The effects of acute administration of losartan, angiotensin II type-1 receptor antagonist, on hemodynamics and oxidative stress parameters in malignant hypertensive rats

Malignant hypertension is a severe form of hypertension which pathogenesis is not fully elucidated. The aim of our study was to investigate the role of Angiotensin II on hemodynamic and oxidative stress parameters in model of malignant hypertension by using losartan. Adult males were divided into three groups: normotensive Wister rats, control SHR and losartan treated SHR. Control and SHR group received a single bolus dosage of saline, while the SHR + LOS group received a losartan. Blood pressure, cardiac output, both total peripheral and carotid vascular resistance and carotid blood flow were measured. CAT, SOD and TBARS were determined in the blood samples. The treatment significantly decreased the blood pressure. There was no significant change in cardiac output or carotid blood flow, but treatment resulted in diminishment of vascular resistances, both total peripheral and carotid. There was a tendency to restore the values of SOD activity towards those of the normotensive group, but there were no change in CAT and TBARS levels. Taken together, our results show that a single application of losartan has a strong hypotensive effect. Angiotensin II seems to have a significant role in the malignant hypertension syndrome and it partially affects oxidative stress parameters.

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Effect of omega-3 fatty acids supplementation on cardio-metabolic and oxidative stress parameters in patients with chronic kidney disease: a systematic review and meta-analysis

BMC Nephrology ◽

10.1186/s12882-021-02351-9 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Siavash Fazelian ◽

Fatemeh Moradi ◽

Shahram Agah ◽

Akramsadat Hoseini ◽

Hafez Heydari ◽

...

Keyword(s):

Oxidative Stress ◽

Systematic Review ◽

Blood Pressure ◽

Meta Analysis ◽

Density Lipoprotein ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Oxidative Stress Parameters ◽

And Oxidative Stress ◽

Stress Parameters

Abstract Background Omega-3 fatty acids (FAs) have been suggested as a beneficial supplement in chronic kidney disease (CKD) patients, but the results of randomized clinical trials (RCTs) are controversial. We conducted a systematic review and meta-analysis to evaluate all the RCTs about the impact of omega-3 FAs supplementation on cardiometabolic outcomes and oxidative stress parameters in patients with CKD. Methods We performed a systematic database search in PubMed/MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Central, up to May 2020. We included all placebo-controlled randomized trials that assessed the effect of omega-3 FAs supplementation on any cardiometabolic outcomes: blood pressure, total cholesterol (TC), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) or triglycerides (TG) and oxidative stress parameters. Data were pooled using DerSimonian–Laird’s random-effects model. Results Finally, thirteen articles met the inclusion criteria for this review omega-3 FAs supplementation significantly decrease TC (SMD: -0.26; 95% CI: − 0.51, − 0.02; I2 = 52.7%), TG (SMD: -0.22; 95% CI: − 0.43, − 0.02; I2 = 36.0%) and Malondialdehyde (MDA) levels (SMD: -0.91; 95% CI: − 1.29, − 0.54; I2 = 00.0%) and also significantly increase superoxide dismutase (SOD) (SMD: 0.58; 95% CI: 0.27, 0.90; I2 = 00.0%) and Glutathione peroxidase (GPx) (SMD: 0.50; 95% CI: 0.14, 0.86; I2 = 00.0%) activities. However our results show that omega-3 FAs supplementation have no significant effects on HDL, LDL and blood pressure. Conclusion This systematic review and meta-analysis supports current evidence for the clinical benefit of omega-3 FAs intake to improve cardiometabolic parameters in CKD patients. However, well-designed RCTs still needed to provide a conclusive picture in this field.

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Homeopathic Medicine Rauwolfia Serpentina Ameliorate Blood Pressure and Oxidative Stress Parameters of Kidney by Modulating Expression of Antioxidant Enzymes in Deoxycorticosterone Acetate (DOCA)-Salt-Induced Hypertensive Rat Model

Journal of Drug Research and Development ◽

10.16966/2470-1009.111 ◽

2016 ◽

Vol 2 (1) ◽

Cited By ~ 1

Author(s):

Kumar S

Keyword(s):

Oxidative Stress ◽

Blood Pressure ◽

Antioxidant Enzymes ◽

Rat Model ◽

Deoxycorticosterone Acetate ◽

Oxidative Stress Parameters ◽

Rauwolfia Serpentina ◽

Homeopathic Medicine ◽

And Oxidative Stress ◽

Stress Parameters

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Acute responses of hemodynamic and oxidative stress parameters to aerobic exercise with blood flow restriction in hypertensive elderly women

Molecular Biology Reports ◽

10.1007/s11033-018-4261-1 ◽

2018 ◽

Vol 45 (5) ◽

pp. 1099-1109 ◽

Cited By ~ 8

Author(s):

Angélica Barili ◽

Vanessa da Silva Corralo ◽

Andréia Machado Cardoso ◽

Aline Mânica ◽

Beatriz da Silva Rosa Bonadiman ◽

...

Keyword(s):

Oxidative Stress ◽

Blood Flow ◽

Aerobic Exercise ◽

Elderly Women ◽

Blood Flow Restriction ◽

Flow Restriction ◽

Oxidative Stress Parameters ◽

Acute Responses ◽

And Oxidative Stress ◽

Stress Parameters

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Omega-3 fatty acids and mood stabilizers alter behavioral and oxidative stress parameters in animals subjected to fenproporex administration

Metabolic Brain Disease ◽

10.1007/s11011-016-9942-7 ◽

2016 ◽

Vol 32 (2) ◽

pp. 519-528 ◽

Cited By ~ 2

Author(s):

Lara M. Gomes ◽

Milena Carvalho-Silva ◽

Letícia J. Teixeira ◽

Joyce Rebelo ◽

Isabella T. Mota ◽

...

Keyword(s):

Oxidative Stress ◽

Fatty Acids ◽

Mood Stabilizers ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Oxidative Stress Parameters ◽

And Oxidative Stress ◽

Stress Parameters

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Behavior and oxidative stress parameters in rats subjected to the animal's models induced by chronic mild stress and 6-hydroxydopamine

Behavioural Brain Research ◽

10.1016/j.bbr.2021.113226 ◽

2021 ◽

Vol 406 ◽

pp. 113226

Author(s):

Talita Tuon ◽

Sandra S. Meirelles ◽

Airam B. de Moura ◽

Thayse Rosa ◽

Laura A. Borba ◽

...

Keyword(s):

Oxidative Stress ◽

Chronic Mild Stress ◽

Mild Stress ◽

Oxidative Stress Parameters ◽

6 Hydroxydopamine ◽

And Oxidative Stress ◽

Stress Parameters

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Conjugated Linoleic Acid-Curcumin Attenuates Cognitive Deficits and Oxidative Stress Parameters in the Ethidium Bromide–Induced Model of Demyelination

Neurotoxicity Research ◽

10.1007/s12640-020-00310-0 ◽

2021 ◽

Author(s):

Behnaz Barzegarzadeh ◽

Homeira Hatami ◽

Gholamreza Dehghan ◽

Nazli Khajehnasiri ◽

Mehdi Khoobi ◽

...

Keyword(s):

Oxidative Stress ◽

Linoleic Acid ◽

Conjugated Linoleic Acid ◽

Ethidium Bromide ◽

Cognitive Deficits ◽

Oxidative Stress Parameters ◽

And Oxidative Stress ◽

Stress Parameters

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Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2021-0020 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Basiru Olaitan Ajiboye ◽

Babatunji Emmanuel Oyinloye ◽

Jennifer Chidera Awurum ◽

Sunday Amos Onikanni ◽

Adedotun Adefolalu ◽

...

Keyword(s):

Oxidative Stress ◽

Body Weight ◽

Protective Role ◽

Diabetic Rats ◽

Gene Expressions ◽

Ki 67 ◽

Oxidative Stress Parameters ◽

And Oxidative Stress ◽

Stress Parameters

Abstract Objectives The current study evaluates the protective role of aqueous extract of Sterculia tragacantha leaf (AESTL) on pancreatic gene expressions (insulin, PCNA, PDX-1, KI-67 and GLP-1R) and oxidative stress parameters in streptozotocin-induced diabetic rats. Methods Diabetes mellitus was induced into the experimental Wistar animals via intraperitoneal (IP) injection of streptozotocin (35 mg/kg body weight) and 5% glucose water was given to the rats for 24 h after induction. The animals were categorized into five groups of 10 rats each as follows normal control, diabetic control, diabetic rats administered AESTL (150 and 300 mg/kg body weight) and diabetic rats administered metformin (200 mg/kg) orally for two weeks. Thereafter, the animals were euthanized, blood sample collected, pancreas harvested and some pancreatic gene expressions (such as insulin, PCNA, PDX-1, KI-67, and GLP-1R)s as well as oxidative stress parameters were analyzed. Results The results revealed that AESTL significantly (p<0.05) reduced fasting blood glucose level, food and water intake, and lipid peroxidation in diabetic rats. Diabetic rats administered different doses of AESTL showed a substantial upsurge in body weight, antioxidant enzyme activities, and pancreatic gene expressions (insulin, PCNA, PDX-1, KI-67, and GLP-1R). Conclusions It can therefore be concluded that AESTL has the ability to protect the pancreas during diabetes mellitus conditions.

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Dopamine Gene Polymorphism, Biochemical and Oxidative Stress Parameters in Geriatric Population with and Without Depression: A Pilot Study

Indian Journal of Clinical Biochemistry ◽

10.1007/s12291-020-00928-z ◽

2021 ◽

Author(s):

Raza Abbas Mahdi ◽

Israr Ahmad ◽

Talha Jilani ◽

Jamal Akhtar Ansari ◽

Farzana Mahdi ◽

...

Keyword(s):

Oxidative Stress ◽

Pilot Study ◽

Gene Polymorphism ◽

Geriatric Population ◽

Oxidative Stress Parameters ◽

And Oxidative Stress ◽

Stress Parameters

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The Influence of Probiotic Supplementation on Depressive Symptoms, Inflammation, and Oxidative Stress Parameters and Fecal Microbiota in Patients with Depression Depending on Metabolic Syndrome Comorbidity—PRO-DEMET Randomized Study Protocol

Journal of Clinical Medicine ◽

10.3390/jcm10071342 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1342

Author(s):

Oliwia Gawlik-Kotelnicka ◽

Anna Skowrońska ◽

Aleksandra Margulska ◽

Karolina H. Czarnecka-Chrebelska ◽

Igor Łoniewski ◽

...

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Study Protocol ◽

Bifidobacterium Longum ◽

White Blood Cells ◽

Fecal Microbiota ◽

Probiotic Supplementation ◽

Oxidative Stress Parameters ◽

And Oxidative Stress ◽

Stress Parameters

There is a huge need to search for new treatment options and potential biomarkers of therapeutic response to antidepressant treatment. Depression and metabolic syndrome often coexist, while a pathophysiological overlap, including microbiota changes, may play a role. The paper presents a study protocol that aims to assess the effect of probiotic supplementation on symptoms of depression, anxiety and stress, metabolic parameters, inflammatory and oxidative stress markers, as well as fecal microbiota in adult patients with depressive disorders depending on the co-occurrence of metabolic syndrome. The trial will be a four-arm, parallel-group, prospective, randomized, double-blind, controlled design that will include 200 participants and will last 20 weeks (ClinicalTrials.gov identifier: NCT04756544). The probiotic preparation will contain Lactobacillus helveticus Rosell®-52, Bifidobacterium longum Rosell®-175. We will assess the level of depression, anxiety and stress, quality of life, blood pressure, body mass index and waist circumference, white blood cells count, serum levels of C-reactive protein, high-density lipoprotein (HDL) cholesterol, triglycerides, fasting glucose, fecal microbiota composition and the level of some fecal microbiota metabolites, as well as serum inflammatory markers and oxidative stress parameters. The proposed trial may establish a safe and easy-to-use adjunctive treatment option in a subpopulation of depressive patients only partially responsive to pharmacologic therapy.

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