Study on Morphological and Clinical Characteristics of Herpes Zoster In A Tertiary Medical College Hospital

Herpes zoster is caused by reactivation of VZV (varicella zoster virus) following primary infection or vaccination. VZV remains latent in sensory dorsal root ganglion cells. The virus begins to replicate in some later time, traveling down the sensory nerve into the skin. Forty one cases (3 children and 38 adults) of Herpes Zoster were assessed over a period of three and half years. Structured questionnaire, check-list and face-to-face interview were used as tools of data collection. The prevalence of herpes zoster amongst Skin & Eye OPD cases were found 0.60 percent. Maximum cases (23; 63.41%) were above 45 years of age. The male female ratio was 1.4:1.0. By socioeconomic status maximum patient from middle class (13; 31.70%), followed by poor (12; 26.26%) and very poor (11; 26.82%). Prodromal syndrome in maximum cases was paresthesia (13; 31.70%) and pain (11; 26.82%). Cases were mostly presented with pain (35; 85.36%). Twenty-three cases had classic herpes zoster followed by necrotic or ulcerated herpes zoster (16 cases) and hemorrhagic herpes zoster (2 case). Trigeminal dermatome was the most common involvement in 18 cases (43.9%) followed by thoracic dermatome 16 cases (39.02%). Unidermatomal involvement was seen in 97.56% cases (40) followed by multidermatomal 1 case (2.43%). Nine cases were screened for HIV-1 by ELISA, but none was detected as seropositive. . The analysis and findings put this recommendation that large scale study needed to examine the correlation ship between VZV infection and socioeconomic status of patients. Medicine Today 2010 Volume 22 Number 02 Page 80-82 DOI: http://dx.doi.org/10.3329/medtoday.v22i2.12439

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Intranasal Splint in Nasal Septal Surgery: Is It Necessary?

Medicine Today ◽

10.3329/medtoday.v32i2.48835 ◽

2020 ◽

Vol 32 (2) ◽

pp. 126-129

Author(s):

Jahangir Alam Mazumder ◽

Md Golam Mustafa ◽

AHM Delwar ◽

Shazibur Rashid ◽

Md Mostafizur Rahaman ◽

...

Keyword(s):

Complete Healing ◽

College Hospital ◽

Female Ratio ◽

Medical College ◽

Septal Surgery ◽

Significant Difference ◽

Group A ◽

Medicine Today ◽

Group B ◽

Male To Female

Introduction: After SMR/septoplasty with or without turbinate surgery, it needs to keep apart the septum and turbinates upto their complete healing otherwise there is a chance of adhesion (synechia) formation. To prevent this there are variousprocedures. To place an intranasal splint in one or both sides of the septum is one of them. Nowadays there raised thequestion of whether the splinting is necessary or not. There is no significant difference in result with or without anintranasal splint. Weighing against the co-morbidities the routine use of an intranasal splint can no longer be justified. Materials and Methods: This is a randomized control study of 200 patients of SMR/septoplasty, done for nasal septaldeviation causing symptoms in Cumilla Medical College Hospital in the period of January 2016 to December 2019. Theywere equally divided into two groups, group-A were operated placing an intranasal splint and group-B with no intranasalsplint. They were followed up for 6 weeks to detect any synechia and co-morbidities. Result: The age of our patients wasranged from 13-49 years with a mean age of 22.45 years. The male to female ratio is 1.78:1. Synechia was found in 4% ofthe splinted group and 6 of the nonsplinted groups. Co-morbidities were detected more in the splinted group than that ofnon-splinted. In INS group these were found as follows: pain in the nose, face and head (26%), faint during removal ofnasal splint (6%), nasal obstruction (38%), the anxiety of splint removal in the postoperative period (35%) and vestibulitisdue to persistent irritation by a splint (17%). Conclusion: There is little significant advantage of using intranasal splintroutinely in septal surgery to prevent synechia formation. Medicine Today 2020 Vol.32(2): 126-129

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A study on clinical characteristics of herpes zoster in a tertiary care center

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20170081 ◽

2017 ◽

Vol 3 (1) ◽

pp. 79

Author(s):

Rachana R. ◽

Shivaswamy K. N. ◽

Anuradha H. V.

Keyword(s):

Herpes Zoster ◽

Clinical Characteristics ◽

Care Center ◽

Tertiary Care ◽

Age Groups ◽

Age Group ◽

Female Ratio ◽

Varicella Zoster ◽

Medical College ◽

Male To Female

Background: Herpes zoster (HZ), also known as shingles, derived from the Latin word Cingulum, for “girdle”. This is because a common presentation of HZ involves a unilateral rash that can wrap around the waist or torso like a girdle. HZ results due to reactivation of an earlier latent infection with the varicella zoster virus (VZV) in dorsal root ganglia. It occurs at all age groups, common over 60 years of age. It is estimated that in non-immune populations, approximately 15 cases per 1000 people occur per year. The objective of the study was to study the clinical characteristics in patients with uncomplicated herpes zoster.Methods: A total of 72 patients attending dermatology OPD at Ramaiah medical college between June 2013 to September 2014 were recruited after obtaining informed consent. A detailed history regarding onset of rash, pain, progression, duration and distribution of the lesions were recorded. Demographic information including age, sex, and any other co morbidities noted. Tzanck smear and serology for HIV was done where-ever necessary.Results: Of the 72 patients, females outnumbered males [M=35(48.61%), F=37 (51.39%)] with male to female ratio of 0.9 to 1. The mean age of presentation was 58±18 years. Majority of the patients (54%) were in the age group of 51 to 70 years followed by 31-50 years (25%). Least number of cases (9%) was in the age group of 21 to 30 years. Of the 72 subjects, thoracic involvement was noted in 30.6%, followed by lumbar (22%), and trigeminal (16%). Cervical (4%) and sacral (2%) involvement was the least. Conclusions: Herpes zoster commonly occurs in old age and the presenting symptom being pain and burning sensation. Thoracic dermatome is the commonest site. Immunocompromised states like diabetes, malignancy and HIV can increase the risk of developing herpes zoster.

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An analytical study on clinical patterns of herpes zoster in this era

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20192071 ◽

2019 ◽

Vol 5 (3) ◽

pp. 641

Author(s):

Ravichandran Velappan ◽

Sindhuja Ramasamy ◽

Kamalanathan Nallu ◽

Arulraja Ganapathi

Keyword(s):

Herpes Zoster ◽

Age Groups ◽

Cell Mediated Immunity ◽

Age Group ◽

Post Herpetic Neuralgia ◽

Herpes Zoster Ophthalmicus ◽

College Hospital ◽

Varicella Zoster ◽

Medical College ◽

History Of

Background: Herpes zoster is a major health burden in all age groups. It is caused by reactivation of varicella zoster virus from dormant form. The immunity that plays a role in this reactivation is cell mediated immunity. Prodromal features like Fever, pain and itch are common before the onset of zoster rash. The most common complication associated with this disease is post-herpetic neuralgia. Complications associated with herpes zoster depend on the age, immune status, and the time of initializing treatment. Treatment with antiviral drugs within 72 hours of onset of rash onset has been shown to reduce severity and complications associated with zoster and the post-herpetic neuralgia.Methods: We analysed 120 cases of herpes zoster patients who attended Dermatology OPD, in Chengalpattu Medical College Hospital from January 2018 to December 2018. The study design was descriptive study. A detailed history taking, thorough clinical examination and appropriate relevant investigations were done.Results: The mean age group of the 120 patients (male-56, female-64) was 35 years. Segmental distribution: Thoracic-60%, cervical-6%, lumbosacral-2%, herpes zoster ophthalmicus-22%, herpes zoster oticus-10%. 34% were diabetic, 2% HIV, 4% following surgery/trauma, 10% on steroid therapy. 13% had history of native treatment. Prodromal symptoms in 34%, post herpetic neuralgia-60%, sepsis in 52%.Conclusions: Herpes zoster occurs in dermatomes in which the rash of varicella achieves highest intensity. Herpes zoster can affect any age group with a higher incidence in elderly patients and in those with immuno-compromised status, treatment with antivirals within 72 hours of onset of rash has shown a reduction in severity and complications.

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Study on Diagnostic Evaluation of Pancytopenic Patients

Medicine Today ◽

10.3329/medtoday.v32i1.44834 ◽

2020 ◽

Vol 32 (1) ◽

pp. 58-61

Author(s):

Md Rezaul Karim Chowdhury ◽

Md Haroon Ur Rashid ◽

Amina Begum ◽

Shamimur Rahman ◽

Md Momenuzzaman Khan

Keyword(s):

Bone Marrow ◽

Bone Marrow Aspiration ◽

Clinical Findings ◽

Medical College Hospital ◽

College Hospital ◽

Female Ratio ◽

Medical College ◽

Presenting Symptoms ◽

Erythroid Hyperplasia ◽

Medicine Today

Introduction: Pancytopenia is a common hematological problem with an extensive differential diagnosis and is a challenging problem to the treating physician. Bone marrow aspiration and biopsy is an important diagnostic test for patient management. The objective of this study is to find out the incidence various causes of pancytopenia in patients attending to the Enam medical college hospital in savar. Materials and Methods: This prospective observational study was done in the department of haematology, Enam Medical College Hospital (EMCH) from July 2012 to June 2019. Results: In our study out of 66 patients, 36 (54.55%) were male, 30 (45.45%) were female and male to female ratio were 1.2:1.Generalized weakness 47 (71.21%) and fever 23 (34.85%) were the most common presenting symptoms followed by bleeding 17 (25.76%), weight loss 6 (12.12%), bodyache 6 (9.09%). Most common clinical findings were anemia 57 (86.36%) and bone tenderness 22 (33.33%). Other physical findings were purpura/brusing 13 (19.70%), splenomegaly 10 (15.15%), lymphadenopathy 4 (6.06%) and hepatomegaly 3 (4.55%). Hematological malignancy 29 (43.94%) and hypoplastic marrow 26 (39.39%) were the most common bone marrow finding of pancytopenic patients followed by megaloblastic anaemia 4 (6.06%), leishmaniasias 5 (7.58), and erythroid hyperplasia 2 (3.03%). Acute myeloid leukaemia was the common haematological malignancy 16 (24.24%), others were acute lymphoblastic leukaemia 5 (7.58%). Myelodysplastic syndrome 3 (4.55%), multiple myeloma 4 (6.06%), chronic myelogenous leukaemia in blastic crisis 1 (1.52%). Conclusion: So we concluded that complete workup is essential for all cases of pancytopenia to find out the treatable cases and to reduce the motality and morbidity in serious diseases. Medicine Today 2020 Vol.32(1): 58-61

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Epidemiological & Clinical Manifestation of Cirrhosis of Liver in a Tertiary Hospital

Medicine Today ◽

10.3329/medtoday.v32i2.48822 ◽

2020 ◽

Vol 32 (2) ◽

pp. 100-103

Author(s):

SK Moazzem Hossain ◽

Farjana Kabir ◽

SM Kamal ◽

Utpal Chandra Chanda ◽

Pritish Tarafder

Keyword(s):

Tertiary Hospital ◽

Medical Problem ◽

Common Symptom ◽

College Hospital ◽

Abdominal Ultrasonography ◽

Female Ratio ◽

Medical College ◽

Cirrhosis Of Liver ◽

Medicine Today ◽

Upper Abdominal

Introduction:Cirrhosis of liver is common Medical problem in our country and causing for significant morbility & mortality. This study was aimed to findout actiology and clinical presentation of cirrhosis in this southern part of Bangladesh. Materials & Methods: An observantional study was conducted in Khulna Medical College Hospital from January 2016 to June 2016. That included adult (>15yrs) cirrhosis patient in medicine ward on the basis of history & clinical examination. Results: Common age is (37-48)yrs, 80% were male patient. Male Female ratio 4:1. Anorexia & dyspepsia were the most common symptom. 78% presented with ascites 34% presented with variceal bledding. Aetiology are Hepatitis B (52%), Hepatitis C (24%) & idiopathic 16%. Conclusion: Screening for chronic liver disease should include history and physical examination, serum transaminase measurement, upper abdominal ultrasonography, and in some case, fibroscan. Management of patient with cirrhosis should be prevention & early intervention to stabilize disease progression and to avoid or delay clinical decompensation and the need for liver transplantation. Medicine Today 2020 Vol.32(2): 100-103

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Utility of Tolonium Chloride Rinse in the Diagnosis of Oral Cancer

Bangladesh Journal of Otorhinolaryngology ◽

10.3329/bjo.v26i1.47947 ◽

2020 ◽

Vol 26 (1) ◽

pp. 11-17

Author(s):

Md Kamruzzaman ◽

Kazi Nurjahan ◽

AS Gazi Sharifuddin ◽

SK Ballav

Keyword(s):

Developing Countries ◽

Oral Cancer ◽

Prospective Study ◽

Diagnostic Delay ◽

College Hospital ◽

Female Ratio ◽

Medical College ◽

Biopsy Report ◽

Patient Side ◽

Tolonium Chloride

Background: Oral cancer burden in developing countries is huge. In Bangladesh and India incidence were 10.6% and 10.4% respectively on 2018. At the same time worldwide incident was only 2%. Majority patients present at advanced stage and their survival rate is poor. Diagnostic delay from patient side and health delivery system side is significantly longer and it is more in developing countries. Like other malignancy early diagnosis can save a lot of these patient. Methods: This prospective study was carried out in Khulna Medical College Hospital from July 2017 to July 2019. Patients who will meet the criteria for this prospective study and capable and willing to give informed consent were enrolled. 20 second rinse/gargle with 10ml of 1% Tolonium chloride solution was done. Biopsy were taken from stained lesion, biopsy report were compared with TC stained lesions. Results: Out of 1650 patients in our outdoor department for various problem and only 30 cases were selected for this study according to selection criteria. Of 30 patients, 18 (60%) were male and 12 (40%) were female. The male-to-female ratio was 3:2. It was found that the sensitivity of 1% Tolonium Chloride rinse for oral precancer and cancer detection was 83.33%, whereas the specificity was 84.21%. Conclusion: Tolonium chloride rinse is a good screening test for oral cancer diagnosis with sensitivity 83.33% and specificity 84.21%. Bangladesh J Otorhinolaryngol; April 2020; 26(1): 11-17

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Surgery at Cranio-vertebral (CV) Junction: Our Experience of 32 Cases

Journal of Bangladesh College of Physicians and Surgeons ◽

10.3329/jbcps.v29i2.7952 ◽

1970 ◽

Vol 29 (2) ◽

pp. 78-84

Author(s):

FH Chowdhury ◽

MR Haque ◽

NKSM Chowdhury ◽

MS Islam ◽

Z Raihan ◽

...

Keyword(s):

Surgical Procedures ◽

Surgical Techniques ◽

Clinical Findings ◽

Type I ◽

College Hospital ◽

Chiari Malformation Type I ◽

Female Ratio ◽

Medical College ◽

Neoplastic Lesion ◽

Wide Range

Cranio vertebral (CV) junction is one of the critical sites for surgery. It's anatomy, physiological aspects and pathological involvement varies in a wide range of margins. Common problems are developmental anomalies, traumatic involvement, inflammatory, infective and neoplastic lesion. Management of these problems varies a lot from each other. Aim of the article is to overview the pathologies in this area and to study presentations, investigations, surgical procedures and results of these pathologies. We prospectively analyzed 32 cases of Cranio-vertebral (CV) region surgery in the Department of Neurosurgery Dhaka Medical College Hospital and Mitford Hospital, Dhaka, from 2000 to 2008. In our series, male and female ratio was 7.2:1. Pathologies were atlanto- axial dislocation (AAD), Chiari malformation type –I, schwannoma, meningioma, hydatid cyst and tuberculosis. Common clinical findings were- neck pain, quadriparesis, quadriplegia, hand atrophy, autonomic dysfunction and hypertension. Various types of surgical procedures were done in this series according to the pathology. Death was in 01 case, neurological deterioration seen in one case, 2 cases were neurologically stable and 28 cases (87.5%) improved neurologically where one was non useful improvement (Frankel grade-C). Complete pre operative radiological study is a very important adjunct for a successful surgical result. Proper evaluation of patients with selection of appropriate surgical procedures along with safe surgical techniques are the necessary things for successful surgery in this area. DOI: http://dx.doi.org/10.3329/jbcps.v29i2.7952 (J Bangladesh Coll Phys Surg 2011; 29: 78-84)

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Predisposing Factors of Scabies among the Patients Attending Skin and Venereal Disease Outdoor of Dhaka Medical College Hospital

Journal of Medicine ◽

10.3329/jom.v9i2.1436 ◽

1970 ◽

Vol 9 (2) ◽

pp. 82-86

Author(s):

Afzalur Rahman Mahmood ◽

Zannatun Nur

Keyword(s):

Standard Deviation ◽

Venereal Disease ◽

Family Members ◽

Predisposing Factors ◽

Medical College Hospital ◽

College Hospital ◽

Socioeconomic Condition ◽

Female Ratio ◽

Level Of Education ◽

Medical College

This cross sectional type of descriptive study was carried out among the patients attending the Skin and Venereal Disease (VD) Out Patient Department (OPD) of Dhaka Medical College Hospital (DMCH) from August 2006 to November 2006 with a view to explore the current situation of scabies and its predisposing factors. In this regard 213 clinically diagnosed scabies contracted patients were interviewed randomly by using pre-tested questionnaire. Risk factors were assessed considering their dwelling places, types of families, number of family members, persons living in each room, using fomites of infected persons, socioeconomic condition, occupation, level of education, regular bathing and cloth washing habit along with age, sex distribution and clinical presentation of scabies. The mean age of the respondents was 13.16 years with a standard deviation (SD) of Â±5.38 years and majority (36.15%) was in the age group of 1-5 years. Male, female ratio was 1.15:1. Major level of education was in the group of class I to V (38%). 50.73% had family members comprised of 4 to 6. Majority (38.50%) belonged to lower middle class (income 3001-6000 taka/month). Among the respondents maximum (54.93%) were infected by family members. 77.94% respondents used fomites of affected persons and 66% respondents shared beds of infected persons. Mean duration of illness was 42 days with standard deviation of Â±4.47 days. Among the male, majority (82.63%) had lesion on lower abdomen and buttock. In contrary, 80.28% female had lesion on hand. 58.68% presented with papule. The study recommends that emphasis should be given on personal hygiene and life style of people as well as educating them about scabies. Key words: Scabies, Predisposing factors, Skin and VD outdoor DOI = 10.3329/jom.v9i2.1436 Â Â J MEDICINE 2008; 9 : 82-86

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Anterior Cervical Decompression and Fusion (ACDF) with Titanium Plate and Screw in Rajshahi Medical College Hospital

Medicine Today ◽

10.3329/medtoday.v23i1.11942 ◽

2012 ◽

Vol 23 (1) ◽

pp. 30-32

Author(s):

Md. Shamsuzzaman Mondle ◽

Sk. Md. Ekramllah

Keyword(s):

Medical College Hospital ◽

Titanium Plate ◽

College Hospital ◽

Medical College ◽

Anterior Cervical Decompression ◽

Medicine Today

Medicine Today 2011 Volume 23 Number 01 Page 30-32 DOI: http://dx.doi.org/10.3329/medtoday.v23i1.11942

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Primary Retroperitoneal Ganglioneuroma: A Retrospective Cohort Study of 32 Patients

Frontiers in Surgery ◽

10.3389/fsurg.2021.642451 ◽

2021 ◽

Vol 8 ◽

Author(s):

Jianchun Xiao ◽

Zixuan Zhao ◽

Binglu Li ◽

Taiping Zhang

Keyword(s):

Growth Pattern ◽

Clinical Manifestations ◽

Incomplete Resection ◽

Radiological Imaging ◽

College Hospital ◽

Laboratory Findings ◽

Female Ratio ◽

Medical College ◽

The Mean ◽

The Masses

Purpose: To investigate the clinical characteristics, diagnosis, differential diagnosis, therapy options, and outcomes of retroperitoneal ganglioneuroma.Methods: In this retrospective study, we collected and analyzed the clinical data of 32 patients diagnosed with retroperitoneal ganglioneuroma and admitted to Peking Union Medical College Hospital from October 2012 to August 2019.Results: Among our 32 cases with retroperitoneal ganglioneuroma, the male-to-female ratio was 1:3 and the mean age was 35. Only 25% of the cases presented with abdominal pain while more than 65% had no specific symptoms. The masses could be found through physical examination in only five patients. Most of the tumors are located near the renal area. They were usually single and displayed an embedded growth pattern with diameters <10 cm, clear borders, and soft texture. For radiological imaging, the majority of tumors demonstrated soft tissue density with mild-to-moderate enhancement on CT imaging and showed hypoecho with moderate blood flow signals in ultrasound. No significantly abnormal laboratory examinations were found in most patients. Of all the 32 patients, 2 chose surveillance after biopsy due to difficulties in operation, while others chose surgical resection. The mean follow-up time was 15.8 months among 26 patients. The tumor remained stable in the surveillance cases. Residual tumors were found in four cases receiving operations with no progress and discomfort. No recurrence was seen in all patients.Conclusions: The retroperitoneal ganglioneuroma is a benign tumor without specific clinical manifestations or significant laboratory findings. Typically, it is shown as low density with a clear border and an embedded growth pattern in radiological imaging. The overall prognosis is good. Surgery is an effective approach with possible severe complications. Incomplete resection or surveillance can be considered for some cases where complete resection is difficult to achieve.

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