scholarly journals Effectiveness and Impact of the Walking Bleach Technique on Esthetic Self-perception and Psychosocial Factors: A Randomized Double-blind Clinical Trial

2017 ◽  
Vol 42 (6) ◽  
pp. 596-605 ◽  
Author(s):  
C Bersezio ◽  
J Martin ◽  
F Peña ◽  
M Rubio ◽  
J Estay ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Psychosocial Factors ◽  
Color Change ◽  
Carbamide Peroxide ◽  
Self Perception ◽  
Dental Esthetics ◽  
Tooth Discoloration ◽  
Significant Difference ◽  
The Impact ◽  
Shade Guide

SUMMARY Objective: This trial evaluates the impact of psychosocial and esthetic self-perceptions of patients undergoing nonvital tooth bleaching using the walking bleach technique. We also assessed the clinical effectiveness of bleaching tooth discoloration. Methods: Fifty volunteers with nonvital tooth discoloration were enrolled. Teeth were randomized into two groups: 35% hydrogen peroxide (n=25) and 37% carbamide peroxide (n=25). Intracoronal bleaching was performed over four sessions using the walking bleach technique. Tooth color was evaluated at each session to measure total color variation. The shade guide was arranged from highest (B1) to lowest (C4) values to assess the color and calculate the color change in the number of shade guide units. Subjective and objective assessments were compared with the tooth counterpart. Esthetic self-perception and psychosocial factors were assessed before and after treatment. Results: Color change was 15.48<5.17 for hydrogen peroxide and 14.02<4.85 for carbamide peroxide. There was no significant difference at any time point (p>0.05) except at sessions 3 and 4 (p<0.05). Overall, whitened teeth values were similar to those of counterpart teeth (p>0.05). There was a decrease in Oral Health Impact Profile and Psychosocial Impact of Dental Esthetics questionnaire scores after treatment compared with baseline (p<0.05). Conclusion: The walking bleach technique was highly effective on nonvital teeth and had a positive effect on self-esthetic perception and psychological impact for the patients.

scholarly journals EFEKTIVITAS EKSTRAK STROBERI DAN JERUK MADU DALAM PERUBAHAN WARNA GIGI SECARA IN VITRO

2021 ◽  
Vol 16 (1) ◽  
pp. 209-213
Author(s):  
Nalem Rika Rahayu
Keyword(s):  
Color Change ◽  
Laboratory Research ◽  
Carbamide Peroxide ◽  
Tooth Color ◽  
Sample Group ◽  
Tooth Discoloration ◽  
Significant Difference ◽  
Experimental Laboratory ◽  
Shade Guide

ABSTRACT   Changing tooth color affects a person's aesthetics. Methods to restore tooth discoloration include the use ofagents bleaching. This study aims to understand the differences in the effectiveness of strawberry and honey orange extracts intooth discoloration in vitro. This type of experimental laboratory research used 45 premolar tooth samples divided into 3 groups (50% strawberry extract and 10% carbamide peroxide concentration, 50% honey orange extract and 10% carbamide peroxide concentration and 10% carbamide peroxide concentration). Samples were immersed in coffee solution for 5 days and recorded color with a shade guide, then samples were immersed in the extract of strawberries, honey oranges and carbamide peroxide for 7 days in an incubator, then recorded color again visually with a shade guide. Data analysis used thestatistical tests Oneway Anova and Posthoc LSD. The color change of the sample group immersed in strawberry extract with carbamide peroxide resulted in a significant difference (p <0.05). Likewise, the sample group immersed in honey orange extract with carbamide peroxide produced a significant difference (p <0.05), but strawberries and honey oranges did not. there is not significant difference (p> 0.05). From the results of the study it can be concluded that the extracts of strawberries and honey oranges were able to increase the discoloration of teeth to become brighter, there was no significant difference between changes in tooth discoloration soaked in strawberry extract and honey orange.   ABSTRAK Warna gigi yang berubah mempengaruhi estetik seseorang, metode untuk mengembalikan perubahan warna gigi diantaranya dengan penggunakan bahan bleaching. Penelitian ini bertujuan untuk memahami perbedaan efektivitas ekstrak buah stroberi dan jeruk madu dalam perubahan warna gigi secara in vitro. Jenis penelitian eksperimental laboratoris menggunakan sampel gigi premolar sebanyak 45 buah dibagi atas 3 kelompok (ekstrak stroberi konsentrasi 50% dan karbamid peroksida konsentrasi 10%, ekstrak jeruk madu konsentrasi 50% dan karbamid peroksida konsentrasi 10% dan karbamid peroksida konsentrasi 10%). Sampel direndam larutan kopi selama 5 hari dan lakukan pencatatan warna dengan shade guide, kemudian sampel direndam ekstrak stroberi, jeruk madu dan karbamid peroksida selama 7 hari di dalam inkubator, lalu dilakukan pencatatan warna kembali secara visual dengan shade guide. Analisis data memakai uji statistik Oneway Anova dan Posthoc LSD. Perubahan warna kelompok sampel direndam ekstrak stroberi dengan karbamid peroksida menghasilkan perbedaan signifikan (p<0,05), begitu pula kelompok sampel yang direndam ekstrak jeruk madu dengan karbamid peroksida menghasilkan perbedaan signifikan (p<0,05), namun stroberi dan jeruk madu tidak ada perbedaan yang signifikan (p>0,05). Dari hasil penelitian dapat disimpulkan bahwa ekstrak  stroberi dan jeruk madu mampu meningkatkan perubahan warna gigi menjadi lebih terang, tidak ada perbedaan signifikan antara perubahan perubahan warna gigi yang direndam ekstrak stroberi dan jeruk madu.

scholarly journals Impact of Bleaching before or after Veneer Preparation on Color Masking Ability of Laminate Veneers: An In Vitro Study

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Gollshang Ahmad Mhammed Dalloo ◽  
Bestoon Mohammed Faraj ◽  
Abdulsalam Rasheed Al-Zahawi
Keyword(s):  
Hydrogen Peroxide ◽  
Color Change ◽  
In Vitro Study ◽  
Tooth Discoloration ◽  
Significant Difference ◽  
Color System ◽  
The Difference ◽  
Laminate Veneers ◽  
Cielab Color

Purpose. This study evaluates the effect of bleaching before or after veneer preparation and the depth of preparation on color masking ability of laminate veneers. Methods. Sixty extracted premolars were artificially stained to vita shade A4, verified by digital spectrophotometer (Vita Easy Shade V), and then divided into three groups: NB = nonbleached , BBP = bleaching before preparation, and BAP = bleaching after preparation. Based on the preparation depths, each group was further divided into two subgroups: S 1 = 0.5   mm and S 2 = 1.0   mm . BBP and BAP were subjected to one session of in-office bleaching using 35% hydrogen peroxide. IPS e-max CAD veneers of 0.5 and 1.0 mm thickness (corresponding to the preparation depths) of the same shade and translucency (HT A1) were cemented immediately to the bleached surfaces. Immediately after cementation, the color change Δ E between the baseline (after staining) and the resulted shades was measured using the Vita Easy Shade V digital spectrophotometer and CIELab color system. Results. Bleached groups exhibited a significant Δ E value compared to the nonbleached group ( p < 0.05 ). BAP showed the highest Δ E value. No significant difference was found between BBP and BAP. S2 revealed a significant Δ E value than S1 ( p < 0.05 ). No significant difference was found between S1of BAP and S2 of NB, BBP, and BAP ( p > 0.05 ). Regarding the color coordinates, the difference between the tested groups was highly significant in lightness ( Δ L ∗ ) ( p < 0.001 ), while no significant differences were found in green/red value ( Δ a ∗ ) and yellow/blue value ( Δ b ∗ ) ( p > 0.05 ). Conclusions. In cases of severe tooth discoloration, one session of in-office bleaching before or after veneer preparation and the preparation depth do not influence the color masking ability of laminate veneers.

scholarly journals Perbedaan efektivitas jus tomat (Lucopersicon esculentum Mill.) dan jus apel (Mallus sylvestris Mill.) sebagai bahan alami pemutih gigi

e-GIGI ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Enny F. S. Lumuhu ◽  
Martha M. Kaseke ◽  
Wulan G. Parengkuan
Keyword(s):  
Apple Juice ◽  
Color Change ◽  
Human Interaction ◽  
Tomato Juice ◽  
Control Group ◽  
Carbamide Peroxide ◽  
Control Group Design ◽  
Anterior Teeth ◽  
Tooth Discoloration ◽  
Significant Difference

Abstract: Teeth appearance plays an important role in human interaction. One of its problems is tooth discoloration which can affect personal self confidence and appearance. Chemicals for whitening the teeth can cause negative effects such as decreased enamel hardness and gingival iritaion. An alternative material that can be used for that purpose is natural substance inter alia tomato juice (Lucopersicon esculentum Mill.) which contains hydrogen peroxide and apple juice (Mallus sylvestris Mill.) which contains malic acid. This study aimed to determine the difference in effectiveness of tomato juice and apple juice as natural bleaching agents. This was a true experimental study with a pretest postest only control group design. There were 30 samples of post-extraction anterior teeth soaked in coffee for 12 days and were further divided into 3 groups, each of 10 samples. Group 1 was immersed in tomato juice; group 2 was immersed in apple juice; and group 3 as the positive control was immersed in carbamide peroxide 10%. Each group was observed after 1 day, 3 days, and 5 days. The color change was measured by using CIEL*a*b method. The results showed that tomato juice, apple juice, and carbamide peroxide 10% could whiten the teeth. However, tomato juice was more effective compared to apple juice and carbamide peroxide 10%. Apple juice and carbamide peroxide 10% did not show any significant difference in color change. Keywords: tomato juice, apple juice, carbamide peroxide 10%, tooth discolorationAbstrak: Penampilan gigi berperan dalam interaksi manusia. Masalah dalam penampilan gigi salah satunya ialah perubahan warna gigi yang dapat memengaruhi kepercayaan diri dan keindahan penampilan seseorang. Penggunaan bahan kimia untuk memutihkan gigi dapat berdampak negatif seperti penurunan kekerasan email dan iritasi gingiva. Bahan alternatif yang dapat digunakan untuk memutihkan gigi yaitu dengan bahan alami antara lain jus tomat (Lucopersicon esculentum Mill.) yang mengandung hidrogen peroksida dan jus apel (Mallus sylvestris Mill.) yang mengandung asam malat. Penelitian ini bertujuan untuk mengetahui perbedaan efektivitas jus tomat dan jus apel sebagai bahan alami pemutih gigi. Terdapat 30 sampel gigi anterior pasca ekstraksi yang direndam kopi selama 12 hari. Sampel dibagi menjadi 3 kelompok masing-masing terdiri dari 10 sampel. Kelompok 1 direndam dalam jus tomat; kelompok 2 direndam dalam jus apel; dan kelompok 3 sebagai kontrol positif menggunakan karbamid peroksida 10%. Setiap kelompok dilakukan pengamatan 1 hari, 3 hari dan 5 hari. Perubahan warna diukur menggunakan metode CIEL*a*b. Hasil penelitian mendapatkan jus tomat, jus apel, dan karbamid peroksida 10% dapat memutihkan gigi. Jus tomat lebih efektif memutihkan gigi dibandingkan jus apel dan karbamid peroksida 10%. Jus apel dan karbamid peroksida 10% tidak memiliki perbedaan memutihkan gigi yang signifikan.Kata kunci: jus tomat, jus apel, karbamid peroksida 10%, perubahan warna gigi

scholarly journals A Clinical Study Comparing the Efficacy and Sensitivity of Home vs Combined Whitening

2011 ◽  
Vol 36 (5) ◽  
pp. 460-466 ◽  
Author(s):  
PFL Dawson ◽  
MO Sharif ◽  
AB Smith ◽  
PA Brunton
Keyword(s):  
Hydrogen Peroxide ◽  
Clinical Study ◽  
Color Change ◽  
Carbamide Peroxide ◽  
Anterior Teeth ◽  
Randomized Clinical Study ◽  
Custom Made ◽  
Significant Difference ◽  
Group A ◽  
Change In Mean

SUMMARY This randomized clinical study assessed efficacy in terms of color change and production of sensitivity after home whitening alone and home whitening supplemented with in-office bleaching. Thirty-six subjects (aged 19 to 58 years) were randomly assigned to one of three different treatment groups: (A) home whitening for two weeks, with 16% carbamide peroxide in custom-made trays; (B) home whitening for two weeks, with 16% carbamide peroxide in custom-made trays supplemented with in-office bleaching with 9% hydrogen peroxide (in the same trays); or (C) home whitening for two weeks, with 16% carbamide peroxide in custom-made trays supplemented with in-office bleaching with 27% hydrogen peroxide (in the same trays). The efficacy of tooth whitening was assessed by determining the color change associated with the six upper anterior teeth using a value-ordered shade guide. Sensitivity was self-assessed with the use of a visual analog scale (VAS). Tooth shade and sensitivity were assessed at the following points: pretreatment; immediately after the home whitening phase; immediately after the in-office phase (groups B and C); and one week post active treatment. At the one week follow-up visit, subjects in group A had a mean (SD) color change of 5.9 (1.83) (teeth were lighter) immediately after cessation of treatment (p&lt;0.01). Subjects in groups B and C experienced a greater change in mean (SD) shade immediately following their respective in-office treatments of 5.1 (1.53) and 5.4 (1.55). However, within one week, the shade of these teeth regressed to a similar degree to that achieved by subjects treated in group A. Overall, no significant difference in shade change or sensitivity was produced between the three groups. Investigators concluded that the in-office element of combined whitening produced no significant difference in tooth color or sensitivity when compared with home whitening alone.

scholarly journals Combined Bleaching Technique Using Low and High Hydrogen Peroxide In-Office Bleaching Gel

2016 ◽  
Vol 41 (4) ◽  
pp. 388-396 ◽  
Author(s):  
M Rezende ◽  
L Ferri ◽  
S Kossatz ◽  
AD Loguercio ◽  
A Reis
Keyword(s):  
Hydrogen Peroxide ◽  
Repeated Measures ◽  
Color Change ◽  
Absolute Risk ◽  
Color Stability ◽  
Fisher Exact Test ◽  
High Hydrogen ◽  
Significant Difference ◽  
Shade Guide ◽  
At Home

SUMMARY Objectives: The aim of this study was to evaluate the efficacy, color stability, risk, and intensity of tooth sensitivity (TS) of combined bleaching techniques performed with 20% or 35% hydrogen peroxide for an in-office protocol. Methods: Thirty patients were randomly divided into two groups and submitted to a single 45-minute in-office bleaching session with 35% hydrogen peroxide or 20% hydrogen peroxide. At-home bleaching was performed with 10% carbamide peroxide for two hours daily over the course of two weeks. The color was evaluated with the value-oriented shade guide Vita Classical at different periods up to 12 months after bleaching. Patients recorded the intensity of TS using a five-point verbal scale. Color change data were submitted to a two-way repeated-measures analysis of variance and Tukey test (α=0.05). The absolute risk and intensity of TS were compared with the Fisher exact test and Mann-Whitney test, respectively (α=0.05). Results: On average, an effective and similar whitening of three units in shade guide was observed for both groups, which remained stable for 12 months. When both protocols were compared, the one with hydrogen peroxide 35% showed a higher risk (p=0.02) and intensity of TS (p=0.04). In regard to the TS intensity, no significant difference was observed up to 48 hours after in-office bleaching (p=0.09) and during the at-home bleaching phase of the study (p=0.71). Conclusion: The combined bleaching technique using at-home bleaching associated with in-office bleaching was effective and stable over the course of 12 months, regardless of the concentration of the hydrogen peroxide used for in-office bleaching. However, the protocol with 20% hydrogen peroxide produced lower risk and intensity of TS.

Efficacy of a Novel At-home Bleaching Technique With Carbamide Peroxides Modified by CPP-ACP and Its Effect on the Microhardness of Bleached Enamel

2011 ◽  
Vol 36 (5) ◽  
pp. 521-528 ◽  
Author(s):  
BCD Borges ◽  
JS Borges ◽  
CD de Melo ◽  
IVA Pinheiro ◽  
AJS dos Santos ◽  
...  
Keyword(s):  
Vickers Microhardness ◽  
Color Change ◽  
Artificial Saliva ◽  
Carbamide Peroxide ◽  
Peroxide Bleaching ◽  
Significant Difference ◽  
Casein Phosphopeptide ◽  
Shade Guide ◽  
At Home

SUMMARY This study was designed to evaluate in vitro the efficacy of a novel at-home bleaching technique using 10% or 16% carbamide peroxide modified by casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and its influence on the microhardness of bleached enamel. A total of 40 bovine incisors were divided into four groups (n=10) according to the bleaching agent used: 10% carbamide peroxide only; a blend of 10% carbamide peroxide and a CPP-ACP paste; 16% carbamide peroxide only; and a blend of 16% carbamide peroxide and a CPP-ACP paste. During the 14-day bleaching regimen, the samples were stored in artificial saliva. The Vickers microhardness and color of the teeth were assessed at baseline (T0) and immediately after the bleaching regimen (T14) using a microhardness tester and a spectrophotometer, respectively. The degree of color change was determined by the Commission Internationale de l'Eclariage (CIE) L*a*b* system (ΔE, ΔL*, Δa*, and Δb*) and Vita shade guide parameters. The data were analyzed by analysis of variance and the Tukey test (p&lt;0.05). The teeth that were bleached with a blend of peroxide (10% or 16%) and the CPP-ACP paste presented increased microhardness values at T14 compared with T0, whereas the samples that were bleached with peroxide only did not show any differences in their microhardness values. All of the bleaching agents were effective at whitening the teeth and did not show a statistically significant difference using the CIEL*a*b* system (ΔE, ΔL*, Δa*, and Δb*) or the Vita shade guide parameters. The use of a CPP-ACP paste with carbamide peroxide bleaching agents increased the bleached enamel's microhardness and did not have an influence on whitening efficacy.

A novel carbamide peroxide polymeric nanoparticle bleaching gel: Color change and hydrogen peroxide penetration inside the pulp cavity

2020 ◽  
Author(s):  
Michael W. Favoreto ◽  
Mariniella P. Madureira ◽  
Viviane Hass ◽  
Bianca M. Maran ◽  
Sibelli O. Parreiras ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Color Change ◽  
Carbamide Peroxide ◽  
Pulp Cavity ◽  
Polymeric Nanoparticle

scholarly journals Combination of at-home and in-office bleaching techniques: case series

2021 ◽  
Vol 69 ◽  
Author(s):  
Marcela Alvarez FERRETTI ◽  
Matheus KURY ◽  
Beatriz Curvello de MENDONÇA ◽  
Marcelo GIANNINI ◽  
Vanessa CAVALLI ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Case Series ◽  
Tooth Bleaching ◽  
Central Incisor ◽  
Carbamide Peroxide ◽  
Tooth Sensitivity ◽  
Tooth Color ◽  
Shade Guide ◽  
At Home

ABSTRACT Tooth bleaching is one of the most conservative aesthetic techniques. At-home and in-office bleaching may be performed, as well as the combination of both techniques. As this combination may be done in different manners, distinct orders of combinations were proposed in this report. A 24 years-old man, whose upper central incisor and canine shades were A2 and A3 respectively, was initially treated by chair-side with 40-min application of 40% hydrogen peroxide (HP) for two sessions. Afterwards, an two-week overnight at-home bleaching was performed with 10% carbamide peroxide (CP). The shade of upper central incisors changed to 1M1 and canine was B1. Conversely, a 30 years-old woman was firstly conducted with at-home bleaching (overnight 4-weeks 10% CP) and, subsequently, with a single appointment of in-office bleaching for 45 minutes (35% HP). The shade of her upper central incisor changed from A1 to 0.5M1 and the upper canine from A3 to B1. The VITA classical (A1-D4) shade guide and VITA Bleached guide 3D-MASTER were used to determine the tooth color during the treatments. In both bleaching treatments, patients reported no significant tooth sensitivity and the final outcomes met their expectation.

Effect of 10% and 15% Carbamide Peroxide on Fracture Toughness of Human Dentin In Situ

2013 ◽  
Vol 38 (2) ◽  
pp. 142-150 ◽  
Author(s):  
LE Tam ◽  
P Bahrami ◽  
O Oguienko ◽  
H Limeback
Keyword(s):  
Fracture Toughness ◽  
Placebo Group ◽  
Color Change ◽  
Carbamide Peroxide ◽  
Tooth Sensitivity ◽  
Custom Made ◽  
Dental Hard Tissues ◽  
Significant Difference

SUMMARY Purpose Although damage to the structural integrity of the tooth is not usually considered a significant problem associated with tooth bleaching, there have been some reported negative effects of bleaching on dental hard tissues in vitro. More studies are needed to determine whether the observed in vitro effects have practical clinical implications regarding tooth structural durability. Objectives This in situ study evaluated the effect of 10% and 15% carbamide peroxide (CP) dental bleach, applied using conventional whitening trays by participants at home, on the fracture toughness of dentin. Methods Ninety-one adult volunteers were recruited (n ≈ 30/group). Compact fracture toughness specimens (approximately 4.5 × 4.6 × 1.7 mm) were prepared from the coronal dentin of recently extracted human molars and gamma-radiated. One specimen was fitted into a prepared slot, adjacent to a maxillary premolar, within a custom-made bleaching tray that was made for each adult participant. The participants were instructed to wear the tray containing the dentin specimen with placebo, 10% CP, or 15% CP treatment gel overnight for 14 nights and to store it in artificial saliva when not in use. Pre-bleach and post-bleach tooth color and tooth sensitivity were also evaluated using ranked shade tab values and visual analogue scales (VASs), respectively. Within 24–48 hours after the last bleach session, the dentin specimens were tested for fracture toughness using tensile loading at 10 mm/min. Analysis of variance, Kruskal-Wallis, χ2, Tukey's, and Mann-Whitney U tests were used for statistical analysis. The level of significance was set at p&lt;0.05 for all tests, except for the Mann-Whitney U tests, which used a Bonferroni correction for post hoc analyses of the nonparametric data (p&lt;0.017). Results The placebo, 10% CP, and 15% CP groups contained 30, 31, and 30 participants, respectively. Mean fracture toughness (+ standard deviation) for the placebo, 10% CP, and 15% CP groups were 2.3 ± 0.9, 2.2 ± 0.7, and 2.0 ± 0.5 MPa*m1/2 respectively. There were no significant differences in mean fracture toughness results among the groups (p=0.241). The tooth sensitivity VAS scores indicated a significantly greater incidence (p=0.000) and degree of tooth sensitivity (p=0.049 for VAS change and p=0.003 for max VAS) in the bleach groups than in the placebo group. The color change results showed generally greater color change in the bleach groups than in the placebo group (p=0.008 for shade guide determination and p=0.000 for colorimeter determination). Conclusions There were no significant differences in in situ dentin fracture toughness results among the groups. The results of this study provide some reassurance that dentin is not overtly weakened by the bleaching protocol used in this study. However, the lack of a statistically significant difference cannot be used to state that there is no effect of bleach on dentin fracture toughness.

Six-month Follow-up of the Effect of Nonvital Bleaching on IL-1β and RANK-L: A Randomized Clinical Trial

2019 ◽  
Vol 44 (6) ◽  
pp. 581-588 ◽  
Author(s):  
C Bersezio ◽  
J Estay ◽  
M Sáez ◽  
F Sánchez ◽  
R Vernal ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Hydrogen Peroxide ◽  
Randomized Clinical Trial ◽  
Gingival Crevicular Fluid ◽  
Color Change ◽  
Double Blind ◽  
Time Points ◽  
Periodontal Tissues ◽  
Significant Difference ◽  
Spearman Test

SUMMARY Objectives: It has been reported that bleaching generates an increase in the activity of osteoclasts in vitro. We quantified the RANK-L and IL-1β biomarkers in a double-blind, randomized clinical trial evaluating the in vivo effect of hydrogen peroxide (35%) and peroxide carbamide (37%) six months after whitening. Methods and Materials: Fifty volunteers participated, each with color change in a nonvital tooth. Fifty teeth were randomly divided into two groups (n=25), and the teeth were bleached using either 35% hydrogen peroxide (G1) or 37% carbamide peroxide (G2). Intracoronal bleaching was carried out by a technical “walking bleach” over four sessions. Gingival crevicular fluid samples were collected and used to quantify the IL-1β and RANK-L secreted levels. Samples of six periodontal sites (three vestibular and three palatal) were collected for up to six months (at the beginning of the study [baseline] and at one week, one month, and six months posttreatment). The color change was visually monitored using the Vita Bleached Guide (ΔSGU). Results: Comparing each time to baseline assessment, a significant increase in the levels of IL-1β and RANK-L across time points was detected (p&lt;0.05). The color change was 4 in G1 and G2, and a statistically significant difference (p&lt;0.05) was found at the month time point between the groups. Using the Spearman test, a strong correlation (&gt;0.8) between the IL-1β and RANK-L levels in both groups at all time points was detected. Conclusions: Nonvital bleaching using a technical walking bleach induces an increase in the IL-1β and RANKL production in periodontal tissues, which persists for six months after treatment. Both biomarkers were highly correlated in both groups and at all time points.

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