The Relative in vitro Sensitivity to Aflatoxin B 1 of Tracheal Organ Cultures Prepared from Day-Old Chickens, Ducks, Japanese Quail, and Turkeys

1973 ◽  
Vol 17 (1) ◽  
pp. 166 ◽  
Author(s):  
W. M. Colwell ◽  
R. C. Ashley ◽  
D. G. Simmons ◽  
P. B. Hamilton
Keyword(s):  
Japanese Quail ◽  
Organ Cultures ◽  
In Vitro Sensitivity ◽  
Aflatoxin B

scholarly journals In Vitro Sensitivity to Antibiotics of Swedish Strains of Mycoplasma Gallisepticum

1965 ◽  
Vol 6 (1) ◽  
pp. 234-238
Author(s):  
Lena Silvén
Keyword(s):  
Mycoplasma Gallisepticum ◽  
In Vitro Sensitivity

In Vitro Sensitivity Analysis of the Gastrointestinal Dissolution Profile of Weakly Basic Drugs in the Stomach-to-Intestine Fluid Changing System: Explanation for Variable Plasma Exposure after Oral Administration

2021 ◽  
Vol 18 (4) ◽  
pp. 1711-1719
Author(s):  
Toshihide Takagi ◽  
Takato Masada ◽  
Keiko Minami ◽  
Makoto Kataoka ◽  
Ken-ichi Izutsu ◽  
...  
Keyword(s):  
Sensitivity Analysis ◽  
Oral Administration ◽  
Dissolution Profile ◽  
Basic Drugs ◽  
Plasma Exposure ◽  
In Vitro Sensitivity

scholarly journals Four years’ monitoring of in vitro sensitivity and candidate molecular markers of resistance of Plasmodium falciparum to artesunate-mefloquine combination in the Thai-Myanmar border

2014 ◽  
Vol 13 (1) ◽  
pp. 23 ◽  
Author(s):  
Papichaya Phompradit ◽  
Poonuch Muhamad ◽  
Raewadee Wisedpanichkij ◽  
Wanna Chaijaroenkul ◽  
Kesara Na-Bangchang
Keyword(s):  
Plasmodium Falciparum ◽  
Molecular Markers ◽  
In Vitro Sensitivity

In Vitro Sensitivity of Probiotics to Human Pancreatic Juice

2008 ◽  
Vol 42 ◽  
pp. S170-S173 ◽  
Author(s):  
Mario Del Piano ◽  
Paolo Strozzi ◽  
Michela Barba ◽  
Serena Allesina ◽  
Francesca Deidda ◽  
...  
Keyword(s):  
Pancreatic Juice ◽  
In Vitro Sensitivity

Ornidazole and Anaerobic Bacteria: In Vitro Sensitivity and Effects on Wound Infections after Appendectomy

1979 ◽  
Vol 139 (5) ◽  
pp. 586-589 ◽  
Author(s):  
A. Palmu ◽  
O.-V. Renkonen ◽  
U. Aromaa
Keyword(s):  
Anaerobic Bacteria ◽  
Wound Infections ◽  
In Vitro Sensitivity

Filamentous microfungi in raw flax and cotton for textile industry and their ciliostatic activity on tracheal organ cultures in vitro

1996 ◽  
Vol 134 (2) ◽  
pp. 91-96 ◽  
Author(s):  
E. Piecková ◽  
Z. Jesenská
Keyword(s):  
Textile Industry ◽  
Organ Cultures

Functional precision medicine in colorectal cancer based on patient-derived tumoroids and in-vitro sensitivity drug testing.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e15567-e15567
Author(s):  
Lars Henrik Jensen ◽  
Anders Kristian Moeller Jakobsen ◽  
Birgitte Mayland Havelund ◽  
Cecilie Abildgaard ◽  
Chris Vagn-Hansen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Trial ◽  
Primary Endpoint ◽  
Drug Testing ◽  
Progression Free Survival ◽  
Patient Specific ◽  
Precision Oncology ◽  
Sensitivity Testing ◽  
In Vitro Sensitivity

e15567 Background: Precision oncology based on in-vitro, functional assays has potential advantages compared to the much more common molecular approach, but the clinical benefit is unknown. We here report the results from the largest prospective interventional clinical trial testing the clinical outcome in colorectal cancer patients treated with drugs showing cytotoxic effect in matched patient-derived tumoroids. Methods: This single-center, phase II trial included patients with metastatic colorectal cancer previously exposed to all standard therapies. Specimens from one to three 18-16 G core needle biopsies were manually dissected, enzymatically treated, cultivated, and incubated to form 3D spherical microtumors, i.e. tumoroids. In the assay for in-vitro sensitivity testing, the tumoroids were challenged with single drugs and combinations thereof to determine patient-specific responses. Using tumoroid screening technology (IndiTreat, 2cureX, Copenhagen, Denmark), results were generated by comparing the sensitivity of the individual patient’s tumoroids with a reference panel from other patients. The testing included standard cytostatics and drugs with proven effect in previous early-phase clinical trials, a total of 15 drugs. The primary endpoint was the fraction of patients with progression-free survival (PFS) at two months. Based on placebo arms in randomized last-line trials, a minimal relevant difference of 20% (20% to 40%) was stated. Using Simon's two-stage design, a sample size of 45 patients was calculated with at least 14 PFS at two months (significance 5%, power 90%). Results: Ninety patients were enrolled from 9/2017 to 9/2020. Biopsies from 82 patients were obtained and sent for tumoroid formation of which 44 (54%, 95% CI 42-65) were successful and at least one treatment was suggested. Thirty-four patients initiated treatment according to the response obtained in the drug assays within a median of 51 days from inclusion (IQR 39-63). The primary endpoint, PFS at two months, was met in 17 of 34 patients (50%, 95%CI 32-68). There were no radiological responses. Median PFS was 81 days (95% CI 51-112) and median OS was 189 days (95% CI 103-277). Conclusions: Precision oncology using a functional approach with patient-derived tumoroids and in-vitro drug sensitivity testing seems feasible. The approach is limited by the fraction of patients with successful tumoroid development. The primary endpoint was met, as half of the patients were without progression at two months. Further clinical studies are justified. Clinical trial information: NCT03251612.

The Culture in vitro of Urogenital Organs of Pleurodeles waltlii

Development ◽  
1962 ◽  
Vol 10 (4) ◽  
pp. 465-470
Author(s):  
Charles L. Foote ◽  
Florence M. Foote
Keyword(s):  
Organ Culture ◽  
Germ Cells ◽  
Culture Medium ◽  
Developmental Stages ◽  
Rana Catesbeiana ◽  
Sex Differentiation ◽  
Organ Cultures ◽  
Tissue And Organ Culture ◽  
Pleurodeles Waltlii

Earlier reports (Foote & Foote, 1958a, b, 1959) describe growth and maintenance in vitro of larval organs, particularly gonads, of Rana catesbeiana and Xenopus laevis. Immature germ cells of both testes and ovaries are well maintained in vitro, especially if the culture medium is supplemented with watersoluble sex-hormonal substances, although germ cells in process of maturation become necrotic. Recently some urogenital organs from the salamander, Pleurodeles waltlii, have been grown in vitro. Tissues and organs from this amphibian might prove to be more suitable for tissue and organ culture investigations than those of Anurans. Animals at three different ages were used in this study: recently hatched larvae, metamorphosing animals, and adults. To determine whether sex differentiation would occur in vitro, trunk portions of young larvae of Pleurodeles waltlii of developmental stages 37–38 (Gallien & Durocher, 1957) were placed in organ cultures.

scholarly journals ATP7B expression is associated with in vitro sensitivity to cisplatin in non-small cell lung cancer

2010 ◽  
Vol 1 (2) ◽  
pp. 279-282 ◽  
Author(s):  
YOSHIMASA INOUE ◽  
HOZUMI MATSUMOTO ◽  
SHUNSUKE YAMADA ◽  
KENJI KAWAI ◽  
HIROSHI SUEMIZU ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
In Vitro Sensitivity
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