scholarly journals Crimean Congo hemorrhagic fever in the COVID-19 pandemic: a case study

2021 ◽  
Author(s):  
Masoud Mardani ◽  
Kouros Aghazadeh ◽  
Shahriar Nikpour ◽  
Atousa Hakamifard
Keyword(s):  
Clinical Features ◽  
Viral Infections ◽  
Hemorrhagic Fever ◽  
The Other ◽  
Crimean Congo Hemorrhagic Fever ◽  
Initial Stage ◽  
Reliable Diagnosis ◽  
Tehran Province

In the COVID-19 pandemic, the overlap of clinical features between the other viral infections, make a reliable diagnosis difficult in the initial stage of illness. We describe the first confirmed case of CCHF in Tehran province during this year, who first misdiagnosed as COVID-19 infection.

scholarly journals MAIN TRENDS OF MONITORING OF VIRAL HEMORRHAGIC FEVERS ACTIVITY IN THE NATURAL FOCI

2018 ◽  
pp. 68-78
Author(s):  
Галина Компанец ◽  
Galina Kompanets
Keyword(s):  
Russian Federation ◽  
Viral Infections ◽  
Hemorrhagic Fever ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fevers ◽  
Innovative Methods ◽  
Viral Hemorrhagic Fevers ◽  
Natural Foci ◽  
Severe Fever

This paper includes review of innovative methods of monitoring of activity of natural foci of epidemically important for Russian Federation such viral infections as hemorrhagic fever with renal syndrome (HFRS) and Crimean-Congo hemorrhagic fever (CCHF), and the analysis of probability to control such «exotic» infections, as Denge fever and severe fever with thrombocytopenia syndrome (SFTS).

Epidemiologic and Clinical Features of Crimean-Congo Hemorrhagic Fever in Southern Africa

1987 ◽  
Vol 36 (1) ◽  
pp. 120-132 ◽  
Author(s):  
R. Swanepoel ◽  
M. J. Erasmus ◽  
G. M. McGillivray ◽  
D. E. Gill ◽  
L. A. Searle ◽  
...  
Keyword(s):  
Clinical Features ◽  
Southern Africa ◽  
Hemorrhagic Fever ◽  
Crimean Congo Hemorrhagic Fever

scholarly journals 675. Crimean-Congo Hemorrhagic Fever Beyond Ribavirin: A Systematic Review

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S439-S440
Author(s):  
Stephanie P Fabara ◽  
Raghavendra Tirupathi ◽  
Juan Fernando Ortiz ◽  
Urvish Patel ◽  
Sashwath Srikanth ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Outcomes ◽  
Acute Infection ◽  
Case Series ◽  
Case Fatality ◽  
Hemorrhagic Fever ◽  
The Other ◽  
Duration Of Symptoms ◽  
Crimean Congo Hemorrhagic Fever ◽  
Significant Difference

Abstract Background The Crimean-Congo Hemorrhagic Fever (CCHF) is a tick-borne virus infection that has been reported in about 30 countries worldwide. Clinical presentation is divided into three phases: pre-hemorrhagic, hemorrhagic, and convalescence. Ribavirin is standard of care treatment for acute infection and prophylaxis. However, the use of other treatments beyond ribavirin is largely unknown. Methods We conducted a systematic review using MOOSE protocol. The inclusion and exclusion criteria are seen in the Prisma diagram. For Bias Analysis we use a Robin-1 tool. Literature review algorithm Results We gathered a total of 10 studies, which included 4 therapeutic plasma exchange (TPE), 2 corticosteroids, 2 IVIG, and 1 with convalescent plasma (CP). TPE in one study showed decreased mortality rate and increased efficacy in patients with severe CCHF. While the other study reported pulmonary embolism related to the use of TPE. Nevertheless, the patients had good outcome in the end. Two case reports used TPE plus ribavirin and supportive measures. Both were discharged home and recovered without sequela. Corticosteroids were found to be beneficial in one study were the case fatality rate was lower with the addition of corticosteroids to ribavirin in severely ill patients (p=0.0014). In a case series of six patients, who received the combination in early stages of the disease had good clinical outcomes with improved survival. IVIG was shown to increase platelet counts in two studies. In the first study, platelet count increased above 150,000/mL in 8.5 +/- 2.5 days. While in the other study the normalization of platelets was seen in 4 - 4.8 days, with no significant difference (P = 0.49). In addition, there was a decrease in the duration of symptoms but there was no statistically significant difference in mortality rates (P = 0.171). CP treatment showed a survival rate of 86% in treated patients. CP was more useful in high-risk patients, defined as having a viral load of 108 copies/mL or more. The main limitations of the studies were the sample size and heterogenicity among the outcomes of the studies. Conclusion TPE, CP, IVIG, and corticosteroids were effective in improving the clinical outcomes of the patients. The use of these treatments beyond ribavirin should be explored in future studies. Disclosures All Authors: No reported disclosures

scholarly journals Seroprevalence of Crimean–Congo hemorrhagic fever among health care workers in a hospital in an endemic region of Turkey

2018 ◽  
Vol 12 (07) ◽  
pp. 587-591 ◽  
Author(s):  
Fatih Temocin ◽  
Hatice Köse ◽  
Tuğba Sarı ◽  
Fazilet Duygu ◽  
Ramazan Oguz Şahin
Keyword(s):  
Risk Factors ◽  
State Hospital ◽  
Hemorrhagic Fever ◽  
The Other ◽  
Central Anatolia ◽  
Endemic Region ◽  
Exact Test ◽  
Crimean Congo Hemorrhagic Fever ◽  
Contact Group ◽  
Group 2

Introduction: Crimean-Congo Hemorrhagic Fever (CCHF) can also be transmitted through unprotected contact directly with blood or body fluids as well as from laboratories. This study aimed to determine the seroprevalence of CCHF disease in the employees of the State Hospital of Yozgat Province, located in Central Anatolia of Turkey, and also to present the risk factors for healthcare workers. Methodology: A total of 112 volunteer employees of Yozgat State Hospital were included in the study. The study volunteers were divided into two groups: one having had a contact with CCHF patients and patient’s samples and the other a non-contact group. Results: In the contact group, 2 (2.9%) out of 67 subjects tested positive for anti-CCHF IgG; however, in the non-contact group, none of the subjects tested positive (Fisher's exact test p > 0.05). Of the two employees who tested positive, one was working at the microbiology laboratory and the other was from the emergency department. Conclusion: Although cases of nosocomial transmission of CCHF have been reported previously, questions on the mode of transmission of the disease are still unanswered. The risk factors for the disease should, therefore, be identified in order to take the necessary measures.

scholarly journals Cross-Reactive anti-Nucleocapsid Protein Immunity against Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus in Multiple Species

2021 ◽  
Author(s):  
Merve Kalkan-Yazıcı ◽  
Elif Karaaslan ◽  
Nesibe Selma Çetin ◽  
Sevde Hasanoğlu ◽  
Filiz Güney ◽  
...  
Keyword(s):  
Surrogate Model ◽  
Nucleocapsid Protein ◽  
Hemorrhagic Fever ◽  
Cross Reactivity ◽  
Polyclonal Antiserum ◽  
The Other ◽  
Crimean Congo Hemorrhagic Fever ◽  
Humoral Immune ◽  
Hemorrhagic Fever Virus ◽  
Multiple Species

The World Health Organization estimates that there may be three billion people at risk of infection by Crimean-Congo Hemorrhagic Fever Virus (CCHFV), a highly lethal, emerging orthonairovirus carried by ticks. On the other hand, the closely related Hazara virus (HAZV), a member of the same serogroup, has not been reported as a pathogen for humans. Given the structural and phylogenetic similarities between these two viruses, we evaluated the immunological similarities of the nucleocapsid protein (NP) of these two viruses in multiple species. Strong antigenic similarities were demonstrated in anti-NP humoral immune responses against HAZV and CCHFV in multiple species using convalescent human CCHF sera, rabbit and mouse polyclonal antiserum raised against CCHFV, and mouse polyclonal antiserum against CCHFV-NP in enzyme immunoassays. We also report a convincing cross-reactivity between NPs in Western blots using HAZV-infected cell lysate as antigen and inactivated CCHFV and CCHFV-NP-immunized mice sera. These results suggest that NPs of HAZV and CCHFV share significant similarities in humoral responses across species and underline the potential utility of HAZV as a surrogate model for CCHFV. IMPORTANCE CCHFV and HAZV, members of the Nairoviridae family, are transmitted to mammals by tick bites. CCHFV is considered to be a severe threat to public health and causes hemorrhagic diseases with a high mortality rate, and there are neither preventative nor therapeutic medications against CCHFV disease. HAZV, on the other hand, is not a pathogen to humans and can be studied under BSL-2 conditions. The antigenic relationship between these viruses is of interest for vaccines and for preventative investigations. Here, we demonstrate cross-reactivity in anti-NP humoral immune response between NPs of HAZV and CCHFV in multiple species. These results underline the utility of HAZV as a surrogate model to study CCHFV infection.

Development and regional planning within the decentralized administrative frame: case study (the Jordanian Experiment)

2018 ◽  
Vol 1 (2) ◽  
pp. 60-72
Author(s):  
Mansour Safran
Keyword(s):  
Regional Planning ◽  
The Other ◽  
Negative Effects ◽  
Administrative Procedures ◽  
The Way

This aims to review and analyze the Jordanian experiment in the developmental regional planning field within the decentralized managerial methods, which is considered one of the primary basic provisions for applying and success of this kind of planning. The study shoed that Jordan has passed important steps in the way for implanting the decentralized administration, but these steps are still not enough to established the effective and active regional planning. The study reveled that there are many problems facing the decentralized regional planning in Jordan, despite of the clear goals that this planning is trying to achieve. These problems have resulted from the existing relationship between the decentralized administration process’ dimensions from one side, and between its levels which ranged from weak to medium decentralization from the other side, In spite of the official trends aiming at applying more of the decentralized administrative policies, still high portion of these procedures are theoretical, did not yet find a way to reality. Because any progress or success at the level of applying the decentralized administrative policies doubtless means greater effectiveness and influence on the development regional planning in life of the residents in the kingdom’s different regions. So, it is important to go a head in applying more steps and decentralized administrative procedures, gradually and continuously to guarantee the control over any negative effects that might result from Appling this kind of systems.   © 2018 JASET, International Scholars and Researchers Association

The Relationship between Working Environment and Internship Satisfaction Level: A Case Study Of A 4-Star Hotel Restaurant In Germany

2019 ◽  
Vol 2 (4) ◽  
pp. 276-291
Author(s):  
Chatarina Natalia Putri
Keyword(s):  
Career Development ◽  
Working Hours ◽  
Learning Opportunities ◽  
Working Environment ◽  
The Other ◽  
Satisfaction Level ◽  
Supervisory Support ◽  
Support Organization ◽  
The Relationship

There are many factors that can lead to internship satisfaction. Working environment is one of the factors that will result to such outcome. However, many organizations discarded the fact of its importance. The purpose of this study is to determine whether there is a significant relationship between working environment and internship satisfaction level as well as to determine whether the dimensions of working environment significantly affect internship satisfaction. The said dimensions are, learning opportunities, supervisory support, career development opportunities, co-workers support, organization satisfaction, working hours and esteem needs. A total of 111 questionnaires were distributed to the respondents and were processed by SPSS program to obtain the result of this study. The results reveal that learning opportunities, career development opportunities, organization satisfaction and esteem needs are factors that contribute to internship satisfaction level. In the other hand, supervisory support, co-workers support and working hours are factors that lead to internship dissatisfaction. The result also shows that organization satisfaction is the strongest factor that affects internship satisfaction while co-workers support is the weakest.

‘Behind the Poetic Fiction’: Freud, Schnitzler and Feminine Subjectivity

2004 ◽  
Vol 6 (2) ◽  
pp. 201-223
Author(s):  
Elizabeth Goodstein
Keyword(s):  
Sigmund Freud ◽  
The Other ◽  
Modernist Literature ◽  
Arthur Schnitzler ◽  
Feminine Subjectivity ◽  
The Uncanny ◽  
Poetic Fiction ◽  
Psychoanalytic Theories

In 1922 Sigmund Freud wrote to fellow Viennese author and dramatist Arthur Schnitzler: ‘I believe I have avoided you out of a sort of fear of my double’. Through a series of reflections on this imagined doubling and its reception, this paper demonstrates that the ambivalent desire for his literary other attested by Freud's confession goes to the heart of both theoretical and historical questions regarding the nature of psychoanalysis. Bringing Schnitzler's resistance to Freud into conversation with attempts by psychoanalytically oriented literary scholars to affirm the Doppengängertum of the two men, it argues that not only psychoanalytic theories and modernist literature but also the tendency to identify the two must be treated as historical phenomena. Furthermore, the paper contends, Schnitzler's work stands in a more critical relationship to its Viennese milieu than Freud's: his examination of the vicissitudes of feminine desire in ‘Fräulein Else’ underlines the importance of what lies outside the oedipal narrative through which the case study of ‘Dora’ comes to be centered on the uncanny nexus of identification with and anxious flight from the other.

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