scholarly journals Treatment of recurrent aphthous stomatitis by laser therapy: A systematic review of the literature

2015 ◽  
Vol 72 (8) ◽  
pp. 722-728 ◽  
Author(s):  
Verica Pavlic ◽  
Vesna Vujic-Aleksic ◽  
Akira Aoki ◽  
Lana Nezic
Keyword(s):  
Laser Therapy ◽  
Treatment Options ◽  
Healing Process ◽  
Cochrane Collaboration ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Cochrane Library ◽  
Original Research ◽  
Treatment Protocols ◽  
Efficient Treatment

Background/Aim. Recurrent aphthous stomatitis (RAS) is defined as multifactor immunologic inflammatory lesions in the oral cavity, characterized by painful, recurrent single/multiple, shallow, round or ovoid ulcerations of mucosal tissues. To date, a considerable number of RAS treatment protocols have been suggested, but since the etiology of RAS is idiopathic, these treatment options have symptomatic rather than curative or preventive effect. Recently, it has been suggested that laser therapy could be successfully used as an efficient treatment approach in therapy of RAS. Therefore, the aim of this review was to estimate the effects of laser therapy in treatment of RAS analyzing results of clinical studies published in peer reviewed journals. Methods. The studies published until 31 December 2013 were obtained from the Medline/PubMed, Science Direct and Cochrane Library of the Cochrane Collaboration (CENTRAL) online databases, using following search terms and key words: ?laser? AND ?recurrent aphthous stomatitis?, ?laser? AND ?aphthous?, and ?laser? AND ?aphthae?. In total 4 original research articles met the all required inclusion/exclusion criteria, and were used for this review. The main outcome measures assessed were: a reduction of pain associated with RAS and a reduction in episode duration (faster RAS healing). Results. The assessed literature demonstrates the benefits of laser therapy mainly due to immediate analgesia and ability to speed up a RAS healing process. Conclusion. Even though the assessed literature suggests beneficial outcomes of laser therapy in treatment of RAS, these results should be interpreted with caution. The issues related to the study designs and different sets of laser irradiation parameters of a limited number of available studies with the same treatment outcomes prevent us from making definite conclusions.

scholarly journals Effectiveness of Laser Therapy in the Management of Recurrent Aphthous Stomatitis: A Systematic Review

Scientifica ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Min Han ◽  
Hui Fang ◽  
Quan-Li Li ◽  
Ying Cao ◽  
Rong Xia ◽  
...  
Keyword(s):  
Systematic Review ◽  
Laser Treatment ◽  
Laser Therapy ◽  
Clinical Effectiveness ◽  
Healing Time ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Cochrane Library ◽  
Large Sample Size ◽  
Security Issue

Objectives. Laser therapy is a promising new treatment for patients with recurrent aphthous stomatitis (RAS). However, the clinical effect and security issue of laser therapy remain controversial. This systematic review was conducted to evaluate the clinical effectiveness and security of laser treatment in RAS patients. Methods. Five electronic databases were searched (MEDLINE (PubMed), EMBASE, ScienceDirect, the Cochrane Library, and Web of Science) to identify all studies that were about randomized controlled clinical trials, involving the effect of laser therapy in RAS patients. Conclusion. Twenty-three studies were retained for full-text analysis after screening the titles and abstracts of potential articles, but only 10 studies satisfied the inclusion criteria after the full texts were reviewed. The included studies reported a comparison of the effectiveness between the laser treatment and placebo laser therapy (or conventional drug therapy) when managing the RAS patients. It can be concluded that laser therapy has the superiority in relieving ulcer pain and shortening healing time when compared with placebo group or medical treatment group. Although laser therapy is a promising effective treatment for RAS, high-quality clinical studies with large sample size must be further performed to confirm the effectiveness of this therapy.

scholarly journals Obesity and Surgical Wound Healing: A Current Review

ISRN Obesity ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Yvonne N. Pierpont ◽  
Trish Phuong Dinh ◽  
R. Emerick Salas ◽  
Erika L. Johnson ◽  
Terry G. Wright ◽  
...  
Keyword(s):  
Wound Healing ◽  
Gene Array ◽  
Nutritional Deficiencies ◽  
Cochrane Library ◽  
Wound Complications ◽  
Treatment Protocols ◽  
Efficient Treatment ◽  
Perioperative Morbidity ◽  
Immune Mediators ◽  
Increased Risk

Objective. The correlation between obesity and deficient wound healing has long been established. This review examines the current literature on the mechanisms involved in obesity-related perioperative morbidity. Methods. A literature search was performed using Medline, PubMed, Cochrane Library, and Internet searches. Keywords used include obesity, wound healing, adipose healing, and bariatric and surgical complications. Results. Substantial evidence exists demonstrating that obesity is associated with a number of postoperative complications. Specifically in relation to wound healing, explanations include inherent anatomic features of adipose tissue, vascular insufficiencies, cellular and composition modifications, oxidative stress, alterations in immune mediators, and nutritional deficiencies. Most recently, advances made in the field of gene array have allowed researchers to determine a few plausible alterations and deficiencies in obese individuals that contribute to their increased risk of morbidity and mortality, especially wound complications. Conclusion. While the literature discusses how obesity may negatively affect health on various of medical fronts, there is yet to be a comprehensive study detailing all the mechanisms involved in obesity-related morbidities in their entirety. Improved knowledge and understanding of obesity-induced physiological, cellular, molecular, and chemical changes will facilitate better assessments of surgical risks and outcomes and create efficient treatment protocols for improved patient care of the obese patient population.

scholarly journals Efficacy and safety of plant-based therapy on recurrent aphthous stomatitis and oral mucositis in the past decade: a systematic review

2021 ◽  
Vol 10 (2) ◽  
pp. 179-187
Author(s):  
Indah Suasani Wahyuni ◽  
Irna Sufiawati ◽  
Wipawee Nittayananta ◽  
Irma Melyani Puspitasari ◽  
Jutti Levita
Keyword(s):  
Oral Mucositis ◽  
Curcuma Longa ◽  
Aloe Vera ◽  
Recurrent Aphthous Stomatitis ◽  
Drug Formulation ◽  
Aphthous Stomatitis ◽  
Licorice Root ◽  
Mucosal Inflammation ◽  
Cochrane Library ◽  
Root Extract

Oral mucosal inflammation is one of the oral diseases causing pain and reducing the quality of human life. The types of oral mucosal inflammation that commonly found were recurrent aphthous stomatitis (RAS) and oral mucositis (OM). Anti-inflammatory drugs, both synthetic and plant-based, have been used to treat RAS and OM. Plant-based drugs have been attracted the attention of some researchers to minimize the side effects of synthetic drugs. However, a comprehensive review addressing the use of plant-based drugs for RAS and OM therapy, including drug formulation and species of plant, has not yet been reported. Here, we reported the article review of 9 publications derived from the databases of PubMed, ScienceDirect, Cochrane Library, and other additional relevant works, in order to find the effectiveness and safety of plant-based drugs for RAS and OM therapy. This review was written by following the PRISMA guidelines, and the risk of bias of the articles was evaluated using the Oxford Quality Scoring System. It was found that the effective and safe drugs for RAS therapy contained acemannan from Aloe vera and curcumin from Curcuma longa, both in an oral gel formulation. For OM therapy, drugs contained curcumin from Curcuma longa; licorice from Glycyrrhiza glabra; Aloe vera and black mulberry from Morus nigra, in soft tablet, mouthwash solution or mucoadhesive film formulation. In conclusion, the most effective and safest plant-based therapy for RAS is Acemannan 0.5% in oral gel, whereas for OM is Licorice root extract 0.18 mg in mucoadhesive film.

scholarly journals Clinical Evaluation of 660 nm Diode Laser Therapy on the Pain, Size and Functional Disorders of Recurrent Aphthous Stomatitis

2019 ◽  
Vol 7 (9) ◽  
pp. 1516-1522 ◽  
Author(s):  
Hisham Abdelmonem Soliman ◽  
Diana Mostafa
Keyword(s):  
Laser Therapy ◽  
Diode Laser ◽  
Pathological Condition ◽  
Ventral Surface ◽  
Healing Time ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Control Group ◽  
Functional Disorders ◽  
Significant Difference

BACKGROUND: Minor recurrent aphthous stomatitis (MiRAS) is one of the most common, recurrent, and painful mucosal pathological condition. It is characterised by round or shallow oval ulcers, less than 10 mm in diameter, surrounded by a thin erythematous halo. It involves non-keratinized mucosa such as the labial and buccal mucosa, the ventral surface or borders of the tongue and the floor of the mouth, but it is uncommon to occur on the keratinised mucosa. It heals spontaneously within 10-14 days without scarring. There is no curative remedy to prevent its recurrence; also, available modalities only reduce the symptoms and severity of the lesion. AIM: Since these lesions may be extremely painful, we decided to estimate the pain-relieving and healing properties of low energy level laser therapy using diode laser 660 nm on MiRAS. MATERIAL AND METHODS: Twenty healthy patients suffering from minor aphthous ulcers were randomly selected from the Out-Patient Clinic of Oral Medicine Department, Faculty of Dentistry, Alexandria University. They were equally divided into two groups, study group who received 660 nm diode laser irradiation while the control group received placebo (sodium bicarbonate rinse). The visual analogue scale, size reduction, effectiveness indices and functional disorders were compared between the groups. RESULTS: Both groups presented a statistically significant difference from baseline to follow up periods. But, diode laser 660 nm treatment showed more remarkable improvements in reduction of healing time, pain and lesion size. CONCLUSION: We concluded that diode laser 660 nm should be further considered as an effective alternative therapeutic regimen to patients who suffer from recurrent aphthous stomatitis.

scholarly journals Efficacy and Safety of Topical Adenosine for Androgenetic Alopecia in Adults: A Systematic Review

2020 ◽  
Vol 54 (3) ◽  
Author(s):  
Blythe N. Ke ◽  
Juan Paolo David S. Villena ◽  
Ma. Lorna F. Frez
Keyword(s):  
Systematic Review ◽  
Adverse Effects ◽  
Hair Loss ◽  
Treatment Options ◽  
Cochrane Collaboration ◽  
Androgenetic Alopecia ◽  
Cochrane Library ◽  
Adult Males ◽  
Efficacy And Safety ◽  
Participant Satisfaction

Background. Androgenetic alopecia (AGA), also known as pattern hair loss, is the most common type of hair loss in men and women. Due to very limited therapeutic options, search for other effective and safe drugs is necessary. Objectives. This review aims to evaluate the efficacy and safety of a potential treatment option, topical adenosine, for AGA in male and female adults. Methods. A search of databases (Cochrane Library, Pubmed Medline, and others) was performed with no time limitations placed. We included human interventional studies published in English involving the use of topical adenosine for AGA in healthy adult males and females. Risk bias assessment was performed using the Cochrane Collaboration criteria. Results. All four trials in this review, with a total of 260 participants, used 0.75% topical adenosine lotion twice a day for a period of 6-12 months. Comparators were placebo, topical niacinamide, and topical minoxidil. Evaluated parameters include improvement in baldness grading as assessed by dermatologists and investigators, improvement and satisfaction as assessed by participants, anagen growth, thick/thin/vellus hair ratio, and hair density. Two trials found significant improvement with thick hair ratio (>60 or >80 μm) with the use of topical adenosine while two trials showed higher overall participant satisfaction with topical adenosine. Few to no adverse effects were reported with its use. Conclusion. This is the first systematic review involving topical adenosine for AGA. Topical adenosine may be effective in increasing thick hair ratio and improving the self-perception of hair growth. With minimal to no adverse effects, it may serve as an adjunct or alternative to present treatment options. However, more studies are needed to strengthen these findings.

scholarly journals Versatility of diode lasers in low-level laser therapy for the management of recurrent aphthous stomatitis

2015 ◽  
Vol 7 (1) ◽  
pp. 49 ◽  
Author(s):  
Butchi Babu ◽  
UdayKiran Uppada ◽  
Bassel Tarakji ◽  
KhajaAmjad Hussain ◽  
SalehNasser Azzeghaibi ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Diode Lasers ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Low Level Laser Therapy ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser

scholarly journals Recurrent Aphthous Stomatitis: Treatment and Management

2021 ◽  
pp. e2021099
Author(s):  
Marco Manfredini ◽  
Stefania Guida ◽  
Matteo Giovani ◽  
Nicola Lippolis ◽  
Enrico Spinas ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Current Literature ◽  
Clinical Condition ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Cochrane Library ◽  
Clinical Appearance ◽  
Genital Area ◽  
Systemic Treatments ◽  
Associated Symptoms

Background: Recurrent aphthous stomatitis consists of the presence of abrasions or ulcerations located on mucosae (oral or genital). Objectives: The aim of this article is to review the current literature providing the main causes related to recurrent aphthous stomatitis and insights into treatment and management of this clinical condition Methods: Articles matching terms that correlated with “recurrent aphthous stomatitis” were searched on PubMed, EMBASE, and Cochrane Library and selected according to their pertinence. Results: Several forms of aphthous stomatitis have been described, based on the extent (minor, major), morphology (herpetiform), and associations to other signs (Behçet syndrome or more complex inflammatory syndromes). Topical as well as systemic treatments have been described to obtain a faster remission of the aphthosis or to reduce associated symptoms such as pain. Conclusions: Recurrent aphthous stomatitis can have a mild-to-severe clinical appearance, being mainly localized on the oral mucosa or at the level of the genital area. Different strategies have been described so far for its management and treatment.

scholarly journals Efficacy and safety of acupuncture for recurrent aphthous stomatitis: a systematic review protocol

BMJ Open ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. e037603
Author(s):  
Feng Zhang ◽  
Hao Zhou ◽  
Songyi Ding ◽  
Da Zhang ◽  
Daoshi Lian ◽  
...  
Keyword(s):  
Systematic Review ◽  
Recurrent Aphthous Stomatitis ◽  
Risk Of Bias ◽  
Mean Difference ◽  
Biomedical Literature ◽  
Aphthous Stomatitis ◽  
Cochrane Library ◽  
Efficacy And Safety ◽  
China National Knowledge Infrastructure ◽  
Positive Effects

IntroductionRecurrent aphthous stomatitis (RAS) is a distressing symptom. There are many ways to treat RAS, such as pudilan anti-inflammatory oral liquid and doxycycline and laser therapy, but these take a long time to produce positive effects and compliance is low. Previous reviews of acupuncture treatment for RAS has been growing, but a systematic review is not available. To assess the efficacy and safety of acupuncture for the management of RAS.Methods and analysisThe following databases will be searched from their inception to 1 February 2020: PubMed, Embase, Cochrane Library, CINAHL, Chinese Biomedical Literature Database, VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure and Wanfang. The randomised controlled trials in English or Chinese associated with acupuncture for patients with RAS will be included. Eligible study conference abstracts and reference lists of manuscripts will also be searched. Two reviewers will select the studies, extract data independently. The Cochrane risk of bias tool will be used to assess the risk of bias for the studies. According to heterogeneity testing, data will be synthesised using a random-effects model. A meta-analysis will be performed using Rev Man V.5.3.5 statistical software for each outcome. Subgroup analysis and sensitivity analysis are planned according to clinical evidence. Mean difference or standardised mean difference for continuous data and risk ratio for dichotomous data will be calculated.Ethics and disseminationNo ethical approval is required. This protocol will not involve individual patient information and endangering participant rights. The results will be reported in a peer-reviewed journal or disseminated in relevant conferences.OSF registration numberDOI 10.17605/OSF.IO/QASUY.

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