scholarly journals Synthesis and antioxidant activity study of pyrazoline carrying arylfuran/thiophene moiety

2014 ◽  
Vol 79 (12) ◽  
pp. 1469-1475 ◽  
Author(s):  
Vidyashree Jois ◽  
Balakrishna Kalluraya ◽  
K.S. Girisha
Keyword(s):  
Antioxidant Activity ◽  
Acetic Acid ◽  
Hydrazine Hydrate ◽  
Mass Spectra ◽  
Moderate Activity ◽  
Acetic Acid Medium ◽  
X Ray ◽  
Thiophene Moiety ◽  
Dpph Scavenging ◽  
Dpph Scavenging Assay

A novel series of N-acetyl-3-aryl-5-(5-(p/o-nitrophenyl)-2-arylfuryl/thienyl) substituted pyrazoline (3a-o) were synthesized by the reaction of 1-aryl-3-(5-(p/o-nitrophenyl)-2-furyl/thienyl)-2-propene-1-one with hydrazine hydrate in acetic acid medium. The structures of the newly synthesized compounds were established by IR, 1H NMR, mass spectra and single crystal X-ray study. The synthesized compounds were subjected to antioxidant activity using DPPH scavenging assay. The compounds 3a, 3f, 3h and 3o showed moderate activity.

scholarly journals Nitration of Jharia basin coals, India: a study of structural modifications by XRD and FTIR techniques

2021 ◽  
Author(s):  
Prabal Boral ◽  
Atul K. Varma ◽  
Sudip Maity
Keyword(s):  
Acetic Acid ◽  
Nitric Acid ◽  
Linear Relationship ◽  
Glacial Acetic Acid ◽  
Vitrinite Reflectance ◽  
Aqueous Media ◽  
Interlayer Spacing ◽  
Acetic Acid Medium ◽  
X Ray ◽  
The Media

AbstractFour coal samples from Jharia basin, India are treated with nitric acid in glacial acetic acid and aqueous media to find out the chemical, petrographic and spatial structure of the organic mass by X-ray diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR) techniques. X-ray parameters of coal like interlayer spacing (d002), crystallite size (Lc), aroamticity (fa), average number of aromatic layers (Nc), and coal rank (I26/I20) have been determined using profile-fitting software. Considerable variation is observed in treated coals in comparison to the demineralized coals. The d002 values of treated coals have increased in both the media showing increase in disordering of organic moieties. A linear relationship has been observed between d002 values with the volatile matter of the coals. Similarly, the d002 values show linear relationship with Cdmf contents for demineralized as well as for the treated coals in both the media. The Lc and Nc values have decreased in treated coals corresponding to demineralized coals. The present study shows that nitration in both the media is capable of removing the aliphatic side chains from the coals and aromaticity (fa) increases with increase in rank and shows a linear relationship with the vitrinite reflectance. The corresponding I26/I20 values are least for treated coals in glacial acetic acid medium followed by raw and then to treated coals in aqueous medium. FTIR studies show that coal arenes of the raw coals are converted into nitro-arenes in structurally modified coals (SMCs) in both the media, the corresponding bands at 1550–1490 and 1355–1315 cm−1 respectively. FTIR study confirms that nitration is the predominant phenomenon, though, oxidation and nitration phenomena takes place simultaneously during treatment with nitric acid to form SMCs. In comparison to raw coals, the SMCs show higher aromaticity and may be easily converted to coal derived products like activated carbon and specialty carbon materials.

Comprehensive GC-MS and FT-IR Profiling of Coleus zeylanicus essential oil and investigation of its anti-fungal and anti - oxidant activities

2021 ◽  
Vol 12 (1) ◽  
pp. 636-642
Author(s):  
Lakshmi M ◽  
Nandagopal S
Keyword(s):  
Antioxidant Activity ◽  
Candida Albicans ◽  
Essential Oil ◽  
Malassezia Furfur ◽  
Fungal Strains ◽  
Anti Oxidant ◽  
Ft Ir ◽  
Dpph Scavenging ◽  
Dpph Scavenging Assay ◽  
Anti Fungal

To evaluate the leaf volatile constituents of essential oil of Coleus zeylanicus and evaluate their anti-oxidant and anti-fungal activity. The Chemical composition of Coleus zeylanicus essential oil was determined using GC-MS and FT-IR analytical techniques. The antioxidant activity was evaluated using DPPH scavenging assay. The anti-fungal effect was tested against two potential pathogenic fungal strains - Candida albicans and Malassezia furfur using agar well diffusion method. The essential oil was profiled by the presence of sesquiterpene hydrocarbons 90.67% of their total composition followed by oxygenated monoterpenes and monoterpene hydrocarbons as 5.3% and 2.1% respectively. The GC-MS results showed 14 compounds from Coleus zeylanicus leaf EO representing 98.07% of the total oil composition. The major component was identified as a-Gurjunene (35.94%), a-bisabolol (10.82%) and G-selinene (4.26%). EO showed remarkable antioxidant activity values of IC50 = 59.78± 3.21µg/ml by DPPH scavenging assay. The essential oil showed interesting anti-fungal effects against two pathogenic fungal strains. The most sensible strains to Coleus zeylanicus EO was Malassezia furfur (32.00±0.50mm) compared to that of Candida albicans (15.00±1.25mm). Hence, Coleus zeylanicus EO has potential application against fungal infection and oxidative stress-related diseases. However, further investigations are necessary to isolate and investigate the action mechanism of these bioactive compounds.

scholarly journals PHYTOCHEMICAL ANALYSIS, ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF THYMUS VULGARIS L.

2020 ◽  
Vol 1 (2) ◽  
Author(s):  
Moaiza Iftikhar ◽  
Salma Batool
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Biologically Active ◽  
Thymus Vulgaris ◽  
Plant Sample ◽  
Phytochemical Analysis ◽  
Bacterial Strains ◽  
Anti Oxidant ◽  
Dpph Scavenging ◽  
Dpph Scavenging Assay

Medicinal activities of Thymus vulgaris L. were studied in the underlying research which was conducted in University of Central Punjab, Lahore. The powdered plant sample was collected and subjected to extraction and filtration by dissolving it in seven different solvents and thus the fractions obtained, were used for further analysis. The qualitative and quantitative analysis was carried out which revealed that this plant contained many biologically active compounds like saponin, alkaloids etc. These compounds have enormous bioactive roles. Antimicrobial activity was also determined in which four bacterial strains were used and the susceptibility of all the fractions of plant extract was determined by their inhibition zones which were calculated in mm. The results showed that water and chloroform extracts of plant has highest activity. The antioxidant activity was also determined by DPPH scavenging assay for which different concentrations of all plant extracts were made and their absorbance was noted to measure the percentage inhibition of each concentration, which revealed that this plant has significant antioxidant activity. The results have been represented using statistical approach that revealed that T. vulgaris plant has significant antibacterial and anti-oxidant activities and phytochemical analysis also proved that it has many useful compounds which have voluminous biological activity and these could be used in the formation of novel drugs.

scholarly journals A Flavonoid Glycoside from the Leaves of Morinda Tinctoria

2008 ◽  
Vol 3 (9) ◽  
pp. 1934578X0800300
Author(s):  
Atish K. Sahoo ◽  
Nisha Narayanan ◽  
S. Rajan ◽  
Pulok K. Mukherjee
Keyword(s):  
Antioxidant Activity ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
First Record ◽  
2D Nmr ◽  
Flavonoid Glycoside ◽  
Dpph Scavenging ◽  
Dpph Scavenging Assay ◽  
Morinda Tinctoria

Tilianin (acacetine-7- O-β-D-glucopyranoside) was isolated from the ethyl acetate extract of Morinda tinctoria Roxb. and its structure established unambiguously by a series of 1D- and 2D-NMR analyses. This is the first record of this compound for this species. The antioxidant activity of tilianin, determined using the DPPH scavenging assay, was measured with an IC50 value of 57.5 μg/mL.

scholarly journals Inhibition of Digestive Enzymes and Antioxidant Activity of Extracts from Fruits of Cornus alba, Cornus sanguinea subsp. hungarica and Cornus florida–A Comparative Study

Plants ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 122
Author(s):  
Joanna Truba ◽  
Iwona Stanisławska ◽  
Marta Walasek ◽  
Wioleta Wieczorkowska ◽  
Konrad Woliński ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Digestive Enzymes ◽  
Flavonoid Glycosides ◽  
Cornus Florida ◽  
Fruit Extract ◽  
Cornus Alba ◽  
Biological Potential ◽  
Phytochemical Profile ◽  
Dpph Scavenging ◽  
Dpph Scavenging Assay

The fruits of some Cornus species (dogwoods) are used in traditional medicine and considered potential anti-diabetic and hypolipemic agents. The aim of the study was to determine the ability of extracts from Cornus alba (CA), Cornus florida (CF), and Cornus sanguinea (CS) to inhibit digestive enzymes namely α-amylase, pancreatic lipase, and α-glucosidase, as well as isolation of compounds from plant material with the strongest effect. In addition, the phytochemical profile and antioxidant activity of extracts from three dogwoods were compared with HPLC-DAD-MS/MS and DPPH scavenging assay, respectively. Among the aqueous-ethanolic extracts, the activity of α-amylase was the most strongly inhibited by the fruit extract of CA (IC50 = 115.20 ± 14.31 μg/mL) and the activity of α-glucosidase by the fruit of CF (IC50 = 38.87 ± 2.65 μg/mL). Some constituents of CA fruit extract, such as coumaroylquinic acid, kaempferol, and hydroxytyrosol derivatives, were isolated. Among the three species of dogwood studied, the greatest biological potential was demonstrated by CA extracts, which are sources of phenolic acids and flavonoid compounds. In contrast, iridoid compounds or flavonoid glycosides found in fruits of CF or CS extracts do not play a significant role in inhibiting digestive enzymes but exert antioxidant activity.

scholarly journals Evaluation of antioxidant activity of Nilapanai kizhangu chooranam through DPPH Scavenging Assay

2017 ◽  
Vol 4 (2) ◽  
pp. 28-31
Author(s):  
S. Sudharsan ◽  
◽  
V. Velpandian ◽  
M. Pitchiah kumar ◽  
V. Banumathi ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Dpph Scavenging ◽  
Dpph Scavenging Assay

scholarly journals Synthesis and Antioxidant activity of novel Pyrazoline derivatives

2018 ◽  
Vol 10 (1) ◽  
pp. 43-49
Author(s):  
B.C. Revanasiddappa ◽  
M.Vijay Kumar ◽  
Hemanth Kumar
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Moderate Activity ◽  
Acetic Acid Medium ◽  
Standard Drug ◽  
Mass Spectral ◽  
Aldehydes And Ketones ◽  
New Compounds ◽  
In Vitro Antioxidant Activity

Plan: A novel series of pyrazolines were synthesized through chalcones. The synthesized compounds were evaluated for various antioxidant activities. Preface: Pyrazolines belongs to five-membered nitrogen classes of compounds. Pyrazolines were reported with widespread chemotherapeutic activities. Methodology: A new series of Chalcones (2a-j) were prepared by reacting substituted aldehydes and ketones in alcohol medium in presence of NaOH. The chalcones (2a-j) undergoes selective cyclization with benzhydrazide (1) in glacial acetic acid medium to yield the title compounds 1, 3, 5-trisubstituted Pyrazolines (3a-j). The new compounds were assigned on the basis of 1H-NMR, IR and Mass spectral data. The newly synthesized compounds were screened for their In-Vitro antioxidant activity by DPPH, superoxide and nitric oxide methods. Outcome: Some of the tested compounds 3e, 3g, and 3f showed moderate activity when compared to the standard drug ascorbic acid.

scholarly journals ANTIOXIDANT ACTIVITY AND TOTAL PHENOLIC CONTENT IN RIPE AND UNRIPE POMEGRANATE (PUNICA GRANATUM L.) FRUIT JUICE

2021 ◽  
pp. 60-63
Author(s):  
MUHAMMAD AMJAD ◽  
ZOBIA ANWER
Keyword(s):  
Antioxidant Activity ◽  
Fruit Juice ◽  
Punica Granatum ◽  
Antioxidant Potential ◽  
Total Phenolic ◽  
Ripe Fruit ◽  
Unripe Fruit ◽  
Water Solvent ◽  
Dpph Scavenging ◽  
Dpph Scavenging Assay

Objective: P. granatum L. is famous for antioxidant activity and utilized as a nourishing foodstuff. This work aimed to recognize the antioxidant activity and TPC in extracts of ripe and unripe fruit juice. Methods: Competency of the solvents (water, methanol, acetone, chloroform, ethanol) were evaluated by analyzing extracts of ripe and unripe P. granatum L. fruit juice for TPC and DPPH* scavenging assay. FTC method measured the level of peroxides. Results: In TPC extraction, the water solvent showed greater potential in both ripe (10.5±2.1) and unripe fruit juice (4.1±0.3) amongst all other solvents. Ethanol and water solvent showed the highest value of DPPH* scavenging activity (96%±6.81 and 72%±3.50 respectively) in ripe and unripe fruit juice. According to absorbance of DPPH radicals, the water solvent showed the highest antioxidant potential in ripe fruit juice (86%±6.78) like chloroform solvent in unripe fruit juice (14%±0.03). Unripe fruit juice showed lowest level of absorbance of DPPH radicals and highest antioxidant potential amid all solvents. In FTC method, unripe fruit juice showed the highest antioxidant activity and low amount of peroxides for consecutively seven days. Conclusion: Ripe fruit juice showed the highest TPC and unripe fruit juice showed the maximum value of antioxidant potential. P. granatum L. provides an excellent supply of antioxidant activity and used in pharmaceutical and food industry.

An unusual reaction of a bridged triterpenoid α-diketone with acetic anhydride

1991 ◽  
Vol 56 (12) ◽  
pp. 2917-2935 ◽  
Author(s):  
Eva Klinotová ◽  
Václav Křeček ◽  
Jiří Klinot ◽  
Miloš Buděšínský ◽  
Jaroslav Podlaha ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Nmr Spectroscopy ◽  
Acetic Anhydride ◽  
Spectral Methods ◽  
X Ray Diffraction ◽  
X Ray ◽  
Mild Conditions ◽  
Condensation Products ◽  
Unsaturated Lactones ◽  
C Nmr

3β-Acetoxy-21,22-dioxo-18α,19βH-ursan-28,20β-olide (IIIa) reacts with acetic anhydride in pyridine under very mild conditions affording β-lactone IVa and γ-lactones Va and VIIa as condensation products. On reaction with pyridine, lactones Va and VIIa undergo elimination of acetic acid to give unsaturated lactones VIIIa and IXa, respectively. Similarly, the condensation of 20β,28-epoxy-21,22-dioxo-18α,19βH-ursan-3β-yl acetate (IIIb) with acetic anhydride leads to β-lactone IVb and γ-lactone Vb; the latter on heating with pyridine affords unsaturated lactone VIIIb and 21-methylene-22-ketone Xb. The structure of the obtained compounds was derived using spectral methods, particularly 1H and 13C NMR spectroscopy; structure of lactone IVa was confirmed by X-ray diffraction.

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