scholarly journals The Interrelationship of Bulk Density, Granule Density, Tablet Weight, and Weight Variation

1967 ◽  
Author(s):  
◽  
Amritkumar Bhandari
Keyword(s):  
Bulk Density ◽  
Weight Variation ◽  
Granule Density

scholarly journals FORMULATION AND EVALUATION OF NILAVEMBU KUDINEERCAPSULES

2019 ◽  
Vol 7 (1) ◽  
pp. 41-45 ◽  
Author(s):  
Ramanathan M ◽  
Subramanian L ◽  
Poongodi T ◽  
Manish S ◽  
Muneeswari E ◽  
...  
Keyword(s):  
Biological Activity ◽  
Herbal Medicine ◽  
Bulk Density ◽  
Water Extract ◽  
Angle Of Repose ◽  
Microbiological Activity ◽  
Weight Variation ◽  
Dried Extract ◽  
Tapped Density ◽  
Better Than

The herbal medicine Nilavembu Kudineer is very effective in viral fevers. The study was effort to prepare a Nilavembu Kudineerherbal capsule from Nilavembu Kudineer churnam. The task of this work is, to detainment of active biomolecules and ensure their biological activity. The Nilavembu Kudineerchurnamwas extracted by ethanol and water solvents, then the extract was dried. The resultant dried extract powder was screened by various chemical and microbiological tests for to ensure the potency.  The results confirms that both the extract haveactive biomolecules and possess their activity. Based on the microbiological activity NVK water extract was comparatively better than the ethanol using extract powder. The dried NVK water extract powder capsules complies with standards of capsule pre and post filling parameters such as angle of repose, bulk density, tapped density, carr’s index and hausner’s ratio. The filled NVK capsule complies the post filling evaluations of weight variation, disintegration. In future stability, dosage titrations and more number of microbial test need to conduct for their effectiveness of the formulation.  

scholarly journals Formulation, Characterization and In-vitro Evaluation of Cetrizine HCL Oral Disintegrating Tablets

1970 ◽  
Vol 7 (5) ◽  
pp. 19-24
Author(s):  
HARITHA PASUPULATI ◽  
Y PHALGUNA ◽  
SANDHYA RUDRA
Keyword(s):  
Bulk Density ◽  
Direct Compression ◽  
Compression Method ◽  
Disintegration Time ◽  
Sodium Starch Glycolate ◽  
Weight Variation ◽  
Wetting Time ◽  
Croscarmellose Sodium ◽  
In Vitro Disintegration

The main objective of this work is to formulate and evaluate Cetirizine HCl MFDT’s using different concentrations of superdisintegrants like croscarmellose sodium (CCS), sodium starch glycolate (SSG) and their combinations in different ratios. The in vitro disintegration time of Cetrizine Hcl prepared by direct compression method by super disintegrates were found to be in the range of 18 to 11sec fulfilling the official requirements. The bulk density and tapped bulk density for the entire formulation blend varied from 0.508 gm/cc to 0.5438 gm/cc and 0.5941 to 0.6408 respectively. The friability was found in all designed formulations in the range 0.42 to 0.74% to be well within the approved range (<1%). The weight variation was found in all designed formulation in the range 97 to 102 mg. The wetting time were found to be in the range of 11 to 18sec. Water absorption ratio for all the formulations found in the range 11 to 16%.combination of sodium starch glycolate and cross carmellose sodium (6% of 25%-ssg&75%ccs)) promotes dissolution rate of drug release when compared to formulation of SSG & CCS alone. It may be due to capillary and wicking mechanism of SSG & CCS.   Keywords:   

A novel approach to white liquor control in a continuous digester using the Box-Jenkins methodology to predict chip bulk density

TAPPI Journal ◽  
2015 ◽  
Vol 14 (6) ◽  
pp. 395-402
Author(s):  
FLÁVIO MARCELO CORREIA ◽  
JOSÉ VICENTE HALLAK D’ANGELO ◽  
SUELI APARECIDA MINGOTI
Keyword(s):  
Bulk Density ◽  
Moving Average ◽  
Pulp Mill ◽  
Statistical Decision ◽  
White Liquor ◽  
Novel Approach ◽  
Cooking Process ◽  
Eucalyptus Kraft Pulp ◽  
Relevant Variables ◽  
Kraft Cooking

Alkali charge is one of the most relevant variables in the continuous kraft cooking process. The white liquor mass flow rate can be determined by analyzing the chip bulk density fed to the process. At the mills, the total time for this analysis usually is greater than the residence time in the digester. This can lead to an increasing error in the mass of white liquor added relative to the specified alkali charge. This paper proposes a new approach using the Box-Jenkins methodology to develop a dynamic model for predicting chip bulk density. Industrial data were gathered on 1948 observations over a period of 12 months from a Kamyr continuous digester at a bleached eucalyptus kraft pulp mill in Brazil. Autoregressive integrated moving average (ARIMA) models were evaluated according to different statistical decision criteria, leading to the choice of ARIMA (2,0,2) as the best forecasting model, which was validated against a new dataset gathered during 2 months of operations. A combination of predictors has shown more accurate results compared to those obtained by laboratory analysis, allowing a reduction of around 25% of the chip bulk density error to the alkali addition amount.

Effects of release modifier on Carvedilol release from Kollidon SR based matrix

2012 ◽  
Vol 1 (8) ◽  
pp. 186 ◽  
Author(s):  
Urmi Das ◽  
Mohammad Salim Hossain
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Microcrystalline Cellulose ◽  
Matrix Tablets ◽  
Dissolution Time ◽  
Release Mechanism ◽  
Matrix Tablet ◽  
Weight Variation ◽  
The Matrix ◽  
Tablet Formulations

<p>Sustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of Microcrystalline Cellulose showed superimposable release pattern with an initial burst effect as confirmed by mean dissolution time and Higuchi release rate data. After 7 hours of dissolution, Carvedilol release from the matrix systems were 91.42%, 83.41%, from formulation F1 and F2 respectively. Formulation F3 exhibited 100 % release at 4 hours. All the tablet formulations showed acceptable pharmaco-technical properties and complied with the in-house specifications for tablet weight variation, friability, hardness, thickness, and diameter. Prepared tablets also showed sustained release property for carvedilol. The drug release mechanism from the matrix tablets of F1 and F2 was found to be followed by Fickian and F3 by Non-Fickian mechanism.</p><p>DOI: <a href="http://dx.doi.org/10.3329/icpj.v1i8.11095">http://dx.doi.org/10.3329/icpj.v1i8.11095</a></p> <p>International Current Pharmaceutical Journal 2012, 1(8): 186-192</p>

SIFAT FISIS MEKANIS BAMBU LAPIS SEBAGAI BAHAN BAKU PRODUK INTERIOR

2011 ◽  
Vol 3 (1) ◽  
pp. 15
Author(s):  
Arhamsyah Arhamsyah
Keyword(s):  
Flexural Strength ◽  
Water Content ◽  
Raw Material ◽  
Technical Aspects ◽  
Material Layer ◽  
Weight Variation

Research on the utilization of bamboo as a raw material layer interior products have been made. This research aims to determine the nature of plybamboo in terms of technical aspects / processes of manufacture, physical and mechanical, the influence of weight variation labur adhesive, adhesive types and kinds of bamboo products plybamboo.This type of bamboo used is sweet bamboo (Gigantochloa atter Kurz) and bamboo lear (Gigantochloa apus Kurz).The adhesive used was adhesive Polyvinil Acetat (PVAc) and Chloroprene with adhesive labur weight each - each 150 gr/m2, 200 gr/m2 and 250 gr/m2. The parameters tested were water content, density, flexural strength of dry and delamination.The results showed that the treatment using bamboo material with adhesive Chloroprene sweet heavy labur 250 gr/m2 produce the best plybamboo.Keywords: bamboo, glue, physical, mechanical

Influence of Formulation Variables and Processing Techniques on Drug Release from Carbopol-971 based Matrix Tablets of Cinnarizine and Nimodipine.

2010 ◽  
Vol 2 (1) ◽  
Author(s):  
Singh K. ◽  
Pandit K. ◽  
Mishra N.
Keyword(s):  
Drug Release ◽  
Release Rate ◽  
Polymer Concentration ◽  
Matrix Tablets ◽  
Wet Granulation ◽  
Weight Variation ◽  
Diffusion Controlled ◽  
The Matrix ◽  
Processing Techniques ◽  
Formulation Variables

The matrix tablets of cinnarizine and nimodipine were prepared with varying ratio of Carbopol- 971P and co-excipients of varying hydrophilicity (i.e. dicalcium phosphate and spray dried lactose) by direct compression and wet granulation using alcoholic mucilage. The prepared tablets were evaluated for weight variation, hardness and friability. The influence of concentration of the matrix forming material and co-excipients on the release rate of the drug was studied. The release rate of Cinnarizine (more soluble drug) from tablets followed diffusion controlled mechanism whereas for nimodipine (less soluble drug), the drug release followed case-II or super case- II transport mechanism based on Korsmeyer- Peppas equation. The results indicated that the drug release from matrix tablets was increases with increase in hydrophilicity of drug and co-excipients. The release of drug also increased with thermal treatment and decreasing polymer concentration.

pH Dependent Release Potential of Natural Polymers in Sustained Release of Ornidazole From Colon Targeted Delivery System)

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Sharma Pankaj ◽  
Tailang Mukul
Keyword(s):  
Drug Release ◽  
Delivery System ◽  
Targeted Delivery ◽  
Guar Gum ◽  
Acidic Environment ◽  
Natural Polymers ◽  
Weight Variation ◽  
Curve Determination ◽  
Preformulation Studies

The aim of present work was to prepare colon specific delivery system of Ornidazole using different ratio of shellac, zein and guar gum. From study of various literature it revealed that shellac, zein and guar gum released drug from dosage form at the pH of 6.9, 11.5, 7-9 respectively. The main problem associated with colon targeted drug delivery system is degradation of drug in the acidic environment of stomach to circumvent the present problem different combinations of shellac, zein and guar gum were employed in the formulation of colon targeted tablet. Several preformulation parameters were determined such as melting point, FTIR spectroscopy, preparation of calibration curve, determination of λmax and partition coefficient. After the preformulation studies, next steps were preparation of core tablets, evaluation of core of tablets and coating of tablets. The data obtained from preformulation study seven formulations were developed and evaluated for various parameters. Based on evaluated parameter such as weight variation, friability, dissolution study, invitro drug release etc. the F7 formulation show better results colon targeted tablets. Drug content in F7 formulation was 95% and drug release after 6 hrs was 96%. Formulation containing combination of shellac, zein and guar gum released least amount of drug in the acidic environment of stomach and released most of the drug in colon. It is evide

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