scholarly journals Supercritical CO2 extraction of steroidal sapogenins from fenugreek (Trigonella foenum-graecum L.)seed

2020 ◽  
Vol 26 (2) ◽  
pp. 171-182
Author(s):  
Aleksandra Bogdanovic ◽  
Vanja Tadic ◽  
Slobodan Petrovic ◽  
Dejan Skala
Keyword(s):  
Supercritical Co2 ◽  
Process Conditions ◽  
Central Composite Rotatable Design ◽  
Supercritical Co2 Extraction ◽  
Optimal Process ◽  
Trigonella Foenum Graecum ◽  
Maximal Yield ◽  
Optimal Values ◽  
Trigonella Foenum Graecum L ◽  
Central Composite

Supercritical CO2 extraction was applied on fenugreek (Trigonella foenum-graecum L., Fabaceae) seeds with the aim to define optimal process conditions to obtain the maximal extract yields content of steroidal sapogenins. Central composite rotatable design (CCRD) combined with response surface methodology (RSM) was applied to determine optimal process conditions defined by the influence and interaction of pressure, temperature and time of extraction through consumption of SC CO2. Optimization experiments revealed that the pressure of 24.73 MPa, the temperature of 38.?C and the consumption of SC CO2 of 19.24 g/gDM were the best process conditions enabling the maximal yield of extract and gain of the highest content of sapogenins. The optimal values of pressure and temperature defined SC CO2 density of 885.47 kg/m3, which provided the maximal yield of the extract with the highest content of steroidal sapogenins. The achieved yield of extract at these conditions was 0.073g/gDM, with 0.774 mg/gDM diosgenin, 0.477 mg/gDM protodioscin, 0.713 mg/gDM sarsapogenin and 0.205 mg/gDM oleanolic and ursolic acid with a significant quantity of 2.475 mg/gDM in the obtained extract.

Trigonella foenum-graecum L. Seed Oil Obtained by Supercritical CO2 Extraction

2012 ◽  
Vol 89 (12) ◽  
pp. 2269-2278 ◽  
Author(s):  
Renming Yang ◽  
Honglun Wang ◽  
Nianhua Jing ◽  
Chenxu Ding ◽  
Yourui Suo ◽  
...  
Keyword(s):  
Supercritical Co2 ◽  
Seed Oil ◽  
Supercritical Co2 Extraction ◽  
Trigonella Foenum Graecum ◽  
Trigonella Foenum Graecum L

Kaempferol Extraction from Cuscuta reflexa using Supercritical Carbon Dioxide and Separation of Kaempferol from the Extracts

2011 ◽  
Vol 7 (4) ◽  
Author(s):  
Pranabendu Mitra ◽  
Kyu -Seob Chang ◽  
Dae-Seok Yoo
Keyword(s):  
Supercritical Co2 ◽  
Extraction Process ◽  
Optimum Conditions ◽  
Supercritical Co2 Extraction ◽  
Independent Variables ◽  
Cuscuta Reflexa ◽  
Optimal Processing ◽  
Layer Chromatography ◽  
Temperature Time ◽  
Central Composite

Kaempferol, a strong antioxidant, was extracted from Cuscuta reflexa (a medicinal plant) using supercritical CO2 and separated using thin-layer chromatography, column chromatography and HPLC analysis. A rotatable central composite design was used to determine the influence of process variables and arrive at optimal processing conditions in the supercritical CO2 extraction process of kaempferol. The kaempferol yield was effectively modelled as a function of the independent variables (temperature, time and pressure). The kaempferol yield increased with the increasing of temperature and time and decreasing of pressure of the supercritical CO2 extraction process. The predicted kaempferol yield at the optimum point was 52.92 µg/g and the optimum conditions were 50.7°C for 132.6 min and 15.9 MPa.

scholarly journals Vaccinium meridionale Swartz Supercritical CO2 Extraction: Effect of Process Conditions and Scaling Up

Materials ◽  
2016 ◽  
Vol 9 (7) ◽  
pp. 519 ◽  
Author(s):  
Alexis López-Padilla ◽  
Alejandro Ruiz-Rodriguez ◽  
Claudia Restrepo Flórez ◽  
Diana Rivero Barrios ◽  
Guillermo Reglero ◽  
...  
Keyword(s):  
Supercritical Co2 ◽  
Scaling Up ◽  
Process Conditions ◽  
Supercritical Co2 Extraction

Fabrication, Optimization and Characterization of Paclitaxel and Spirulina Loaded Nanoparticles for Enhanced Oral Bioavailability

2020 ◽  
Vol 16 (5) ◽  
pp. 723-733
Author(s):  
Keerthi G.S. Nair ◽  
Yamuna Ravikumar ◽  
Sathesh Kumar Sukumaran ◽  
Ramaiyan Velmurugan
Keyword(s):  
Gastric Cancer ◽  
Oral Bioavailability ◽  
Surfactant Concentration ◽  
Polymer Concentration ◽  
Central Composite Rotatable Design ◽  
Normal Cells ◽  
Stirring Time ◽  
Nanoparticle Formulation ◽  
Central Composite

Background: Paclitaxel and spirulina when administered as nanoparticles, are potentially useful. Methods: Nanoformualtions of Paclitaxel and Spirulina for gastric cancer were formulated and optimized with Central composite rotatable design (CCRD) using Response surface methodology (RSM). Results: The significant findings were the optimal formulation of polymer concentration 48 mg, surfactant concentration 45% and stirring time of 60 min gave rise to the EE of (98.12 ± 1.3)%, DL of (15.61 ± 1.9)%, mean diameter of (198 ± 4.7) nm. The release of paclitaxel and spirulina from the nanoparticle matrix at pH 6.2 was almost 45% and 80% in 5 h and 120 h, respectively. The oral bioavailability for the paclitaxel spirulina nanoparticles developed is 24.0% at 10 mg/kg paclitaxel dose, which is 10 times of that for oral pure paclitaxel. The results suggest that RSM-CCRD could efficiently be applied for the modeling of nanoparticles. The paclitaxel and spirulina release rate in the tumor cells may be higher than in normal cells. Paclitaxel spirulina nanoparticle formulation may have higher bioavailability and longer sustainable therapeutic time as compared with pure paclitaxel. Conclusion: Paclitaxel-Spirulina co-loaded nanoparticles could be effectively useful in gastric cancer as chemotherapeutic formulation.

scholarly journals Optimized Supercritical CO2 Extraction Enhances the Recovery of Valuable Lipophilic Antioxidants and Other Constituents from Dual-Purpose Hop (Humulus lupulus L.) Variety Ella

Antioxidants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 918
Author(s):  
Nóra Emilia Nagybákay ◽  
Michail Syrpas ◽  
Vaiva Vilimaitė ◽  
Laura Tamkutė ◽  
Audrius Pukalskas ◽  
...  
Keyword(s):  
Supercritical Co2 ◽  
Antioxidant Properties ◽  
Extraction Yield ◽  
Biologically Active ◽  
High Yield ◽  
Acid Extraction ◽  
Supercritical Co2 Extraction ◽  
Bioactive Constituents ◽  
Total Extract

The article presents the optimization of supercritical CO2 extraction (SFE-CO2) parameters using response surface methodology (RSM) with central composite design (CCD) in order to produce single variety hop (cv. Ella) extracts with high yield and strong in vitro antioxidant properties. Optimized SFE-CO2 (37 MPa, 43 °C, 80 min) yielded 26.3 g/100 g pellets of lipophilic fraction. This extract was rich in biologically active α- and β-bitter acids (522.8 and 345.0 mg/g extract, respectively), and exerted 1481 mg TE/g extract in vitro oxygen radical absorbance capacity (ORAC). Up to ~3-fold higher extraction yield, antioxidant recovery (389.8 mg TE/g pellets) and exhaustive bitter acid extraction (228.4 mg/g pellets) were achieved under the significantly shorter time compared to the commercially used one-stage SFE-CO2 at 10–15 MPa and 40 °C. Total carotenoid and chlorophyll content was negligible, amounting to <0.04% of the total extract mass. Fruity, herbal, spicy and woody odor of extracts could be attributed to the major identified volatiles, namely β-pinene, β-myrcene, β-humulene, α-humulene, α-selinene and methyl-4-decenoate. Rich in valuable bioactive constituents and flavor compounds, cv. Ella hop SFE-CO2 extracts could find multipurpose applications in food, pharmaceutical, nutraceutical and cosmetics industries.

scholarly journals Supercritical CO2 extraction of Moroccan argan (Argania spinosa L.) oil: Extraction kinetics and solubility determination

2021 ◽  
Vol 46 ◽  
pp. 101458
Author(s):  
Adil Mouahid ◽  
Isabelle Bombarda ◽  
Magalie Claeys-Bruno ◽  
Sandrine Amat ◽  
Emmanuelle Myotte ◽  
...  
Keyword(s):  
Supercritical Co2 ◽  
Oil Extraction ◽  
Supercritical Co2 Extraction ◽  
Extraction Kinetics ◽  
Argania Spinosa ◽  
Solubility Determination

scholarly journals Supercritical CO2 Extraction of Palladium Oxide from an Aluminosilicate-Supported Catalyst Enhanced by a Combination of Complexing Polymers and Piperidine

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 684
Author(s):  
Andrea Ruiu ◽  
Bernhard Bauer-Siebenlist ◽  
Marin Senila ◽  
W. S. Jennifer Li ◽  
Karine Seaudeau-Pirouley ◽  
...  
Keyword(s):  
Energy Saving ◽  
Supercritical Co2 ◽  
Supported Catalyst ◽  
Precious Metals ◽  
Palladium Oxide ◽  
Supercritical Co2 Extraction ◽  
Wide Range

Precious metals, in particular Pd, have a wide range of applications in industry. Due to their scarcity, precious metals have to be recycled, preferably with green and energy-saving recycling processes. In this article, palladium extraction from an aluminosilicate-supported catalyst, containing about 2 wt% (weight%) of Pd (100% PdO), with supercritical CO2 (scCO2) assisted by complexing polymers is described. Two polymers, p(FDA)SH homopolymer and p(FDA-co-DPPS) copolymer (FDA: 1,1,2,2-tetrahydroperfluorodecyl acrylate; DPPS: 4-(diphenylphosphino)styrene), were tested with regards to their ability to extract palladium. Both polymers showed relatively low extraction conversions of approximately 18% and 30%, respectively. However, the addition of piperidine as activator for p(FDA-co-DPPS) allowed for an increase in the extraction conversion of up to 60%.

Sign in / Sign up

Export Citation Format

Share Document