scholarly journals Efficacy and safety of plant-based therapy on recurrent aphthous stomatitis and oral mucositis in the past decade: a systematic review

2021 ◽  
Vol 10 (2) ◽  
pp. 179-187
Author(s):  
Indah Suasani Wahyuni ◽  
Irna Sufiawati ◽  
Wipawee Nittayananta ◽  
Irma Melyani Puspitasari ◽  
Jutti Levita
Keyword(s):  
Oral Mucositis ◽  
Curcuma Longa ◽  
Aloe Vera ◽  
Recurrent Aphthous Stomatitis ◽  
Drug Formulation ◽  
Aphthous Stomatitis ◽  
Licorice Root ◽  
Mucosal Inflammation ◽  
Cochrane Library ◽  
Root Extract

Oral mucosal inflammation is one of the oral diseases causing pain and reducing the quality of human life. The types of oral mucosal inflammation that commonly found were recurrent aphthous stomatitis (RAS) and oral mucositis (OM). Anti-inflammatory drugs, both synthetic and plant-based, have been used to treat RAS and OM. Plant-based drugs have been attracted the attention of some researchers to minimize the side effects of synthetic drugs. However, a comprehensive review addressing the use of plant-based drugs for RAS and OM therapy, including drug formulation and species of plant, has not yet been reported. Here, we reported the article review of 9 publications derived from the databases of PubMed, ScienceDirect, Cochrane Library, and other additional relevant works, in order to find the effectiveness and safety of plant-based drugs for RAS and OM therapy. This review was written by following the PRISMA guidelines, and the risk of bias of the articles was evaluated using the Oxford Quality Scoring System. It was found that the effective and safe drugs for RAS therapy contained acemannan from Aloe vera and curcumin from Curcuma longa, both in an oral gel formulation. For OM therapy, drugs contained curcumin from Curcuma longa; licorice from Glycyrrhiza glabra; Aloe vera and black mulberry from Morus nigra, in soft tablet, mouthwash solution or mucoadhesive film formulation. In conclusion, the most effective and safest plant-based therapy for RAS is Acemannan 0.5% in oral gel, whereas for OM is Licorice root extract 0.18 mg in mucoadhesive film.

scholarly journals EFFECTIVENESS OF THE NATURAL-BASED PRODUCTS AND MUCOADHESIVE FOR RECURRENT APHTHOUS STOMATITIS THERAPY: A SYSTEMATIC REVIEW

2021 ◽  
pp. 7-13
Author(s):  
IIN HELDAYANI ◽  
INDAH SUASANI WAHYUNI
Keyword(s):  
Systematic Review ◽  
Curcuma Longa ◽  
Controlled Trial ◽  
Aloe Vera ◽  
Punica Granatum ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Mucoadhesive Polymers ◽  
Relieve Pain ◽  
Effective Combination

The objective was to describe and recommend the most effective combination of Natural-Based Product (NBP) and mucoadhesive for Recurrent Aphthous Stomatitis (RAS) treatment. This systematic review writing was based on PRISMA guidelines. The articles published in the last 10 y were selected using PubMed and Google Scholar database carried out during May 2021. The keywords were: natural-based product, mucoadhesive, and Recurrent Aphthous Stomatitis. The risk of bias was assessed using the Oxford Quality Scoring System. Six articles of Randomized Controlled Trial were selected. The NBP were: Aloe vera, Myrrh, Curcuma longa, propolis, ginger, Punica granatum flower, and sesame oil. The drug’s formulation was: gel, film, and spray. The mucoadhesive polymers as vehicles were Hydroxy Propyl Ethyl Cellulose (HPEC), Hydroxy Propyl Methylcellulose (HPMC), Benzocaine, Tragacanth Gum, Carbomer 934, Sodium CMC (carboxymethyl cellulose), and chitosan. Curcuma longa 10 mg/g with HPMC was the most effective to relieve pain, while Punica granatum flower extract with Carbomer 934 and Sodium CMC was the most effective to reduce the ulcer size in RAS. Both of the formulations were in gel form.

scholarly journals Herbal Medication of Recurrent Aphthous Stomatitis: A Narrative Review

2021 ◽  
Vol 6 (1) ◽  
pp. 1318-1323
Author(s):  
Taufik Septiyan ◽  
Gofarana Wilar ◽  
Nasrul Wathoni
Keyword(s):  
Curcuma Longa ◽  
Aloe Vera ◽  
Psidium Guajava ◽  
Recurrent Aphthous Stomatitis ◽  
Persea Americana ◽  
Aphthous Stomatitis ◽  
In Vitro Tests ◽  
Blood Disorders ◽  
Mouth Ulcer

A mouth ulcer or recurrent aphthous stomatitis (RAS) is a mouth mucous tissue inflammation. This disease mainly occurs in patients 10-40 years of age, preferably in women and high socioeconomic backgrounds. The cause of mouth ulcers or RAS could be trauma, infection, digestive problems, or blood disorders. Herbal practitioners widely use herbs, folks, and society to treat various diseases. This research aimed to describe the herbal treatment for RAS. The review results show there are nine plants with the ability to cure RAS, they are Persea americana Mill., Averrhoa bilimbi L., Abrus precatorius Linn., Camellia sinensis (L.) Kuntze., Psidium guajava L., Kaempferia galanga Linn., Aloe vera, Curcuma longa and Citrus hystrix DC. The most parameters used in the studies are clinical trials and in vitro tests.

scholarly journals Effectiveness of Laser Therapy in the Management of Recurrent Aphthous Stomatitis: A Systematic Review

Scientifica ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Min Han ◽  
Hui Fang ◽  
Quan-Li Li ◽  
Ying Cao ◽  
Rong Xia ◽  
...  
Keyword(s):  
Systematic Review ◽  
Laser Treatment ◽  
Laser Therapy ◽  
Clinical Effectiveness ◽  
Healing Time ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Cochrane Library ◽  
Large Sample Size ◽  
Security Issue

Objectives. Laser therapy is a promising new treatment for patients with recurrent aphthous stomatitis (RAS). However, the clinical effect and security issue of laser therapy remain controversial. This systematic review was conducted to evaluate the clinical effectiveness and security of laser treatment in RAS patients. Methods. Five electronic databases were searched (MEDLINE (PubMed), EMBASE, ScienceDirect, the Cochrane Library, and Web of Science) to identify all studies that were about randomized controlled clinical trials, involving the effect of laser therapy in RAS patients. Conclusion. Twenty-three studies were retained for full-text analysis after screening the titles and abstracts of potential articles, but only 10 studies satisfied the inclusion criteria after the full texts were reviewed. The included studies reported a comparison of the effectiveness between the laser treatment and placebo laser therapy (or conventional drug therapy) when managing the RAS patients. It can be concluded that laser therapy has the superiority in relieving ulcer pain and shortening healing time when compared with placebo group or medical treatment group. Although laser therapy is a promising effective treatment for RAS, high-quality clinical studies with large sample size must be further performed to confirm the effectiveness of this therapy.

scholarly journals Babosa (Aloe Vera) e camomila (Matricaria chamomilla) no tratamento da estomatite aftosa recorrente

2020 ◽  
Vol 8 (11) ◽  
Author(s):  
Aliny Thaisy Araújo Costa ◽  
Júlia Kiara da Nóbrega Holanda ◽  
Lara Danúbia Galvão de Souza ◽  
Lorena Layanne Pereira Custódio ◽  
Louise de Araújo Rodas ◽  
...  
Keyword(s):  
Aloe Vera ◽  
Sao Paulo ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Therapeutic Effects ◽  
São Paulo ◽  
Matricaria Chamomilla ◽  
Aloe Barbadensis ◽  
Matricaria Recutita ◽  
Revisión Sistemática

A utilização de extratos de plantas medicinais, como a Camomila (Matricaria chamomilla) e a Babosa (Aloe vera), no desenvolvimento de formulações para tratamento de lesões como a úlcera aftosa recorrente apresentam menos efeitos colaterais e tóxicos para o organismo, exibindo inúmeras propriedades (anti-inflamatória, cicatrizante, etc.), vantagens e custo benefício satisfatórios para pacientes. Este estudo tem como objetivo compreender o uso da Babosa e Camomila em úlceras, através de buscas em bancos de dados computadorizados e livros para elaboração de revisão narrativa de literatura. As bases de dados utilizadas foram Google Acadêmico, PubMed e LILACS, acessadas no período de novembro e dezembro de 2018. Critérios de inclusão foram publicações entre 2000 a 2018, em inglês e português, utilizando os descritores: Aloe vera, Matricaria chamomilla, estomatite aftosa, odontologia. O uso da Aloe vera pode ser opção eficaz na promoção da redução de úlcera através de efeito anti-inflamatório, de re-epitelização, ativação de fibroblastos e propriedades imunomoduladoras, podendo contribuir para cicatrização de feridas. Estudos mostraram que pacientes portadores de úlceras aftosas recorrentes, que fizeram uso da pomada à base de extrato fluido de Matricaria recutita (Ad-Muc®), com proposta ação anti-inflamatória, antibacteriana e propriedades auxiliadoras na cicatrização de lesões da mucosa bucal, obtiveram sucesso terapêutico em 94% dos casos. Assim, conclui-se que a utilização de tais fitoterápicos mostra-se necessária e promissora dentro da odontologia e outras áreas de saúde, visando o desenvolvimento de métodos alternativos de tratamento cada vez mais eficazes. Entretanto, mais estudos clínicos precisam ser realizados para confirmar esta utilização em seres humanos.Descritores: Aloe; Matricaria; Estomatite Aftosa; Odontologia.ReferênciasAleluia CM, Procópio VC, Oliveira MTG, Furtado PGS, Giovannini JFG, Mendonça SMS. Fitoterápicos na Odontologia. Rev Odontol Univ Cid São Paulo. 2015;27(2):126.Brasil. Ministério da Saúde, Secretaria de Atenção à Saúde, Departamento de Atenção Básica. Práticas integrativas e complementares: plantas medicinais e fitoterapia na Atenção Básica. Brasília: Ministério da Saúde, 2012.Borges FV, Sales MDC. Políticas públicas de plantas medicinais e fitoterápicos no Brasil: sua história no sistema de saúde. Pensar Acadêmico. 2018;16(1):13-27.Monteiro MH, Fraga S. Fitoterapia na odontologia: levantamento dos principais produtos de origem vegetal para saúde bucal. Fitos. 2015;9(4):253-303.Gupta V, Mittal P, Bansal P, Khokra SL, Kaushik D. Pharmacological potential of Matricaria recutita-A review. Int J Pharm Sci Drug Res. 2010;2(1):12-6.Neville BW, Damm DD, Allen CM, Chi AC. Patologia Oral e Maxilofacial. 4 ed. Rio de Janeiro: Elsevier; 2016.Fonseca CME, Quirino MRS, Patrocínio MC, Anbinder AL. Effects of Chamomilla recutita (L.) on oral wound healing in rats. Med Oral Patol Oral Cir Bucal. 2011;16(6):e716-21.Catão MHCV, Silva MSP, Silva ADL, Costa RO. Estudos clínicos com plantas medicinais no tratamento de afecções bucais: uma revisão de literatura. UNOPAR Cient Ciênc Biol Saúde 2012;14(4):279-85.Costa GBF, Castro JFL. Etiologia e tratamento da estomatite aftosa recorrente - revisão de literatura. Medicina (Ribeirao Preto Online). 2013;46(1):1.Miziara ID. O tratamento da estomatite aftóide recorrente ainda intriga. Rev Assoc Med Bras. 2009;55(2):96.Azul AM, Trancoso PF. Patologia mais frequente da mucosa oral. Rev Port Clin Geral. 2006;22(3):369-77.Ximenes Filho JA, Miziara ID. Estomatite aftóide recorrente: atualização no tratamento. Arq Fund Otorrinolaringol. 2001;5(4):199-201.Quijano D, Rodríguez M. Corticoides tópicos en la estomatitis aftosa recurrente. Revisión sistemática. Acta Otorrinolaringol Esp. 2008;59(6):298-307.Weckx LLM, Hirata CHW, Abreu MAMM, Fillizolla VC, Silva OMP. Levamisol não previne lesões de estomatite aftosa recorrente: um ensaio clínico randomizado, duplo-cego e controlado por placebo. Rev Assoc Med Bras. 2009;55(2):132-38.Gorsky M, Epstein J, Rabenstein S, Elishoov H, Yarom N. Topical minocycline and tetracycline rinses in treatment of recurrent aphthous stomatitis: a randomized cross-over study. Dermatol Online J. 2007;13(2):1.Mimura MAM, Hirota SK, Sugaya NN, Sanches Jr JA, Migliari DA. Systemic treatment in severe cases of recurrent aphthous stomatitis: an open trial. Clinics (São Paulo). 2009;64(3):193-98.Gorsky M, Epstein J, Raviv A, Yaniv R, Truelove E. Topical minocycline for managing symptoms of recurrent aphthous stomatitis. Spec Care Dentist. 2008;28(1):27-31.Lorenzi H, Matos FJA. Plantas medicinais no brasil - nativas e exóticas. Nova Odessa: Instituto Plantarum; 2002.Baracuhy J, Furtado D, Francisco PR, Lima J, Pereira J. Plantas Medicinais de uso comum no Nordeste do Brasil. Plantas Medicinais de uso comum no Nordeste do Brasil. Campina Grande: UFCG; 2016.Surjushe A, Vasani R, Saple DG. Aloe vera: A short review. Indian J Dermatol. 2008;53(4):163-66.Rodríguez-González V, Femenia A, González-Laredo R, Rocha-Guzmán N, Gallegos-Infante J, Candelas-Cadillo M et al. Effects of pasteurization on bioactive polysaccharide acemannan and cell wall polymers from Aloe barbadensis Miller. Carbohydr Polym. 2011;86(4):1675-83.El-Batal AI, Ahmed SF. Therapeutic effect of Aloe vera and silver nanoparticles on acid-induced oral ulcer in gamma-irradiated mice. Braz oral res. 2018;32:e0004.Babaee N, Zabihi E, Mohseni S, Moghadamnia AA. Evaluation of the therapeutic effects of Aloe vera gel on minor recurrent aphthous stomatitis. Dent Res J(Isfhan). 2012;9(4):381-85.Oliveira BP. Teor e composição química do óleo essencial em amostras comerciais de camomila Matricaria chamomilla L [tese doutorado]. Viçosa: Universidade Federal de Viçosa; 2012.Singh O, Khanam Z, Misra N, Srivastava MK. Chamomile (Matricaria chamomilla L.): An overview. Pharmacogn Rev. 2011;5(9):82-95.Stanojevic LP, Marjanovic-Balaban ZR, Kalaba VD, Stanojevic JS, Cvetkovic DJ. Chemical composition, antioxidant and antimicrobial activity of chamomile flowers essential oil (Matricaria chamomilla L.). J Essent Oil Bear Pl. 2016;19(8):2017-28.Wehba C, Fernandes F, Oppi EC. Aplicação de pomada a base de extrato de camomila como coadjuvante na redução de sintomatologia dolorosa das lesões ulceradas de mucosa oral. RBM Rev Bras Med. 2008;65(5):129-32.

scholarly journals Management of Recurrent Aphthous Stomatitis in a Patient with High Recurrence Frequency

2020 ◽  
Vol 4 (4) ◽  
pp. 102-108
Author(s):  
Sri Hernawati
Keyword(s):  
Female Patient ◽  
Buccal Mucosa ◽  
Soft Tissues ◽  
Aloe Vera ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Vitamin B ◽  
Dental Hospital ◽  
Recurrence Frequency ◽  
Multiple Ulcers

RAS (Recurrent Aphthous Stomatitis) is an inflammation of soft tissues of the oral cavity characterized by recurrent and painful ulcers. These lesions can be marked early on with a burning sensation, and when the wound has formed, the pain is getting worse. Occasional symptoms of precursors, paresthesia and hyperesthesia, are sometimes reported. Pain and discomfort arise along movement around the ulcer e.g. eating, talking and swallowing. Characteristics of RAS are usually single or multiple ulcers occurring recursively on the oral mucosa, round or oval in shape, clearly demarcated, with a grayish-yellow necrotic center and reddish edges. Lesions occur at young ages i.e. children and puberty, and may occur in adults as well. Ulcers usually last in 1 week or month. This disorder is classified into three categories according to size i.e. recurrent aphthous stomatitis minor, major and herpetiformis. The aim of this report is to show the management of cases of Recurrent Aphthous Stomatitis Minor on the left side of tongue, left buccal mucosa, and lower labial mucosa in female patient aged 19 years. A 19-year-old female patient came to the Dental Hospital of Jember University with complaints of thrush on the left side of her tongue, left buccal mucosa and lower labial mucosa, pain, and feeling disturbed due to the pain when eating, talking, and laughing. In this case, the diagnosis showed Recurrent Aphthous Minor Stomatitis on the left side of the tongue, left buccal mucosa, and lower labial mucosa. The therapy was using nonsteroidal anti-inflammatory mouthwash containing aloe Vera and hyaluronic acid as well as giving multivitamin of becomzet (vitamin B complex, A, C, E, and Zinc). Keywords: recurrent aphthous stomatitis; high recurrence

scholarly journals Treatment of recurrent aphthous stomatitis by laser therapy: A systematic review of the literature

2015 ◽  
Vol 72 (8) ◽  
pp. 722-728 ◽  
Author(s):  
Verica Pavlic ◽  
Vesna Vujic-Aleksic ◽  
Akira Aoki ◽  
Lana Nezic
Keyword(s):  
Laser Therapy ◽  
Treatment Options ◽  
Healing Process ◽  
Cochrane Collaboration ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Cochrane Library ◽  
Original Research ◽  
Treatment Protocols ◽  
Efficient Treatment

Background/Aim. Recurrent aphthous stomatitis (RAS) is defined as multifactor immunologic inflammatory lesions in the oral cavity, characterized by painful, recurrent single/multiple, shallow, round or ovoid ulcerations of mucosal tissues. To date, a considerable number of RAS treatment protocols have been suggested, but since the etiology of RAS is idiopathic, these treatment options have symptomatic rather than curative or preventive effect. Recently, it has been suggested that laser therapy could be successfully used as an efficient treatment approach in therapy of RAS. Therefore, the aim of this review was to estimate the effects of laser therapy in treatment of RAS analyzing results of clinical studies published in peer reviewed journals. Methods. The studies published until 31 December 2013 were obtained from the Medline/PubMed, Science Direct and Cochrane Library of the Cochrane Collaboration (CENTRAL) online databases, using following search terms and key words: ?laser? AND ?recurrent aphthous stomatitis?, ?laser? AND ?aphthous?, and ?laser? AND ?aphthae?. In total 4 original research articles met the all required inclusion/exclusion criteria, and were used for this review. The main outcome measures assessed were: a reduction of pain associated with RAS and a reduction in episode duration (faster RAS healing). Results. The assessed literature demonstrates the benefits of laser therapy mainly due to immediate analgesia and ability to speed up a RAS healing process. Conclusion. Even though the assessed literature suggests beneficial outcomes of laser therapy in treatment of RAS, these results should be interpreted with caution. The issues related to the study designs and different sets of laser irradiation parameters of a limited number of available studies with the same treatment outcomes prevent us from making definite conclusions.

scholarly journals Recurrent Aphthous Stomatitis: Treatment and Management

2021 ◽  
pp. e2021099
Author(s):  
Marco Manfredini ◽  
Stefania Guida ◽  
Matteo Giovani ◽  
Nicola Lippolis ◽  
Enrico Spinas ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Current Literature ◽  
Clinical Condition ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Cochrane Library ◽  
Clinical Appearance ◽  
Genital Area ◽  
Systemic Treatments ◽  
Associated Symptoms

Background: Recurrent aphthous stomatitis consists of the presence of abrasions or ulcerations located on mucosae (oral or genital). Objectives: The aim of this article is to review the current literature providing the main causes related to recurrent aphthous stomatitis and insights into treatment and management of this clinical condition Methods: Articles matching terms that correlated with “recurrent aphthous stomatitis” were searched on PubMed, EMBASE, and Cochrane Library and selected according to their pertinence. Results: Several forms of aphthous stomatitis have been described, based on the extent (minor, major), morphology (herpetiform), and associations to other signs (Behçet syndrome or more complex inflammatory syndromes). Topical as well as systemic treatments have been described to obtain a faster remission of the aphthosis or to reduce associated symptoms such as pain. Conclusions: Recurrent aphthous stomatitis can have a mild-to-severe clinical appearance, being mainly localized on the oral mucosa or at the level of the genital area. Different strategies have been described so far for its management and treatment.

scholarly journals Efficacy and safety of acupuncture for recurrent aphthous stomatitis: a systematic review protocol

BMJ Open ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. e037603
Author(s):  
Feng Zhang ◽  
Hao Zhou ◽  
Songyi Ding ◽  
Da Zhang ◽  
Daoshi Lian ◽  
...  
Keyword(s):  
Systematic Review ◽  
Recurrent Aphthous Stomatitis ◽  
Risk Of Bias ◽  
Mean Difference ◽  
Biomedical Literature ◽  
Aphthous Stomatitis ◽  
Cochrane Library ◽  
Efficacy And Safety ◽  
China National Knowledge Infrastructure ◽  
Positive Effects

IntroductionRecurrent aphthous stomatitis (RAS) is a distressing symptom. There are many ways to treat RAS, such as pudilan anti-inflammatory oral liquid and doxycycline and laser therapy, but these take a long time to produce positive effects and compliance is low. Previous reviews of acupuncture treatment for RAS has been growing, but a systematic review is not available. To assess the efficacy and safety of acupuncture for the management of RAS.Methods and analysisThe following databases will be searched from their inception to 1 February 2020: PubMed, Embase, Cochrane Library, CINAHL, Chinese Biomedical Literature Database, VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure and Wanfang. The randomised controlled trials in English or Chinese associated with acupuncture for patients with RAS will be included. Eligible study conference abstracts and reference lists of manuscripts will also be searched. Two reviewers will select the studies, extract data independently. The Cochrane risk of bias tool will be used to assess the risk of bias for the studies. According to heterogeneity testing, data will be synthesised using a random-effects model. A meta-analysis will be performed using Rev Man V.5.3.5 statistical software for each outcome. Subgroup analysis and sensitivity analysis are planned according to clinical evidence. Mean difference or standardised mean difference for continuous data and risk ratio for dichotomous data will be calculated.Ethics and disseminationNo ethical approval is required. This protocol will not involve individual patient information and endangering participant rights. The results will be reported in a peer-reviewed journal or disseminated in relevant conferences.OSF registration numberDOI 10.17605/OSF.IO/QASUY.

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