scholarly journals Treatment of Dystonia Caused by Several Etiologies with DBS

2018 ◽  
Vol 26 (3) ◽  
pp. 203-210
Author(s):  
Ana Maria Ribeiro De Moura ◽  
Paulo Henrique Pires De Aguiar ◽  
Luana Ajala Christiano ◽  
Camila Pereira Barretto ◽  
Giovanna Matricardi ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Rank Test ◽  
Posterior Portion ◽  
Signed Rank ◽  
Wilcoxon Signed Rank Test ◽  
Signed Rank Test ◽  
Deep Brain ◽  
Stimulation Of

Introduction: This meta-analysis of reported cases of deep brain stimulation (DBS) for dystonia evaluates the effect using the globus pallidus internus (GPi) as target, and the factors that significantly have influenced the outcome related to the target. The Burke-Fahn-Marsden (BFM) movement scale, the most reported measure, was chosen as the primary outcome measure for this analysis. Material and Methods: MEDLINE searches on English literature identified 137 patients who underwent DBS for dystonia in 24 studies that had individual BFM scores. The study was done with statistical analysis by intention to treat. Statistical analysis was made with a significant p-value of 0.05. For the comparison of pre- and postoperative scores, a Wilcoxon signed-rank test was used. Results: The mean BFM percentage change (improvement in postoperative score from baseline) was 46.3% (range 34% to 100%). At last follow-up, disease severity and degree of disability and pain on the BFM were significantly improved by 70.4%, and 67.8%, respectively (p < 0.05, Wilcoxon signed-rank test). Significantly better outcomes were achieved with stimulation of the GPI than with stimulation of the posterior portion of the ventral lateral (VLp) nucleus of the thalamus (p < 0.05). The etiology of the dystonia also had a significant effect on outcomes. Statistically significant improvements in outcomes were seen for all etiologic categories, except encephalitis. Dystonia due to birth injury and encephalitis had significantly worse outcomes of patients who were DYT1, or had pantothenate-kinase-associated neurodegeneration (PKAN), tardive dyskinesia, and idiopathic and posttraumatic dystonias. Longer duration of dystonia symptoms correlated negatively with surgical outcome. Conclusion: Deep Brain Stimulation of the GPi provides improvement in BFM scores in a variety of dystonic conditions.

Orthodontic Treatment Planning: Do Orthodontists Treat to Cephalometric Norms?

2003 ◽  
Vol 4 (4) ◽  
pp. 12-27 ◽  
Author(s):  
Khalid M. Al-Balkhi
Keyword(s):  
Statistical Analysis ◽  
Treatment Planning ◽  
Orthodontic Treatment ◽  
Rank Test ◽  
Mean Values ◽  
Kappa Test ◽  
Signed Rank ◽  
Wilcoxon Signed Rank Test ◽  
Signed Rank Test ◽  
Paired T Test

Abstract Cephalometric norms are important to orthodontists in their diagnosis, treatment, and evaluation of orthodontic treatment outcomes. The purpose of the present study is to establish if orthodontists treat and finish their cases to the cephalometric means or norms. Pre- and post-cephalometric radiographs and dental casts of 35 orthodontically treated cases were analyzed. The Kappa test, Wilcoxon Signed-Rank test, Paired t- test, and Z-test were used for the statistical analysis of the data. The result revealed that orthodontists do not reach the cephalometric mean values post-treatment. However, sagittal maxillomandibular relationship and interlabial gap are the main areas of improvements. This leads to improvement of soft tissue esthetics by camouflaging the skeletal and dental relationship. Citation Al-Balkhi KM. Orthodontic Treatment Planning: Do Orthodontists Treat to Cephalometric Norms? J Contemp Dent Pract 2003 November;(4)4:012-027.

scholarly journals PENGARUH STIMULASI PERMAINAN ULAR TANGGA TENTANG GINGIVITIS TERHADAP PENGETAHUAN ANAK USIA 8-11 TAHUN Studi terhadapSiswa SD Negeri Kuningan 04, Kecamatan Semarang Utara

2015 ◽  
Vol 2 (1) ◽  
pp. 25
Author(s):  
Syarifah Nur Laili Siyam ◽  
Arlina Nurhapsari ◽  
Benni Benyamin
Keyword(s):  
Health Education ◽  
Simple Random Sampling ◽  
Health Problems ◽  
Rank Test ◽  
Signed Rank ◽  
Wilcoxon Signed Rank Test ◽  
Post Test ◽  
Signed Rank Test ◽  
Independent Variable ◽  
Stimulation Of

Background: Health education was an attempt to increase the knowledge of children to health problems. The provision of health education can be done through stimulation using Educational Educative Equipment (APE) form snakes and ladders game . One of the health problems that was unfamiliar to the child that is gingivitis. Purpose: This study was conducted to determine the effect of stimulation of gingivitis snakes and ladders game against the knowledge of children ages 8-11 years. Method: This research method using descriptive analytic with pre and post test design. Samples were collected using simple random sampling method comprising 102 respondents based on inclusion criteria of the SD N Kuningan 04. The independent variable is the stimulation of snakes and ladders game. The dependent variable is the child's knowledge about gingivitis. Data were collected using a questionnaire and analyzed the Wilcoxon Signed Rank test. Result: Based on the Wilcoxon Signed Rank test showed significance value 0.00 (p <0.05), so it can be concluded that health education using stimulation of snakes and ladders game has the effect to increase the knowledge of gingivitis in children. Conclusion: From these results it can be concluded that education using the stimulation of snakes and ladders game effect to increase children's knowledge about gingivitis.

scholarly journals Model psikologi komparatif ketidaksetaraan jumlah pembagian sumber daya: Studi pada Macaca fascicularis

2021 ◽  
Vol 19 (1) ◽  
pp. 7-25
Author(s):  
Dwi Atmoko Agung Nugroho ◽  
Dondin Sajuthi ◽  
Sri Soepraptini Mansjoer ◽  
Entang Iskandar ◽  
Huda Shalahuddin Darusman
Keyword(s):  
Statistical Analysis ◽  
Sample Size ◽  
Macaca Fascicularis ◽  
Comparative Psychology ◽  
Rank Test ◽  
Lower Response ◽  
Signed Rank ◽  
Wilcoxon Signed Rank Test ◽  
Signed Rank Test ◽  
Red Grape

  This study aims to promote Macaca fascicularis as a comparative psychology model in finding the root and solution of resource inequity by exploring inhibitor effect on refusal behavior, acceptance, and aggression toward the feed distribution numbers in six pairs of female long-tailed macaques. We observed the frequency of refusal behavior, acceptance, and aggression toward the distribution of red grape with a ratio of: a) 1:1, 0:2, 1:3 without environmental inhibitors (with an opened-aclyric tray) and b) ratios 1:1 with an environmental inhibitor (with a transparent restriction box) in 60 trials per condition. The sample size was N = 10. Non-parametric statistical analysis of Wilcoxon Signed-Rank Test showed that 1:1 ratio with environmental inhibitor produces a lower response of refusal behavior compared to 1:3 without inhibitor. It produced a lower response of aggression compared to other ratios. It produced a greater acceptance compared to other ratios. These long-tailed macaques do not accept the equity conditions except with environmental inhibitors. Based on this fact, we conclude that long-tailed macaques are a good spontaneous model for the comparative psychology of inequity.

Statistical Analysis of the Influence of Students‟ Involvement in School Politics on Their Academic Performance

2017 ◽  
Vol 3 (04) ◽  
Author(s):  
Babalola B. T. ◽  
Olubiyi O. A. ◽  
Ayemidotun D. ◽  
Solomon A. P.
Keyword(s):  
Academic Performance ◽  
Statistical Analysis ◽  
Descriptive Statistics ◽  
Rank Test ◽  
Signed Rank ◽  
Wilcoxon Signed Rank Test ◽  
University Politics ◽  
Signed Rank Test ◽  
School Politics

The study investigates the effect that students’ involvement in University politics has on their academic performance by comparing their results when they were not involved in politics with the results after involving in active politics. The data used for the study was gotten from questionnaires in a University in Nigeria. The Wilcoxon signed rank test was employed for analysis and other descriptive statistics were considered.

Deep brain stimulation modulates hypothalamic-brainstem fibers in cluster headache: case report

2020 ◽  
Vol 132 (3) ◽  
pp. 717-720 ◽  
Author(s):  
Sérgio A. F. Dantas ◽  
Eduardo J. L. Alho ◽  
Juliano J. da Silva ◽  
Nilson N. Mendes Neto ◽  
Erich Talamoni Fonoff ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Cluster Headache ◽  
Brain Stimulation ◽  
Clinical Effects ◽  
Chronic Stimulation ◽  
Mammillary Bodies ◽  
Fiber Tracts ◽  
White Matter Region ◽  
Deep Brain ◽  
Stimulation Of

Hypothalamic deep brain stimulation (DBS) has been used for more than a decade to treat cluster headache (CH) but its mechanisms remain poorly understood. The authors have successfully treated a patient with CH using hypothalamic DBS and found that the contact used for chronic stimulation was located in a white matter region posterior to the mammillary bodies. Fiber tracts crossing that region were the medial forebrain bundle and those interconnecting the hypothalamus and brainstem, including the dorsal longitudinal fasciculus. Because the stimulation of axons is an important mechanism of DBS, some of its clinical effects in CH may be related to the stimulation of fibers interconnecting the hypothalamus and brainstem.

Reoperation for device infection and erosion following deep brain stimulation implantable pulse generator placement

2020 ◽  
Vol 133 (2) ◽  
pp. 403-410 ◽  
Author(s):  
Travis J. Atchley ◽  
Nicholas M. B. Laskay ◽  
Brandon A. Sherrod ◽  
A. K. M. Fazlur Rahman ◽  
Harrison C. Walker ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Movement Disorders ◽  
Pulse Generator ◽  
Rank Test ◽  
Implantable Pulse Generator ◽  
Device Infection ◽  
Deep Brain

OBJECTIVEInfection and erosion following implantable pulse generator (IPG) placement are associated with morbidity and cost for patients with deep brain stimulation (DBS) systems. Here, the authors provide a detailed characterization of infection and erosion events in a large cohort that underwent DBS surgery for movement disorders.METHODSThe authors retrospectively reviewed consecutive IPG placements and replacements in patients who had undergone DBS surgery for movement disorders at the University of Alabama at Birmingham between 2013 and 2016. IPG procedures occurring before 2013 in these patients were also captured. Descriptive statistics, survival analyses, and logistic regression were performed using generalized linear mixed effects models to examine risk factors for the primary outcomes of interest: infection within 1 year or erosion within 2 years of IPG placement.RESULTSIn the study period, 384 patients underwent a total of 995 IPG procedures (46.4% were initial placements) and had a median follow-up of 2.9 years. Reoperation for infection occurred after 27 procedures (2.7%) in 21 patients (5.5%). No difference in the infection rate was observed for initial placement versus replacement (p = 0.838). Reoperation for erosion occurred after 16 procedures (1.6%) in 15 patients (3.9%). Median time to reoperation for infection and erosion was 51 days (IQR 24–129 days) and 149 days (IQR 112–285 days), respectively. Four patients with infection (19.0%) developed a second infection requiring a same-side reoperation, two of whom developed a third infection. Intraoperative vancomycin powder was used in 158 cases (15.9%) and did not decrease the infection risk (infected: 3.2% with vancomycin vs 2.6% without, p = 0.922, log-rank test). On logistic regression, a previous infection increased the risk for infection (OR 35.0, 95% CI 7.9–156.2, p < 0.0001) and a lower patient BMI was a risk factor for erosion (BMI ≤ 24 kg/m2: OR 3.1, 95% CI 1.1–8.6, p = 0.03).CONCLUSIONSIPG-related infection and erosion following DBS surgery are uncommon but clinically significant events. Their respective timelines and risk factors suggest different etiologies and thus different potential corrective procedures.

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