scholarly journals A SUCCESSFUL CLINICAL STUDY ON MANAGEMENT OF HERPES ZOSTER (VISARPA) THROUGH COMBINATION THERAPY

2021 ◽  
Vol 10 (3) ◽  
pp. 3043-3045
Author(s):  
S Wairagade
Keyword(s):  
Herpes Zoster ◽  
Combination Therapy ◽  
Cost Effective ◽  
Brief Pain Inventory ◽  
Research Centre ◽  
Future Research ◽  
Complete Relief ◽  
College Hospital ◽  
Varicella Zoster ◽  
Delayed Treatment

Herpes zoster infection is a painful worldwide disease. The inappropriate and delayed treatment causes prolongation of the disease with debilitating symptoms and postherpetic neuralgia. Herpes zoster is commonly known as shingle's caused by varicella zoster virus (VZV). Current studies have shown that exosomes play a significant role in pathogenesis as well as the spread of herpes. Combination therapy has shown pain reduction, reduction in burning, and arrest progression of the disease. This technique is cost effective and easy to apply. In Ayurveda herpes can be correlated with Pittaj visarpa. Principle of treatment is Raktmokshan (Bloodletting) and Pradeha (Local application of medicines). A 50-year-old male presented in OPD of Kayachikitsa at Datta Meghe Ayurved Medical College Hospital and Research Centre. We treated his Herpes zoster on the basic principles of management of Vata-Pittaj Visarpa. A rapid decrease in pain severity was observed after 7 days of Combination Therapy according to Zoster Specific Brief Pain Inventory (ZBPI) Questionnaire. Lesions of Herpes Zoster were found completely crusted and healed within 2 weeks. Repeated application of Ayurvedic Formulation Lepa along with internal medications gave complete relief. Adaptive trials are necessary to discover further practical applicability of Ayurveda and modern treatment together. Future research on the effect of combination therapy on exosomes is necessary.

Evidence-Based Homoeopathic Treatment of Acute Herpes Zoster (Shingles): A Case Report

2021 ◽  
Vol 34 (04) ◽  
pp. 307-310
Author(s):  
Yogeshwari Gupta ◽  
Khushbu Pandey
Keyword(s):  
Herpes Zoster ◽  
Causal Attribution ◽  
Complete Recovery ◽  
Future Research ◽  
Evidence Based ◽  
Acute Case ◽  
Varicella Zoster ◽  
Time Period ◽  
Short Time ◽  
Positive Results

AbstractHerpes zoster (HZ), also known as shingles, occurs due to reactivation of varicella zoster. It is manifested by unilateral, painful, vesicular rashes following a dermatome. Homoeopathy is well known for its tremendous results in chronic cases. This article presents the evidence-based significant result of single homoeopathic remedy in an acute case of HZ within a short time period without any post-herpetic neuralgia which usually follows the HZ for months. Three to four doses of Hypericum 30 CH provided significant relief within a day and complete recovery within 10 days. Modified Naranjo score is 9, indicating definite causal attribution. This case proves that by selecting appropriate similimum, promising and positive results are achieved by homoeopathy, be it acute or chronic cases in a safe and gentle way. No such existing homoeopathic literature provides any characteristic information particularly related to HZ in Hypericum. So, future research and clinical trials could be beneficial for better validation of Hypericum as a therapeutic for HZ.

scholarly journals Study on Morphological and Clinical Characteristics of Herpes Zoster In A Tertiary Medical College Hospital

2012 ◽  
Vol 22 (2) ◽  
pp. 80-82
Author(s):  
Md. Rokon Uddin ◽  
Md. Motahar Hossain Bhuyain ◽  
Farzana Akhter
Keyword(s):  
Socioeconomic Status ◽  
Herpes Zoster ◽  
Large Scale ◽  
Ganglion Cells ◽  
Sensory Nerve ◽  
College Hospital ◽  
Female Ratio ◽  
Varicella Zoster ◽  
Medical College ◽  
Medicine Today

Herpes zoster is caused by reactivation of VZV (varicella zoster virus) following primary infection or vaccination. VZV remains latent in sensory dorsal root ganglion cells. The virus begins to replicate in some later time, traveling down the sensory nerve into the skin. Forty one cases (3 children and 38 adults) of Herpes Zoster were assessed over a period of three and half years. Structured questionnaire, check-list and face-to-face interview were used as tools of data collection. The prevalence of herpes zoster amongst Skin & Eye OPD cases were found 0.60 percent. Maximum cases (23; 63.41%) were above 45 years of age. The male female ratio was 1.4:1.0. By socioeconomic status maximum patient from middle class (13; 31.70%), followed by poor (12; 26.26%) and very poor (11; 26.82%). Prodromal syndrome in maximum cases was paresthesia (13; 31.70%) and pain (11; 26.82%). Cases were mostly presented with pain (35; 85.36%). Twenty-three cases had classic herpes zoster followed by necrotic or ulcerated herpes zoster (16 cases) and hemorrhagic herpes zoster (2 case). Trigeminal dermatome was the most common involvement in 18 cases (43.9%) followed by thoracic dermatome 16 cases (39.02%). Unidermatomal involvement was seen in 97.56% cases (40) followed by multidermatomal 1 case (2.43%). Nine cases were screened for HIV-1 by ELISA, but none was detected as seropositive. . The analysis and findings put this recommendation that large scale study needed to examine the correlation ship between VZV infection and socioeconomic status of patients. Medicine Today 2010 Volume 22 Number 02 Page 80-82 DOI: http://dx.doi.org/10.3329/medtoday.v22i2.12439

scholarly journals An analytical study on clinical patterns of herpes zoster in this era

2019 ◽  
Vol 5 (3) ◽  
pp. 641
Author(s):  
Ravichandran Velappan ◽  
Sindhuja Ramasamy ◽  
Kamalanathan Nallu ◽  
Arulraja Ganapathi
Keyword(s):  
Herpes Zoster ◽  
Age Groups ◽  
Cell Mediated Immunity ◽  
Age Group ◽  
Post Herpetic Neuralgia ◽  
Herpes Zoster Ophthalmicus ◽  
College Hospital ◽  
Varicella Zoster ◽  
Medical College ◽  
History Of

<p class="abstract"><strong>Background:</strong> Herpes zoster is a major health burden in all age groups. It is caused by reactivation of varicella zoster virus from dormant form. The immunity that plays a role in this reactivation is cell mediated immunity. Prodromal features like Fever, pain and itch are common before the onset of zoster rash. The most common complication associated with this disease is post-herpetic neuralgia. Complications associated with herpes zoster depend on the age, immune status, and the time of initializing treatment. Treatment with antiviral drugs within 72 hours of onset of rash onset has been shown to reduce severity and complications associated with zoster and the post-herpetic neuralgia.</p><p class="abstract"><strong>Methods:</strong> We analysed 120 cases of herpes zoster patients who attended Dermatology OPD, in Chengalpattu Medical College Hospital from January 2018 to December 2018. The study design was descriptive study. A detailed history taking, thorough clinical examination and appropriate relevant investigations were done.<strong></strong></p><p class="abstract"><strong>Results:</strong> The mean age group of the 120 patients (male-56, female-64) was 35 years. Segmental distribution: Thoracic-60%, cervical-6%, lumbosacral-2%, herpes zoster ophthalmicus-22%, herpes zoster oticus-10%. 34% were diabetic, 2% HIV, 4% following surgery/trauma, 10% on steroid therapy. 13% had history of native treatment. Prodromal symptoms in 34%, post herpetic neuralgia-60%, sepsis in 52%.</p><p class="abstract"><strong>Conclusions:</strong> Herpes zoster occurs in dermatomes in which the rash of varicella achieves highest intensity. Herpes zoster can affect any age group with a higher incidence in elderly patients and in those with immuno-compromised status, treatment with antivirals within 72 hours of onset of rash has shown a reduction in severity and complications.</p>

scholarly journals Management and Prevention of Herpes Zoster: A Canadian Perspective

2010 ◽  
Vol 21 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Guy Boivin ◽  
Roman Jovey ◽  
Catherine T Elliott ◽  
David M Patrick
Keyword(s):  
Herpes Zoster ◽  
Burden Of Illness ◽  
Cost Effective ◽  
Virus Reactivation ◽  
Zoster Vaccine ◽  
Varicella Zoster ◽  
Canadian Context ◽  
Canadian Perspective ◽  
Herpes Zoster Incidence ◽  
Main Complication

Varicella-zoster virus reactivation leads to herpes zoster – the main complication of which is postherpetic neuralgia (PHN). Rapid antiviral therapy initiated within 72 h of rash onset has been shown to accelerate rash healing, reduce the duration of acute pain and, to some extent, attenuate the development and duration of PHN. Other adjunctive therapies such as analgesics, antidepressants and some anticonvulsants are frequently required in the management of severe PHN. A live, attenuated zoster vaccine has been recently shown to significantly decrease herpes zoster incidence, PHN and the overall burden of illness when administered to adults older than 60 years of age. This new prophylactic modality has been reported to be cost-effective in the Canadian context, especially in the 60- to 75-year-old age group.

scholarly journals Evaluation of effectiveness of rupatadine and olopatadine in patients of allergic rhinitis at Indore: a randomized control trial

2017 ◽  
Vol 6 (7) ◽  
pp. 1753
Author(s):  
Jay Shah ◽  
Poonam Patel
Keyword(s):  
Allergic Rhinitis ◽  
Cost Effective ◽  
Nasal Symptom ◽  
Research Centre ◽  
Differential Count ◽  
Double Blind ◽  
College Hospital ◽  
Treatment Groups ◽  
Medical College ◽  
Parallel Group

Background: Allergic rhinitis (AR) is one of the most prevalent atopic disorders that affect productivity and quality of life. Although individually olopatadine and rupatadine are efficacious in AR, data on the head to head study of these drugs in Indian population are scanty, so present study was undertaken with an aim to compare the efficacy, safety, and cost effectiveness of rupatadine and olopatadine in patients’ of allergic rhinitis.Methods: A prospective, randomized, double blind, parallel group, comparative 2 weeks clinical study conducted in eighty patients of AR in the Department of Pharmacology, Index Medical College Hospital and Research Centre, Indore. Following inclusion and exclusion criteria, 67 patients were recruited and randomized to two treatment groups and received the respective drugs for 2 weeks. At follow-up, parameters assessed were total nasal symptom score (TNSS), change in total and differential count of eosinophil.Results: In olopatadine group, there was a significantly higher reduction in TNSS (P < 0.05) than that of rupatadine. Both the drugs significantly reduced the absolute eosinophil count, but olopatadine (P <0.001) was found to be superior. The incidence of adverse effects was found to be less in olopatadine group when compared with rupatadine group.Conclusions: Both rupatadine and olopatadine provide effective relief of the symptoms of AR. However, clinical benefit occurs significantly more with olopatadine. However, rupatadine was more cost‑effective than olopatadine in treating the patients of AR in term of effectiveness.

scholarly journals Varicella-Zoster Virus-Specific Enzyme-Linked Immunospot Assay Responses and Zoster-Associated Pain in Herpes Zoster Subjects

2012 ◽  
Vol 19 (9) ◽  
pp. 1411-1415 ◽  
Author(s):  
Stephen K. Tyring ◽  
Jon E. Stek ◽  
Jeffrey G. Smith ◽  
Jin Xu ◽  
Marco Pagnoni ◽  
...  
Keyword(s):  
Herpes Zoster ◽  
Varicella Zoster Virus ◽  
Pain Score ◽  
Geometric Mean ◽  
Age Groups ◽  
Brief Pain Inventory ◽  
Cell Mediated Immunity ◽  
Specific Cell ◽  
Varicella Zoster ◽  
Ifn Γ

ABSTRACTVaricella-zoster virus (VZV)-specific cell-mediated immunity (CMI) responses were compared over time following an episode of herpes zoster (HZ) with those of age-, race-, and gender-matched healthy controls (HC) without HZ, using a validated gamma interferon (IFN-γ) enzyme-linked immunospot (ELISPOT) assay. The zoster brief-pain inventory (ZBPI) was used to assess zoster-associated pain. HZ patients (n= 140) had significantly higher IFN-γ ELISPOT responses to VZV antigen than did HC (n= 140). ELISPOT geometric mean count (GMC) responses (with 95% confidence intervals [CI]) for subjects who presented within 72 h were as follows: for HZ patients ≥ 60 years of age, at day 0 the GMC was 110 and at week 2 the GMC was 235; for HZ patients 21 to 59 years of age, at day 0 the GMC was 111 and at week 2 the GMC was 198; for HC ≥ 60 years of age, at day 0 the GMC was 19 and at week 2 the GMC was 18; and for HC 21 to 59 years of age, at day 0 the GMC was 59 and at week 2 the GMC was 56. The mean pain score (95% CI) across age groups at 1 week postrash (n= 106) was 6.0 (5.5, 6.5) and at 2 weeks postrash (n= 119) was 3.5 (2.9, 4.0). The percentage of HZ patients with substantial pain (score ≥ 3) at 6 weeks postrash increased with age from 8% for patients 21 to 49 years of age to 16% for patients 50 to 59 years of age to 22% for patients ≥ 60 years of age. The VZV-specific CMI response was substantially boosted by an episode of HZ, as measured by ELISPOT results. Older adults had lower VZV-specific cellular immunity than younger subjects at baseline, but the boosting effect of HZ was substantial for all age groups. HZ patients experienced considerable zoster-associated acute (1 to 2 weeks after rash) pain across age groups, while chronic pain increased with age.

Physical and Psychological Benefits of Written Emotional Expression

2015 ◽  
Vol 20 (4) ◽  
pp. 242-251 ◽  
Author(s):  
Éva Kállay
Keyword(s):  
Mental Health ◽  
Expressive Writing ◽  
Mental Health Problems ◽  
Cost Effective ◽  
Health Problems ◽  
Future Research ◽  
Psychological Benefits ◽  
Cost Effective Treatment ◽  
Meta Analyses

Abstract. The last several decades have witnessed a substantial increase in the number of individuals suffering from both diagnosable and subsyndromal mental health problems. Consequently, the development of cost-effective treatment methods, accessible to large populations suffering from different forms of mental health problems, became imperative. A very promising intervention is the method of expressive writing (EW), which may be used in both clinically diagnosable cases and subthreshold symptomatology. This method, in which people express their feelings and thoughts related to stressful situations in writing, has been found to improve participants’ long-term psychological, physiological, behavioral, and social functioning. Based on a thorough analysis and synthesis of the published literature (also including most recent meta-analyses), the present paper presents the expressive writing method, its short- and long-term, intra-and interpersonal effects, different situations and conditions in which it has been proven to be effective, the most important mechanisms implied in the process of recovery, advantages, disadvantages, and possible pitfalls of the method, as well as variants of the original technique and future research directions.

SIGNIFICANCE OF PLACENTAL HISTOPATHOLOGICAL FINDINGS IN PRETERM/TERM BIRTH

2020 ◽  
Vol 4 (5) ◽  
Author(s):  
Monika Kushwaha ◽  
Sanjeev Narang
Keyword(s):  
Preterm Birth ◽  
Comparative Study ◽  
Pregnancy Outcome ◽  
Neonatal Morbidity ◽  
Research Centre ◽  
College Hospital ◽  
Cross Sectional ◽  
Chorionic Villi ◽  
Term Birth ◽  
Medical College

Background: This study is cross-sectional, observational and comparative study, at Index Medical College, Hospital & Research Centre, Indore, Madhya Pradesh from July 2017 to July 2019 with sample size 100 placentae. Method: The placenta received was evaluated blinded of maternal pregnancy outcome. The pattern of morphology was evaluated both qualitatively (type of lesion) and quantitatively (number of lesions). Result: In Present study 79% of the deliveries were term deliveries and 21% were preterm deliveries. On placental macroscopy, placenta weight was significantly low among the neonates of preterm deliveries (370.00±60.49) as compared to term deliveries (440.89±55.22). Preterm placenta had higher number of abnormal placental lesion compared to term pregnancies. Conclusion: The uteroplacental insufficiency defined as placental infarct, fibrosis of chorionic villi, thickening of blood vessels, and poor vascularity of chorionic villi. Placental histopathological lesions are strongly associated with maternal under perfusion and uteroplacental insufficiency. These are the reasons for preterm birth. Thus, knowledge of the etiological factor can be use to reduce maternal and neonatal morbidity and mortility. Keywords: Placenta, Term & Preterm.

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