Synthesis of the 4’-desmethoxy analogue of RU79115
2004 ◽
Vol 69
(11)
◽
pp. 855-859
◽
The synthesis, and biological activity in vitro of the 4?-desmethoxy analogue (3) of RU 79115 (2) is described. Comparison of the biological activity of the two analogues clearly indicated the importance of the 4?-methoxy group in conferring good gyrase B inhibitory activity as well as antibacterial activity.