scholarly journals Determining a threshold measurement of Endometrial Thickness for Asymptomatic Postmenopausal Women: A single-centre case series

2021 ◽  
Author(s):  
Amy Stewart ◽  
Gurjot Gill ◽  
Emma Readman ◽  
Sonia Grover ◽  
Samantha Mooney
Keyword(s):  
Postmenopausal Women ◽  
Endometrial Hyperplasia ◽  
Endometrial Thickness ◽  
Case Series ◽  
Retrospective Case ◽  
Endometrial Sampling ◽  
Pathology Classification ◽  
Menopausal Women ◽  
The Mean ◽  
Post Menopausal

Objective: To determine the endometrial thickness at which endometrial sampling is indicated in asymptomatic post-menopausal women referred with thickened endometrium on ultrasound. Design: Retrospective case series Setting: Mercy Hospital for Women, Melbourne Population: Post-menopausal women without bleeding, undergoing hysteroscopy for thickened endometrium Methods: Logistic regression was used to examine the association between a range of variables and pre-malignant or malignant pathology and endometrial thickness Main outcome measures: The primary outcome was endometrial malignancy/pre-malignancy and its relation to endometrial thickness. Secondary outcomes focused on identifying additional predictors which may influence endometrial malignancy such as ultrasound findings, years since menopause, age, obesity, diabetes, and tamoxifen use. Results: A total of 404 postmenopausal women met the inclusion criteria for this study. The mean (SD) age of patients at presentation was 65 (9.09) years and the mean BMI was 29.86 kg/m2 (6.52). Of these women, nine (2.2%) were diagnosed with endometrial carcinoma and 7 (1.7%) had endometrial hyperplasia with atypia. The most common histopathological finding was of a benign endometrial polyp (153, 37.9%). When including hyperplasia with or without atypia in histopathology of interest, a cut-off of ≥9mm provides the greatest sensitivity (83.3%) and specificity (63.8%) for a diagnosis of pre-malignant or malignant pathology (classification accuracy of 64.8%; AUROC: 0.7358, 95%CI: 0.6439, 0.8278) in this cohort. Conclusions: Using an endometrial thickness of ≥9mm can be safely used as a cut-off for endometrial sampling in post-menopausal women without bleeding. Funding: Norman Beischer Medical Research Foundation, 2018 NBMRF Grant Keywords: Endometrial thickness, Post-menopausal, endometrial hyperplasia

Depressive symptoms and bone mineral density in menopause and postmenopausal women: A still increasing and neglected problem

2016 ◽  
Vol 33 (S1) ◽  
pp. S119-S119
Author(s):  
A. Bener
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Diastolic Blood Pressure ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Smoking Habits ◽  
Menopausal Women ◽  
The Mean ◽  
Post Menopausal

ObjectiveThe objective of current study was to investigate whether associaction exist between depression and low BMD during menopausal and post-menopausal period.MethodsA cross-sectional descriptive study and 1650 women aged 45–65 years were included during 1182 women agreed to participate (71.6%). Data on body mass index (BMI), clinical biochemistry variables including serum 25-hydroxyvitamin D were collected. The Beck Depression Inventory (BDI) was administered for depression purposes.ResultsA total of 1182 women agreed to participate and responded to the study. The mean age and SD of the menopausal age were 48.71 ± 2.96 with depressed and 50.20 ± 3.22 without depressed (P < 0.001). Also, the mean and SD of postmenopausal age were 58.55 ± 3.27 depressed and 57.78 ± 3.20 without depressed (P < 0.001). There were statistically significance differences between menopausal stages with regards to number of parity, and place of living. There were statistically significance differences between menopausal stages with regards to BMI, systolic and diastolic blood pressure, vitamin D deficiency, calcium deficiency and sheesha smoking habits. Overall, osteopenia and osteoporosis and bone loss were significantly lower in post-menopausal women than in menopausal women (P < 0.001). Similarly, T-score and z-score were lower with depressed menopause and postmenopausal women (P < 0.001).ConclusionThe multivariate logistic regression analyses revealed that the depression, the mean serum vitamin D deficiency, calcium level deficiency, less physical activity, co-morbidity, number of parity, systolic and diastolic blood pressure and sheesha smoking habits were considered as the main risk factors associated with bone mineral loss after adjusting for age, BMI and other variables.Disclosure of interestThe author has not supplied his/her declaration of competing interest.

scholarly journals False Endometrial Thickening in Postmenopausal Patients Using Anticoagulants or Antiplatelets Agents

2021 ◽  
Author(s):  
Nahit Ata ◽  
Nur Kulhan
Keyword(s):  
Postmenopausal Women ◽  
Endometrial Thickness ◽  
Antiplatelet Agents ◽  
Control Group ◽  
Drug Status ◽  
Endometrial Sampling ◽  
Endometrial Thickening ◽  
First Results ◽  
The Mean ◽  
Key Words Anticoagulants

Objective There is no report that anticoagulant or antiplatelet use may lead to abnormal endometrial sonographic findings. This retrospective study reports our first results associated with endometrial sampling in asymptomatic postmenopausal women using anticoagulants or antiplatelet. Materials methods A total of 268 postmenopausal patients who applied to our gynecology outpatient clinic for any reasons except postmenopausal bleeding were included in the study. Patients were divided into three groups according to using drug status: first healty control group (HCG), second anticoagulants agents group (ACG), and third antiplatelet agents group (APG). The effects of anticoagulant and antiplatelet agents on endometrial thickness were compared with histopathological findings. Results The mean endometrial thickness was significantly greater in group ACG (5.2 mm) and APG (4.1 m) than in group HCG (3.3 mm). No significant differences were found in the mean endometrial thickness between groups HCG and APG. However, it is noteworthy that the average endomeric thickness in the ACG group is more than the other two groups and this is statistically significant (p < 0.05). Conclusion If the thickness of the endometrium was > 4 mm. endometrial sampling may be recommended in in asymptomatic postmenopausal women using anticoagulants or antiplatelet agents. Key words: Anticoagulants, antiplatelets, biopsy, endometrial thickness, menopause, ultrasonography

scholarly journals False Endometrial Thickening in Postmenopausal Patients Using Anticoagulants or Antiplatelets Agents

2021 ◽  
Vol 3 (2) ◽  
pp. 25-28
Author(s):  
Nahit Ata ◽  
Nur Gözde Kulhan
Keyword(s):  
Postmenopausal Women ◽  
Endometrial Thickness ◽  
Antiplatelet Agents ◽  
Control Group ◽  
Drug Status ◽  
Postmenopausal Bleeding ◽  
Endometrial Sampling ◽  
Endometrial Thickening ◽  
First Results ◽  
The Mean

Objective There is no report that anticoagulant or antiplatelet use may lead to abnormal endometrial sonographic findings. This retrospective study reports our first results associated with endometrial sampling in asymptomatic postmenopausal women using anticoagulants or antiplatelet. Materials methods A total of 268 postmenopausal patients who applied to our gynecology outpatient clinic for any reasons except postmenopausal bleeding were included in the study. Patients were divided into three groups according to using drug status: first healty control group [HCG], second anticoagulants agents group [ACG], and third antiplatelet agents group [APG]. The effects of anticoagulant and antiplatelet agents on endometrial thickness were compared with histopathological findings. Results The mean endometrial thickness was significantly greater in group ACG [5.2 mm] and APG [4.1 m]  than in group HCG [3.3 mm]. No significant differences were found in the mean endometrial thickness between groups HCG and APG. However, it is noteworthy that the average endomeric thickness in the ACG group is more than the other two groups and this is statistically significant [p < 0.05].   Conclusion If the thickness of the endometrium was > 4 mm. endometrial sampling may be recommended in in asymptomatic postmenopausal women using anticoagulants or antiplatelet agents.  

scholarly journals A direct approach to the estimation of the origin of oestrogens and androgens in elderly men by comparison with hormone levels in postmenopausal women

2005 ◽  
Vol 152 (2) ◽  
pp. 261-268 ◽  
Author(s):  
Willem de Ronde ◽  
Albert Hofman ◽  
Huibert A P Pols ◽  
Frank H de Jong
Keyword(s):  
Postmenopausal Women ◽  
Elderly Men ◽  
Adrenal Androgens ◽  
Men And Women ◽  
Hormone Levels ◽  
Menopausal Women ◽  
The Mean ◽  
Post Menopausal ◽  
Design And Methods ◽  
Circulating Levels

Objective: The origin of oestrogens in men is only partly understood. From infusion studies with radioactively labelled hormones, we know that oestradiol (E2) and oestrone (E1) are either directly secreted by the testes and adrenal glands or peripherally produced from testicular or adrenal androgens. Design and methods: We determined E2, E1, androstenedione, testosterone and dehydroepiandroster-one sulphate (DHEAS) in 292 elderly men and 367 postmenopausal women. We considered post-menopausal women as men without testes, assuming that the postmenopausal ovary is not endocrinologically active and that the testes do not contribute to circulating levels of DHEAS. Subjects were stratified by DHEAS levels to adjust for differences in DHEAS levels between sexes. For men and women separately, mean levels of E2, E1, androstenedione and testosterone were calculated per DHEAS stratum. The relative direct and indirect contributions of the testes to steroid levels in men were calculated by the formula [(Cm −Cf)/Cm] × 100%, in fwhich Cm and Cf represent the mean concentrations of the steroid in men and women respectively. Results: The relative contributions (%) of the testes to hormone levels per DHEAS stratum (<2, 2–4, 4–6 and >6 μmol/l) respectively were, for E2, 72%, 60%, 52% and 44%; for E1, 54%, 47%, 35% and 34%; for androstenedione, 14%, 4%, 12% and 0%; and, for testosterone, 88%, 88%, 87% and 83%. Conclusions: We conclude that in elderly men dependent on DHEAS levels, 44–72% of E2 and 34–54% of E1 originate directly or indirectly from the testes.

scholarly journals Prevalence of menopausal symptoms and perceptions about menopause among postmenopausal women attending Gynaecology OPD at GMC Idukki, India

2017 ◽  
Vol 6 (2) ◽  
pp. 413 ◽  
Author(s):  
Leena A. Joseph ◽  
Acka Priya Varghese
Keyword(s):  
Postmenopausal Women ◽  
Menopausal Symptoms ◽  
Outpatient Department ◽  
Treatment Seeking ◽  
Cross Sectional ◽  
Medical College ◽  
Menopausal Women ◽  
Seeking Behavior ◽  
The Mean ◽  
Post Menopausal

Background: Idukki is a hilly tract area in the state of Kerala. No studies regarding menopause has been reported from Idukki. This study is done among postmenopausal women in an attempt to shed light on the prevalence of menopausal symptoms and perceptions of postmenopausal women in a panchayat in Idukki district which is typically a rural area. Primary objectives of the study were to find the prevalence of menopausal symptoms in post-menopausal women attending the outpatient department of Government Medical College, Idukki, India and to find the perceptions about menopause among these post-menopausal women. Secondary objectives were to find the mean age and pattern of attainment of menopause among postmenopausal women and to find the treatment seeking behavior of the post-menopausal women residing in this area.Methods: A cross-sectional observational study is done among 100 postmenopausal women attending the outpatient department of Obstetrics and Gynaecology. Questions are asked based on interview schedule. The results are then analyzed.Results: The mean age of menopause was 45.69± 4.35. 78% of population had one or more symptoms in the menopausal period. Only 19.5% of the symptomatic women took treatment. 77% had positive perceptions.Conclusions: The awareness of these women in this area is poor thus limiting the treatment seeking behavior. Improvement of awareness is a must to improve the quality of life of post-menopausal women.

CORRELATION OF SERUM CHOLESTEROL AND BONE MINERAL DENSITY IN POST MENOPAUSAL WOMEN

2021 ◽  
Vol 5 (12) ◽  
Author(s):  
Sawai Singh ◽  
Lokesh Soni
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Cholesterol Level ◽  
Bone Mineral ◽  
Serum Cholesterol ◽  
Mineral Density ◽  
Menopausal Women ◽  
The Mean ◽  
Group Ii ◽  
Post Menopausal

Background: To find a correlation between serum cholesterol and Bone mineral density in post menopausal women Methods: The study was carried on matched cases and controls. The experimental group consisted of 100 females at postmenopausal age, in which by the DEXA method was diagnosed osteoporosis while the control group consisted of 50 females in a postmenopausal age but without diagnosed osteoporosis who served as controls. Results: Postmenopausal women in the BMI range 18.5 to 25 (normal)were only included in the study. Others were excluded from the study to avoid confounding factors. The mean BMI in women with osteoporosis was 22.13±1.76 and in Group-II was 21.26±2.06. The results were statistically insignificant. Analyzing the average values of serum cholesterol in our study,we found that the mean cholesterol level in group-I was 210.32 ±34.21 mg/dl and 183.21 ±56.32 mg/dl in group-II. The mean cholesterol level was significantly higher in women with osteoporosis. Conclusion: On the decrease in bone mineral density and osteoporosis in postmenopausal women influence many risk factors. Preventive strategies for development of osteoporosis should be initiated in women with elevated serum cholesterol levels. Keywords: Osteoporosis, Menopause, Lipid Profile, BMI.

scholarly journals Effect of Aromatase Inhibitors in the Treatment of Endometrial Hyperplasia in Post Menopausal Women

2016 ◽  
Vol 29 (2) ◽  
pp. 78-82
Author(s):  
Jannatul Ferdous ◽  
Mosammat Rashida Begum ◽  
Shahana Pervin ◽  
Sheuli Chowdhury ◽  
Khoorshed Jahan Maula
Keyword(s):  
Longitudinal Study ◽  
Aromatase Inhibitors ◽  
Endometrial Hyperplasia ◽  
Outcome Measure ◽  
Endometrial Thickness ◽  
Histopathologic Examination ◽  
Main Outcome Measure ◽  
Menopausal Women ◽  
Post Menopausal

Objective: To explore the effect of aromatase inhibitors in the treatment of endometrial hyperplasia in post menopausal women.Materials and Methods: This observational longitudinal study was undertaken in 21 postmenopausal women diagnosed as having endometrial hyperplasia in a private clinic in Dhaka between July, 2009 to January 2014. Initially hyperplasia was diagnosed by thickened endometrium by ultrasound and confirmed by histopathologic examination of fractional curretage. Among the patients, 7 had complex hyperplasia without atypia; 14 had simple hyperplasia without atypia. All the patients were treated with letrozole 2.5 mg per day for 12 months and were monitored by transvaginal ultrasonogram every 3 months, subsequently followed up by history and transvaginal ultrasonogram 6 monthly for another 12 months. Main outcome measure was reduction of endometrial thickness. Informed written consent was obtained before enrollment in the study.Results: Mean endometrial thickness decreased by 81.66% following 12 months of treatment and the endometrial thickness was not increased in next 12 months follow up period. All patients were symptom free during this treatment.Conclusion: The results of this study indicate that treatment of endometrial hyperplasia with aromatase inhibitors can reduce endometrial thickness. So, aromatase inhibitors deserve attention for the conservative treatment of endometrial hyperplasia.Bangladesh J Obstet Gynaecol, 2014; Vol. 29(2) : 78-82

The Relation between Plasma Androstenedione, Plasma Oestrone and Androstenedione to Oestrone Conversion Rates in Postmenopausal Women with and without Fractures

1978 ◽  
Vol 54 (2) ◽  
pp. 125-131
Author(s):  
B. Pelc ◽  
D. H. Marshall ◽  
P. Guha ◽  
M. Y. Khan ◽  
B. E. C. Nordin
Keyword(s):  
Femoral Neck ◽  
Postmenopausal Women ◽  
Conversion Rate ◽  
Significant Contribution ◽  
Femoral Neck Fractures ◽  
Main Determinant ◽  
Conversion Rates ◽  
Menopausal Women ◽  
The Mean ◽  
Post Menopausal

1. Plasma androstenedione, plasma oestrone and the conversion of plasma androstenedione into oestrone were measured in 19 post-menopausal women without fractures (six of them oophorectomized) and 18 with vertebral or femoral neck fractures (four of them oophorectomized). 2. In the series as a whole, the main determinant of the plasma oestrone level was the plasma androstenedione concentration. Only in the small oophorectomized group did the variation in conversion rate make a significant contribution to the variation in plasma oestrone. 3. The conversion rates were not different as between non-fracture and fracture cases but the mean plasma androstenedione and oestrone concentrations were lower (though not significantly) in the latter.

scholarly journals Postarthroscopy Imaging in Femoroacetabular Impingement: Persistent Pain May Be Due to an Insufficient Correction of Preoperative Abnormalities

Joints ◽  
2017 ◽  
Vol 05 (01) ◽  
pp. 021-026 ◽  
Author(s):  
Cosimo Tudisco ◽  
Salvatore Bisicchia ◽  
Sandro Tormenta ◽  
Amedeo Taglieri ◽  
Ezio Fanucci
Keyword(s):  
Case Series ◽  
Persistent Pain ◽  
Retrospective Case ◽  
Level Of Evidence ◽  
Mean Values ◽  
Center Edge ◽  
Patient Groups ◽  
The Mean ◽  
Magnetic Resonance Imaging Mri

Purpose The purpose of this study was to evaluate the effect of correction of abnormal radiographic parameters on postoperative pain in a group of patients treated arthroscopically for femoracetabular impingement (FAI). Methods A retrospective study was performed on 23 patients affected by mixed-type FAI and treated arthroscopically. There were 11 males and 12 females with a mean age of 46.5 (range: 28–67) years. Center-edge (CE) and α angles were measured on preoperative and postoperative radiographic and magnetic resonance imaging (MRI) studies and were correlated with persistent pain at follow-up. Results The mean preoperative CE and α angles were 38.6 ± 5.2 and 67.3 ± 7.2 degrees, respectively. At follow-up, in the 17 pain-free patients, the mean pre- and postoperative CE angle were 38.1 ± 5.6 and 32.6 ± 4.8 degrees, respectively, whereas the mean pre- and postoperative α angles at MRI were 66.3 ± 7.9 and 47.9 ± 8.9 degrees, respectively. In six patients with persistent hip pain, the mean pre- and postoperative CE angles were 39.8 ± 3.6 and 35.8 ± 3.1 degrees, respectively, whereas the mean pre- and postoperative α angles were 70.0 ± 3.9 and 58.8 ± 2.6 degrees, respectively. Mean values of all the analyzed radiological parameters, except CE angle in patients with pain, improved significantly after surgery. On comparing patient groups, significantly lower postoperative α angles and lower CE angle were observed in patients without pain. Conclusion In case of persistent pain after arthroscopic treatment of FAI, a new set of imaging studies must be performed because pain may be related to an insufficient correction of preoperative radiographic abnormalities. Level of Evidence Level IV, retrospective case series.

Sign in / Sign up

Export Citation Format

Share Document