scholarly journals Identification of markers of opportunistic infections in frequently ill children in the North-Eastern regions of Russia

2019 ◽  
Vol 18 (4) ◽  
pp. 5-11 ◽  
Author(s):  
N. V. Karazhas ◽  
L. V. Feklisova ◽  
T. A. Semenenko ◽  
M. N. Kornienko ◽  
T. N. Rybalkina ◽  
...  
Keyword(s):  
Immune Complexes ◽  
Opportunistic Infections ◽  
Solid Phase ◽  
Acute Infection ◽  
Physiological Mechanism ◽  
The Body ◽  
Circulating Immune Complexes ◽  
The North ◽  
North Eastern ◽  
Regions Of Russia

The study is devoted to the clinical examination of frequently ill children in the North-Eastern regions of Russia and the laboratory detection of markers of herpesvirus infections, as well as pneumocystosis and the establishment of the relationship with their immune status.62 children aged 8—15 years were examined. Samples of serum and blood cells, sputum on markers of herpesvirus infections and pneumocystosis by ELISA, indirect immunofluorescence reaction and rapid culture method were studied. Assessment of humoral immunity and determination of circulating immune complexes was performed by solid-phase enzyme immunoassay and immune turbodimetric analysis.The study shows the etiological role of herpesviruses. Active infection (acute, reactivation) was caused in 9.7% of cases of HSV-1,2, 12.9% — EBV, 6.5% — CMV, 19.4% — HHV-6. This is indicated by a large number of convalescents: with EBVI — 40.3%, HSVI — 27.4%, HHVI-6 — 8.1%, CMVI — 4.8%. Also, a significant number of children were found and latent form. The formation of the circulating immune complexes (CIC) is a physiological mechanism of protection of the body, and their excessive accumulation indicates the development of inflammatory processes and autoimmune diseases. In the increase in CIC observed mainly in individuals with latent infection: HSVI — 29.4%; HHVI-6 — 20.8%; CMVI — 16.7%, EBVI — 11.9%. It is important to note that in almost half of the cases the increase in CIC level occurred simultaneously with the increase in the concentration of total IgE. A survey of children on Pneumocystis showed that among them, dominated native — 11.3%, in which the sputum was identified pnevmotsisty. It should be noted that one child was found mixed infection with reactivated CMVI. Acute infection was diagnosed only in 6.4% of the patients.

Circulating Immune Complexes in Human Malignant Melanoma

1982 ◽  
Vol 68 (6) ◽  
pp. 469-472 ◽  
Author(s):  
Raffaele D'Amelio ◽  
Brian Cooke ◽  
John R. Hobbs
Keyword(s):  
Malignant Melanoma ◽  
Immune Complexes ◽  
Solid Phase ◽  
Serum Antibody ◽  
Specific Protein ◽  
Circulating Immune Complexes ◽  
Serum Samples ◽  
Human Malignant Melanoma ◽  
Third Stage ◽  
Solid Phase Assay

The sera from 34 patients with malignant melanoma at various clinical stages of the disease were examined for the presence of circulating immune complexes (CIC) by the C1q solid-phase assay. Their urine and serum samples had been previously examined for the presence of an urinary melanoma-specific protein (MSP) and the corresponding serum antibody. Low levels of CIC (only in the third stage of the disease) and no positive correlation with the presence of MSP were found. The discordance between our and other author's data stresses again the fact that the different laboratory methods for CIC evaluation reveal in a different way the various CIC populations occurring in several diseases.

Demonstration of HBsAg as the antigen component in circulating immune complexes detected by peg-solid phase test

1986 ◽  
Vol 14 (2) ◽  
pp. 141-151 ◽  
Author(s):  
D.E. Sansonno ◽  
P. Detomaso ◽  
M.V. Primavera ◽  
M.A. Papanice ◽  
R. Donnaloia ◽  
...  
Keyword(s):  
Immune Complexes ◽  
Solid Phase ◽  
Circulating Immune Complexes

scholarly journals The Pseudo-Schick Reaction and the Intradermol Toxoid Test of Moloney: their Relationship and Significance

1935 ◽  
Vol 35 (4) ◽  
pp. 512-533 ◽  
Author(s):  
Maurice Mitman
Keyword(s):  
The State ◽  
The Body ◽  
Fever Hospital ◽  
New Members ◽  
The North ◽  
North Eastern ◽  
The Subject ◽  
Relationship Of

A total of 212 new members of the staff of the North-Eastern Fever Hospital were Schick and Moloney tested. The Schick-positive reactors were immunised with formol toxoid and post-Schick and Moloney tests were performed. The following conclusions were reached:(1) The intradermal toxoid test of Moloney or Zoeller corresponds exactly with the pseudo response in the Schick test.(2) The pseudo response is as efficient as the Moloney for detecting possible reactors to immunising doses of toxoid, and is a more accurate control of the Schick test. The Moloney therefore appears redundant.(3) A positive MP (Moloney or pseudo) reaction accurately indicates those who will react to immunisation; but a negative MP is no guarantee that the subject will not react.(4) The MP-reaction is evidence of bacterial hypersensitiveness to specific products of the body of the diphtheria bacillus.(5) Zoeller's theory that hypersensitiveness is a half-way stage between susceptibility and immunity, is incorrect.(6) MP-reactions usually, but not invariably, develop pari passu with immunity. Because of this parallelism tests of hypersensitiveness give information as to the state of immunity.The significance of tests of infection, hypersensitiveness and immunity are considered; and the possible relationship of MP-reactions with bacterial immunity suggested.

scholarly journals The upper respiratory tract microbiome of indigenous Orang Asli in north-eastern Peninsular Malaysia

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
David W. Cleary ◽  
Denise E. Morris ◽  
Rebecca A. Anderson ◽  
Jessica Jones ◽  
Ahmed Ghazi Alattraqchi ◽  
...  
Keyword(s):  
Respiratory Health ◽  
Acute Infection ◽  
Peninsular Malaysia ◽  
Upper Respiratory Tract ◽  
Pneumococcal Serotypes ◽  
Orang Asli ◽  
Eastern State ◽  
The North ◽  
Vaccine Type ◽  
North Eastern

AbstractMuch microbiome research has focused on populations that are predominantly of European descent, and from narrow demographics that do not capture the socio-economic and lifestyle differences which impact human health. Here we examined the airway microbiomes of the Orang Asli, the indigenous peoples of Malaysia. A total of 130 participants were recruited from two sites in the north-eastern state of Terengganu in Peninsular Malaysia. Using 16S rRNA sequencing, the nasal microbiome was significantly more diverse in those aged 5–17 years compared to 50+ years (p = 0.023) and clustered by age (PERMANOVA analysis of the Bray–Curtis distance, p = 0.001). Hierarchical clustering of Bray–Curtis dissimilarity scores revealed six microbiome clusters. The largest cluster (n = 28; 35.4%) had a marked abundance of Corynebacterium. In the oral microbiomes Streptococcus, Neisseria and Haemophilus were dominant. Using conventional microbiology, high levels of Staphylococcus aureus carriage were observed, particularly in the 18–65 age group (n = 17/36; 47.2% 95% CI: 30.9–63.5). The highest carriage of pneumococci was in the <5 and 5 to 17 year olds, with 57.1% (4/7) and 49.2% (30/61), respectively. Sixteen pneumococcal serotypes were identified, the most common being the nonvaccine-type 23A (14.6%) and the vaccine-type 6B (9.8%). The prevalence of pneumococcal serotypes covered by pneumococcal conjugate vaccines support introduction into a Malaysian national immunisation schedule. In addition, the dominance of Corynebacterium in the airway microbiomes is intriguing given their role as a potentially protective commensal with respect to acute infection and respiratory health.

scholarly journals Indicators of total homeostasis in cows in different periods of lactations

2021 ◽  
Vol 51 (2) ◽  
pp. 56-64
Author(s):  
E. A. Dementyeva ◽  
S. N. Mager
Keyword(s):  
Immune Complexes ◽  
Relative Number ◽  
The Body ◽  
Mononuclear Phagocytes ◽  
Circulating Immune Complexes ◽  
High Rate ◽  
Control Group ◽  
Dry Period ◽  
Birth Process ◽  
Significant Difference

The immunomorphological parameters of cattle in different periods of lactation were studied. In the first 3 months of lactation, excluding 7 days of the colostrum period, 59.3 units of circulating immune complexes were found in the serum, in the middle of lactation (4–7 months) – 94.2 (p <0.05), at the end (8–10 months) – 94.1 units (p <0.05). The significant difference between the indicator in the first 3 months and in the subsequent periods of lactation is due to the fact that at the beginning of lactation the cows were not yet pregnant. In the colostrum period, a high rate of circulating immune complexes of 116.1 units (p <0.05) was determined as a consequence of a fetal prenatal immune attack on the cow's body, when the system of mononuclear phagocytes had not yet coped with the elimination of neutralization products. During the dry period, the number of circulating immune complexes was 87.6 units (p <0.05). The decrease in the indicator occurred due to an increase in the activity of mononuclear phagocytes and the absence of lactation effect on the body. The content of segmental, functionally mature leukocytes at the beginning of lactation was 39.4%, in the middle of lactation this indicator decreased to 24.8% (p<0.05), at the end it was 26.3% (p<0.05). A significant difference was found in the relative number of segmented neutrophils in the control group and in non-lactating cows in the dry period – 29.9% (p <0.05). During the colostrum period, the level of lymphocytes in the blood of animals was 62.0% (p <0.05) and it significantly differed from the control – 43.6%. In the middle and at the end of lactation, there was also a significant difference between the indicator and the control, up to 58.9–59.4% (p<0.05). A significant difference with the group of down-calving dry cows was established – 53.9% (p <0.05). In the first 1–3 months of lactation, cows are either not yet pregnant, or a close bond (placenta) between the mother and the fetus has not yet been formed, therefore a low activity of specific immunity at this time is caused by the absence of foreign fetal antigens in the blood of cows. The findings suggest that the birth process may be initiated by the immune system.

scholarly journals Peculiarities of the formation and subsequent removal of the circulating immune complexes from the bloodstream during the process of digestion

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 618
Author(s):  
Sergej B. Landa ◽  
Pavel V. Korabliov ◽  
Elena V. Semenova ◽  
Michael V. Filatov
Keyword(s):  
Immune Complexes ◽  
Biological Process ◽  
Biological Fluids ◽  
The Body ◽  
Circulating Immune Complexes ◽  
Physical Parameters ◽  
Kinetic Characteristics ◽  
Large Protein ◽  
Subsequent Removal ◽  
Cellular Mechanisms

Background: Large protein aggregates, known as circulating immune complexes (CICs), are formed in biological fluids as a result of the development of the body's immune response to various provoking factors. The kinetic characteristics of the formation and removal of immune complexes (ICs), their physical parameters, the isotypic composition of immunoglobulins (Igs) and the antigenic component of the CICs may reflect certain aspects of certain pathological and metabolic processes taking place in humans and animals. The aim of this study is to assess the kinetic characteristics of the formation and removal of the CICs that form in blood after eating. We also analyze the changes in the isotypic composition of Igs of ICs that accompany this biological process in rodents and humans. Methods: We identified the CICs, which differed in size and class of Igs, using dynamic light scattering. To remove ICs from the plasma, we used immune-affinity sedimentation. Monoclonal antibodies for the Igs of different isotypes were added to the plasma samples to determine the isotypic composition of the ICs. Results: A large number of ICs were formed in the blood of rats and humans after eating (food CICs). In rats, food ICs are almost immediately filtered in the liver, without circulating in the bloodstream through the body. In humans, the level of food ICs in the blood increases for 3.5 h after ingestion, then within 7–8 h their gradual removal takes place. It was found that in the process of digestion in humans, the isotypic composition of Igs in the CICs changes and becomes more diverse. Conclusions: The molecular–cellular mechanisms of the formation and utilization of food CICs in humans and rodents do not match completely.

scholarly journals D. T. BEREZOVETS AND NETAILIVKA BURIAL GROUND OF SALTIV CULTURE: DISCOVERY, MODERN RESEARCHES, RESULTS

2021 ◽  
Vol 40 (3) ◽  
pp. 342-353
Author(s):  
V. S. Aksonov
Keyword(s):  
The Body ◽  
Burial Ground ◽  
Funeral Rite ◽  
The North ◽  
Natural Factors ◽  
Literary Sources ◽  
North Eastern ◽  
Ancient Times ◽  
Bulgarian Population ◽  
Made In

Peculiarity of the Netailivka burial ground, noted by its discoverer D. T. Berezovets, is the total predominance of burials where the bones of the buried people are completely absent. At the same time the burials often contain grave goods located in the places when the bodies of the deceased should have been lied. This fact allowed D. T. Berezovets to suppose that initially the burial was performed on the surface of the earth where the body was exposed to natural factors and only after that it was re-buried into a pit. However, the researches of recent years show that burials were made in full accordance with the funeral rite of the Proto-Bulgarian population of the Saltiv culture. The absence of human remains in most of the burial pits should be associated with the specific hydrological conditions prevailing at the site of the necropolis in the post-Saltiv period. In a number of burials of the burial ground the later activity in the burial pits, associated with ritual actions performed in ancient times, were recorded. These actions testify the existence of the so-called «final ceremony» among the Netailivka people, the holding of which meant the end of mourning for the deceased person and made the death of a relative complete and final for the living. The study of the chronological markers of the site made it possible to attribute the time of the burial ground to the stage of the formation of the Saltiv culture in the region and to date the earliest burials of the necropolis to the 740—790 AD. The set of decorations and brooches from early burials shows that the original area of the migration of this population was the North-Eastern Caucasus (the territory of modern Chechnya and Dagestan). The location of the horse remains in the burials of the horsemen indicates the mixed Turkic-Ugric character of the population, which was part of the tribal union of the «Bulgars». The date of the burial ground and the probable area of residence of the population which made it, allows us to identify the «Netailivka» people with the representatives of the nomadic Bulgar union known from literary sources as «Sabirs / Savirs»

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