Inhibitory Effect of Ascorbic Acid 2-O-.ALPHA.-Glucoside on the Pigmentation of Skin by Exposure to Ultraviolet Light.

1. The feasibility of improving iron nutrition by fortifying cane sugar with ascorbic acid was studied.2. The absorption of Fe added to maize-weal porridge was measured in 116 volunteer multiparous Indian women using the radio-Fe erythrocyte utilization method. The meals were fed with and without tea or coffee and with and without varying amounts of ascorbic acid.3. The mean absorption of Fe from maize-meal porridge was very low (3.8 %), being even further reduced (2.1 %) when tea was drunk with the meal.4. The addition of 50 or 100 mg ascorbic acid to maize-meal porridge caused approximately a 10-fold increase in Fe absorption. The increase was much less when tea was present, being 2-fold and 5-fold with 50 and 100 mg ascorbic acid respectively. The inhibitory effect of tea on Fe absorption could, however, be overcome by giving larger doses of ascorbic acid (250 and 500 mg).5. When contaminating Fe (2.5 mg) in the form of labelled rust (Fe2O3) or ferric hydroxide was added to maize-meal porridge it was poorly absorbed (mean values were 0.01 % and 1.5 % respectively). The addition of 100 mg ascorbic acid increased the mean Fe absorption rates to 0.5 % and 6.7 % with Fe2O3 and Fe(OH)3 respectively. Fe(OH)3 was found to be absorbed about half as well as the intrinsic Fe present in maize-meal porridge.6. It is concluded that ascorbic acid is capable of improving Fe absorption from a cereal source. It can partially overcome the inhibitory effect of tea and might be expected to facilitate the absorption of at least some forms of Fe that may contaminate food.

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Enhancing or Inhibitory Effect of Fruit or Vegetable Bioactive Compound on Aspergillus niger and A. oryzae

Journal of Fungi ◽

10.3390/jof8010012 ◽

2021 ◽

Vol 8 (1) ◽

pp. 12

Author(s):

Gülru Bulkan ◽

Sitaresmi Sitaresmi ◽

Gerarda Tania Yudhanti ◽

Ria Millati ◽

Rachma Wikandari ◽

...

Keyword(s):

Ascorbic Acid ◽

Aspergillus Niger ◽

Bioactive Compounds ◽

Ellagic Acid ◽

Microbial Growth ◽

Biomass Yield ◽

Antimicrobial Effect ◽

Bioactive Compound ◽

Inhibitory Effect ◽

Processing Wastes

Fruit and vegetable processing wastes are global challenges but also suitable sources with a variety of nutrients for different fermentative products using bacteria, yeast or fungi. The interaction of microorganisms with bioactive compounds in fruit waste can have inhibitory or enhancing effect on microbial growth. In this study, the antimicrobial effect of 10 bioactive compounds, including octanol, ellagic acid, (−)-epicatechin, quercetin, betanin, ascorbic acid, limonene, hexanal, car-3-ene, and myrcene in the range of 0–240 mg/L on filamentous fungi Aspergillus oryzae and Aspergillus niger were investigated. These fungi were both found to be resistant to all compounds except octanol, which can be used as a natural antifungal agent, specifically against A. oryzae and A. niger contamination. On the contrary, polyphenols (quercetin and ellagic acid), ascorbic acid, and hexanal enhanced A. niger biomass yield 28%, 7.8%, 16%, and 6%, respectively. Furthermore, 240 mg/L car-3-ene was found to increase A. oryzae biomass yield 8%, while a 9% decrease was observed at lower concentration, 24 mg/L. Similarly, up to 17% decrease of biomass yield was observed from betanin and myrcene. The resistant nature of the fungi against FPW bioactive compounds shows the potential of these fungi for further application in waste valorization.

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Inhibitory Effect of Ascorbic Acid on β-Amylase

Nippon Nōgeikagaku Kaishi ◽

10.1271/nogeikagaku1924.27.762 ◽

1953 ◽

Vol 27 (11) ◽

pp. 762-766

Author(s):

Masaharu ITÔ ◽

Michio ABE

Keyword(s):

Ascorbic Acid ◽

Inhibitory Effect

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Dietary ascorbic acid lowers the concentration of soluble copper in the small intestinal lumen of rats

British Journal Of Nutrition ◽

10.1079/bjn19940177 ◽

1994 ◽

Vol 71 (5) ◽

pp. 701-707 ◽

Cited By ~ 10

Author(s):

G. J. Van Den Berg ◽

S. YU ◽

A. G. Lemmens ◽

A. C. Beynen

Keyword(s):

Ascorbic Acid ◽

Small Intestine ◽

Liquid Phase ◽

Inhibitory Effect ◽

Male Rats ◽

Intestinal Lumen ◽

Distal Intestine ◽

Small Intestinal ◽

Ascorbic Acid Supplementation

We tested the hypothesis that ascorbic acid in the diet of rats lowers the concentration of soluble Cu in the small intestine, causing a decrease in apparent Cu absorption. Male rats were fed on diets adequate in Cu (5 mg Cu/kg) without or with 10 g ascorbic acid/kg. The diet with ascorbic acid was fed for either 6 or 42 d. Ascorbic acid depressed tissue Cu concentrations after a feeding period of 42, but not after 6 d. Dietary ascorbic acid lowered apparent Cu absorption after 6, but not after 42 d. The lowering of tissue Cu concentrations after long-term ascorbic acid feeding may have increased the efficiency of Cu absorption, and thus counteracted the inhibitory effect of ascorbic acid. Dietary ascorbic acid caused a significant decrease in the Cu concentrations in the liquid phase of both the proximal and distal parts of the small intestinal lumen. This effect was due to both a decrease in the amount of Cu in the liquid digesta and an increase in the volume of the liquid phase; only the latter effect for the distal intestine was statistically significant. We conclude that ascorbic acid supplementation lowers Cu absorption by decreasing the concentration of soluble Cu in the small intestine.

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Ascorbic acid, sucrose and olive oil lipids mitigate the inhibitory effects of pectin on the bioaccessibility and Caco-2 cellular uptake of ferulic acid and naringenin

Food & Function ◽

10.1039/d0fo00129e ◽

2020 ◽

Vol 11 (5) ◽

pp. 4138-4145

Author(s):

Johanita Kruger ◽

Nadine Sus ◽

Jan Frank

Keyword(s):

Ascorbic Acid ◽

Ferulic Acid ◽

Olive Oil ◽

Cellular Uptake ◽

Inhibitory Effect ◽

Inhibitory Effects

Sucrose and olive oil successfully negate the inhibitory effect of pectin on the overall in vitro availability of ferulic acid and naringenin by substantially increasing the bioaccessibility and not cellular uptake of the phenolics.

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Inhibitory effect of irradiation of DNA with near ultraviolet light in the presence of 8-methoxypsoralen on cleavage by restriction endonucleases.

Journal of Radiation Research ◽

10.1269/jrr.27.99 ◽

1986 ◽

Vol 27 (1) ◽

pp. 99-104 ◽

Cited By ~ 1

Author(s):

KANG WEI ◽

SATORU TOMITA ◽

ETSUKO YANAGAWA ◽

KENSHI SUZUKI

Keyword(s):

Ultraviolet Light ◽

Inhibitory Effect ◽

Restriction Endonucleases ◽

Near Ultraviolet

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Effect of Some Flavonic Compounds and Ascorbic Acid on Lactoferrin Stimulation of Erythrocyte Glycolysis and Na+/K+-ATPase Activity

Zeitschrift für Naturforschung C ◽

10.1515/znc-2008-9-1025 ◽

2008 ◽

Vol 63 (9-10) ◽

pp. 773-779 ◽

Cited By ~ 1

Author(s):

Ana Maneva ◽

Borislava Taleva

Keyword(s):

Ascorbic Acid ◽

Atpase Activity ◽

Specific Binding ◽

Lactate Production ◽

Inhibitory Effect ◽

High Concentration ◽

Transport Chain ◽

Strong Inhibitory Effect ◽

Lactate Formation ◽

Stimulation Of

The aim of the present study was to assess if some flavonic compounds (quercetin, piceatannol and apigenin) and ascorbic acid could interfere with the Lf stimulatory effect on the erythrocyte function. Quercetin (1.5 μm) and piceatannol (30 μm) showed an additive effect on Lf stimulation of Na+/K+-ATPase when used together with Lf. The enhancement of Lf stimulation on Na+/K+-ATPase in the presence of flavonoids was probably due to their antioxidative properties and/or to their involvement in the erythrocyte signaling. None of the estimated flavonoids showed an effect on Lf stimulation of the lactate production. Quercetin itself enhanced the ATPase activity but did not affect the lactate formation. Apigenin (1.5 μm) enhanced reliably the lactate generation, but it did not exert any effect on the ATPase activity. High concentration of ascorbic acid (60 mm) did not change the Lf stimulatory effect on Na+/K+-ATPase, but decreased the Lf-specific-binding. A significantly strong inhibitory effect on the Lf-specific binding exerted the electron acceptors NAD+ (2 mm) and FAD (2 mm). These effects concern most likely the competition with Lf for electron(s) which is (are) provided from the erythrocyte intercellular electron transport chain(s).

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