Cognitive Dysfunction Is Associated With Poor Diabetes Control in Older Adults

This study aimed to determine whether daily physical activity in young and older adults with T2DM is associated with diabetes control. A prospective correlational study involving 206 young (≤65 years) and older (>65 years) adults was conducted. The International Physical Activity Questionnaire was used to assess their daily physical activity levels. Patients’ mean HbA1c level was 7.8% (±1.4), and 95.9% of patients had unsatisfactory diabetes control. Performing more minutes per week of moderate-intensity daily physical activity was associated with a lower risk of glycemia in both young and older adults. Furthermore, moderate daily physical activity significantly lowered the risk of glycemia. Health personnel must encourage patients to engage in moderate daily physical activities to improve diabetes control.

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Abstract P340: Prevalence of Cognitive Dysfunction Among Older Adults With Diabetes

Circulation ◽

10.1161/circ.131.suppl_1.p340 ◽

2015 ◽

Vol 131 (suppl_1) ◽

Author(s):

Andreea Rawlings ◽

A. Richey Sharrett ◽

David Knopman ◽

Christina Parrinello ◽

Priya Palta ◽

...

Keyword(s):

Older Adults ◽

Executive Function ◽

Cognitive Dysfunction ◽

Management Practices ◽

Self Management ◽

Healthy Population ◽

Cross Sectional ◽

Adjusted Scores ◽

Multiple Domains ◽

Sectional Analysis

Introduction: Among older adults with diabetes, cognitive dysfunction is of particular concern as it has implications for treatment adherence and diabetes self-management. The prevalence of cognitive dysfunction has not been well characterized in this population. Methods: We conducted a cross-sectional analysis of 5509 participants (1815 with diabetes) from visit 5 (2011-2013) of the ARIC Study. Diabetes was defined based on self-reported physician diagnosis, diabetes medication use, or HbA1c ≥ 6.5%. Cognitive function was measured using 8 neuropsychological tests, which were grouped into three cognitive domains representing memory, executive function, and language. Participants were categorized as having cognitive dysfunction if test scores were more than 1.5 standard deviations below age-, race-, and education-adjusted scores derived from a cognitively healthy population. We calculated crude prevalence estimates and used Poisson regression to estimate adjusted prevalence ratios (PRs), comparing cognitive dysfunction in persons with and without diabetes. We adjusted for demographic and clinical characteristics. Results: The mean age of participants was 75 years, 59% were female, 79% were white, and 33% had diabetes. In each domain, the prevalence of cognitive dysfunction among persons with diabetes ranged from 14% to 27%. Persons with diabetes were more likely than persons without diabetes to have dysfunction in multiple domains (PR = 1.29, 95% CI: 1.12, 1.49). Prevalence of cognitive dysfunction was significantly higher in persons with versus without diabetes for memory (PR=1.13, 95% CI: 1.02, 1.25), language (PR=1.24, 95% CI: 1.09, 1.45), and executive function (PR=1.10, 95% CI: 1.00, 1.22)(Figure). PRs were similar in crude models. Conclusions: The prevalence of cognitive dysfunction among older adults with diabetes is high. These results have implications for how physicians educate patients in appropriate self-management practices and for the prevention of diabetes-related complications.

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Stability of neuropsychological test performance in older adults serving as normative controls for a study on postoperative cognitive dysfunction

BMC Research Notes ◽

10.1186/s13104-020-4919-3 ◽

2020 ◽

Vol 13 (1) ◽

Cited By ~ 4

Author(s):

Insa Feinkohl ◽

Friedrich Borchers ◽

Sarah Burkhardt ◽

Henning Krampe ◽

Antje Kraft ◽

...

Keyword(s):

Older Adults ◽

Cognitive Dysfunction ◽

Test Performance ◽

Neuropsychological Test ◽

Postoperative Cognitive Dysfunction

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Postural control in older adults with cognitive dysfunction

Physical Therapy Reviews ◽

10.1179/108331906x144055 ◽

2006 ◽

Vol 11 (3) ◽

pp. 169-170

Author(s):

Leigh Hale

Keyword(s):

Older Adults ◽

Postural Control ◽

Cognitive Dysfunction

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Farmers’ Market Voucher Initiative to Improve Diabetes Control in Older Adults

The Journal for Nurse Practitioners ◽

10.1016/j.nurpra.2021.09.010 ◽

2021 ◽

Author(s):

Jacqulene Pick Harris ◽

Carol Bett ◽

Voncella McCleary-Jones

Keyword(s):

Older Adults ◽

Diabetes Control ◽

Farmers Market

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Sleep quality mediates the relationship between frailty and cognitive dysfunction in non-demented middle aged to older adults

International Psychogeriatrics ◽

10.1017/s1041610220000150 ◽

2020 ◽

Vol 32 (5) ◽

pp. 663-663

Author(s):

Sonya Kaur ◽

Nikhil Banerjee ◽

Michelle Miranda ◽

Mitchell Slugh ◽

Ni Sun Suslow ◽

...

Keyword(s):

Older Adults ◽

Sleep Quality ◽

Cognitive Dysfunction ◽

Middle Aged ◽

The Relationship

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Hyperglycemia and Metformin Use Are Associated With B Vitamin Deficiency and Cognitive Dysfunction in Older Adults

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2018-01791 ◽

2019 ◽

Vol 104 (10) ◽

pp. 4837-4847 ◽

Cited By ~ 14

Author(s):

Kirsty M Porter ◽

Mary Ward ◽

Catherine F Hughes ◽

Maurice O’Kane ◽

Leane Hoey ◽

...

Keyword(s):

Older Adults ◽

Vitamin B12 ◽

Cognitive Dysfunction ◽

Vitamin B6 ◽

Vitamin Deficiency ◽

Community Dwelling ◽

Metformin Treatment ◽

Fortified Foods ◽

B Vitamin ◽

The Impact

AbstractContextEmerging evidence suggests that deficiencies of folate-related B vitamins can arise with metformin treatment and are independently linked with cognitive dysfunction, a comorbidity of diabetes.ObjectiveTo determine the impact of hyperglycemia and metformin use on relevant B vitamin biomarkers and cognitive outcomes in older adults.Setting and ParticipantsCommunity-dwelling older adults (74.1 ± 8.3 years, n = 4160) without dementia, recruited to the Trinity, Ulster and Department of Agriculture cohort study in 2008 to 2012, were classified as normoglycemic (n = 1856) or hyperglycemic, based on HbA1c ≥5.7% (39 mmol/mol), either with (n = 318) or without (n = 1986) metformin treatment.Main Outcome MeasuresBiomarkers of folate, vitamin B12, vitamin B6, and riboflavin were measured. Cognitive assessments included the Repeatable Battery for Assessment of Neuropsychological Status (RBANS) and the Frontal Assessment Battery (FAB).ResultsMetformin use was associated with higher risk of deficiency of vitamin B12 (combined B12 index ≤−1; OR 1.45; 95% CI, 1.03 to 2.02) and vitamin B6 (plasma pyridoxal 5-phosphate <30.0 nmol/L; OR 1.48; 95% CI, 1.02 to 2.15). Fortified foods when eaten regularly had a positive impact on all relevant B vitamin biomarkers, even with hyperglycemia. After adjustment for relevant covariates, metformin use was associated with an increased risk of cognitive dysfunction as assessed with the RBANS (OR 1.36; 95% CI, 1.03 to 1.80) and FAB (OR 1.34; 95% CI, 1.03 to 1.74).ConclusionsUse of metformin by older adults is associated with poorer cognitive performance; B vitamin deficiency may be implicated. Fortified foods can optimize B vitamin status and may be beneficial for maintaining better cognitive health in older people with or at risk for diabetes.

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Television Viewing and Cognitive Dysfunction of Korean Older Adults

Healthcare ◽

10.3390/healthcare8040547 ◽

2020 ◽

Vol 8 (4) ◽

pp. 547

Author(s):

Mi Sook Jung ◽

Eunyoung Chung

Keyword(s):

Older Adults ◽

Cognitive Dysfunction ◽

Cognitive Aging ◽

Significant Risk ◽

Multivariate Logistic Regression Analysis ◽

Later Life ◽

Significant Risk Factor ◽

Tv Viewing ◽

Increased Risk ◽

The Impact

This study examined the association between television (TV) viewing and cognitive dysfunction in elderly Koreans. Among participants of the 2014 National Survey of Older Koreans, 9644 were considered in this study. To better identify the association between two factors, propensity score (PS) matching with exact method was used. Finally, 168 viewers and non-viewers each were selected based on estimated PS on key variables and eliminating double matches. Multivariate logistic regression analysis was performed when controlling for possible covariates. Viewers were more likely to have cognitive dysfunction than non-viewers, with significant differences in most covariates. After correcting confounding effects of these covariates with PS matching, TV viewing was found to be a significant risk factor of cognitive dysfunction, along with absence of diagnosed hypertension and non-participation in physical leisure activities. TV viewing might be associated with increased risk of cognitive dysfunction in later life. Appropriate education and strategies to minimize TV viewing among older adults should be established to contribute to attenuating cognitive aging. More interventional studies can help older adults, caregivers, and healthcare professionals explore the cognitively beneficial alternatives to TV use considering the impact of socioeconomic factors of selecting TV viewing as a preferred leisure activity.

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