scholarly journals Perbedaan efektivitas jus tomat (Lucopersicon esculentum Mill.) dan jus apel (Mallus sylvestris Mill.) sebagai bahan alami pemutih gigi

e-GIGI ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Enny F. S. Lumuhu ◽  
Martha M. Kaseke ◽  
Wulan G. Parengkuan
Keyword(s):  
Apple Juice ◽  
Color Change ◽  
Human Interaction ◽  
Tomato Juice ◽  
Control Group ◽  
Carbamide Peroxide ◽  
Control Group Design ◽  
Anterior Teeth ◽  
Tooth Discoloration ◽  
Significant Difference

Abstract: Teeth appearance plays an important role in human interaction. One of its problems is tooth discoloration which can affect personal self confidence and appearance. Chemicals for whitening the teeth can cause negative effects such as decreased enamel hardness and gingival iritaion. An alternative material that can be used for that purpose is natural substance inter alia tomato juice (Lucopersicon esculentum Mill.) which contains hydrogen peroxide and apple juice (Mallus sylvestris Mill.) which contains malic acid. This study aimed to determine the difference in effectiveness of tomato juice and apple juice as natural bleaching agents. This was a true experimental study with a pretest postest only control group design. There were 30 samples of post-extraction anterior teeth soaked in coffee for 12 days and were further divided into 3 groups, each of 10 samples. Group 1 was immersed in tomato juice; group 2 was immersed in apple juice; and group 3 as the positive control was immersed in carbamide peroxide 10%. Each group was observed after 1 day, 3 days, and 5 days. The color change was measured by using CIEL*a*b method. The results showed that tomato juice, apple juice, and carbamide peroxide 10% could whiten the teeth. However, tomato juice was more effective compared to apple juice and carbamide peroxide 10%. Apple juice and carbamide peroxide 10% did not show any significant difference in color change. Keywords: tomato juice, apple juice, carbamide peroxide 10%, tooth discolorationAbstrak: Penampilan gigi berperan dalam interaksi manusia. Masalah dalam penampilan gigi salah satunya ialah perubahan warna gigi yang dapat memengaruhi kepercayaan diri dan keindahan penampilan seseorang. Penggunaan bahan kimia untuk memutihkan gigi dapat berdampak negatif seperti penurunan kekerasan email dan iritasi gingiva. Bahan alternatif yang dapat digunakan untuk memutihkan gigi yaitu dengan bahan alami antara lain jus tomat (Lucopersicon esculentum Mill.) yang mengandung hidrogen peroksida dan jus apel (Mallus sylvestris Mill.) yang mengandung asam malat. Penelitian ini bertujuan untuk mengetahui perbedaan efektivitas jus tomat dan jus apel sebagai bahan alami pemutih gigi. Terdapat 30 sampel gigi anterior pasca ekstraksi yang direndam kopi selama 12 hari. Sampel dibagi menjadi 3 kelompok masing-masing terdiri dari 10 sampel. Kelompok 1 direndam dalam jus tomat; kelompok 2 direndam dalam jus apel; dan kelompok 3 sebagai kontrol positif menggunakan karbamid peroksida 10%. Setiap kelompok dilakukan pengamatan 1 hari, 3 hari dan 5 hari. Perubahan warna diukur menggunakan metode CIEL*a*b. Hasil penelitian mendapatkan jus tomat, jus apel, dan karbamid peroksida 10% dapat memutihkan gigi. Jus tomat lebih efektif memutihkan gigi dibandingkan jus apel dan karbamid peroksida 10%. Jus apel dan karbamid peroksida 10% tidak memiliki perbedaan memutihkan gigi yang signifikan.Kata kunci: jus tomat, jus apel, karbamid peroksida 10%, perubahan warna gigi

scholarly journals EFEKTIVITAS EKSTRAK STROBERI DAN JERUK MADU DALAM PERUBAHAN WARNA GIGI SECARA IN VITRO

2021 ◽  
Vol 16 (1) ◽  
pp. 209-213
Author(s):  
Nalem Rika Rahayu
Keyword(s):  
Color Change ◽  
Laboratory Research ◽  
Carbamide Peroxide ◽  
Tooth Color ◽  
Sample Group ◽  
Tooth Discoloration ◽  
Significant Difference ◽  
Experimental Laboratory ◽  
Shade Guide

ABSTRACT   Changing tooth color affects a person's aesthetics. Methods to restore tooth discoloration include the use ofagents bleaching. This study aims to understand the differences in the effectiveness of strawberry and honey orange extracts intooth discoloration in vitro. This type of experimental laboratory research used 45 premolar tooth samples divided into 3 groups (50% strawberry extract and 10% carbamide peroxide concentration, 50% honey orange extract and 10% carbamide peroxide concentration and 10% carbamide peroxide concentration). Samples were immersed in coffee solution for 5 days and recorded color with a shade guide, then samples were immersed in the extract of strawberries, honey oranges and carbamide peroxide for 7 days in an incubator, then recorded color again visually with a shade guide. Data analysis used thestatistical tests Oneway Anova and Posthoc LSD. The color change of the sample group immersed in strawberry extract with carbamide peroxide resulted in a significant difference (p <0.05). Likewise, the sample group immersed in honey orange extract with carbamide peroxide produced a significant difference (p <0.05), but strawberries and honey oranges did not. there is not significant difference (p> 0.05). From the results of the study it can be concluded that the extracts of strawberries and honey oranges were able to increase the discoloration of teeth to become brighter, there was no significant difference between changes in tooth discoloration soaked in strawberry extract and honey orange.   ABSTRAK Warna gigi yang berubah mempengaruhi estetik seseorang, metode untuk mengembalikan perubahan warna gigi diantaranya dengan penggunakan bahan bleaching. Penelitian ini bertujuan untuk memahami perbedaan efektivitas ekstrak buah stroberi dan jeruk madu dalam perubahan warna gigi secara in vitro. Jenis penelitian eksperimental laboratoris menggunakan sampel gigi premolar sebanyak 45 buah dibagi atas 3 kelompok (ekstrak stroberi konsentrasi 50% dan karbamid peroksida konsentrasi 10%, ekstrak jeruk madu konsentrasi 50% dan karbamid peroksida konsentrasi 10% dan karbamid peroksida konsentrasi 10%). Sampel direndam larutan kopi selama 5 hari dan lakukan pencatatan warna dengan shade guide, kemudian sampel direndam ekstrak stroberi, jeruk madu dan karbamid peroksida selama 7 hari di dalam inkubator, lalu dilakukan pencatatan warna kembali secara visual dengan shade guide. Analisis data memakai uji statistik Oneway Anova dan Posthoc LSD. Perubahan warna kelompok sampel direndam ekstrak stroberi dengan karbamid peroksida menghasilkan perbedaan signifikan (p<0,05), begitu pula kelompok sampel yang direndam ekstrak jeruk madu dengan karbamid peroksida menghasilkan perbedaan signifikan (p<0,05), namun stroberi dan jeruk madu tidak ada perbedaan yang signifikan (p>0,05). Dari hasil penelitian dapat disimpulkan bahwa ekstrak  stroberi dan jeruk madu mampu meningkatkan perubahan warna gigi menjadi lebih terang, tidak ada perbedaan signifikan antara perubahan perubahan warna gigi yang direndam ekstrak stroberi dan jeruk madu.

scholarly journals PENGARUH PEMBERIAN JUS BUAH TOMAT (LYCOPERSICON ESCULENTUM MILL.) TERHADAP PEMBERSIHAN STAIN EKSTRINSIK PADA RESIN KOMPOSIT

e-GIGI ◽  
2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Kartika Ibrahim ◽  
Shirley E. S. Kawengian ◽  
Paulina N. Gunawan
Keyword(s):  
Mineral Water ◽  
Composite Resin ◽  
Tomato Juice ◽  
Wilcoxon Test ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Intrinsic Factors ◽  
Anterior Teeth ◽  
Uv Visible

Abstract: Discoloration of the composite resin is an aesthetic problem that often occurs primarily in anterior teeth caused by extrinsic and intrinsic factors. Bleaching is a kind of treatment that can improve the problem of composite discoloration. One of the bleaching materials oftenly used in dentistry is H2O2. H2O2 compound contained in tomatoes can be used as an alternative treatment to cope with the composite discoloration. This study aimed to determine the effect of tomato juice as extrinsic stain cleaner of the composite resin. This was a laboratory experimental study with a pre and post control group design. Samples were 20 resin composites molded in 5mm diameter and 2mm thickness. Samples were soaked in coffee solution for 10 days to get the extrinsic stain and then discoloration was measured with a spectrophotometer discoloration Libra S12 UV / Visible Biochrom. After that, samples were divided into 2 groups: the control group, immersed in mineral water; and the treatment group, immersed in tomato juice for 3 days. After immersion, measurements were done again with a spectrophotometer. The results were tested statistically using the Wilcoxon test with a P value < 0.05. Conclusion: Tomato juice was a significant extrinsic stain cleaner of the composite resin.Keywords: tomato juice, extrinsic stain, resin compositesAbstrak: Perubahan warna tumpatan komposit merupakan masalah estetik yang sering terjadi terutama pada gigi anterior yang disebabkan oleh faktor ekstrinsik dan intrinsik. Salah satu perawatan untuk menangani masalah ini ialah bleaching dengan H2O2. Senyawa H2O2 terkandung dalam buah tomat yang dapat digunakan sebagai perawatan alternatif untuk mengatasi perubahan warna komposit. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian jus buah tomat terhadap pembersihan stain ekstrinsik pada resin komposit. Jenis penelitian ini ialah eksperimental laboratorium dengan desain pre and post control group. Jumlah sampel penelitian 20 resin komposit yang dibentuk dengan diameter 5mm dan tebal 2mm. Sampel direndam dalam larutan kopi selama 10 hari untuk melihat adanya stain ekstrinsik kemudian dilakukan pengukuran perubahan warna dengan spektrofotometer Libra S12 UV/Visible BIOCHROM. Setelah itu sampel dibagi menjadi 2 kelompok, yaitu kelompok kontrol direndam dalam air mineral dan kelompok perlakuan di dalam jus buah tomat selama 3 hari. Setelah perendaman dilakukan pengukuran kembali dengan spektrofotometer. Hasil penelitian diuji secara statistik dengan uji Wilcoxon mendapatkan nilai P < 0,05. Simpulan: Jus buah tomat berpengaruh secara bermakna terhadap pembersihan stain ekstrinsik pada resin komposit.Kata kunci: jus buah tomat, stain ekstrinsik, resin komposit

scholarly journals A Clinical Study Comparing the Efficacy and Sensitivity of Home vs Combined Whitening

2011 ◽  
Vol 36 (5) ◽  
pp. 460-466 ◽  
Author(s):  
PFL Dawson ◽  
MO Sharif ◽  
AB Smith ◽  
PA Brunton
Keyword(s):  
Hydrogen Peroxide ◽  
Clinical Study ◽  
Color Change ◽  
Carbamide Peroxide ◽  
Anterior Teeth ◽  
Randomized Clinical Study ◽  
Custom Made ◽  
Significant Difference ◽  
Group A ◽  
Change In Mean

SUMMARY This randomized clinical study assessed efficacy in terms of color change and production of sensitivity after home whitening alone and home whitening supplemented with in-office bleaching. Thirty-six subjects (aged 19 to 58 years) were randomly assigned to one of three different treatment groups: (A) home whitening for two weeks, with 16% carbamide peroxide in custom-made trays; (B) home whitening for two weeks, with 16% carbamide peroxide in custom-made trays supplemented with in-office bleaching with 9% hydrogen peroxide (in the same trays); or (C) home whitening for two weeks, with 16% carbamide peroxide in custom-made trays supplemented with in-office bleaching with 27% hydrogen peroxide (in the same trays). The efficacy of tooth whitening was assessed by determining the color change associated with the six upper anterior teeth using a value-ordered shade guide. Sensitivity was self-assessed with the use of a visual analog scale (VAS). Tooth shade and sensitivity were assessed at the following points: pretreatment; immediately after the home whitening phase; immediately after the in-office phase (groups B and C); and one week post active treatment. At the one week follow-up visit, subjects in group A had a mean (SD) color change of 5.9 (1.83) (teeth were lighter) immediately after cessation of treatment (p&lt;0.01). Subjects in groups B and C experienced a greater change in mean (SD) shade immediately following their respective in-office treatments of 5.1 (1.53) and 5.4 (1.55). However, within one week, the shade of these teeth regressed to a similar degree to that achieved by subjects treated in group A. Overall, no significant difference in shade change or sensitivity was produced between the three groups. Investigators concluded that the in-office element of combined whitening produced no significant difference in tooth color or sensitivity when compared with home whitening alone.

scholarly journals Effectiveness and Impact of the Walking Bleach Technique on Esthetic Self-perception and Psychosocial Factors: A Randomized Double-blind Clinical Trial

2017 ◽  
Vol 42 (6) ◽  
pp. 596-605 ◽  
Author(s):  
C Bersezio ◽  
J Martin ◽  
F Peña ◽  
M Rubio ◽  
J Estay ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Psychosocial Factors ◽  
Color Change ◽  
Carbamide Peroxide ◽  
Self Perception ◽  
Dental Esthetics ◽  
Tooth Discoloration ◽  
Significant Difference ◽  
The Impact ◽  
Shade Guide

SUMMARY Objective: This trial evaluates the impact of psychosocial and esthetic self-perceptions of patients undergoing nonvital tooth bleaching using the walking bleach technique. We also assessed the clinical effectiveness of bleaching tooth discoloration. Methods: Fifty volunteers with nonvital tooth discoloration were enrolled. Teeth were randomized into two groups: 35% hydrogen peroxide (n=25) and 37% carbamide peroxide (n=25). Intracoronal bleaching was performed over four sessions using the walking bleach technique. Tooth color was evaluated at each session to measure total color variation. The shade guide was arranged from highest (B1) to lowest (C4) values to assess the color and calculate the color change in the number of shade guide units. Subjective and objective assessments were compared with the tooth counterpart. Esthetic self-perception and psychosocial factors were assessed before and after treatment. Results: Color change was 15.48&lt;5.17 for hydrogen peroxide and 14.02&lt;4.85 for carbamide peroxide. There was no significant difference at any time point (p&gt;0.05) except at sessions 3 and 4 (p&lt;0.05). Overall, whitened teeth values were similar to those of counterpart teeth (p&gt;0.05). There was a decrease in Oral Health Impact Profile and Psychosocial Impact of Dental Esthetics questionnaire scores after treatment compared with baseline (p&lt;0.05). Conclusion: The walking bleach technique was highly effective on nonvital teeth and had a positive effect on self-esthetic perception and psychological impact for the patients.

scholarly journals Tooth discoloration induced by a novel mineral trioxide aggregate-based root canal sealer

2016 ◽  
Vol 10 (03) ◽  
pp. 403-407 ◽  
Author(s):  
Dae-Sung Lee ◽  
Myung-Jin Lim ◽  
Yoorina Choi ◽  
Vinicius Rosa ◽  
Chan-Ui Hong ◽  
...  
Keyword(s):  
Root Canal ◽  
Color Change ◽  
Mineral Trioxide Aggregate ◽  
Control Group ◽  
Similar Amount ◽  
Root Canal Sealer ◽  
Tooth Discoloration ◽  
Significant Difference ◽  
Total Color Change ◽  
And Control

ABSTRACT Objectives: The aim of this study was to evaluate tooth discoloration caused by contact with a novel injectable mineral trioxide aggregate (MTA)-based root canal sealer (Endoseal; Maruchi, Wonju, Korea) compared with a widely used resin-based root canal sealer (AHplus; Dentsply De Trey, Konstanz, Germany) and conventional MTA (ProRoot; Dentsply, Tulsa, OK, USA). Materials and Methods: Forty standardized bovine tooth samples were instrumented and divided into three experimental groups and one control group (n = 10/group). Each material was inserted into the cavity, and all specimens were sealed with a self-adhesive resin. Based on CIE Lab system, brightness change (ΔL) and total color change (ΔE) of each specimen between baseline and 1, 2, 4, and 8 weeks were obtained. Results: At all time points, Endoseal showed no significant difference in ΔL and ΔE compared to AHplus and control group (P > 0.05), whereas the ProRoot group showed significantly higher ΔL and ΔE values than the Endoseal group at 2, 4, and 8 weeks (P < 0.05). Therefore, Endoseal showed less discoloration than conventional MTA and a similar color change to AHplus. Conclusions: Within the limitations of this study, our data indicate that the MTA-based sealer produces a similar amount of tooth discoloration as AHplus which is considered to be acceptable.

Effect of Chitosan on Mineral Content of Human Tooth After Bleaching: An SEM-EDX Study

2019 ◽  
Vol 10 (2) ◽  
pp. 161-164 ◽  
Author(s):  
Samet Tosun
Keyword(s):  
Mineral Content ◽  
Human Tooth ◽  
Elemental Content ◽  
Control Group ◽  
Elemental Distribution ◽  
Carbamide Peroxide ◽  
Carrier System ◽  
Edx Analysis ◽  
Anterior Teeth ◽  
Significant Difference

Aim and Background: 35% carbamide peroxide can cause adverse effects on the structure and composition of teeth. However, the addition of calcium and fluoride in bleaching agents may reduce enamel demineralization. The aim of the study is to evaluate the chemical changes in a tooth submitted to 35% of carbamide peroxide containing chitosan and carbopol as a carrier system using scanning electron microscopy/energy dispersive x-ray analysis (SEM-EDX). Materials and Methods: 30 freshly extracted anterior teeth were given root canal treatment. The teeth were randomly divided into 3 groups. Group 1 was Opalescence PF (35% carbamide peroxide), group 2 was chitosan with 35% carbamide peroxide, and group 3 was a control group (no treatment). All canals were filled with 0.06 tapered gutta-percha and AH-plus sealer. Then, intracoronal bleaching was applied. SEM-EDX analysis was performed to determine whether bleaching procedures changed the mineral content of the tooth. While SEM-EDX analysis, the tooth was analyzed based on elemental content and elemental distribution from standardized points under 300× magnification. Statistical analysis was performed with one way analysis of variance. Results: There was no significant difference in C, O, Na, P, Mg, K, and S values and the Ca/P ratio obtained by SEM-EDX analysis among groups ( P > .05), whereas the Ca level was significantly lower in Opalescence PF group than the control group ( P < .05). Conclusions: The results of this study show that chitosan does not cause mineral loss and dissolution in the inorganic content of a tooth. Thus, chitosan can be used as an alternative carrier system in the bleaching agent.

scholarly journals PERBEDAAN PENGARUH HIDROGEN PEROKSIDA 35% DAN KARBAMID PEROKSIDA 35% TERHADAP MICROLEAKAGE PADA RESIN KOMPOSIT NANOHYBRID

2015 ◽  
Vol 2 (1) ◽  
pp. 20
Author(s):  
Istianah Istianah ◽  
Endah Aryati Ekoningtyas ◽  
Benni Benyamin
Keyword(s):  
Hydrogen Peroxide ◽  
Methylene Blue ◽  
Composite Resin ◽  
Laboratory Method ◽  
Control Group ◽  
Carbamide Peroxide ◽  
Control Group Design ◽  
Maxillary Central Incisor ◽  
Tooth Discoloration ◽  
Nanohybrid Composite

Background: Intrinsic tooth discoloration is an aesthetic problem for most people. One of the Intracoronal bleaching treatment used hydrogen peroxide 35% and carbamide peroxide 35%. Tooth whitening material reported increase microleakage in composite resin. Purpose: This research aims to determine the differences effect of hydrogen peroxide 35% and carbamide peroxide 35 % toward microleakage in the nanohybrid composite resin. Method: This research was an experimental laboratory method with post test only control group design. The research was conducted by doing the root canal treatment on 27 samples of maxillary central incisor with the base, then the procedure of intracoronal bleaching was done using hydrogen peroxide 35 % as group 1, carbamide peroxide 35 % as group 2 and distilled water as control group. After nanohybrid composite resin restorative procedure, coated with nail varnish then immersion in methylene blue 5%. Furthermore, slit the teeth and methylene blue penetration depth measured using metalography  microscope. Result: Based on one way ANOVA test found that there was a difference in each group with a significance of 0,000 (p < 0,05) it can be interpreted that there are differences between groups. Based on LSD Post Hoc test, found that there was a difference in the effect on the group of hydrogen peroxide 35% and carbamide peroxide 35% with a significance of 0,004 (p<0,05). Conclusion: The results of this research can be concluded that there was differences in the effect of hydrogen peroxide 35% and carbamide peroxide 35% towardmicroleakage in the nanohybrid composite resin.Keywords: intracoronal bleaching, hydrogen peroxide 35%, carbamide peroxide 35 %, microleakage, nanohybrid compositeresin

scholarly journals The Effect of Manalagi and Fuji Apple Juice on Triglyceride Level in Elderly

2021 ◽  
Vol 4 (1) ◽  
pp. 279-289
Author(s):  
Rizki Dwi Agustin Harsono ◽  
Yulia Lanti Retno Dewi ◽  
Anik Lestari
Keyword(s):  
Apple Juice ◽  
Intervention Group ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Significant Difference ◽  
Post Test ◽  
Fuji Apple ◽  
Determine Effect ◽  
Test Control

The purpose of this study is to determine effect of manalagi and fuji apples juice on triglyceride levels in in elderly. This study is an experimental study conducted on 39 elderly for 14 days, divided into 3 groups through randomized pre-post test control group design. G-0 was the control group, G-1 was the intervention group administered with manalagi apple juice, and G-2 was the intervention group given fuji apple juice. The data obtained were analyzed using Kruskal-Wallis and Mann-Whitney test. Trygliceride levels in the G-0 increased, whereas the G-1 and G-2 decreased. There was a significant difference (P <0.05) between the G-0 and the intervention group. Consumption of manalagi and fuji apples juice could reduce triglyceride levels in elderly.

Effectiveness Of Toilet Training Education On Mother's Behavior And Toddler Age Toilet Training Ability (18-36 Months)

2020 ◽  
Vol 5 (2) ◽  
pp. 49-55
Author(s):  
Hafiko Andresni ◽  
Zahtamal Zahtamal ◽  
Winda Septiani ◽  
Mitra Mitra ◽  
Lita Lita
Keyword(s):  
Sampling Technique ◽  
T Test ◽  
The Body ◽  
Toilet Training ◽  
Wilcoxon Test ◽  
Control Group ◽  
Maternal Knowledge ◽  
Control Group Design ◽  
Significant Difference

ABSTRACT Toilet training is an effort to train children to be able to control and urinate (BAK) and defecate (BAB). Toilet training is one of the main tasks of children at toddler age. Toilet training is one of the main tasks of children in toddler age which is very important to be done to create independence in children in controlling BAK and BAB and children know the parts of the body and their functions. Data in 2012 shows that ± 60% of parents do not teach toilet training to children from an early age. The aim of the study was to find out the effectiveness of toilet training education on maternal behavior and toilet skills in toddler age training (18-36 months). The study was conducted in July-August 2018. This type of quantitative research used the design of the Quasy pretest and posttest experiment with non-equivalent control group design. Samples were 36 mothers and 36 children with purposive sampling technique. Data analysis used Paired t test, Wilcoxon test, Man-Whitney test an Independent t test. The results showed that toilet training education through lecture methods, modules and maze games was more effective than toilet training education through lecture and leaflet methods on children's knowledge and abilities. Conversely, for the role of mothers in supervision there is no significant difference in effectiveness. Health education is recommended in health promotion programs to increase maternal knowledge, the role of mothers and the ability of toilet training children independently. Keywords: Toilet training, Lecture method, Module, Maze game, Leaflet, Knowledge, Role of mother, Children's ability.

TOKSISITAS AKUT INFUSA KULIT ARI KACANG TANAH (Arachis hypogea L.) PADA MENCIT BALB/ C

2018 ◽  
Vol 15 (2) ◽  
pp. 62
Author(s):  
Risha Fillah Fithria ◽  
Ririn Lispita Wulandari ◽  
Devi Nisa Hidayati ◽  
Lilis Rejeki
Keyword(s):  
Single Dose ◽  
Color Change ◽  
Negative Control ◽  
Control Group ◽  
Hair Color ◽  
Peanut Shell ◽  
Control Group Design ◽  
Safety Standards ◽  
Arachis Hypogea ◽  
Passive Behavior

ABSTRACTPeanut shell (PS) infusion has been shown to be antithrombocytopenia, but there has been no research on safety standards. This study aims to identify the symptoms of toxic effects, the potency of toxicity and histopathology of liver male Balb/C mice after a single dose of PS infusion. This research uses randomized matched posttest only control group design. Twenty five mice were divided into 5 orally dosage groups, ie, PS infusion with a dose of 0,026; 0.052; 0.104; 0.208 g/20gBW; and negative control of CMC Na 0.5%. The observation period is for 14 days. The results showed that single dose of PS infusion had a pseudo LD50 value ie > 0.208g/20gBW which was practically non toxic. Symptoms to watch out for the BW infusion were passive behavior, bradycnea, hair color change, hair loss, and weight loss at doses of 3 and 4. It is unclear whether liver damage ie inflammation, necrosis, and albuminous degeneration caused by PS infusion or other causes.keywords: acute toxicity, infusion, peanut shell

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