scholarly journals Histo-Epidemiological Profile of Endometrial Cancer in the Oran Region

2020 ◽  
Vol 10 (5-s) ◽  
pp. 143-148
Author(s):  
Anissa FIZAZI ◽  
Imene BOUZOUINA ◽  
Assala Nesrine BOUZIANI ◽  
Amina BELHADJ ◽  
Sonia SEDDIKI ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endometrial Cancer ◽  
Medical Oncology ◽  
Endometrioid Adenocarcinoma ◽  
Keywords Cancer ◽  
Spss Software ◽  
Epidemiological Profile ◽  
Age Of Menarche ◽  
Therapeutic Profile ◽  
Oran Region

Objective: The aim of the present study is to describe the epidemiological, histopathological and therapeutic profile of endometrial cancers in the region of Oran. Methods: We conducted a retrospective study by exploring the medical files of 25 female patients diagnosed of endometrial cancer and treated at the level of the EHU November 1, 1954’s medical oncology department in Oran during the period from January 2015 to December 2019. For data collection, we used a structured exploitation sheet to obtain necessary information. Variables were analyzed using SPSS Software Version 20.0. Results: The median age of patients was 59 years with extremes ranging from 42 to 83 years. More than 56% of our patients were over 50 years old, 40% of the patients were nulliparous and 80% postmenopausal. The average age of menarche was 14.09 ± 1.44 years with extremes ranging from 12 to 17 years. The indication for anatomopathological examination was dominated by metrorrhagia (80%). Histopathologically, endometrioid adenocarcinoma was the most common at 75% of cases. We also note that 62.5% were classified in stage I and 37.5% in stage II. Myometrium infiltration was observed in 66.67% of cases. The basic treatment for endometrial cancer remains surgical. Conclusion: At the end of this work, we concluded that this pathology remains essentially that of postmenopausal women. Endometrioid adenocarcinoma was the most common histologic type. This study also revealed many risk factors for endometrial cancer, such as advanced age, hypertension and nulliparity. Keywords: Cancer, Endometrium, Epidemiology, Anathomopathology, Risk factors

Assessment of the Role of Intraoperative Frozen Section in Guiding Surgical Staging for Endometrial Cancer

2016 ◽  
Vol 26 (5) ◽  
pp. 918-923 ◽  
Author(s):  
Xiaoyuan Wang ◽  
Li Li ◽  
Janiel M. Cragun ◽  
Setsuko K. Chambers ◽  
Kenneth D. Hatch ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endometrial Cancer ◽  
Tumor Size ◽  
Frozen Section ◽  
Medical Center ◽  
Myometrial Invasion ◽  
Surgical Staging ◽  
Endometrioid Adenocarcinoma ◽  
Intraoperative Frozen Section

ObjectiveThe aim of this study was to assess the role of intraoperative frozen section (FS) in guiding decision making for surgical staging of endometrioid endometrial cancer (EC).MethodsMedical records were collected retrospectively on 112 patients with endometrioid EC, who underwent total hysterectomy and bilateral salpingo-oophorectomy at the University of Arizona Medical Center from January 1, 2010, to December 31, 2014. Only patients with endometrioid adenocarcinoma, grade 1, less than 50% myometrial invasion, and tumor size less than 2 cm determined by intraoperative FS omitted lymphadenectomy; otherwise, surgical staging was performed with lymph node dissection. The FS results were compared with the permanent paraffin sections (PSs) to assess the diagnostic accuracy.ResultsThe concordance rate of different variables between FS and PS in EC was 100%, 89.3% (100/112), 97.3% (109/112), and 95.5% (107/112), respectively, with respecting to histological subtype, grade, myometrial invasion, and tumor size. Diagnostic accurate rate of combined risk factors deciding surgical staging at the time of FS was 95.5% (107/112), and the discordance rate of all risk factors considered between FS and PS was 4.5%, resulting 3 cases (2.7%) undertreated and 2 cases (1.8%) overtreated.ConclusionsDespite nonideal FS evaluation, intraoperative FS diagnosis for EC is highly reliable by providing guidance for the intraoperative decisions of surgical staging at our institution, and such guidelines may be referenced by the institutions with sufficient gynecologic pathology expertise.

scholarly journals Endometrial Carcinoma in a 26-Year-Old Patient with Bardet-Biedl Syndrome

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Olga Grechukhina ◽  
Gregory M. Gressel ◽  
William Munday ◽  
Serena Wong ◽  
Alessandro Santin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endometrial Cancer ◽  
Endometrial Adenocarcinoma ◽  
Clinical Signs ◽  
Young Patients ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Endometrioid Adenocarcinoma ◽  
Bardet Biedl Syndrome ◽  
Obesity And Diabetes

Background. Bardet-Biedl Syndrome (BBS) is a rare genetic condition characterized by cognitive impairment, dysmorphism, central obesity, and diabetes mellitus, among other abnormalities. Although some of these characteristics are known independent risk factors for endometrial cancer and its precursors, the association between BBS and endometrial cancer is underreported. Case. We present the case of a 26-year-old patient with BBS and clinical signs of hyperestrogenism who presented with abnormal uterine bleeding and was diagnosed with endometrioid adenocarcinoma. She ultimately underwent definitive surgical treatment with hysterectomy and bilateral salpingectomy. Conclusions. This is one of only a few reports in the literature describing the association of BBS and endometrioid endometrial adenocarcinoma. Given the association of BBS with risk factors for hyperestrogenism such as truncal obesity, hyperinsulinemia, and ovulatory dysfunction, providers should have increased suspicion for endometrial cancer in young patients with BBS and abnormal uterine bleeding.

scholarly journals Survival in endometrial cancer in relation to minimally invasive surgery or open surgery – a Swedish Gynecologic Cancer Group (SweGCG) study

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Christer Borgfeldt ◽  
Erik Holmberg ◽  
Janusz Marcickiewicz ◽  
Karin Stålberg ◽  
Bengt Tholander ◽  
...  
Keyword(s):  
Risk Factors ◽  
Overall Survival ◽  
Endometrial Cancer ◽  
Minimally Invasive ◽  
Cancer Patients ◽  
Surgical Approach ◽  
Open Surgery ◽  
Gynecologic Cancer ◽  
Multivariable Analysis ◽  
Figo Stage

Abstract Background The aim of this study was to analyze overall survival in endometrial cancer patients’ FIGO stages I-III in relation to surgical approach; minimally invasive (MIS) or open surgery (laparotomy). Methods A population-based retrospective study of 7275 endometrial cancer patients included in the Swedish Quality Registry for Gynecologic Cancer diagnosed from 2010 to 2018. Cox proportional hazard models were used in univariable and multivariable survival analyses. Results In univariable analysis open surgery was associated with worse overall survival compared with MIS hazard ratio, HR, 1.39 (95% CI 1.18–1.63) while in the multivariable analysis, surgical approach (MIS vs open surgery) was not associated with overall survival after adjustment for known risk factors (HR 1.12, 95% CI 0.95–1.32). Higher FIGO stage, non-endometrioid histology, non-diploid tumors, lymphovascular space invasion and increasing age were independent risk factors for overall survival. Conclusion The minimal invasive or open surgical approach did not show any impact on survival for patients with endometrial cancer stages I-III when known prognostic risk factors were included in the multivariable analyses.

Risk Factors for Young Premenopausal Women With Endometrial Cancer

2005 ◽  
Vol 105 (3) ◽  
pp. 575-580 ◽  
Author(s):  
Pamela T. Soliman ◽  
Jonathan C. Oh ◽  
Kathleen M. Schmeler ◽  
Charlotte C. Sun ◽  
Brian M. Slomovitz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endometrial Cancer ◽  
Premenopausal Women

scholarly journals The diagnostic value of human epididymis protein 4 for endometrial cancer is moderate

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jing Liu ◽  
Lili Han ◽  
Zhen Jiao
Keyword(s):  
Endometrial Cancer ◽  
Sensitivity And Specificity ◽  
Diagnostic Value ◽  
Critical Value ◽  
Chief Complaint ◽  
Human Epididymis Protein 4 ◽  
Human Epididymis ◽  
Clinical Stages ◽  
Spss Software ◽  
Xinjiang Uyghur Autonomous Region

AbstractHuman epididymis protein 4 (HE4) has been used as a biomarker of endometrial cancer (EC) in clinical practice. However, there remains a lack of systemic research on the critical values of HE4 for diagnosing different clinical stages and pathological types of EC. This study investigated the accuracy of human epididymis protein 4 (HE4) in the diagnosis of EC. Patients who were hospitalized for a chief complaint of abnormal vaginal hemorrhage at Xinjiang Uyghur Autonomous Region People's Hospital between 2014 and 2019 were consecutively included. Pathological biopsy confirmed the diagnosis of EC; there were a total of 136 EC patients and 127 non-EC patients. The accuracy of HE4 in the diagnosis of EC was assessed with SPSS software. The accuracy of HE4 for diagnosing different clinical stages and pathological types of EC was also explored. The critical value of HE4 for endometrial cancer was 52.40 mmol/L, with a sensitivity of 57.35% and a specificity of 76.38%. For different stages of EC, the critical value was 36.9 mmol/L, and the sensitivity and specificity were 28% and 87.39%, respectively. For different pathological types, the critical value was 30.60 mmol/L, and the sensitivity and specificity were 93.85% and 33.33%, respectively. The diagnostic value of HE4 for EC is moderate, and the serum HE4 level cannot reflect the stage and type of EC.

scholarly journals Risk factors for recurrence amongst high intermediate risk patients with endometrioid adenocarcinoma

2012 ◽  
Vol 23 (4) ◽  
pp. 257 ◽  
Author(s):  
Agnes Y. Bahng ◽  
Christina Chu ◽  
Paul Wileyto ◽  
Stephen Rubin ◽  
Lilie L. Lin
Keyword(s):  
Risk Factors ◽  
Endometrioid Adenocarcinoma ◽  
Intermediate Risk ◽  
Risk Patients ◽  
Risk Factors For Recurrence
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