scholarly journals Iron absorption from a cereal-based meal containing cane sugar fortified with ascorbic acid

1977 ◽  
Vol 38 (2) ◽  
pp. 261-269 ◽  
Author(s):  
D. Derman ◽  
M. Sayers ◽  
S. R. Lynch ◽  
R. W. Charlton ◽  
T. H. Bothwell ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Ferric Hydroxide ◽  
Fold Increase ◽  
Inhibitory Effect ◽  
Cane Sugar ◽  
Iron Nutrition ◽  
Indian Women ◽  
Mean Values ◽  
Maize Meal ◽  
The Mean

1. The feasibility of improving iron nutrition by fortifying cane sugar with ascorbic acid was studied.2. The absorption of Fe added to maize-weal porridge was measured in 116 volunteer multiparous Indian women using the radio-Fe erythrocyte utilization method. The meals were fed with and without tea or coffee and with and without varying amounts of ascorbic acid.3. The mean absorption of Fe from maize-meal porridge was very low (3.8 %), being even further reduced (2.1 %) when tea was drunk with the meal.4. The addition of 50 or 100 mg ascorbic acid to maize-meal porridge caused approximately a 10-fold increase in Fe absorption. The increase was much less when tea was present, being 2-fold and 5-fold with 50 and 100 mg ascorbic acid respectively. The inhibitory effect of tea on Fe absorption could, however, be overcome by giving larger doses of ascorbic acid (250 and 500 mg).5. When contaminating Fe (2.5 mg) in the form of labelled rust (Fe2O3) or ferric hydroxide was added to maize-meal porridge it was poorly absorbed (mean values were 0.01 % and 1.5 % respectively). The addition of 100 mg ascorbic acid increased the mean Fe absorption rates to 0.5 % and 6.7 % with Fe2O3 and Fe(OH)3 respectively. Fe(OH)3 was found to be absorbed about half as well as the intrinsic Fe present in maize-meal porridge.6. It is concluded that ascorbic acid is capable of improving Fe absorption from a cereal source. It can partially overcome the inhibitory effect of tea and might be expected to facilitate the absorption of at least some forms of Fe that may contaminate food.

Studies on the fortification of cane sugar with iron and ascorbic acid

1975 ◽  
Vol 34 (1) ◽  
pp. 141-152 ◽  
Author(s):  
P. B. Disler ◽  
S. R. Lynch ◽  
R. W. Charlton ◽  
T. H. Bothwell ◽  
R. B. Walker ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Ferrous Sulphate ◽  
Fold Increase ◽  
Cane Sugar ◽  
Iron Nutrition ◽  
Indian Women ◽  
Maize Meal ◽  
Storage Properties

1. The feasibility of improving iron nutrition by fortifying cane sugar with Fe and ascorbic acid was studied.2. It was found to be possible to add a number of Fe salts together with ascorbic acid to sugar without affecting its appearance or storage properties.3. The absorption of Fe from fortified sugar eaten with maize-meal porridge or made into jam or biscuits was measured in ninety-four volunteer multiparous Indian women using the59Fe erythrocyte utilization method.4. The absorption of Fe from sugar fortified with ascorbic acid and ferrous sulphate and eaten with maize-meal porridge was increased about twofold if the ratio, ascorbic acid: Fe was 10:1 by weight. If the ratio was increased to 20:1, Fe absorption was increased a further threefold.5. Sugar fortified with soluble Fe salts, including FeSO4. 7H2O, discoloured both tea and coffee; sugar fortified with ferric orthophosphate did not have this effect.6. Fe from FePO4. H2O was poorly absorbed when added with sugar to maize-meal porridge, and also when added with adequate quantities of ascorbic acid. This form of Fe was absorbed much less well than was the intrinsic Fe present in the maize.7. When sugar fortified with FePO4.H2O and ascorbic acid was added to maize-meal porridge before cooking or was made into jam there was a several-fold increase in the amount of Fe absorbed.

scholarly journals Iron absorption from rice meals cooked with fortified salt containing ferrous sulphate and ascorbic acid

1974 ◽  
Vol 31 (3) ◽  
pp. 367-375 ◽  
Author(s):  
M. H. Sayers ◽  
S. R. Lynch ◽  
R. W. Charlton ◽  
T. H. Bothwell ◽  
R. B. Walker ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Iron Absorption ◽  
Ferrous Sulphate ◽  
Striking Difference ◽  
Red Cell ◽  
Indian Women ◽  
Threefold Increase ◽  
Cooking Process ◽  
Wide Range ◽  
The Mean

1. Iron absorption from rice-containing meals was measured by red cell utilization of radioactive Fe in sixty-six volunteer multiparous Indian women.2. In all the studies salt added during the cooking process was used as the carrier for supplemental inorganic Fe and ascorbic acid.3. Intrinsic Fe in the rice and supplementary inorganic Fe were absorbed to the same extent, with a wide range of absorption values.4. There was a striking difference between the mean absorption of a 3 mg dose of ferrous Fe given to fasting subjects in a solution containing 30 mg ascorbic acid and that of Fe in a rice meal (48.7 and 3.5% respectively).5. When ascorbic acid was added during cooking there was a threefold increase in the absorption of both intrinsic Fe and supplementary Fe when a sufficient quantity (60 mg) was present.6. It is concluded that the Fe nutrition of rice-eating communities could be improved significantly by the addition of ascorbic acid to the diet.

scholarly journals Impact of decalcification on antibacterial properties of eggshell against selected poultry pathogens

2021 ◽  
Vol 22 (2) ◽  
pp. 204-210
Author(s):  
T.V. Balogu ◽  
B.C. Chukwueze ◽  
T.P. Okonkwo
Keyword(s):  
Antibacterial Effect ◽  
Antibacterial Properties ◽  
Fine Powder ◽  
Inhibitory Effect ◽  
Diffusion Method ◽  
Mean Values ◽  
Significance Level ◽  
E Coli ◽  
Zone Diameter ◽  
The Mean

Background: Eggshell which is primarily composed of more than 98% calcium carbonate crystal, serves as the physical protective and active barrier structure of egg content. Recently, antimicrobial properties of eggshell are fast becoming center of interest among stakeholders of poultry industry. However, few studies have focused on the rigidity factor of calcium components of eggshell as antimicrobial agent. Thus, this study was designed to determine the effect of decalcification on the ability of eggshell to inhibit common poultry and egg bacterial pathogens.Methods: Raw eggshell denoted as calcified eggshell (CES) and decalcified eggshell (DES) were extracted and made into fine powder. Standard protocol was used for preparations of CES and DES at concentrations of 10, 5, 2.5 and 1.25 mg/ml, and their antibacterial assays on selected bacterial pathogens (Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli and Salmonella Typhi) were performed by agar diffusion method. Gentamicin 80mg solution (CC1) and distilled water (CC2) served as controls. Data were analysed with SPSS version 20.0 and presented as mean±SD for descriptive statistics. Friedman's two-way test ANOVA was used to compare the differences in mean values between CES, DES, CC1 and CC2 at significance level of p<0.05.Results: The mean zone diameter of inhibition produced by DES (range 13–28mm) for the isolates was significantly higher (p<0.05) than that produced by CES (range 10-21mm). However, the mean zone diameter of inhibition produced by CC1 (gentamicin) (range 16-40mm) was higher than that produced by DES or CES (p<0.05). The concentrations of DES and CES have no significant antibacterial effect on B. subtilis and K. pneumoniae (p>0.05), but had inverse effect on P. aeruginosa. Overall, DES had a better inhibitory effect than CES against B. subtilis, K. pneumoniae and P. aeruginosa, but notably, neither DES nor CES had inhibitory effect on E. coli and S. Typhi.Conclusion: Poor antibacterial effect of CES may be attributed to the calcium-protein interactions within bacterial cell membrane, which hinders absorption or mobility mechanism of the antibacterial factor of the eggshell, but decalcification had significant impact on the antibacterial profile of the eggshell for some bacterial isolates. However, S. Typhi and E. coli were totally resistant to both DES and CES. Breed of eggs with minimal calcified eggshell to withstand transportation fragility, may enhance antibacterial index and shelf-life of table eggs. Keywords: Decalcification; Antibacterial; Eggshell; Poultry; Pathogens

scholarly journals Effects of flunixin and florfenicol combined with vitamins E and/or C on selected immune mechanisms in cattle under conditions of adaptive stress

2015 ◽  
Vol 59 (2) ◽  
pp. 295-301
Author(s):  
Renata Urban-Chmiel ◽  
Rafał Stachura ◽  
Piotr Hola ◽  
Andrzej Puchalski ◽  
Marta Dec ◽  
...  
Keyword(s):  
Vitamin E ◽  
Inhibitory Effect ◽  
Morbidity Rate ◽  
Control Group ◽  
Integrin Receptors ◽  
Mean Values ◽  
Immune Mechanisms ◽  
Vitamins E And C ◽  
The Mean ◽  
Intracellular Metabolism

Abstract The aim of the study was to evaluate the effect of flunixin and florfenicol administered in combination with vitamin E or C on selected leukocyte immune mechanisms and on the inflammatory process during the first few weeks in the feedlot. Fifty calves divided into 5 groups (n = 10) received florfenicol and flunixin with vitamin E or C. Blood was collected on the 1st, 3rd, 7th, 14th, 21st, and 28th d of the experiment. Intracellular metabolism (NBT), apoptosis, chemotaxis, susceptibility to M. haemolytica leukotoxin, and expression of β2-integrins were determined in leukocytes. The symptoms of respiratory tract infection were observed in 40% of calves in control group, while in the other groups the morbidity rate ranged from 10% to 20%. Leukocytes showed decreased NBT, and the mean values for apoptosis ranged from 14% to 24%. The lowest percentage of apoptotic cells was observed in the calves that received florfenicol with flunixin and vitamins E and C. The chemotactic activity confirmed the significant inhibitory effect of the preparations on migration of the cells. A significant decrease (P ≤ 0.05) in the susceptibility of leukocytes to leukotoxin was noted in the group that received florfenicol and flunixin with vitamin E. Expression of β2-integrin receptors was the lowest in calves receiving florfenicol with flunixin and vitamin E or C. The application of an antibiotic and a non-steroidal anti-inflammatory drug with antioxidants protected the leukocytes involved in defence against M. haemolytica virulence factors and effectively limited oxidative stress in the calves.

scholarly journals Factors affecting the absorption of iron from Fe(III)EDTA

1981 ◽  
Vol 45 (2) ◽  
pp. 215-227 ◽  
Author(s):  
A. P. MacPhail ◽  
T. H. Bothwell ◽  
J. D. Torrance ◽  
D. P. Derman ◽  
W. R. Bezwoda ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Potent Inhibitor ◽  
Fold Increase ◽  
Indian Women ◽  
Factors Affecting ◽  
Common Pool ◽  
A Value ◽  
Relative Value ◽  
Haemoglobin Synthesis

1. The modification of iron absorption from Fe(III)EDTA by agents known to promote or inhibit absorption was examined in 101 volunteer multiparous Indian women. Fe absorption from Fe(III)EDTA was compared with absorption of intrinsic food Fe in a further twenty-eight subjects. Finally the urinary excretion of radio-Fe after oral administration of59Fe(III)EDTA was studied in twenty-four subjects and evidence of intraluminal exchange of Fe was examined.2. Fe absorption from maize porridge fortified with Fe(III)EDTA was more than twice that from porridge fortified with FeSO4. 7H2O.3. Although bran decreased Fe absorption from FeSO4. 7H2O approximately 11-fold, it had no significant effect on Fe absorption from Fe(III)EDTA. Nevertheless tea, which is a more potent inhibitor of Fe absorption, decreased absorption from Fe(III)EDTA 7-fold.4. Fe absorption from Fe(III)EDTA given in water was only increased 40% by addition of 3 mol ascorbic acid/mol Fe but by 7-fold when the relative proportions were increased to 6:1. This enhancing effect was blunted when the Fe(III)EDTA was given with maize porridge. In these circumstances, an ascorbate:iron value of 3:1 (which doubles absorption from FeSO4. 7H2O) produced no significant increase in Fe absorption, while a value of 6:1 produced only a 2.5-fold increase.5. Fe absorption from Fe(III)EDTA was not altered by addition of maize porridge unless ascorbic acid was present.6. Less than 1% of59Fe administered as59Fe(III)EDTA was excreted in the urine and there was an inverse relationship between Fe absorption and the amounts excreted (r0.58,P> 0.05).7. Isotope exchange between55Fe(III)EDTA and59FeSO4. 7H2O was demonstrated by finding a similar relative value for the two isotopes in urine and erythrocytes when the two labelled compounds were given together orally. This finding was confirmed by in vitro studies, which showed enhanced59Fe solubilization from59FeSO4. 7H2O in maize porridge when unlabelled Fe(III)EDTA was added.8. Although Fe absorption from Fe(III)EDTA was marginally higher it appeared to form a common pool with intrinsic food iron in most studies. It is postulated that the mechanism whereby Fe(III)EDTA forms a common pool with intrinsic food Fe differs from that occurring with simple Fe salts. When Fe is present in the chelated form it remains in solution and is relatively well absorbed because it is protected from inhibitory ligands. Simple Fe salts, however, are not similarly protected and are absorbed as poorly as the intrinsic food Fe.9. It is concluded that Fe(III)EDTA may be a useful compound for food fortification of cereals because the Fe is well absorbed and utilized for haemoglobin synthesis. The substances in cereals which inhibit absorption of simple Fe salts do not appear to inhibit absorption of Fe from Fe(III)EDTA.

Studies on the metabolism of fowls: III. The determination of the comparative nett energy of Sussex ground oats and white maize meal for fattening cockerels

1940 ◽  
Vol 30 (3) ◽  
pp. 463-484 ◽  
Author(s):  
T. Deighton ◽  
J. C. D. Hutchinson
Keyword(s):  
Dry Matter ◽  
Metabolizable Energy ◽  
Mean Values ◽  
Digestible Energy ◽  
Significant Difference ◽  
Maize Meal ◽  
The Mean ◽  
Image Position

1. The comparative nett energy for fattening of Sussex ground oats and white maize meal have been determined on Light Sussex cockerels by difference experiments with a direct calorimeter.2. The mean values for nett energy per gram dry matter, nett energy/ metabolizable energy, metabolizable energy per gross feed energy and digestible energy per gross feed energy were as follows:3. There was no significant difference in the utilization of metabolizable energy from the two cereals. The higher nett energy of the white maize meal was due to its higher digestibility.We again welcome the opportunity of expressing our indebtedness to Mr G. A. Childs for his assistance in carrying out the experiments.

344. A Note on Certain Vitamins of Sow's Colostrum

1946 ◽  
Vol 14 (3) ◽  
pp. 414-418 ◽  
Author(s):  
R. Braude
Keyword(s):  
Ascorbic Acid ◽  
Vitamin A ◽  
Vitamin C ◽  
Ascorbic Acid Content ◽  
Vitamin B ◽  
Large White ◽  
Mean Values ◽  
Total Solids ◽  
The Mean ◽  
Β Carotene

1. Eighteen samples of colostrum obtained from Large White sows during parturition were examined for total solids, fat, vitamin A, vitamin B^ riboflavin and vitamin C.2. The mean values and ranges for the total solids (fourteen samples) and fat (fifteen samples) were 23.9% (20.6–27.2%) and 3.4% (1.7–5.8%) respectively.3. The mean vitamin A content of eighteen samples was 247 i.u./100 ml. with a range of 103.462 i.u./lOO ml., or 89 i.u./g. fat with a range of 42–137 i.u./g. fat. No β-.carotene was detected in any of the samples.4. The mean vitamin B1 content of seventeen samples was 145 /µg./100 ml. with a range of 81.260 µg./100 ml.5. The mean riboflavin content of sixteen samples was 45.6 µg./100 ml. with a range of 21–78 µg./100 ml.6. The mean ascorbic acid content of seventeen samples was 23.8 mg./100ml. with a range of 12–36 mg./100 ml.

Articulatory Behavior Pre and Post Full-Mouth Tooth Extraction and Alveoloplasty

1980 ◽  
Vol 23 (3) ◽  
pp. 630-645 ◽  
Author(s):  
Gerald Zimmermann ◽  
J.A. Scott Kelso ◽  
Larry Lander
Keyword(s):  
Control Subject ◽  
High Speed ◽  
Tooth Extraction ◽  
Kinematic Parameters ◽  
Experimental Conditions ◽  
Mean Values ◽  
Articulatory Movements ◽  
The Mean ◽  
Experimental Subjects ◽  
Normal Speech

High speed cinefluorography was used to track articulatory movements preceding and following full-mouth tooth extraction and alveoloplasty in two subjects. Films also were made of a control subject on two separate days. The purpose of the study was to determine the effects of dramatically altering the structural dimensions of the oral cavity on the kinematic parameters of speech. The results showed that the experimental subjects performed differently pre and postoperatively though the changes were in different directions for the two subjects. Differences in both means and variabilities of kinematic parameters were larger between days for the experimental (operated) subjects than for the control subject. The results for the Control subject also showed significant differences in the mean values of kinematic variables between days though these day-to-day differences could not account for the effects found pre- and postoperatively. The results of the kinematic analysis, particularly the finding that transition time was most stable over the experimental conditions for the operated subjects, are used to speculate about the coordination of normal speech.

Selective Inhibition of Thromboxane Synthetase with Dazoxiben - Basis of Its Inhibitory Effect on Platelet Adhesion

1983 ◽  
Vol 49 (02) ◽  
pp. 096-101 ◽  
Author(s):  
V C Menys ◽  
J A Davies
Keyword(s):  
Arachidonic Acid ◽  
Platelet Adhesion ◽  
Fold Increase ◽  
Selective Inhibition ◽  
Inhibitory Effect ◽  
Selective Inhibitor ◽  
Coated Glass ◽  
Thromboxane Synthetase ◽  
Pre Treatment

SummaryPlatelet adhesion to rabbit aortic subendothelium or collagen-coated glass was quantitated in a rotating probe device by uptake of radio-labelled platelets. Under conditions in which aspirin had no effect, dazoxiben, a selective inhibitor of thromboxane synthetase, reduced platelet adhesion to aortic subendothelium by about 40% but did not affect adhesion to collagen-coated glass. Pre-treatment of aortic segments with 15-HPETE, a selective inhibitor of PGI2-synthetase, abolished the inhibitory effect of dazoxiben on adhesion. Concentrations of 6-oxo-PGFlα in the perfusate were raised in the presence of dazoxiben alone, and following addition of thrombin (10 units/ml) there was a 2-3 fold increase in concentration. Perfusion of damaged aorta with platelets labelled with (14C)-arachidonic acid in the presence of thrombin and dazoxiben resulted in the appearance of (14C)-labelled-6-oxo-PGFiα. Inhibition of thromboxane synthetase limits platelet adhesion probably by promoting vascular synthesis of PGI2 from endoperoxides liberated from adherent platelets, which subsequently promotes detachment of cells from the surface.

Comparative Study of Intranasal, Subcutaneous and Intravenous Administration of Desamino-D-Arginine Vasopressin (DDAVP)

1986 ◽  
Vol 55 (01) ◽  
pp. 108-111 ◽  
Author(s):  
M Köhler ◽  
P Hellstern ◽  
C Miyashita ◽  
G von Blohn ◽  
E Wenzel
Keyword(s):  
Factor Viii ◽  
Von Willebrand Factor ◽  
Factor Xii ◽  
Additional Advantage ◽  
Mean Values ◽  
Routes Of Administration ◽  
The Mean ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Factor Antigen

SummaryThis study was performed to evaluate the influence of different routes of administration on the efficacy of DDAVP treatment. Ten healthy volunteers received DDAVP intranasally (i.n.), subcutaneously (s.c.) and intravenously (i.v.) in a randomized cross-over trial. Factor XII and high molecular weight (HMW)-kininogen levels increased only slightly after DDAVP administration. The mean increase of factor VIII: C was 3.1 (i. v.), 2.3 (s. c.), and 1.3 (i.n.) - fold over baseline. Ristocetin cofactor (von Willebrand factor antigen) increased 3.1 (2.5), 2.0 (2.3) and 1.2 (1.2) - fold over baseline mean values after i.v., s.c. and i.n. DDAVP, respectively. The half-disappearance time of factor VIII and von Willebrand factor (vWF) after DDAVP ranged from five (factor VIII: C) to eight hours (vWF). The mean increase of fibrinolytic activity was more pronounced after i.v. DDAVP. The antidiuretic effect was moderate with no apparent differences between the routes of application. This study provides further evidence that both i.v. and s.c. DDAVP administration result in an appropriate and reliable stimulation of haemostasis. An additional advantage of s. c. administration is its suitability for home treatment.

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