scholarly journals Complement in structure and immune homeostasis in placenta

2021 ◽  
Author(s):  
Sanshan Jin ◽  
Canrong Wu ◽  
Yingchun Zhang
Keyword(s):  
Immune System ◽  
Complement Activation ◽  
Individual Case ◽  
Innate Immune ◽  
Complement Protein ◽  
Complement Dysregulation ◽  
Pathological Pregnancy ◽  
Structural Homeostasis ◽  
Fetal Antigens

Aberrant complement activation can induce “thrombo-inflammation” attacks to host tissue. Beside kidney and blood vessel, the placenta is also susceptible to these attacks. Complement dysregulation is recently classified as one of the new mechanisms leading to pregnancy disorders. Studies have indicated that dampening complement activation can ameliorate pregnancy outcomes. During pregnancy, the mother’s immune system is finely domesticated to accept the semi-allogeneic fetal antigens. As an important part of the innate immune system, some interesting changes have also taken place in complement system during pregnancy. The complement proteins are highly expressed in placenta, and their split products are increased. They are tuned in maintain placental immunity and structural homeostasis. An abundance of evidence shew that complement protein deficiency lead to autoimmunity disease and pathological pregnancy marked by excessive inflammation. Although complement suppressing strategies have been proven effective in treating some pathological pregnancy in individual case studies. we should take the dual role of the complement into consideration that fully and completely inhibit of complement may not be a wise choice.

Role of Innate Immune System in Environmental Lung Diseases

2021 ◽  
Vol 21 (5) ◽  
Author(s):  
Marissa A. Guttenberg ◽  
Aaron T. Vose ◽  
Robert M. Tighe
Keyword(s):  
Immune System ◽  
Innate Immune System ◽  
Lung Diseases ◽  
Innate Immune

scholarly journals Role of the Innate Immune System in Acute Viral Myocarditis

2009 ◽  
Vol 104 (3) ◽  
pp. 228-237 ◽  
Author(s):  
Chien-Hua Huang ◽  
Jesus G. Vallejo ◽  
George Kollias ◽  
Douglas L. Mann
Keyword(s):  
Immune System ◽  
Innate Immune System ◽  
Viral Myocarditis ◽  
Innate Immune ◽  
Acute Viral Myocarditis

scholarly journals Adipocytes, Innate Immunity and Obesity: A Mini-Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Alecia M. Blaszczak ◽  
Anahita Jalilvand ◽  
Willa A. Hsueh
Keyword(s):  
Adipose Tissue ◽  
Immune System ◽  
Immune Cells ◽  
Adaptive Immune System ◽  
Innate Immune ◽  
Lymphoid Cells ◽  
Innate Immune Cells ◽  
Adaptive Immune

The role of adipose tissue (AT) inflammation in obesity and its multiple related-complications is a rapidly expanding area of scientific interest. Within the last 30 years, the role of the adipocyte as an endocrine and immunologic cell has been progressively established. Like the macrophage, the adipocyte is capable of linking the innate and adaptive immune system through the secretion of adipokines and cytokines; exosome release of lipids, hormones, and microRNAs; and contact interaction with other immune cells. Key innate immune cells in AT include adipocytes, macrophages, neutrophils, and innate lymphoid cells type 2 (ILC2s). The role of the innate immune system in promoting adipose tissue inflammation in obesity will be highlighted in this review. T cells and B cells also play important roles in contributing to AT inflammation and are discussed in this series in the chapter on adaptive immunity.

Role of the innate immune system in the development of chronic colitis

2002 ◽  
Vol 37 (S14) ◽  
pp. 38-42 ◽  
Author(s):  
Takanori Kanai ◽  
Ryoichi Iiyama ◽  
Takahiro Ishikura ◽  
Koji Uraushihara ◽  
Teruji Totsuka ◽  
...  
Keyword(s):  
Immune System ◽  
Innate Immune System ◽  
Innate Immune ◽  
Chronic Colitis

scholarly journals Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Wenjin Zheng ◽  
Qing Xu ◽  
Yiyuan Zhang ◽  
Xiaofei E ◽  
Wei Gao ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Immune System ◽  
Signaling Pathways ◽  
Critical Role ◽  
Innate Immune ◽  
Host Cells ◽  
Main Body ◽  
Current Perspective ◽  
Viral Components

Abstract Background In the past decades, researchers have demonstrated the critical role of Toll-like receptors (TLRs) in the innate immune system. They recognize viral components and trigger immune signal cascades to subsequently promote the activation of the immune system. Main body Herpesviridae family members trigger TLRs to elicit cytokines in the process of infection to activate antiviral innate immune responses in host cells. This review aims to clarify the role of TLRs in the innate immunity defense against herpesviridae, and systematically describes the processes of TLR actions and herpesviridae recognition as well as the signal transduction pathways involved. Conclusions Future studies of the interactions between TLRs and herpesviridae infections, especially the subsequent signaling pathways, will not only contribute to the planning of effective antiviral therapies but also provide new molecular targets for the development of antiviral drugs.

scholarly journals Eculizumab, a novel potential treatment for acute kidney injury associated with preeclampsia/HELLP syndrome

2019 ◽  
Vol 12 (9) ◽  
pp. e228709 ◽  
Author(s):  
Hatem Elabd ◽  
Mennallah Elkholi ◽  
Lewis Steinberg ◽  
Anjali Acharya
Keyword(s):  
Acute Kidney Injury ◽  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Complement Activation ◽  
Hellp Syndrome ◽  
Kidney Injury ◽  
Complement Protein ◽  
Igg Antibody ◽  
Elevated Liver Enzymes

The kidney is one of the major organs affected in preeclampsia. There is evidence suggesting a role for excessive complement activation in the pathogenesis of preeclampsia. We describe a case of preeclampsia with severe features, including HELLP syndrome (hemolysis, elevated liver enzymes, low platelets) and acute kidney injury (AKI) that developed following caesarian section. The patient required renal replacement therapy. A trial of daily plasma exchange was not effective. The patient received a single dose of eculizumab, a humanised monoclonal IgG antibody that binds to complement protein C5. One week post administration of eculizumab, there was significant improvement in haematologic, hepatic and renal function. Blood pressure had normalised and renal replacement therapy was discontinued. The use of eculizumab may have contributed to recovery of kidney function further supporting the role of complement activation in the pathogenesis of preeclampsia and associated AKI.

Sign in / Sign up

Export Citation Format

Share Document