scholarly journals Health Beneficial Effects and Chemical Profiles of Special Oolong Teas

2021 ◽  
Author(s):  
Narawadee Rujanapun ◽  
Wuttichai Jaidee ◽  
Thidarat Duangyod ◽  
Pravaree Phuneerub ◽  
Chakree Wattanasiri ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Biological Activities ◽  
Apium Graveolens ◽  
Flavonoid Glycosides ◽  
Dependent Manner ◽  
Tea Leaves ◽  
Pharmacological Activities ◽  
Solanum Torvum ◽  
Chemical Profiles

Abstract Background: Tea blended with medicinal plants usually consists of a mixture of active compounds that can increase the beneficial health effects. Eternity tea is dried tea leaves blended with ginger (Zingiber officinale), lemongrass (Cymbopogon citratus), and celery (Apium graveolens L.), and peaceful rest tea is dry tea leaves blended with Indian gooseberry (Phyllanthus emblica), Turkey berry (Solanum torvum Swartz), and wild betel leaf bush leaves (Piper sarmentosum Roxb.). These teas have been widely used for their ability to reduce blood sugar levels. However, there are no previous reports on their pharmacological activities. This work investigates the chemical profiles and pharmacological activities, especially the antidiabetes activity, of special oolong teas blended with local Thai medicinal plants (peaceful rest tea and eternity tea).Method: Eternity, Peaceful rest, and Oolong (Camellia sinensis) leaf samples were collected from Doi Chang organic tea plantation in Chiang Rai, Thailand. The chemical profiles of all tea samples were characterized by UHPLC-QTOF-MS. The extracts of these teas were investigated for their biological activities, including antioxidant, antiinflammatory, anticancer, and antidiabetic activities.Results: Catechins were found in eternity and oolong teas. Peaceful rest tea contained catechins/dimeric catechins, flavonoid glycosides, and alkaloids. Biological testing showed that peaceful rest and eternity tea extracts inhibited nitric oxide formation in a dose-dependent manner with IC50 values of 42.6 and 48.9 µg/mL, respectively. Peaceful rest tea extracts inhibited the growth of K562 human erythroleukemia cells. Furthermore, peaceful rest tea with both ethanol and water extracts demonstrated higher α-glucosidase inhibition activities than acarbose (IC50 = 75.71 µg/mL), with IC50 values of 10.6 and 1.22 µg/mL, respectively.Conclusions: Major antidiabetic compounds (5-O-Caffeoylquinic acid, kaempferol 3-O-glucosylrutinoside, and procyanidin B2) were found in peaceful rest tea. This finding corroborates that peaceful rest tea has greater antidiabetic effects than other teas against glucose and lipid levels. In vivo and clinical studies are therefore recommended to provide implications for the potential anti-diabetic properties of special oolong teas.

Botany, Phytochemistry, Pharmacology and Toxicity of Strychnos nux-vomica L.: A Review

2018 ◽  
Vol 46 (01) ◽  
pp. 1-23 ◽  
Author(s):  
Rixin Guo ◽  
Ting Wang ◽  
Guohong Zhou ◽  
Mengying Xu ◽  
Xiankuo Yu ◽  
...  
Keyword(s):  
Biological Activities ◽  
Iridoid Glycosides ◽  
Animal Experiments ◽  
Flavonoid Glycosides ◽  
Antitumor Effects ◽  
Detoxification Mechanism ◽  
The Family ◽  
Pharmacology And Toxicology

Strychnos nux-vomica L. belongs to the genus Strychnos of the family Loganiaceae and grows in Sri Lanka, India and Australia. The traditional medicinal component is its seed, called Nux vomica. This study provides a relevant and comprehensive review of S. nux-vomica L., including its botany, ethnopharmacology, phytochemistry, pharmacology and toxicology, thus providing a foundation for future studies. Up to the present day, over 84 compounds, including alkaloids, iridoid glycosides, flavonoid glycosides, triterpenoids, steroids and organic acids, among others, have been isolated and identified from S. nux-vomica. These compounds possess an array of biological activities, including effects on the nervous system, analgesic and anti-inflammatory actions, antitumor effects, inhibition of the growth of pathogenic microorganisms and regulation of immune function. Furthermore, toxicity and detoxification methods are preliminarily discussed toward the end of this review. In further research on S. nux-vomica, bioactivity-guided isolation strategies should be emphasized. Its antitumor effects should be investigated further and in vivo animal experiments should be performed alongside in vitro testing. The pharmacological activity and toxicology of strychnine [Formula: see text]-oxide and brucine [Formula: see text]-oxide should be studied to explore the detoxification mechanism associated with processing more deeply.

scholarly journals Brine Shrimp Lethality Assay of the Aqueous and Ethanolic Extracts of the Selected Species of Medicinal Plants

Proceedings ◽  
2019 ◽  
Vol 41 (1) ◽  
pp. 47
Author(s):  
Sandeep Waghulde ◽  
Mohan K. Kale ◽  
VijayR. Patil
Keyword(s):  
Medicinal Plants ◽  
Brine Shrimp ◽  
Pharmacological Effects ◽  
Bioactive Components ◽  
Pharmacological Activities ◽  
Brine Shrimp Lethality ◽  
Brine Shrimp Lethality Assay ◽  
Ethanolic Extracts ◽  
Annona Reticulata

The present study was conducted to test for in vivo Brine Shrimp Lethality Assay (BSLA) of the Aqueous and ethanolic extracts of Annona reticulata with Allium fistolisum and Brassica oleraceaeand correlate cytotoxicity results with known pharmacological activities of the plants. Cytotoxicity was evaluated in terms of LC50 (lethality concentration). Ten nauplii were added into three replicates of each concentration of the plant extract. After 24 h the surviving brine shrimp larvae were counted and LC50 was assessed. Results showed that the extracts of Annona reticulata with Allium fistolisumand Brassica oleraceaewere potent against the brine shrimp when compared alone with combined extracts. It indicated that bioactive components are present in these plants that could be accounted for its pharmacological effects. Thus, the results support the uses of these plant species in traditional medicine.

scholarly journals The Multifunctional Effects of Nobiletin and Its MetabolitesIn VivoandIn Vitro

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Hao Huang ◽  
Linfu Li ◽  
Weimei Shi ◽  
Hai Liu ◽  
Jianqiong Yang ◽  
...  
Keyword(s):  
Biological Activities ◽  
Signaling Cascades ◽  
Pharmacological Effects ◽  
Pharmacological Activities ◽  
Promising Candidate ◽  
Beneficial Effects ◽  
Pharmaceutical Agent ◽  
Intracellular Targets ◽  
Anti Inflammation

Nobiletin (NOB) chemically known as 5,6,7,8,3′,4′-hexamethoxyflavone is a dietary polymethoxylated flavonoid found inCitrusfruits. Recent evidences show that NOB is a multifunctional pharmaceutical agent. The various pharmacological activities of NOB include neuroprotection, cardiovascular protection, antimetabolic disorder, anticancer, anti-inflammation, and antioxidation. These events may be underpinned by modulation of signaling cascades, including PKA/ERK/MEK/CREB, NF-κB, MAPK, Ca2+/CaMKII, PI3K/Akt1/2, HIF-1α, and TGFβsignaling pathways. The metabolites may exhibit stronger beneficial effects than NOB on diseases pathogenesis. The biological activities of NOB have been clarified on many systems. This review aims to discuss the pharmacological effects of NOB with specific mechanisms of actions. NOB may become a promising candidate for potential drug development. However, further investigations of NOB on specific intracellular targets and clinical trials are still needed, especially forin vivomedical applications.

Procoagulant and prothrombotic activation of human erythrocytes by phosphatidic acid

2010 ◽  
Vol 299 (2) ◽  
pp. H347-H355 ◽  
Author(s):  
Ji-Yoon Noh ◽  
Kyung-Min Lim ◽  
Ok-Nam Bae ◽  
Seung-Min Chung ◽  
Sang-Wook Lee ◽  
...  
Keyword(s):  
Phosphatidic Acid ◽  
Thrombus Formation ◽  
Biological Activities ◽  
Human Erythrocytes ◽  
Erythrocyte Aggregation ◽  
Dependent Manner ◽  
Disease States ◽  
Thrombosis Model ◽  
Intracellular Ca

Increased phosphatidic acid (PA) and phospholipase D (PLD) activity are frequently observed in various disease states including cancers, diabetes, sepsis, and thrombosis. Previously, PA has been regarded as just a precursor for lysophosphatidic acid (LPA) and diacylglycerol (DAG). However, increasing evidence has suggested independent biological activities of PA itself. In the present study, we demonstrated that PA can enhance thrombogenic activities in human erythrocytes through phosphatidylserine (PS) exposure in a Ca2+-dependent manner. In freshly isolated human erythrocytes, treatment of PA or PLD induced PS exposure. PA-induced PS exposure was not attenuated by inhibitors of phospholipase A2or phosphatidate phosphatase, which converts PA to LPA or DAG. An intracellular Ca2+increase and the resultant activation of Ca2+-dependent PKC-α appeared to underlie the PA-induced PS exposure through the activation of scramblase. A marginal decrease in flippase activity was also noted, contributing further to the maintenance of exposed PS on the outer membrane. PA-treated erythrocytes showed strong thrombogenic activities, as demonstrated by increased thrombin generation, endothelial cell adhesion, and erythrocyte aggregation. Importantly, these procoagulant activations by PA were confirmed in a rat in vivo venous thrombosis model, where PA significantly enhanced thrombus formation. In conclusion, these results suggest that PA can induce thrombogenic activities in erythrocytes through PS exposure, which can increase thrombus formation and ultimately contribute to the development of cardiovascular diseases.

scholarly journals Overview of Phytochemical Compounds and Pharmacological Activities of Ananas Comosus L. Merr

2020 ◽  
Vol 11 (3) ◽  
pp. 4760-4766
Author(s):  
Hartati R ◽  
Suarantika F ◽  
Fidrianny I
Keyword(s):  
Traditional Medicine ◽  
Biological Activities ◽  
Scientific Work ◽  
Ananas Comosus ◽  
Pharmacological Activities ◽  
Phytochemical Compounds ◽  
Anti Inflammatory ◽  
Vitro Analysis

Ananas comosus L. Merr, known as pineapple, belongs to the Bromeliaceae family. This plant has been used as traditional medicine and continues until now in conventional herbal medicine. The pineapple was distributed in some countries such as China, India, Indonesia, Malaysia, Thailand and originated from South America. This article delved the scientific work about Ananas comosus focussing their usage as traditional medicine, chemical compounds and biological activities. All of the pieces of information were obtained from the scientific literature such as Science Direct, Google Scholar, Scopus and PubMed. Based on the literature survey,different parts of pineapple (Ananas comosus) are used in traditional medicine, used asan anti-inflammatory agent,anti-oedema, digestive disorder, antimicrobial, vermicide, and purgative. Phytochemical compounds from A. comosus have been provided, including ascorbic acid, quercetin, flavones-3-ol, flavones, and ferulic acid. The crude extracts of A. comosus have many pharmacological activities such as anti-fungal, anti-inflammatory, antioxidant, antibacterial. This discovery becomes possible due to scientific isolation and in vivo or in vitro analysis of A.comosus.

scholarly journals Active status on phytochemistry and pharmacology of Pergularia daemia Forsk. (Trellis-vine): a review

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Devanesan Arul Ananth ◽  
Garlapati Deviram ◽  
Vijayaraghavan Mahalakshmi ◽  
V. Ratna Bharathi
Keyword(s):  
Medicinal Plants ◽  
Chronic Diseases ◽  
Molecular Mechanisms ◽  
Human Beings ◽  
Pharmacological Activities ◽  
Pubmed Central ◽  
Synthetic Drugs ◽  
Anti Cancer

Abstract Background Medicinal plants play a significant role in the progress of persuasive therapeutic agents. Earlier to the innovation of synthetic drugs, human beings completely relied on the plants for the treatment of various ailments. Natural product extracts, particularly those derived from different plant species, provided the main source of Siddha, Ayurveda and Folk medicines. P. daemia is a perennial climber, traditionally reported for the treatment in a variety of diseases. In present review, we focused on the present status of phytochemical and pharmacological activities P. daemia. Methodology With the support of electronic databases such as Science Direct, Google Scholar, Mendeley, Scirus and PubMed central. Traditional knowledge information collected by Indian taxonomical books, survey from local rural and tribal peoples. Pharmacological data’s obtained from scientific journals published from 2000 to 2020. Results P. daemia extract, contains several phytochemicals, especially rich in flavonoids. These secondary metabolites synthesized from P. daemia have been reported for the treatment of various chronic diseases. In recent years, P. daemia phytoconstituents set as a key role in natural drug development as it harbours many in vitro and in vivo pharmacological activities such as anti-inflammatory, anti-cancer, anti-fertility, anti-arthritic and antimicrobial etc., Conclusion P. daemia was the less studied plant compared to other medicinal plants. In this context more emphasis has to be laid on studies that discuss on the secondary metabolite activities and molecular mechanisms that work against various chronic diseases.

scholarly journals Phytosterols: Potential Metabolic Modulators in Neurodegenerative Diseases

2021 ◽  
Vol 22 (22) ◽  
pp. 12255
Author(s):  
Niti Sharma ◽  
Mario A. Tan ◽  
Seong Soo A. An
Keyword(s):  
Natural Products ◽  
Neurodegenerative Diseases ◽  
Plant Species ◽  
Biological Activities ◽  
Herbal Medicines ◽  
Pharmacological Activities ◽  
Isolated Structures ◽  
Biological And Pharmacological Activities

Phytosterols constitute a class of natural products that are an important component of diet and have vast applications in foods, cosmetics, and herbal medicines. With many and diverse isolated structures in nature, they exhibit a broad range of biological and pharmacological activities. Among over 200 types of phytosterols, stigmasterol and β-sitosterol were ubiquitous in many plant species, exhibiting important aspects of activities related to neurodegenerative diseases. Hence, this mini-review presented an overview of the reported studies on selected phytosterols related to neurodegenerative diseases. It covered the major phytosterols based on biosynthetic considerations, including other phytosterols with significant in vitro and in vivo biological activities.

scholarly journals Ethnopharmacological Survey of Medicinal Plants Used in the Management of HIV and AIDS-Related Conditions in Makete District, Southern Highlands of Tanzania

2020 ◽  
pp. 56-83
Author(s):  
Alphonce Ignace Marealle ◽  
Ester Innocent ◽  
Kerstin Andrae- Marobela ◽  
Michael Qwarse ◽  
Mainen Moshi
Keyword(s):  
Medicinal Plants ◽  
Plant Species ◽  
Chronic Wounds ◽  
Biological Activities ◽  
Hiv And Aids ◽  
Systematic Evaluation ◽  
Pharmacological Activities ◽  
Sexually Transmitted ◽  
Health Authorities ◽  
Hiv 1

Aims: Plants used in traditional medicine have contributed to the development of modern medicines, but in order to boost the discovery of novel drugs to fight diseases such as HIV/AIDS and emerging new diseases, systematic evaluation of many more plants needs to continue. The aim of the present study was to document medicinal plants used in the management of HIV and AIDS-related conditions in Makete District, Tanzania. Study Design:  This was qualitative ethnopharmacological survey. Place and Duration of Study: Makete District in Njombe Region, Tanzania between March and April 2019. Methodology: This ethnopharmacological survey was conducted using a semi-structured questionnaire. The study focused only on traditional health practitioners (THP) registered by government health authorities in Makete District. The HIV and AIDS-related conditions considered in this study were tuberculosis, Herpes zoster, candidiasis, sexually transmitted infections, cough, skin rashes, frequent fevers, chronic diarrhea, chronic wounds, warts, oral thrush and weight loss. Literature survey was carried out to evaluate strength of the THP claims based on similar ethnopharmacological claims and proven pharmacological activities of the plants. Results: Among the ten THP interviewed seven were male and three were female. The average age and years of practice were 57.5 and 26.5 years, respectively. Thirty-seven plant species representing 36 genera and 27 families were reported to be used for the treatment of different HIV and AIDS-related conditions. Twelve (32.4 %) and 15 (40.5 %) species did not have previously reported ethnopharmacological and pharmacological activities, respectively. Among the 37 plant species identified 13 species (35%) have been previously reported for similar ethnopharmacological uses and 12 (32%) species had literature reports on respective biological activities. Nine species have reported antiviral activity and seven of them displayed specific activities against HIV-1. Conclusion: A significant number of medicinal plants identified in this study are reported here for the first time in relation to their use for HIV and AIDS-related conditions. The study also provides information that correlates well with previously published ethnopharmacological information or laboratory results of tests against HIV-1 or related conditions, thus justifying the need for screening and detailed studies intended to isolate and characterize compounds active against HIV and related conditions.

scholarly journals Phytochemical Constituents, Biological Activities, and Health-Promoting Effects of the Melissa officinalis

2021 ◽  
Vol 2021 ◽  
pp. 1-20
Author(s):  
Javad Sharifi-Rad ◽  
Cristina Quispe ◽  
Jesús Herrera-Bravo ◽  
Muhammad Akram ◽  
Wafa Abbaass ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Quantitative Research ◽  
Biological Activities ◽  
Phenolic Antioxidants ◽  
Special Focus ◽  
Melissa Officinalis ◽  
Beneficial Effects ◽  
Health Promoting

Medicinal plants are being used worldwide for centuries for their beneficial properties. Some of the most popular medicinal plants belong to the Melissa genus, and different health beneficial effects have already been identified for this genus. Among these species, in particular, the Melissa officinalis L. has been reported as having many biological activities, such as antioxidant, antimicrobial, antitumour, antiviral, antiallergic, anti-inflammatory, and also flatulence inhibiting effects. The beneficial properties of the Melissa officinalis, also known as “lemon balm herb”, can be related to the bioactive compounds such as terpenoids, alcohols, rosmarinic acid, and phenolic antioxidants which are present in the plant. In this updated review, the botanical, geographical, nutritional, phytochemical, and traditional medical aspects of M. officinalis have been considered as well as in vitro and in vivo and clinically proven therapeutic properties have been reviewed with a special focus on health-promoting effects and possible perspective nutraceutical applications. To evidence the relevance of this plant in the research and completely assess the context, a literature quantitative research analysis has been performed indicating the great interest towards this plant for its beneficial properties.

scholarly journals URARIA PICTA (JACQ.): A REVIEW ON ETHNOMEDICAL USES, PHYTOCHEMISTRY, AND BIOLOGICAL ACTIVITIES

2021 ◽  
pp. 40-44
Author(s):  
JAYKUMAR MANE ◽  
DHEERAJ NAGORE ◽  
SOHAN CHITLANGE
Keyword(s):  
Biological Activities ◽  
Future Research ◽  
Phytochemical Analysis ◽  
Pharmacological Activities ◽  
Technological Potential ◽  
Depth Study ◽  
Toxicological Research ◽  
Commercial Research

The aim of this systematic review is to provide an in-depth study of ethnological uses, phyto-chemistry, pharmacological activities, and toxicological research in Uraria picta (Jacq.), to identify remaining gaps, and to provide a basis for future research. By searching for the words “U. picta” and “Prishnaparni” in electronic databases such as SciFinder, Web of Science, PubMed, and Google Scholar, information on common uses, phytochemistry, and pharmacological activities was systematically collected. Phytochemical analysis of U. picta shows various components such as alkaloids, flavonoids, steroids, terpenoids, phenols, and saponins. The extracts and their isolated components showed numerous in vitro and in vivo pharmacological effects, including urinary tract diseases, tumors, edema, smoking, and dyspnea. On the other hand, searches of patent databases found almost seven applications, highlighting the differences between a large number of published scientific articles and non-existent patent applications. This event demonstrates the technological potential of undiscovered species. Ethnographic research shows that U. picta, an important Asian medicinal plant, is used to treat many diseases. In this review, the ethnobotanical, phytochemical, pharmacological, and ethnological properties of various morphological parts of the U. picta plant are highlighted. Future research has provided information for commercial research and has shown that this herb has tremendous potential for pharmaceutical and nutritional applications.

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