scholarly journals Qualitative Phytochemical Screening of Selected Medicinal Plants

2021 ◽  
Vol 11 (2) ◽  
pp. 141-144
Author(s):  
E Mohan ◽  
S Suriya ◽  
S Shanmugam ◽  
K Rajendran
Keyword(s):  
Medicinal Plants ◽  
Quantitative Estimation ◽  
Acorus Calamus ◽  
Leaf Extracts ◽  
Solanum Torvum ◽  
Chemical Structures ◽  
Soxhlet Apparatus ◽  
Solanum Trilobatum ◽  
Senna Alata

Phytochemicals have great potency as therapeutic agents. There is continuous and urgent need to discover new therapeutic compounds with diverse chemical structures and novel mechanism of action because there has been an alarming increase in the incidence of new and re-emerging infectious diseases. Hence, the present investigation was carried out to assess the phytoconstituents of leaf extracts of four different medicinal plants viz. Acorus calamus, Senna alata, Solanum torvum and Solanum trilobatum. The leaves of four plants were collected from their wild habitats, washed, air dried and then powdered. The solvent extracts of the respective leaves were prepared using Soxhlet apparatus with acetone, ethanol and petroleum ether. The extracts were subjected to preliminary phytochemical analyses as per standard procedures. The results showed that alkaloids were present in all the four plants analyzed and all the three solvents extracted. Meanwhile, carbohydrates and proteins were absent in the same. It was also indicated that the ethanol extract of Solanum trilobatum leaf showed the presence of 7 compounds among 9 phytochemicals analyzed. The result of this study is encouraging further quantitative estimation and the need for clinical studies to determine the potential effectiveness of particular phytochemical in vivo. Keywords: Preliminary phytochemical analyses, Acorus calamus, Senna alata, Solanum torvum and Solanum trilobatum.

Potential Antiulcer Agents From Plants: A Comprehensive Review

2019 ◽  
Vol 5 (3) ◽  
pp. 170-231
Author(s):  
Minky Mukhija ◽  
Bhuwan Chandra Joshi
Keyword(s):  
Medicinal Plants ◽  
Developed Countries ◽  
Scientific Data ◽  
Antiulcer Activity ◽  
Peptic Ulcers ◽  
Comprehensive Review ◽  
Chemical Structures ◽  
Mucosal Thickness

Background: Peptic ulcer is a deep gastrointestinal erosion disorder that involves the entire mucosal thickness and can even penetrate the muscular mucosa. Nowadays, several plants and compounds derived from it have been screened for their antiulcer activity. In the last few years, there has been an exponential growth in the field of herbal medicine. This field has gained popularity in both developing and developed countries because of their natural origin and less side effects. Objective: This review aims to provide a comprehensive summary of currently available knowledge of medicinal plants and phytoconstituents reported for their anti-ulcer properties. Methods: The worldwide accepted database like SCOPUS, PUBMED, SCIELO, NISCAIR, ScienceDirect, Springerlink, Web of Science, Wiley, SciFinder and Google Scholar were used to retrieve available published literature. Results: A comprehensive review of the present paper is an attempt to list the plants with antiulcer activity. The review narrates the dire need to explore potential chemical moieties that exert an antiulcer effect, from unexploited traditional plants. Furthermore, the present study reveals the intense requirement to exploit the exact mechanism through which either the plant extracts or their active constituents exhibit their antiulcer properties. Conclusion: This article is the compilation of the plants and its constituents reported for the treatment of peptic ulcers. The Comprehensive data will surely attract the number of investigators to initiate further research that might lead to the drugs for the treatment of ulcers. As sufficient scientific data is not available on plants, most of the herbals cannot be recommended for the treatment of diseases. This can be achieved by research on pure chemical structures derived from plants or to prepare new lead compounds with proven beneficial preclinical in vitro and in vivo effects. However, a lot remains to be done in further investigations for the better status of medicinal plants.

scholarly journals Antiepileptic and Antioxidant Activity of Some Medicinal Plants: A Review

2017 ◽  
Vol 9 (10) ◽  
Author(s):  
Jeenu Joseph ◽  
Lincy Joseph ◽  
Mathew George
Keyword(s):  
Medicinal Plants ◽  
Cell Activity ◽  
Acorus Calamus ◽  
Herbal Drugs ◽  
Clinical Testing ◽  
Bacopa Monniera ◽  
Ficus Religiosa ◽  
Antiepileptic Agents

Medicinal plants are the oldest form of healthcare known to mankind. Antioxidants are considered to be important in fighting against the damages done by the free radicals produced due to oxidative stress. Antiepileptic drugs help to minimize or to irradiate the convulsive shocks and seizures as a result of abnormal and excessive nerve cell activity. Standardized, well established in vitro and in vivo methods are available for experimental evaluation of antioxidant and antiepileptic agents. A step wise procedure from in vitro and in vivo seems reasonable to reduce the large quantity of potential drugs to a few promising agents for further clinical testing. This review has focused on some herbal drugs with both antioxidant and antiepileptic property such as Brassica nigra, Bacopa monniera, Ficus religiosa, Convolvulus pluricalis, Jatamansi and Acorus calamus.

Exploring the potential effect of Methanolic extract of Salvia officinalis against UV exposed skin aging: In vivo and In vitro model

2019 ◽  
Vol 12 ◽  
Author(s):  
Ruchi Khare ◽  
Neeraj Upmanyu ◽  
Megha Jha
Keyword(s):  
Medicinal Plants ◽  
Inhibitory Concentration ◽  
Methanolic Extract ◽  
Treated Group ◽  
Salvia Officinalis ◽  
Antioxidant Potential ◽  
Meoh Extract ◽  
Soxhlet Apparatus

Context: The medicinal plants have enormous pharmacological properties and having fewer side effects. Today there is increasing demand of medicinal plants as an anti-aging and anti-wrinkle agent. Objective: The aim of this study is to evaluate antioxidant, anti-aging and anti-wrinkle potential of Salvia officinalis. Materials and Methods: Salvia officinalis (Lamiaceae) is folk medicine of Asia and Latin America. Powdered crude drug 100 g were successively extracted in a soxhlet apparatus with petroleum ether (60-80ºC), chloroform and methanol. After successive solvents extraction methanolic extract was used for testing of antioxidant potential using DPPH assay. Further, antiaging potential of extract was investigated by inhibitory effect of various enzymatic estimations i.e. Col-I, Ela-I and Hya-I inhibitory assays on early aging human skin fibroblasts. Antiwrinkle potential of plant Salvia officinalis was done by using UV light induced photo aging model. Results: Phytochemical analysis showed the presence of glycosides, alkaloids flavonoids, and triterpenoids, saponins and Phenolic compounds in high level. Extract showed inhibitory concentration (IC50:24.65) and ascorbic acid the standard antioxidant showed inhibitory concentration (IC50:20.10). In enzymatic estimations assay, the Col-I, Ela-I and Hya-I of extract were assessed showing inhibitory concentration as Col-I (IC50:21.36), Ela-I (IC50:35.05) and Hya-I (IC50:23.44) respectively. Thus, MeOH extract of Salvia officinalis able to inhibit 50% of the activity of aging related enzymes Col-I, Ela-I and Hya-I. The wrinkle score of negative control i.e. UV treated group was 2.83±0.408 and MeOH extract of Salvia officinalis treated group is 1.83 ±0.753. Conclusion: This study concluded that MeOH extract of Salvia officinalis has confirmed the high antioxidant potential and In vitro and In vivo inhibitory potential of antiaging enzymes assessed, thus they could be used for further development of cosmetic products and nutraceuticals.

scholarly journals Allelopathic Effect of Extracts of Medicinal Plants on Mungbean in Vivo Conditions

2016 ◽  
Vol 4 (1) ◽  
pp. 120-124
Author(s):  
Priyanka Gupta
Keyword(s):  
Medicinal Plants ◽  
Ocimum Sanctum ◽  
Calotropis Procera ◽  
Allelopathic Effect ◽  
Alcoholic Extract ◽  
Leaf Extracts ◽  
Alkaline Extract ◽  
Negative Effect ◽  
Positive Effect

The experiments were conducted at Chaudhary Sarwan Kumar Krishi Vishavidhyalaya,Palampur, Himachal Pradesh, India to see the allelopathic effect of medicinal leaf extracts of Ocimum sanctum L., Calotropis procera(Ait.) Ait.f and Astragalus tribuloides Delile on the plumule length of mungbean (Vigna radiata L. Wilczek) in vivo conditions. The results indicated that different extracts such as alcoholic,aqueous acidic and alkaline extract of Ocimum sanctum L., Calotropis procera(Ait.) Ait.f and Astragalus tribuloides Delile showed different plumule length of mungbean in vivo conditions. All the extracts of Ocimum sanctum L.showed no effect in comparison of control. The alcoholic extract of Calotropis procera(Ait.) Ait.f, produce considerably higher as compared to control followed by aqueous, acidic but alkaline extract showed negative effect on plumule length of mungbean. However, the alcoholic and alkaline extracts of Astragalus tribuloides Delile showed positive effect than aqueous acidic extract on the plumule of mungbean.

scholarly journals An Update on Oligosaccharides and Their Esters from Traditional Chinese Medicines: Chemical Structures and Biological Activities

2015 ◽  
Vol 2015 ◽  
pp. 1-23 ◽  
Author(s):  
Xiang-Yang Chen ◽  
Ru-Feng Wang ◽  
Bin Liu
Keyword(s):  
Medicinal Plants ◽  
Biological Activities ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Chemical Structures ◽  
Naturally Occurring ◽  
Prevention And Treatment ◽  
Chinese Medicinal Plants

A great number of naturally occurring oligosaccharides and oligosaccharide esters have been isolated from traditional Chinese medicinal plants, which are used widely in Asia and show prominent curative effects in the prevention and treatment of kinds of diseases. Numerousin vitroandin vivoexperiments have revealed that oligosaccharides and their esters exhibited various activities, including antioxidant, antidepressant, cytotoxic, antineoplastic, anti-inflammatory, neuroprotective, cerebral protective, antidiabetic, plant growth-regulatory, and immunopotentiating activities. This review summarizes the investigations on the distribution, chemical structures, and bioactivities of natural oligosaccharides and their esters from traditional Chinese medicines between 2003 and 2013.

scholarly journals Preliminary Phytochemical Appraisal of Selected Medicinal Plants

2021 ◽  
Vol 11 (2-S) ◽  
pp. 56-58
Author(s):  
E Mohan ◽  
S Suriya ◽  
S Shanmugam ◽  
CP Muthupandi ◽  
K Rajendran
Keyword(s):  
Chemical Constituents ◽  
Petroleum Ether Extract ◽  
Acetone Extract ◽  
Acorus Calamus ◽  
Ether Extract ◽  
Solanum Torvum ◽  
Plant Parts ◽  
Phytochemical Constituents ◽  
Pharmacologically Active ◽  
Senna Alata

Preliminary phytochemical tests played a significant role in finding and locating chemical constituents which are source of pharmacologically active principles. By consider the medicinal importance of tuber of Acorus calamus, flower of Senna alata and fruit of Solanum torvum, the present study was designed to screen the phytochemical constituents present in such plant parts preliminarily. The phytochemical analyses were conducted by employing standard methods to detect the presence/absence of alkaloids, carbohydrates, flavonoids, glycosides, phenols, phytosterols, proteins, saponins and tannins. The results of present study revealed that alkaloids were found to be present in all the three plants analyzed and all the three solvents extracted, whereas, glycosides and phenols were absent. The acetone extract of Acorus calamus and Solanum torvum showed the presence more number of phytochemicals (4 each) and petroleum ether extract of Senna alata and Solanum torvum revealed the presence of only one compound. The potential active principles of the detected compounds should be quantified and pharmacologically evaluated. Keywords: Preliminary phytochemical analyses, Acorus calamus tuber, Senna alata flower, Solanum torvum fruit.

scholarly journals Mass spectroscopic and phytochemical screening of phenolic compounds in the leaf extract of Senna alata (L.) Roxb. (Fabales: Fabaceae)

2016 ◽  
Vol 3 (5) ◽  
pp. 209 ◽  
Author(s):  
Solomon Oluwole Oladeji ◽  
Funmilayo Enitan Adelowo ◽  
Kehinde Abraham Odelade
Keyword(s):  
Antimicrobial Activity ◽  
Molecular Ions ◽  
Diffusion Method ◽  
Phytochemical Analysis ◽  
Bioactive Components ◽  
Leaf Extracts ◽  
Agar Disc ◽  
Soxhlet Apparatus ◽  
Ethanolic Extracts ◽  
Senna Alata

Senna alata (L.) Roxb. (Fabales: Fabaceae) is a medicinal plant basically used as antifungal and sometimes as antibacterial. Local people believe it is the amount of the plant consumed that constitutes to its potency, other believe it is the incantation thereby disregarding the bioactive components present in the leaf of S. alata. Therefore, there is a need to examine this claim by examining the bioactive components that are present in the plant. The methanolic and ethanolic extracts were obtained using soxhlet apparatus and the concentrated extracts were purified using column chromatography; the fractions were eluted and screened for their phytochemical and the mass spectroscopic analysis was performed using a mass spectrophotometer. The antimicrobial activity was carried out using agar disc diffusion method. The phytochemical analysis revealed the presence of important secondary metabolites such as anthraquinone, flavonoid and saponins while steroids was absent in the leaf extracts. The molecular ions of 250, 250, and 222 were obtained from the mass spectra. This showed the presence of methaqualone, cinnamic acid and isoquinoline. Ethanolic extracts showed a higher antimicrobial activity when compared with the methanolic extracts but less activity when compared with the standard used (amoxicillin). It could be concluded that the presence of these phytochemicals could be responsible for the observed antifungal and antibacterial activities on the susceptible organisms studied of the plant and also can be a natural source of antimicrobial substances of high importance.

scholarly journals Health Beneficial Effects and Chemical Profiles of Special Oolong Teas

2021 ◽  
Author(s):  
Narawadee Rujanapun ◽  
Wuttichai Jaidee ◽  
Thidarat Duangyod ◽  
Pravaree Phuneerub ◽  
Chakree Wattanasiri ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Biological Activities ◽  
Apium Graveolens ◽  
Flavonoid Glycosides ◽  
Dependent Manner ◽  
Tea Leaves ◽  
Pharmacological Activities ◽  
Solanum Torvum ◽  
Chemical Profiles

Abstract Background: Tea blended with medicinal plants usually consists of a mixture of active compounds that can increase the beneficial health effects. Eternity tea is dried tea leaves blended with ginger (Zingiber officinale), lemongrass (Cymbopogon citratus), and celery (Apium graveolens L.), and peaceful rest tea is dry tea leaves blended with Indian gooseberry (Phyllanthus emblica), Turkey berry (Solanum torvum Swartz), and wild betel leaf bush leaves (Piper sarmentosum Roxb.). These teas have been widely used for their ability to reduce blood sugar levels. However, there are no previous reports on their pharmacological activities. This work investigates the chemical profiles and pharmacological activities, especially the antidiabetes activity, of special oolong teas blended with local Thai medicinal plants (peaceful rest tea and eternity tea).Method: Eternity, Peaceful rest, and Oolong (Camellia sinensis) leaf samples were collected from Doi Chang organic tea plantation in Chiang Rai, Thailand. The chemical profiles of all tea samples were characterized by UHPLC-QTOF-MS. The extracts of these teas were investigated for their biological activities, including antioxidant, antiinflammatory, anticancer, and antidiabetic activities.Results: Catechins were found in eternity and oolong teas. Peaceful rest tea contained catechins/dimeric catechins, flavonoid glycosides, and alkaloids. Biological testing showed that peaceful rest and eternity tea extracts inhibited nitric oxide formation in a dose-dependent manner with IC50 values of 42.6 and 48.9 µg/mL, respectively. Peaceful rest tea extracts inhibited the growth of K562 human erythroleukemia cells. Furthermore, peaceful rest tea with both ethanol and water extracts demonstrated higher α-glucosidase inhibition activities than acarbose (IC50 = 75.71 µg/mL), with IC50 values of 10.6 and 1.22 µg/mL, respectively.Conclusions: Major antidiabetic compounds (5-O-Caffeoylquinic acid, kaempferol 3-O-glucosylrutinoside, and procyanidin B2) were found in peaceful rest tea. This finding corroborates that peaceful rest tea has greater antidiabetic effects than other teas against glucose and lipid levels. In vivo and clinical studies are therefore recommended to provide implications for the potential anti-diabetic properties of special oolong teas.

scholarly journals In Vivo Antimalarial Activity of Leaf Extracts and a Major Compound Isolated from Ranunculus multifidus Forsk

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6179
Author(s):  
Betelhem Sirak ◽  
Lea Mann ◽  
Adrian Richter ◽  
Kaleab Asres ◽  
Peter Imming
Keyword(s):  
Antimalarial Activity ◽  
Hydrolysis Product ◽  
Preparative Thin Layer Chromatography ◽  
Antimycobacterial Activity ◽  
Major Constituent ◽  
African Countries ◽  
Leaf Extracts ◽  
Chemical Structures

The leaves of Ranunculus multifidus Forsk. are traditionally used for the treatment of malaria in several African countries. In the present study, 80% methanol (RM-M) and hydrodistilled (RM-H) extracts of fresh leaves from R. multifidus and its major constituent anemonin were tested for their in vivo antimalarial activity against Plasmodium berghei in mice. Anemonin was also tested for its in vitro antimycobacterial activity against Mycobacterium smegmatis and M. abscessus in a microbroth dilution assay, and bacterial growth was analyzed by OD measurement. The isolation of anemonin from RM-H was carried out using preparative thin layer chromatography (PTLC). The chemical structures of anemonin and its hydrolysis product were elucidated using spectroscopic methods (HR–MS; 1D and 2D-NMR). Results of the study revealed that both RM-M and RM-H were active against P. berghei in mice, although the latter demonstrated superior activity (p < 0.001), as compared to the former. At a dose of 35.00 mg/kg/day, RM-H demonstrated a chemosuppression value of 70% in a 4-day suppressive test. In a 4-day suppressive, Rane’s and prophylactic antimalarial tests, anemonin showed median effective doses (ED50s) of 2.17, 2.78 and 2.70 μM, respectively. However, anemonin did not inhibit the growth of M. smegmatis and M. abscessus.

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