
Vineet Joshi ◽  
Sanjay Singh
Keyword(s):  
Diabetes Mellitus ◽  
Raw Materials ◽  
Nigella Sativa ◽  
Low Cost ◽  
Herbal Medicines ◽  
Analytical Techniques ◽  
Herbal Drugs ◽  
Herbal Products ◽  
High Blood Glucose ◽  
Glucose Levels

Diabetes mellitus is one of the most common metabolic disorders associated with disturbed hormonal secretion. Diabetes is characterized by high blood glucose levels over a prolonged period of time. High sugar levels are due to abnormal metabolism of carbohydrates and lipids which is caused by absolute or relative insulin deficiency. Herbal medicines have been the highly esteemed source of medicine throughout the human history. Herbs are becoming more popular today because of their least side effects, holistic beliefs, easy availability and low cost. Individual herbal products and formulations are gaining popularity because of their quality manufacturing using modern analytical techniques and standardized raw materials. Herbal drugs are widely used for the treatment of diabetes worldwide in various dosage forms. India has a long list of native herbal drugs with scientifically proven blood sugar lowering properties. The seeds of Nigella sativa, Olea europaea, fruits of Aegle marmelos, Momordica charantia, Coccinia indica, Nigella sativa,Gymnema sylvestre leaves,whole plant of Pterocarpus marsupium, Syzygium cumini fruits, Swertia punicea, Urtica dioica, gum of Ferula assa-foetida and seeds of Trigonella foenum graecum were discussed along with their reported mechanisms of action. In this review paper an attempt has been made to give an overview of certain Indian plants which have shown their anti-diabetic activity in various pre-clinical studies.

Identification and Detection of Undeclared Herbal Slimming Adulterants

2016 ◽  
Vol 2 (1 and 2) ◽  
pp. 73-78
Author(s):  
Mohammad Kamil
Keyword(s):  
Public Health ◽  
Raw Materials ◽  
Health And Safety ◽  
Herbal Medicines ◽  
Cost Effective ◽  
Herbal Drugs ◽  
Visual Evaluation ◽  
Synthetic Drugs ◽  
Artery Disease

The Food and Drug Administration (FDA) is advising consumers to stop using multiple weight-loss products that contain the undeclared drug ingredients e.g. sibutramine, which was removed from the market in 2010 for safety reasons and may present significant risks for those with coronary artery disease and other heart issues. Sibutramine and similar undeclared ingredients in herbal medicines are a real challenge for the public health and safety. In recent years, the need for quality assurance tools to ensure the identity, purity, and quality of botanical material has risen dramatically. HPTLC has emerged as a versatile, high throughput, and cost-effective technology, that is uniquely suited to meet these requirements. Most separation techniques do not allow parallel analysis of numerous samples at the same time and they often face problems in separating complex mixtures of substances. However, visual evaluation of HPTLC plates allows for convenient comparison of many samples side by side, where similarities and differences can clearly be seen. The quality of raw materials is rapidly and easily determined by HPTLC. For the identification of herbal drugs and other naturally derived materials standardized HPTLC is the method of choice and recommended by pharmacopoeias worldwide, furthermore adulterated samples are reliably identified. The main objective of the present study is to check pharmaceutical analogue adulteration of nonprescription and prescription slimming products in the laboratory using chromatographic techniques and to discuss its side effects in the interest of consumers and public health safety. Since intentional adulteration of “natural herbalmedicines” with unknown synthetic drugs or chemicals is a common and dangerous phenomenon of alternative medicine, it is important to modify and validate analytical tools to monitor and evaluate these herbal drugs.

scholarly journals Plant-Based Drugs as an Adjuvant to Cancer Chemotherapy

2020 ◽  
Author(s):  
Lakshmi Mohan
Keyword(s):  
Natural Products ◽  
Cancer Chemotherapy ◽  
Herbal Medicines ◽  
Modern Medicine ◽  
Aquatic Life ◽  
Traditional Medicines ◽  
Synthetic Drugs ◽  
History Of ◽  
Drug Leads

Humans have turned to natural products, obtained from plants, animals and aquatic life for treating diseases since time immemorial. Modern medicine is based on ancient wisdom transferred over generations. Drug development relies mainly on natural sources. Herbal medicines are making a comeback due to lower side effects, and positive results in the long term when compared to synthetic drugs. The current drug discovery process relies on identifying traditional medicines followed by Bioactivity-guided fractionation to isolate significant lead molecules. Plants have a history of long-term use by humans and hence it can be presumed that the bioactive compounds obtained from plants will have low human toxicity. There exists a huge potential for discovering new antitumor drug leads by screening natural products either in the form of crude extracts purified phytochemicals which have already been described in the literature. The fact that phytochemicals like paclitaxel, vinblastine, vincristine and camptothecin are being successfully used in clinical practice and several others like combretastatin and noscapine are in different stages of clinical trials implies the importance of plants in cancer chemotherapy.

scholarly journals Controversy, Adulteration and Substitution: Burning Problems in Ayurveda Practices

2021 ◽  
Author(s):  
Puneshwar Keshari
Keyword(s):  
Medicinal Plants ◽  
Herbal Medicines ◽  
Modern Medicine ◽  
Knowledge Systems ◽  
Raw Material ◽  
Correct Identification ◽  
Herbal Drugs ◽  
Traditional System ◽  
Ayurvedic Drugs ◽  
The Common

Ayurveda is an Indian traditional system of medicine. In present era, world is looking towards herbal medicine because of acceptability and safety. Medicinal plants constitute an effective source of Ayurvedic and other traditional system of medicines as well as modern medicine. In India, about 80% of the rural population depends on herbal medicines in primary health care level. A large percentage of plants used in herbal industries are subject of controversy. Non-availability of plants, poor understanding and parallel evolved knowledge systems are some of the reasons attributed to it. The existing practices of polynomial nomenclature system of Sanskrit, different perceptions in various communities, vernacular equivalents, all are cumulative factors for controversy, adulteration and substitution. “ Sandigdha Dravaya “ is a term used for that type of medicinal plants which are mentioned in Ayurvedic classics but their exact botanical source is not known. Adulterants and substitutes are the common practices in herbal raw material trade. Adulteration is a debasement of an article. The motives for intentional adulteration are normally commercial that which involves deterioration, admixture, sophistication, inferiority, spoilage and other unknown reasons. Substitution is a replacement of equivalent drugs in place of original drugs. The principles to select substitute drugs are based on similar Rasa, Guna, Virya, Vipaka and mainly the Karma. At present the adulteration and Substitution of the herbal drugs is the burning problem in herbal industry and in Ayurvedic practices. So it is necessary to develop reliable methodologies for correct identification, standardization and quality assurance of Ayurvedic drugs.

scholarly journals ISOLATION AND INVESTIGATION OF PHYTOCHEMICALS AND PHARMACOLOGICAL SCREENING OF TAGETES ERECTA L. LEAVES EXTRACT

2018 ◽  
Vol 6 (4) ◽  
pp. 39-44
Author(s):  
Thorat Kranti Jayavant
Keyword(s):  
Drug Development ◽  
Development Process ◽  
Cancer Cell Line ◽  
Extraction Process ◽  
Herbal Drugs ◽  
Synthetic Drugs ◽  
Muscular Pain ◽  
Plant Constituents ◽  
Tagetes Erecta L ◽  
Pharmacological Screening

Extraction and isolation of plant constituents plays an important role as a therapeutic remedy. Isolation of active plant constituents helps in developing lead molecule in drug development process. Aim of present study is to extract, isolate plant constituents and spectral and pharmacological investigation. The major advantage of herbal drugs to synthetic drugs is that they produce more therapeutic effect and fewer side effects. Herbal drugs also have potential in drug development by generating a lead molecule which helps in designing of synthetic drugs. Tagetes species belonging to family Asteraceae, are most common in plant kingdom, which is used in different areas like cosmetic preparation, medicines as well as it is most commonly used as ornamentals. Flowers are mainly used for all these purposes by using extraction process. Tagetes species contains mainly lutien such as carotenoids or xanthophylls containing two cyclic end groups and basic C-40 isoprene unit. The leaves are reported to possess wound healing, antiulcer, muscular pain relief activities10. The basic criteria of present work are to isolate the active plant constituents from these plants and to avail about its anticancer activity on cancer cell line

High-Performance Liquid Chromatography (HPLC) as a Tool for Standardization of Complex Herbal Drugs

2019 ◽  
Vol 102 (4) ◽  
pp. 986-992
Author(s):  
Raghavan Govindarajan ◽  
Vyas Tejas ◽  
Palpu Pushpangadan
Keyword(s):  
High Performance ◽  
Functional Foods ◽  
Modern Medicine ◽  
Therapeutic Agents ◽  
Quality Assurance Program ◽  
Herbal Drugs ◽  
Synthetic Drugs ◽  
Active Chemical ◽  
Quantitative Analyses ◽  
Herbal Formulations

Abstract Background: Herbal formulations have reached tremendous acceptability as therapeutic agents for several diseases mainly due to the indiscriminate use of modern medicine such as antibiotics, steroids and other synthetic drugs. The increasing popularity in plant-based drugs is leading to a fast growing market for plant-based drugs pharmaceuticals, nutraceuticals, functional foods, and even cosmeceuticals. Objective: The development of authentic analytical methods for complex herbal drugs, especially poly herbal formulations which can reliably profile the phytochemical composition, including quantitative analyses of marker/bioactive compounds and other major constituents, is a major challenge to scientists. Standardization is an important step for the establishment of a consistent biological activity, a consistent chemical profile, or simply a quality assurance program for production and manufacturing of herbal drugs. Methods/Results: HPLC as a tool has been widely used in the standardization of complex herbal drugs because of its ability to estimate the presence of active (chemical or biological) markers both qualitatively and quantitatively. Conclusions: An overview of various HPLC techniques that can be used for standardization of herbal drugs has been presented.

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