scholarly journals Gross characteristics of placentas from an assisted reproduction program

2006 ◽  
Vol 59 (1-2) ◽  
pp. 47-50 ◽  
Author(s):  
Dunja Tabs ◽  
Tihomir Vejnovic ◽  
Dusan Lalosevic ◽  
Nebojsa Radunovic
Keyword(s):  
Umbilical Cord ◽  
Assisted Reproduction ◽  
Intrauterine Insemination ◽  
Study Group ◽  
Vitro Fertilization ◽  
Significant Difference ◽  
The Mean ◽  
Natural Conception ◽  
Umbilical Cords

Introduction. Even though placentas from assisted reproduction programs often differ from placentas of women who conceived naturally, they are rarely examined. The aim of our investigation was to determine some gross characteristics of placentas of women who conceived with assisted reproduction. Material and methods. We examined 30 placentas from an assisted reproduction program (20 from in vitro fertilization and 10 from intrauterine insemination) and 30 placentas of women who conceived naturally. All women were age matched. All the women were at term. Results. The mean weight of placentas from assisted reproduction program was 573 g and of those after natural conception - 582.67g. The mean length of the umbilical cords was 64.3cm after assisted reproduction and 66.3cm after natural conception. The mean placenta thickness after assisted reproduction was 2,22 cm and after natural conception 2.28 cm. Eight pla?centas of the study group had a marginal insertion of the umbilical cord, which lead to a statistically significant difference when compared to placentas of women who conceived naturally: ?? =7.07; p>0.01. Discussion. Marginal cord insertion into the placenta after assisted reproduction is also often described in the literature (as a possible "consequence " of embryo-transfer). Conclusion. There were no statistically significant differences in the mean weight and dimensions of placentas, length of the umbilical cord, gross pathological features of placentas and cords, mean birth weight of babies and placental/fetal ratios between women from assisted reproduction program and those who conceived naturally. .

scholarly journals Preterm and premature rupture of membranes in pregnancies after in vitro fertilization

2005 ◽  
Vol 58 (7-8) ◽  
pp. 375-379 ◽  
Author(s):  
Dunja Tabs ◽  
Tihomir Vejnovic ◽  
Nebojsa Radunovic
Keyword(s):  
In Vitro Fertilization ◽  
Intrauterine Insemination ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Fertilization Program ◽  
Vitro Fertilization ◽  
Preterm Premature Rupture ◽  
Natural Conception ◽  
Singleton Pregnancies

Women conceiving by assisted reproduction are at higher risk for preterm and premature rupture of membranes. The aim of our study was to estimate and compare incidence of preterm premature rupture of membranes in singleton pregnancies of women who conceived by intrauterine insemination and in vitro fertilization, from 1999 to 2003. We investigated 87 women from the intrauterine insemination, and 102 from the in vitro fertilization program. There were no statistically significant differences in regard to preterm and premature rupture of membranes: p>0.75 in two groups. The incidence of premature rupture of membranes was 2.30% (after intrauterine insemination) and 2.94% (after in vitro fertilization). There was no statistically significant differences in regard to preterm and premature rupture of membranes in women who conceived by insemination and in vitro fertilization. Estimated incidence of preterm and premature rupture of membranes was similar to the literature data and also similar to incidence after natural conception.

Effectiveness of Nursing Counseling on Coping and Depression in Women Undergoing in Vitro Fertilization

2007 ◽  
Vol 100 (2) ◽  
pp. 365-374 ◽  
Author(s):  
Nermin Gürhan ◽  
Aygül Akyüz ◽  
Fahriye Oflaz ◽  
Derya Atici ◽  
Gulsen Vural
Keyword(s):  
In Vitro Fertilization ◽  
Coping Strategies ◽  
Study Groups ◽  
Study Group ◽  
Vitro Fertilization ◽  
Individual Interviews ◽  
Care Services ◽  
Significant Difference ◽  
And Coping

The purpose of present study was to evaluate the effectiveness of counseling provided by nurses on depression and coping strategies of infertile women undergoing in vitro fertilization ( N = 67). Of the 84 women who were interviewed, 30 were accepted as a comparison group, and 37 were included in the study group. The study group women were given counseling in addition to routine nursing care services, including group education and individual interviews about treatment and coping strategies. The nurses also provided support by accompanying the women during the invasive procedures. The Beck Depression Inventory and Jalowiec's Coping Strategies Form were used for measurements. All the women were using emotional coping and had moderate depression prior to the study. There was no statistically significant difference between the comparison and study groups before or after the counseling with respect to depression and coping strategies. Parameters to evaluate the efficacy of counseling are discussed.

scholarly journals Does Acupuncture Have Any Benefit in the IVF Treatment of Couples with Unexplained Infertility; A Prospective Randomized Controlled Trial

2019 ◽  
pp. 1
Author(s):  
Songul Ece Gonen ◽  
Pınar Kadirogullari ◽  
Kerem Doga Seckin ◽  
Bunyamin Borekci
Keyword(s):  
In Vitro Fertilization ◽  
Embryo Transfer ◽  
Controlled Trial ◽  
Unexplained Infertility ◽  
Controlled Study ◽  
Control Group ◽  
Study Group ◽  
Vitro Fertilization ◽  
Significant Difference

<p><strong>Objective:</strong> We aimed to investigate the effect of acupuncture performed as an adjuvant therapy to in vitro fertilization, on pregnancy rates by performing acupuncture on the day of embryo transfer, one hour before the procedure and one hour after the procedure.</p><p><strong>Study Design:</strong> In this open-label randomized prospective controlled study, 60 unexplained infertility patients enrolled for in vitro fertilization treatment were randomized by a computer-based number generator for acupuncture performance and no-treatment. All patients received rFSH (Gonal-F®) for ovulation induction and the antagonist Cetrorelix (Cetrotide®) to prevent premature ovulation. Ovulation was triggered by using hCG (Ovitrelle®) and egg collection was done after 36-48 hours. In the study group, acupuncture was performed by intradermal needling, bilaterally with a sterile needle, both one hour before and one hour after the embryo transfer. Acupuncture was not performed on the control group. The results of the treatment were evaluated 12 days after embryo transfer.</p><p><strong>Results:</strong> Thirty patients were randomized into the study group and 30 patients were randomly placed in the control group. Although there was no statistically significant difference between groups in terms of β-hCG positivity, it was 43.3% in the study group and 36.7% in the control group (p&gt;0.05).</p><p><strong>Conclusion:</strong> The success rate of in vitro fertilization was higher in terms of pregnancy rate in the patient group who received acupuncture procedure as well, but the difference was not statistically significant. This may be due to the type of acupuncture procedure selected or insufficient sample size. As a result, further studies involving larger numbers of participants and using different acupuncture techniques are needed.</p>

scholarly journals Risk Assessment of the Increased Occurrence of Congenital Cardiac and Non-Cardiac Defects in Fetuses with a Normal Karyotype after Assisted Fertilization in Comparison to Natural Fertilization Based on Ultrasound Diagnostics

2021 ◽  
Vol 10 (23) ◽  
pp. 5630
Author(s):  
Dawid Serafin ◽  
Beniamin Oskar Grabarek ◽  
Dariusz Boroń ◽  
Andrzej Madej ◽  
Bartosz Czuba
Keyword(s):  
Assisted Reproduction ◽  
Artificial Insemination ◽  
Intrauterine Insemination ◽  
Heart Defects ◽  
First Trimester ◽  
Ductus Venosus ◽  
Crown Rump Length ◽  
Vitro Fertilization ◽  
Ultrasound Diagnostics

The goal of the study was to assess changes in parameters based on ultrasound examinations—these were Crown Rump Length (CRL), Nuchal Translucency (NT), Fetal Heart Rate (FHR), and Pulsatility Index for Ductus Venosus (DV-PI)—in the first trimester of pregnancy in women in which there was a natural initiation of the pregnancy due to spontaneous ovulation, women in which the pregnancy was initiated as a result of stimulated ovulation, as well as in the group in which pregnancy was achieved through the use of In-Vitro Fertilization (IVF)-assisted reproduction. A total of 1581 women became pregnant without the use of assisted reproduction methods. Out of 283 pregnancies, in 178 patients, induced ovulation was utilized. Next, 137 women had sexual intercourse and became pregnant; 41 of them became pregnant through Intrauterine Insemination (IUI) as a result of Artificial Insemination by Husband (AIH), and 13 became pregnant after Artificial Insemination by Donor (AID). The third group consisted of 105 women subjected to Controlled Ovarian Hyperstimulation (COH). In this group of pregnant women, 53 pregnancies were resultant of Intracytoplasmic Sperm Injection (ICSI), and 52 pregnancies were the result of Intracytoplasmic Morphologically selected Sperm Injection (IMSI). The obtained results did not indicate that the chosen method of fertilization or the chosen ovulation method had a statistically significant effect on the development risk of congenital heart or non-heart defects in the fetus.

scholarly journals Intrauterine Insemination Success Rates Between Patients TSH Level of 2.5 mIU/L and 2.5-4.5 mIU/L

2021 ◽  
Vol 3 (1) ◽  
pp. 27-35
Author(s):  
Gizem Berfin Uluutku ◽  
Basak Ergin ◽  
İbrahim Kale ◽  
Rahime Nida Bayık
Keyword(s):  
Intrauterine Insemination ◽  
Threshold Value ◽  
Control Group ◽  
Study Group ◽  
Success Rates ◽  
Ongoing Pregnancy ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Mean ◽  
Infertility Patients

The aim of this study to assess whether there is a need to decrease the TSH level below 2.5 mIU/L in unexplainable infertility patients who were undergoing intrauterine insemination and determining the difference between patients with a TSH level of 2.5 mIU / L and patients with a TSH level of 2.5-4.5 mIU/L in terms of the success of intrauterine insemination. This study conduct via cross-sectional examinations of the 272 patients who applied to Ümraniye Training and Research Hospital infertility outpatient clinic between 01.06.2017-01.10.2019, who underwent intrauterine insemination with the diagnosis of unexplained infertility. Results research the mean age of the cases participating in our study is 31.65 ± 5.28, and the mean BMI measured as 24.17 ± 4.30 kg / m2. TSH values range from 0.3 to 5.2, with an average of 1.84 ± 0.93; while TSH value of 174 cases (77.3%) is below 2.5 mIU/L, TSH value of 51 cases (22.7%) is between 2.5-4.5mIU/L. Within the control group with TSH <2.5 mIU/L, the cycle was canceled in 13 cases (7.5%), pregnancy did not occur in 143 cases (82.2%). While ongoing pregnancy was achieved in 17 cases (9.8%), clinical pregnancy was achieved in 1 case (0,6%). Also, within the study group with a TSH value of 2.5-4.5 mIU/L, cycles were canceled in 7 cases (13.7%), pregnancy did not occur in 40 cases (78.4%), and ongoing pregnancy was achieved in 4 patients (7.8%). There was no statistically significant difference in terms of intrauterine insemination success between the control group with TSH <2.5 mIU / L and the study group with TSH 2.5-4.5 mIU/L. Widespread randomized controlled prospective studies need to determine the optimal TSH threshold value before TSH treatment of the women receiving infertility treatment.

scholarly journals A comparison of in vitro fertilization-embryo transfer outcome by two types of soft embryo transfer catheters

2020 ◽  
Vol 7 (3) ◽  
pp. 3678-3685
Author(s):  
Soghra Rabiei ◽  
Mahnaz Yavangi ◽  
Marzieh Farimani ◽  
Iraj Amiri ◽  
Mohamad Fallah ◽  
...  
Keyword(s):  
Clinical Trial ◽  
In Vitro Fertilization ◽  
Embryo Transfer ◽  
Vitro Fertilization ◽  
Significance Level ◽  
Significant Difference ◽  
Group A ◽  
The Mean ◽  
Group B

Introduction: One of the remaining challenges in assisted reproductive procedures, especially in vitro fertilization (IVF), is proper embryo transfer. The aim of this clinical trial was to compare IVFembryo transfer outcome by two types of soft embryo transfer catheters in Hamadan Endometrics and Endometriosis Research Center (Iran). Methods: In this clinical trial study, 100 patients who were candidates for IVF were evaluated. Patients were randomly assigned into two groups (A=50 and B=50). The IVF was identical for both groups until the embryo transfer stage. For group A, soft catheter CH3 PM TRANS SET MINI was used and in group B, KITAZATO soft catheter was used for embryo transfer. All transfers were performed by one person. Patients were recruited using checklists, demographic information, infertility history, beta-human chorionic gonadotropin (ß-hCG) serum levels at day 14 post-transfer, and pregnancy bag 28 days after transfer. The results were analyzed by SPSS software version 16 and using descriptive statistics, chi-square and t-test. The significance level was < 0.05. Results: The mean age of group A and group B was 30.12 and 29.24 years, respectively (p=0.341). The mean duration of infertility in both groups was not statistically significant, and in groups A and B were 4.89 and 4 years, respectively. Ninety % of group A experienced their first IVF experience, while in group B it was slightly lower than 86%, which was not statistically significant. The mean number of eggs obtained in group A was 9.84 and in the group B was 9.88 (p=0.962). The mean number of embryos formed in group A was 6.24 and in group B was 5.72 (p=0.405). There was no statistically significant difference between the two groups in using of Tenaculum, the quality of transmission, and the contamination of the catheter head into the blood or mucus. Conclusion: According to the findings of the present study, the use of KITAZATO catheter compared to PM TRANS SET MINI CH3 catheter for fetal transfer in IVF patients showed no significant difference in pregnancy success rate. However, patients who received the KITAZATO catheter had a slightly higher chance of pregnancy that could be clinically valuable.  

scholarly journals Preoperative follicle-stimulating hormone: A factor associated with semen parameter improvement after microscopic subinguinal varicocelectomy

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Vinayak Madhusoodanan ◽  
Ruben Blachman-Braun ◽  
Premal Patel ◽  
Lunan Ji ◽  
Thomas A. Masterson ◽  
...  
Keyword(s):  
Intrauterine Insemination ◽  
Sperm Count ◽  
Small Sample Size ◽  
Follicle Stimulating Hormone ◽  
Small Sample ◽  
Vitro Fertilization ◽  
Semen Parameter ◽  
Natural Conception ◽  
Stimulating Hormone

Introduction: Currently, there exists no serum biomarker to predict patients likely to benefit from varicocelectomy. The purpose of this study was to assess the association between baseline follicle-stimulating hormone (FSH) and semen parameter changes after subinguinal microscopic varicocelectomy. Methods: We retrospectively reviewed all men who underwent microscopic subinguinal varicocelectomy between August 2015 and October 2018. Pre- and postoperative semen analyses were stratified per total motile sperm count (TMSC): TMSC <5, 5–9, and >9 million (based on TMSC required for in vitro fertilization, intrauterine insemination (IUI), and natural conception, respectively). Then, variables were analyzed to determine the correlation with postoperative TMSC values and upgrade in TMSC category. Results: Among the 66 men analyzed, 55 (83.3%) and 11 (16.7%) had a preoperative TMSC of <5 million and 5–9 million, respectively. A total of 33 (50%) patients upgraded in TMSC category, 26 of them achieving levels corresponding to natural conception and seven achieving those of IUI. Additionally, a significant correlation was observed between postoperative TMSC and preoperative TMSC (r=0.528; p<0.001), and preoperative FSH (r=-0.314; p=0.010). A lower preoperative FSH (odds ratio [OR] 0.82; 95% confidence interval [CI] 0.68–0.98; p=0.028) and a higher preoperative TMSC (OR 1.37; 95% CI 1.06–1.76; p=0.015) were associated with upgrade in TMSC category. Conclusions: Lower preoperative FSH and higher TMSC are associated with improvement in TMSC category after varicocelectomy, although small sample size limited the study. FSH can be useful to identify men who are most likely to benefit from varicocele repair.

P–323 Ovarian response to stimulation according to endometrioma size, in women with deep infiltrating endometriosis – A comparative study

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Y Dahan ◽  
M Bourdon ◽  
C Maignien ◽  
C Patrat ◽  
L Marcellin ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Transvaginal Ultrasound ◽  
Live Birth Rate ◽  
Deep Infiltrating Endometriosis ◽  
Ovarian Endometriosis ◽  
Vitro Fertilization ◽  
Significant Difference ◽  
The Mean ◽  
Infiltrating Endometriosis

Abstract Study question Does endometrioma (OMA) size affect the number of oocytes retrieved after ovarian stimulation (OS) in women with deep infiltrating endometriosis (DIE)? Summary answer: No significant difference in the number of oocytes retrieved was observed according to the endometrioma size. What is known already Ovarian endometriosis lesions (OMA) per se and above all, the surgical excision, appears to result in a risk of alteration of the ovarian reserve. In vitro fertilization (IVF) is a validated therapeutic option to treat infertility related to endometriosis. Nevertheless, it has been described that the presence of OMA could have a detrimental impact on ovarian responsiveness to hyperstimulation involving mechanisms still unclear. Some recent studies suggest that the size of the OMA may be relevant and that there may be a threshold in cyst diameter above which ovarian responsiveness might be affected. Study design, size, duration: This was an observational study using data prospectively collected in a cohort of infertile women aged between 18 and 43 years presenting OMA associated with DIE lesions, between December 2012 and July 2019. Every patient underwent their first in vitro fecundation or intracytoplasmic sperm injection (IVF/ICSI) cycle. Included women were women with an adequate imaging work up with Transvaginal ultrasound and/or magnetic resonance imaging (TVUS/MRI) performed by senior radiologists before the beginning of the OS. Participants/materials, setting, methods One hundred and eighty-two women were included in the study. Women were allocated in 5 groups according to the largest diameter of their ovarian endometriosis lesions: OMA &lt; 2 cm, 2 cm ≤ OMA &lt; 4 cm, 4 cm ≤ OMA &lt; 6 cm, 6 cm ≤ OMA &lt; 8 cm, OMA ≥ 8 cm. The main outcome was the number of oocytes retrieved. Main results and the role of chance Mean age of the included women was 32.8 years. 96(52.7%) women had unilateral endometrioma and 86 (47.3%) had bilateral endometriomas. The mean OMA size was 3.63 cm for right ovary and 3.60 cm for left ovary. Considering the largest diameter of OMA retained, the mean size was 4.12 cm. Repartition among groups, according to the size of the largest OMA diameter was: OMA &lt; 2cm group (n = 32); 2 £OMA&lt; 4 cm (n = 70); 4 £OMA&lt; 6 cm, (n = 37); 6 £OMA&lt; 8 cm (n = 27); OMA8 cm (n = 16). Mean number of oocytes retrieved was not significantly different between groups (p = 0.635): 8.4±5.7 for OMA&lt; 2 cm, 7.3 ± 5.4 for 2 cm≤OMA&lt;4 cm, 6.6 ± 3.9 for 4 cm≤OMA&lt; 6 cm, 8.6 ± 5.8 for 6 cm ≤OMA&lt;8 cm and 7.1 ± 3.6 for OMA≥8 cm. Mean number of matures oocytes was also comparable between groups (p = 0.674). Clinical pregnancy rate and live birth rate was similar between groups (p = 0.798 and p = 0.913). No significant difference was found concerning the number of cancelled cycles between groups (p = 0.703). Limitations, reasons for caution For almost half of the included women, endometriosis diagnosis was based on imaging technics, without histological proof of endometriosis. However, it was performed by specialized seniors radiologists. Wider implications of the findings: Our study suggests that whatever endometrioma size, OS can be benefit for women with endometrioma, even for largest ones, without the requirement of prior treatment to reduce their size Trial registration number NA

scholarly journals The developmental competence of bovine oocytes matured in vitro using thymosin beta 4

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Joanna Romanek ◽  
Joanna Jurkiewicz ◽  
Agnieszka Wierzchoś-Hilczer ◽  
Jolanta Opiela
Keyword(s):  
Developmental Competence ◽  
Vitro Fertilization ◽  
Thymosin Beta 4 ◽  
Maturation Medium ◽  
Significant Difference ◽  
The Mean ◽  
Bovine Oocytes ◽  
Positive Effect

AbstractThe aim of this study was to examine the effect of thymosin beta 4 (Tβ4) during in vitro maturation (IVM) of oocytes and subsequent embryonic development after in vitro fertilization as well as to assess the quality of obtained blastocysts. COCs were matured in vitro in 4 different media: 1. control medium; 2. control media supplemented with 50 ng/mL Tβ4; 3. control media supplemented with 0.5 mg/mL Tβ4; and 4. control media supplemented with 1 mg/mL Tβ4. The quality of the developed blastocysts was analysed by the TUNEL method. The number of cleaved eggs was significantly higher (P < 0.05) when gametes were matured in the presence of 50 ng/mL Tβ4 than it was using the other types of media. Additionally, the largest number of blastocysts was observed when 0.5 mg Tβ4 was added to the medium (P < 0.05). No significant difference was noted in the mean number of apoptotic nuclei per blastocyst or in the mean number of nuclei per blastocyst in any of the analysed groups. In conclusion, Tβ4 supplementation (50 ng/mL) in maturation medium increased the number of cleaved oocytes, and the number of blastocysts obtained increased when 0.5 mg/mL Tβ4 was used. This positive effect was not observed when higher a higher concentration of Tβ4 (1 mg/mL) was used.

Unexplained infertility and expectant management in women aged 39 or above: is it acceptable to ask couples to wait one year before receiving IVF? A retrospective cohort study

2020 ◽  
Author(s):  
Andrea Roberto Carosso ◽  
Rik van EEKELEN ◽  
Alberto Revelli ◽  
Stefano CANOSA ◽  
Noemi MERCALDO ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Live Birth ◽  
Expectant Management ◽  
Unexplained Infertility ◽  
Vitro Fertilization ◽  
Age Related ◽  
Significant Difference ◽  
Natural Conception ◽  
One Year

Abstract Background: in older women, it is difficult to distinguish between ‘true’ unexplained infertility and age-related infertility. Unexplained infertile couples can have further expectant management before starting assisted reproductive treatments to avoid unnecessary, invasive and expensive treatment. However, ovarian reserve rapidly declines after 39 years or more, as the live birth rate after in vitro fertilization. It is thus uncertain if such a waiting policy, is also appropriate for women of advanced age.Methods: couples who had access to a waiting list for approximately one year before receiving reimbursed public IVF were compared with those paying for access to immediate private treatment at the IVF unit of S. Anna academic hospital and its private appendix. To allow for comparisons between these two strategies, we followed up couples who opted to pay for one year after the last embryo transfer from their first cycle. Clinical procedures regarding diagnosis and treatment were the same for both groups. We calculated the proportion of live births in both groups and compared these using a two-sample Z test for equality of proportions. The imbalance between these groups in terms of prognosis was accounted for using inverse probability weighting.Results: 635 couples were evaluated. Out of 359 couples in the immediate group, 70 (19.5%) had a live birth of which 11 after natural conception and 59 after IVF. Out of 276 couples in the waiting group, 57 (20.7%) had a live birth of which 37 after natural conception and 20 after IVF. There was no statistically significant difference between the two strategies in terms of the cLBR (19.5% immediate versus 20.7% waiting, 95% CI for difference: -0.07to 0.05), also after weighting (16.8% immediate versus 26.6% waiting, bootstrap 95%, CI for difference: -0.20 to 0.01).Conclusion(s): the cLBR for the ‘waiting before in vitro fertilization’ and the ‘immediate’ strategies were similar. Further studies are necessary to validate these findings and to better characterize these patients in order to individualize treatment and optimize economic resources, particularly in a setting of publicly-funded IVF.Trial registration: retrospectively registered

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