scholarly journals Antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata

2020 ◽  
Vol 4 (1) ◽  
pp. 49
Author(s):  
Gracielle Oliveira Sabbag Cunha ◽  
Ana Paula Terezan ◽  
Andreia Pereira Matos ◽  
Marcela Carmen De Melo Burger ◽  
Paulo Cezar Vieira ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Methyl Esters ◽  
Carboxyl Group ◽  
Isomeric Mixture ◽  
E Coli ◽  
Bacillus Subtilis Atcc ◽  
Derivatives Of

This study evaluated the antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata (Melastomataceae) against five microorganisms: Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Bacillus subtilis (ATCC 6623), Pseudomonas aeruginosa (ATCC 15442), and Candida albicans (ATCC 10231). The isomeric mixture of ursolic and oleanolic acids was active against S. aureus (MIC = 250 μg mL-1) and against E. coli, B. subtilis, and P. aeruginosa (MIC = 500 μg mL-1). The flavone 5,6,7-trihydroxy-4’-methoxyflavone and the methyl esters, semisynthetic derivatives of a mixture of ursolic and oleanolic acids, showed no activity against the tested microorganisms. These results suggest that the carboxyl group present in the triterpenes may contribute to antimicrobial activity.

scholarly journals Synthesis of new derivatives of hydrazinecarbothioamides and 1,2,4-triazoles and evaluation of their antimicrobial activities

2015 ◽  
Vol 80 (12) ◽  
pp. 1461-1470 ◽  
Author(s):  
Laura Socea ◽  
Gabriel Saramet ◽  
Constantin Draghici ◽  
Bogdan Socea ◽  
Vlad Constantin ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Shigella Flexneri ◽  
13C Nmr Spectroscopy ◽  
Antimicrobial Activities ◽  
Bacillus Subtilis Atcc ◽  
Naoh Solution ◽  
New Compounds ◽  
Derivatives Of

A new series of hydrazinecarbothioamides 6-9 bearing 5H-dibenzo[a,d][7]annulene moiety were synthesized. Cyclization of 6-9 in NaOH solution produced the corresponding 1,2,4-triazoles-3(4H)-thiol 10-13, which proved to be axial isomers. The thioethers 14-17 were prepared by alkylation of 10-13 with methyl iodide. All new compounds were characterized by elemental analysis, IR-, UV-, 1H-NMR and 13C-NMR spectroscopy. The evaluation for antimicrobial activity against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, Bacillus subtilis ATCC 6663, Salmonella tiphimurium ATCC 14028, Shigella flexneri ATCC 12022, Candida albicans ATCC 90028 was performed.

scholarly journals Antibacterial and Antifungal Activity of the Extracts of Different Parts of Avicennia marina (Forssk.) Vierh

Plants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 252
Author(s):  
Mohammad K. Okla ◽  
Abdulrahman A. Alatar ◽  
Saud S. Al-amri ◽  
Walid H. Soufan ◽  
Altaf Ahmad ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Aspergillus Fumigatus ◽  
Ethanolic Extract ◽  
Avicennia Marina ◽  
E Coli

Increased problems associated with side effects and bacterial resistance of chemical drugs has prompted the research focus on herbal medicines in the past few decades. In the present investigation, the antimicrobial activity of the various parts of Avicennia marina (AM), a mangrove plant, has been evaluated. The plants were collected from the Jazan area of the Kingdom of Saudi Arabia. Primary extracts of roots, stem, leaves, fruits, and seeds were made in ethanol and fractioned in ethanol, ethyl acetate, petroleum ether, chloroform, and water. Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of the extracts were determined against Bacillussubtilis, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. It has been observed that the chloroform extract of roots of the AM exhibited inhibitory effects against both S. aureus (MIC = 1.5 ± 0.03 mg/mL) and E. coli (MIC = 1.7 ± 0.01 mg/mL). The ethanolic extract of the AM roots has shown antibacterial activity against Pseudomonas aeruginosa (MIC = 10.8 ± 0.78 mg/mL), Bacillussubtilis (MIC = 6.1 ± 0.27 mg/mL), Staphylococcus aureus (MIC = 2.3 ± 0.08 mg/mL), and Escherichia coli (MIC = 6.3 ± 0.28 mg/mL). The leaf extract of the AM in ethyl acetate showed antibacterial activity against S. aureus and E. coli. Antifungal activity of these extracts was also investigated against Aspergillus fumigatus and Candida albicans. Ethanolic extract of roots and seeds of the AM has shown antifungal activity against Aspergillus fumigatus when applied individually. Ethanolic extract of the AM fruits has shown an inhibitory effect on the growth of Aspergillus fumigatus and Candida albicans. It is suggested that the plant extracts of AM have tremendous antimicrobial activity against a group of microbes, and this effect depends on both the plant part and the solvent used for extraction. Therefore, this plant can be considered to treat various diseases caused by antibiotic-resistant bacteria.

scholarly journals Purpurin Esters Containing a Saturated Cyclic Fragment with Antimicrobial Activity

2020 ◽  
Vol 22 (1) ◽  
pp. 43 ◽  
Author(s):  
Т.V. Kharlamova ◽  
R.B. Seidakhmetova ◽  
K.D. Praliyev
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Acid Chlorides ◽  
Bacillus Subtilis Atcc ◽  
Cyclic Fragment ◽  
Mic Value

The present study is a continuation of the scientific research works for the synthesis of anthraquinonе-containing derivatives with cyclic ring systems by the interaction of 1,2,4-trihydroxyanthraquinone (purpurin) with cyclic carboxylic acid chlorides. Series of purpurin esters containing a saturated cyclic fragment was studied for antibacterial activity about museum strains of microorganisms. The effects of these preparations in vitro about Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Pseudomonas aeruginosa АТСС 27853 and fungus Сandida albicans АТСС 10231 were studied. It has been found that the compounds with the cyclohexane fragment have possess an antimicrobial activity with strains of microorganisms Staphylococcus aureus АТСС 6538 for which the MIC value was 31.25 μg/ml.

scholarly journals Sintesis del óxido de cobre nanoestructurado asistida con irradiación gamma o ultrasonido y sus propiedades antimicrobianas

2019 ◽  
pp. 3-7
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Copper Oxide ◽  
Gamma Irradiation ◽  
Antimicrobial Properties ◽  
Ultrasound Irradiation ◽  
Cuo Nanoparticles ◽  
E Coli

Sintesis del óxido de cobre nanoestructurado asistida con irradiación gamma o ultrasonido y sus propiedades antimicrobianas Synthesis of nanostructured copper oxide assisted with Gamma or ultrasound irradiation and its antimicrobial properties Kety León, Alcides López, Javier Gago, José Solís División de Materiales, Dirección de Investigación y Desarrollo, Instituto Peruano de Energía Nuclear. Av Canadá 1470, San Borja Facultad de Ciencias, Universidad Nacional de Ingeniería. Av. Túpac Amaru 210, Rímac. DOI: https://doi.org/10.33017/RevECIPeru2011.0001/ RESUMEN Se han sintetizado nanopartículas de óxido de cobre (CuO) mediante irradiación gamma o ultrasonido. La actividad antimicrobiana de las nanopartículas de CuO se determinaron mediante el método de excavación en placa cultivo, con 3 cepas microbianas: Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922 y Pseudomonas aeruginosa ATCC 27853. La concentración bacteriana inicial fue 1x107 UFC / mL, y fueron sembradas sobre Agar Muller Hinton e incubadas a 37ºC por 24 h. Las nanopartículas de CuO obtenidas mediante ultrasonido son nanoesferas con una mayor actividad antimicrobiana para la bacteria S. aureus que para E. coli y sin actividad frente a P. aeruginosa; mientras que las nanopartículas de CuO obtenidas con radiación gamma con una dosis de 8 kGy tienen actividades antimicrobianas similares para S. aureus y E. coli y las obtenidas a dosis de 15 y 25 kGy solo tienen actividad antimicrobiana frente a E. coli. Descriptores: Nanopartículas, actividad antimicrobiana, sonoquímica, radiación gamma. ABSTRACT Copper oxide (CuO) nanoparticles have been synthesized using gamma irradiation or ultrasound. The antimicrobial activity of CuO nanoparticles was determined by excavation method in plate culture in three microbial strains: Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853. The initial bacterial concentration was 1x107 CFU / mL and seeded onto Muller Hinton Agar and incubated at 37 °C for 24 h. The CuO nanoparticles obtained by ultrasound are nanospheres with a higher antimicrobial activity for S. aureus than for E. coli and no activity against P. aeruginosa, while CuO nanoparticles obtained by gamma irradiation with a dose of 8 kGy have antimicrobial activity similar to S. aureus and E. coli and those obtained at doses of 15 and 25 kGy only have antimicrobial activity against E. coli. Keywords: Nanoparticles, antimicrobial activity, sonochemistry, gamma radiation.

scholarly journals Synthesis and antimicrobial activity of s-substituted derivatives of 1,2,4-triazol-3-thiol

2021 ◽  
pp. 64-69
Author(s):  
Yevhen Karpun ◽  
Nataliia Polishchuk
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Biological Screening ◽  
Antimicrobial Substances ◽  
Pharmaceutical Ingredients ◽  
Wide Range ◽  
Derivatives Of

The aim of the work. 1,2,4-triazole derivatives possess a wide range of pharmacological activity, so they are used for the development of drugs and active pharmaceutical ingredients. Due to the reactivity of 1,2,4-triazoles there are many options for their further structural modification on different reaction centers. Therefore, the aim of the work was to obtain new S-substituted derivatives of 1,2,4-triazole-3-thiols, study physicochemical parameters of the substances synthesized, evaluate the antimicrobial activity of new S-derivatives of the 4-R1-5-((3-(pyridin-4-yl)-1H-1,2,4-triazol-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thiol series, and study some regularities of the “structure – biological activity” relationship for the synthesized compounds as well. Materials and methods. The subject of the study was new S-substituted 1,2,4-triazoles containing 2-oxopropan-1-yl and 2-aryl-2-oxoethan-1-yl substituents. The antimicrobial activity was studied by double serial dilutions on test cultures of Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), and Candida albicans (ATCC 885-653). The results of the biological screening showed that at a concentration of 125 g/mL, all synthesized substances showed activity (MIC – in the range of 31.25 - 62.5 μg/mL, MBCK - in the range of 62.5–125 μg/mL) against strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans. Variation of substituents on the sulfur atom did not lead to a significant change in antimicrobial and antifungal activities among derivatives of 4-R1-5-((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl) thio)methyl)-4H-1,2,4-triazole-3-thiols. Conclusions. Biological screening data indicate the prospects for the search for new antimicrobial substances among the abovementioned derivatives of 1,2,4-triazoles. The most active compounds were 1-((4-ethyl-5-((3-(pyridin-4-yl)-1H-1,2,4-triazol-5-yl)thio)methyl)-4H-1,2,4-triazol-3-yl)thio)propan-2-one and 1-(4-methoxyphenyl)-2-(4-ethyl-5-(((3-(pyridin-4-yl)-1H)-1,2,4-triazol-5-yl)thio)methyl)-4H-1,2,4-triazol-3-yl)thio)ethanone, which showed the most pronounced antimicrobial activity against the Pseudomonas aeruginosa strain (MIC – 31.25 μg/mL, MBcK - 62.5 μg/mL)

TiO2 antifouling coating based on epoxy-modified tung oil waterborne resin

2021 ◽  
pp. 096739112110111
Author(s):  
Hailiang Hu ◽  
Minmin Chen ◽  
Mengye Cao
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Survival Rate ◽  
Light Irradiation ◽  
Fouling Resistance ◽  
Tung Oil ◽  
E Coli ◽  
Antifouling Coating ◽  
Waterborne Epoxy

The eco-friendly functionalized TiO2/polymer antifouling (AF) coating was successfully synthesized by dispersing TiO2 nanoparticles in waterborne epoxy-modified tung oil resin. The AF effectiveness of coating was evaluated toward Staphylococcus aureus ( S. aureus, ATCC6538), Escherichia coli ( E. coli, ATCC8739) and diatom ( Cyclotella sp., FACHB-1635). The nanoTiO2/polymer AF coating showed good antimicrobial activity both under the light and dark conditions by comparison with the pristine TiO2 nanoparticles and bulk polymer. Under light irradiation for 50 min, the AF coating showed only 8.4% and 8% survival rate for S. aureus and E. coli. In addition, The AF coatings exhibited favorable inhibition efficacy toward the growth and adhesion of Cyclotella sp., and the efficacy was enhanced with the increase of TiO2 content. It can be concluded that TiO2 nanoparticles endow the AF coatings with promoted fouling resistance properties.

scholarly journals Fabrication of a Novel AgBr/Ag2MoO4@InVO4 Composite with Excellent Visible Light Photocatalytic Property for Antibacterial Use

Nanomaterials ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1541
Author(s):  
Jie Zhang ◽  
Jia Wang ◽  
Qingjun Zhu ◽  
Binbin Zhang ◽  
Huihui Xu ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Degradation Rate ◽  
Photocatalytic Property ◽  
Photocatalytic Reaction ◽  
Composite Photocatalyst ◽  
E Coli ◽  
Radical Trapping ◽  
Visible Light Photocatalytic

A novel AgBr/Ag2MoO4@InVO4 composite photocatalyst with different heterojunction structures was successfully constructed by compounding InVO4 with Ag2MoO4 and AgBr. According to the degradation, antibacterial and free radical trapping data, the photocatalytic antibacterial and antifouling activities of AgBr/Ag2MoO4@InVO4 composite were evaluated, and the corresponding photocatalytic reaction mechanism was proposed. Adding AgBr/Ag2MoO4@InVO4 composite, the degradation rate of ciprofloxacin (CIP) achieved 95.5% within 120 min. At the same time, the antibacterial rates of Escherichia coli (E. coli), Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) achieved 99.99%. The AgBr/Ag2MoO4@InVO4 composite photocatalyst showed promising usage in photocatalytic antibacterial and purification areas.

scholarly journals Estudio fitoquímico y actividad antimicrobiana de plantas medicinales empleadas para el control de infecciones urinarias

2021 ◽  
Vol 16 (1) ◽  
pp. 43-56
Author(s):  
Lida Vanessa Hernández Moreno ◽  
Ludy Cristina Pabón Baquero ◽  
Patricia Hernández-Rodríguez
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Zingiber Officinale ◽  
Taraxacum Officinale ◽  
Portulaca Oleracea ◽  
Uncaria Tomentosa ◽  
E Coli ◽  
Anthoxanthum Odoratum ◽  
Parietaria Officinalis

Las enfermedades infecciosas han sido un desafío para la humanidad. A pesar de los avances en la ciencia, aún muchas infecciones no tienen tratamientos efectivos o los microorganismos han generado resistencia a los antibióticos, de manera que las plantas medicinales son una alternativa de tratamiento y reducción de la resistencia. El objetivo de este estudio fue realizar un análisis fitoquímico preliminar y evaluar la actividad antimicrobiana de doce extractos etanólicos deplantas empleadas en la medicina tradicional colombiana como control de infecciones urinarias (IU). Las especies Anthoxanthum odoratum (grama), Urera caracasana (ortigón), Equisetum bogotenses (cola de caballo), Parietaria officinalis (parietaria), Achyrocline bogotensis (vira vira), Kohleria hirsuta (caracola), Taraxacum officinale (diente de león), Sedum praealtum (siempre viva), Portulaca oleracea (verdolaga), Petroselinum sativum (perejil), Zingiber officinale (jengibre) y Uncaria tomentosa (uña de gato) fueron adquiridas en la plaza de mercado Soacha (Cundinamarca) y sometidas a maceración con etanol a temperatura ambiente. La actividad antimicrobiana se evaluó por difusión en agar, microdilución en placa y bioautografía frente a Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 25923) y Pseudomonas aeruginosa (ATCC 9027). Se determino que S. aureus y P. aeruginosa presentaron inhibición frente a cinco extractos en los tres métodos realizados, mientras que E. coli no fue inhibida por ningún extracto. Se estableció mediante bioautografía con reveladores específicos que los esteroides y/o triterpenoides, fenoles y flavonoides son los posibles metabolitos responsables de la actividad. Este tipo de investigaciones propicia estudios orientados al aislamiento de principios activos con utilidad en la elaboración de medicamentos para tratar IU.

scholarly journals Characterization and antimicrobial activity of vaginal lactobacillus isolate

2011 ◽  
Vol 63 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Gordana Zavisic ◽  
Zeljka Radulovic ◽  
Valentina Vranic ◽  
Jelena Begovic ◽  
L. Topisirovic ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Survival Rate ◽  
Bile Salts ◽  
Antimicrobial Effect ◽  
Low Ph ◽  
Probiotic Potential ◽  
Pathogenic Escherichia Coli

The aim of this study was to investigate the probiotic potential of bacteriocin-producing lactobacilli strain Lactobacillus plantarum G2 isolated from the vaginal mucus of healthy women. The antimicrobial effect of G2 was confirmed in the mixed culture with pathogenic Escherichia coli, Staphylococcus aureus, Salmonella abony and Pseudomonas aeruginosa, while bacteriocine activity was detected against S. aureus and S. abony only. The strain showed an excellent survival rate in low pH and in the presence of bile salts. The percentage of adhered cells of L. plantarum G2 to hexadecane was 63.85?2.0 indicating the intermediate hydrophobicity.

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