scholarly journals Nitric oxide as prediction factor of gingival inflammation in orthodontic patients

2018 ◽  
Vol 75 (9) ◽  
pp. 856-863
Author(s):  
Predrag Janosevic ◽  
Ivana Stojanovic ◽  
Mirjana Janosevic ◽  
Gordana Filipovic ◽  
Maja Stosic
Keyword(s):  
Nitric Oxide ◽  
Gingival Crevicular Fluid ◽  
Orthodontic Appliances ◽  
Clinical Parameters ◽  
Gingival Inflammation ◽  
Fixed Orthodontic Appliances ◽  
Oxide Concentration ◽  
Nitric Oxide Concentration ◽  
Orthodontic Patients ◽  
Crevicular Fluid

Background/Aim. Nowadays therapy with fixed orthodontic appliances is widely spread, having in mind positive effects it has in malocclusion treatments The side effect is increased gingivial inflammation in treated patients. The aims of this research are to estimate the inflammatory condition of gingiva in the first 6 months of orthodontic therapy on the basis of clinical parameters of sulcus bleeding index, plaque index, gingival crevicular fluid and salivary nitric oxide concentration, and to investigate role of nitric oxide as predicting factor of gingival inflammation in orthodontic patients. Methods. In this study, 30 patients of the Dental Clinic treated with fixed orthodontic appliances (11 males and 19 females), aged 15-22 years, were examined. Clinical parameters were evaluated and gingival crevicular fluid and saliva were collected, before the beginning of orthodontics therapy, and then, three and six months after it. Results. The approximate values of clinical parameters, gingival crevicular fluid and salivary nitric oxide concentration progressively increased. Low statistical significance of correlations among gingival crevicular fluid and salivary nitric oxide concentration and the measured clinical parameters were found. There is a statistically significant correlation between gingival crevicular fluid and salivary nitric oxide concentration. Conclusion. According to the obtained results, we can conclude that gingival crevicular fluid and saliva are reliable mediums for monitoring of the gingival inflammatory condition. More studies are needed to investigate a potential role of nitric oxide as predicting factor of gingival inflammation in orthodontic patients.

scholarly journals Pengaruh konsumsi suplemen ekstrak kulit manggis (Garcinia mangostana L.) terhadap inflamasi gingiva pada pasien ortodonti cekat (kajian jumlah leukosit cairan sulkus gingiva)

2017 ◽  
Vol 3 (2) ◽  
pp. 93
Author(s):  
P. Prayitno ◽  
Anggy Natya Listyaningrum
Keyword(s):  
Gingival Crevicular Fluid ◽  
T Test ◽  
Orthodontic Appliances ◽  
Gingival Inflammation ◽  
Garcinia Mangostana ◽  
Mangosteen Peel ◽  
Fixed Orthodontic Appliances ◽  
Leukocyte Counts ◽  
Crevicular Fluid ◽  
Peel Extract

Effect of taking mangosteen peel extract (Garcinia mangostana L.) supplement on gingival inflammation in fixed orthodontic patients (A study of leukocyte count of gingival crevicular fluid). Patients with fixed orthodontic appliances have a high risk of gingival inflammation. Gingival inflammation is characterized by an increase in leukocyte count of gingival crevicular fluid resulting in proinflammatory cytokines that are capable of damaging the gingival tissue. Mangosteen peel (Garcinia mangostana L) contains xantone which has anti-inflammatory properties. The objective of this study was to determine the effect of consuming mangosteen peel extract (Garcinia mangostana L) supplement on gingival inflammation in patients with fixed orthodontic by studying the leukocyte counts of gingival crevicularuid. Twenty patients with fixed orthodontic appliances were divided into two groups: 10 subjects in the control group and 10 subjects in the treatment group. They were selected based on the following criteria: age 18-24 years, suffering from mild to moderate gingivitis, and using fixed orthodontic appliances in the final phase. The subjects in both groups underwent initial therapy in the form of scaling, then the subjects in the treatment group took 2 capsules of mangosteen peel extract supplements three times a day for seven days. The sampling of gingival crevicular fluid of both groups was taken on day 0 and 8 in the lower anterior region, that is 3 samples of gingival crevicular fluid per subject. Leukocytes were seen from the results of staining with Turk’s reagents through microscope with a magnification of 400 times. The average leukocyte counts were analyzed using Pair T-test and Independent Sample T-test. The results showed that taking mangosteen peel extract (Garcinia mangostana L) supplements has significant effect on the decrease in leukocyte counts of gingival crevicular fluids (p<0.05). The conclusion of this study is the consumption of mangosteen peel extract (Garcinia mangostana L) supplement signicantly influences the reduction of gingival inflammation in patients with fixed orthodontic appliances, evident from the decline in the leukocyte counts of gingival crevicular fluids. ABSTRAKPasien pemakai ortodonti cekat memiliki resiko tinggi mengalami inflamasi gingiva. Inflamasi gingiva ditandai dengan meningkatnya jumlah leukosit cairan sulkus gingiva yang menghasilkan sitokin proinflamasi yang mampu merusak jaringan gingiva. Kulit manggis (Garcinia mangostana L) mengandung xantone yang memiliki sifat antiinflamasi. Tujuan penelitian ini adalah untuk mengetahui pengaruh konsumsi suplemen ekstrak kulit manggis (Garcinia mangostanaL) terhadap inflamasi gingiva pada pasien ortodonti cekat dengan kajian jumlah leukosit pada cairan sulkus gingiva. Dua puluh pasien ortodonti cekat dibagi menjadi dua kelompok, 10 subjek pada kelompok kontrol dan 10 subjek pada kelompok perlakuan yang diseleksi berdasarkan kriteria: usia 18-24 tahun, menderita gingivitis ringan hingga sedang, dan menggunakan alat ortodonti cekat pada fase akhir. Subjek pada kedua kelompok dilakukan initial therapy berupa scaling, kemudian subjek pada kelompok perlakuan mengkonsumsi suplemen ekstrak kulit manggis 2 kapsul 3 kali sehari selama 7 hari. Pengambilan sampel cairan sulkus gingiva kedua kelompok dilakukan pada hari ke-0 dan ke-8 pada regio anterior bawah sebanyak 3 sampel cairan sulkus gingiva tiap subjek. Leukosit dilihat dari hasil pewarnaan reagen Turk melalui mikroskop dengan perbesaran 400 kali. Hasil rerata jumlah leukosit dianalisis menggunakan uji Pair T-test dan uji Independent Sample T-test. Hasil penelitian menunjukkan bahwa mengkonsumsi suplemen ekstrak kulit manggis (Garcinia mangostana L) berpengaruh terhadap penurunan jumlah leukosit  cairan sulkus  gingiva secara signifikan  (p < 0,05). Kesimpulan dari penelitian ini adalah konsumsi suplemen ekstrak kulit manggis (Garcinia mangostana L) berpengaruh secara signifikan terhadap penurunan inflamasi gingiva pada pasien ortodonti cekat dilihat dari penurunan jumlah leukosit cairan sulkus gingivanya.

scholarly journals A randomized controlled trial of a power brush/irrigator/mouthrinse routine on plaque and gingivitis reduction in orthodontic patients

2018 ◽  
Vol 89 (3) ◽  
pp. 378-384 ◽  
Author(s):  
Christina Erbe ◽  
Malgorzata Klukowska ◽  
Hans C Timm ◽  
Matthew L Barker ◽  
Janneke van der Wielen ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Positive Control ◽  
Analysis Of Covariance ◽  
Control Treatment ◽  
Orthodontic Appliances ◽  
Gingival Inflammation ◽  
Gingival Bleeding ◽  
Fixed Orthodontic Appliances ◽  
Orthodontic Patients ◽  
And Control

ABSTRACT Objectives: To assess plaque and gingivitis reduction in orthodontic patients after 4 weeks' use of an oscillating-rotating power brush, irrigator, and mouthrinse. Materials and Methods: This was a randomized, examiner-blind, clinical trial comparing plaque and gingivitis outcomes for an experimental power brush/irrigator/mouthrinse oral hygiene routine vs a dental prophylaxis followed by regular manual brushing (positive control). Fifty-one participants with fixed orthodontic appliances in the upper and lower jaw and a minimum of 15 gingival bleeding sites were randomly assigned to experimental or positive control treatment. Both groups were instructed to use their products at least twice daily. At baseline, week 1, and week 4, plaque was evaluated using digital plaque imaging analysis and a conventional subjective index. Gingival inflammation and bleeding were also measured. Analysis of covariance was used to compare groups. Results: Fifty-one participants (mean age = 13.9 years) were randomized; 50 (25 per group) completed the study. At baseline, group means were not statistically different (P &gt; .1) for gingival inflammation or bleeding. At week 4, the experimental and control groups had a 10.0% to 32.7% and 5.9% to 6.7% reduction vs baseline, respectively, in plaque (across both methods); 12.6% and 8.3% reduction, respectively, in gingival inflammation; and 50.6% and 37.8% reduction, respectively, in bleeding. At week 4, group differences favoring the experimental group were statistically significant (P &lt; .05) for gingival inflammation, gingival bleeding, and plaque (by conventional and digital imaging indexes). Conclusions: Use of a power brush/irrigator/mouthrinse resulted in statistically significantly greater plaque and gingivitis reductions than prophylaxis followed by manual brushing in patients with fixed appliances over 4 weeks.

Longitudinal changes in gingival crevicular fluid after placement of fixed orthodontic appliances

2011 ◽  
Vol 139 (6) ◽  
pp. 735-744 ◽  
Author(s):  
Jan van Gastel ◽  
Wim Teughels ◽  
Marc Quirynen ◽  
Sofie Struyf ◽  
Jozef Van Damme ◽  
...  
Keyword(s):  
Gingival Crevicular Fluid ◽  
Orthodontic Appliances ◽  
Longitudinal Changes ◽  
Fixed Orthodontic Appliances ◽  
Crevicular Fluid

Detection of gingival crevicular fluid cytokines in children and adolescents with and without fixed orthodontic appliances

2008 ◽  
Vol 66 (3) ◽  
pp. 169-173 ◽  
Author(s):  
Catherine Giannopoulou ◽  
Andrea Mombelli ◽  
Kyriaki Tsinidou ◽  
Vassilis Vasdekis ◽  
Joanna Kamma
Keyword(s):  
Children And Adolescents ◽  
Gingival Crevicular Fluid ◽  
Orthodontic Appliances ◽  
Fixed Orthodontic Appliances ◽  
Crevicular Fluid

scholarly journals Effectiveness of a motionless ultrasonic toothbrush in reducing plaque and gingival inflammation in patients with fixed orthodontic appliances

2016 ◽  
Vol 87 (2) ◽  
pp. 279-285 ◽  
Author(s):  
Thayika Saruttichart ◽  
Pintu-on Chantarawaratit ◽  
Chalermpol Leevailoj ◽  
Panida Thanyasrisung ◽  
Waranuch Pitiphat ◽  
...  
Keyword(s):  
Mutans Streptococci ◽  
Plaque Index ◽  
Orthodontic Appliances ◽  
Gingival Inflammation ◽  
Fixed Orthodontic Appliances ◽  
Significant Difference ◽  
Before And After ◽  
Orthodontic Patients ◽  
Manual Toothbrush ◽  
Better Than

ABSTRACT Objective: To compare the effectiveness of a motionless ultrasonic toothbrush to a manual toothbrush in reducing dental plaque, gingival inflammation, and mutans streptococci in patients with fixed orthodontic appliances. Materials and Methods: Twenty-five orthodontic patients were recruited to this crossover study. The patients were randomized into two groups starting with manual or motionless ultrasonic toothbrushes for 30 days. After a 30-day washout period, the patients switched to the other toothbrush type for 30 days. Plaque and gingival indices were evaluated by two calibrated-blinded examiners before and after each 30-day period of brushing. Salivary samples were also collected for quantification of mutans streptococci. Results: On the bracket side, the motionless ultrasonic toothbrush showed a significantly higher mean plaque index bracket score after 30-day usage than baseline (P = .049), while the manual toothbrush group showed no difference between the before and after brushing periods (P = .10). The changes in plaque index bracket score were significantly more favorable in the manual toothbrush group than in the ultrasonic toothbrush group (P = .04). In contrast, no difference was observed on the nonbracket side. There was no significant difference in the changes of gingival index or the numbers of mutans streptococci between the two groups. Conclusion: Manual toothbrushing performed better than brushing with the motionless ultrasonic toothbrush in plaque removal on the bracket side in orthodontic patients. However, no difference was observed in terms of gingival status and the numbers of mutans streptococci.

scholarly journals Origin of MMP-8 and Lactoferrin levels from gingival crevicular fluid, salivary glands and whole saliva

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Liza L. Ramenzoni ◽  
Deborah Hofer ◽  
Alex Solderer ◽  
Daniel Wiedemeier ◽  
Thomas Attin ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Salivary Glands ◽  
Gingival Crevicular Fluid ◽  
Clinical Parameters ◽  
Pocket Depth ◽  
Active Matrix ◽  
Probing Pocket Depth ◽  
Whole Saliva ◽  
Biomarker Testing ◽  
Crevicular Fluid

Abstract Background Pathologically elevated levels of matrix metalloproteinase-8 (MMP-8) and Lactoferrin in oral fluids have been associated with the presence of gingivitis/periodontitis. This study aimed to assess the origin of MMP-8 and Lactoferrin in periodontitis patients and to identify the degree to which conventional clinical parameters correlate with their presence. Methods A total of ten periodontitis and ten healthy patients were included in this study. Whole saliva (stimulated and unstimulated), parotid/sublingual glandular fluid and gingival crevicular fluid from pockets and sulci were tested for MMP-8 and Lactoferrin and protein concentrations were quantified using an ELISA assay. Clinical parameters were checked for potential associations with MMP-8 and Lactoferrin levels. Results Periodontal patients presented higher concentrations of MMP-8 and Lactoferrin in pockets than other sources (P = 0.03). Lactoferrin measurement was higher in the parotid compared to sublingual glandular fluid in periodontitis patients (P = 0.03). Increased probing pocket depth was positively correlated with high MMP-8 and Lactoferrin levels. Conclusions Periodontal pockets appear to be the major source of active matrix metalloproteinase and Lactoferrin, which also may also enter the oral cavity through the salivary glands. Since clinically healthy sites in periodontitis patients also had elevated biomarker levels, gingival crevicular fluid biomarker testing may be more predictive of future tissue breakdown than conventional clinical parameters.

Effect of round window membrane application of nitric oxide on hearing and nitric oxide concentration in perilymph

2003 ◽  
Vol 67 (6) ◽  
pp. 585-590 ◽  
Author(s):  
Jonathan B. Hanson ◽  
Paul T. Russell ◽  
Andy T.A. Chung ◽  
Claire S. Kaura ◽  
Samantha H. Kaura ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Round Window ◽  
Round Window Membrane ◽  
Oxide Concentration ◽  
Nitric Oxide Concentration
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