Prospects in treatment of multiple sclerosis: near future

2020 ◽  
Vol 28 (3) ◽  
pp. 377-390
Author(s):  
Gennadii E. Sheiko ◽  
Anna N. Belova ◽  
Maksim N. Kudykin
Keyword(s):  
Multiple Sclerosis ◽  
Modern Science ◽  
Therapeutic Approaches ◽  
New Methods ◽  
New Therapeutic Approaches ◽  
The Central Nervous System ◽  
Unclear Etiology ◽  
Near Future ◽  
The Given ◽  
Methods Of Treatment

Multiple sclerosis (MS) is a widespread dysimmune-neurodegenerative disease of the central nervous system of unclear etiology. Despite significant achievements in the therapy of MS, the level of progressing disability and early mortality remains alarmingly high. The main aim of the given review is to give a detailed description of new promising medical drugs for treatment of MS. In the article the data of preclinical and clinical trials are given, presumptive mechanisms of the medical drugs under development are described. Development of new therapeutic approaches in treatment of MS is of great interest in modern science. The given review highlights new methods of treatment that are now undergoing clinical trialы and will probably come to the clinical practice in the near future.

scholarly journals Comorbidity in multiple sclerosis: Past, present and future

2019 ◽  
Vol 42 (1) ◽  
pp. E5-E12 ◽  
Author(s):  
Ruth Ann Marrie
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Chronic Disease ◽  
Disease Course ◽  
Comorbid Conditions ◽  
Therapeutic Approaches ◽  
Neurologic Diseases ◽  
New Therapeutic Approaches ◽  
Source Studies ◽  
The Central Nervous System

Purpose: Multiple sclerosis (MS) is an inflammatory and degenerative condition affecting the central nervous system. Like many neurologic diseases, it is chronic and incurable, and confers a substantial burden on affected individuals, their families and society. Although many individuals suffering from a serious chronic disease also suffer from comorbid conditions, the important consequences of their interaction often receive little attention. This was particularly true for MS two decades ago. Broadening our perspective by better understanding the effects of comorbidity on an individual with a particular chronic disease offers us an opportunity to improve understanding of prognosis, personalize disease management, develop new therapeutic approaches and illuminate the pathophysiology of disease. Source: Studies examining the incidence, prevalence and outcomes related to comorbidity in MS will be discussed, along with areas requiring further investigation. Conclusion: Comorbidity is highly prevalent in MS throughout the disease course. Comorbid conditions, including depression, anxiety, hypertension, hyperlipidemia, diabetes and chronic lung disease, adversely affect a broad range of outcomes. Less is known about the effects of MS on outcomes related to these comorbid conditions. These findings highlight an urgent need to determine how to best prevent and treat comorbidity in MS.

Cortical and meningeal pathology in progressive multiple sclerosis: a new therapeutic target?

2019 ◽  
Vol 30 (3) ◽  
pp. 221-232 ◽  
Author(s):  
Berenice Anabel Silva ◽  
Carina Cintia Ferrari
Keyword(s):  
Multiple Sclerosis ◽  
Progressive Multiple Sclerosis ◽  
Cortical Lesions ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches ◽  
Meningeal Inflammation ◽  
Relapsing Remitting ◽  
The Central Nervous System ◽  
Therapeutic Alternatives ◽  
Ms Pathogenesis

Abstract Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease that involves an intricate interaction between the central nervous system and the immune system. Nevertheless, its etiology is still unknown. MS exhibits different clinical courses: recurrent episodes with remission periods (‘relapsing-remitting’) that can evolve to a ‘secondary progressive’ form or persistent progression from the onset of the disease (‘primary progressive’). The discovery of an effective treatment and cure has been hampered due to the pathological and clinical heterogeneity of the disease. Historically, MS has been considered as a disease exclusively of white matter. However, patients with progressive forms of MS present with cortical lesions associated with meningeal inflammation along with physical and cognitive disabilities. The pathogenesis of the cortical lesions has not yet been fully described. Animal models that represent both the cortical and meningeal pathologies will be critical in addressing MS pathogenesis as well as the design of specific treatments. In this review, we will address the state-of-the-art diagnostic and therapeutic alternatives and the development of strategies to discover new therapeutic approaches, especially for the progressive forms.

New insights of CRISPR technology in human pathogenic fungi

2019 ◽  
Vol 14 (14) ◽  
pp. 1243-1255 ◽  
Author(s):  
Elvira Román ◽  
Daniel Prieto ◽  
Rebeca Alonso-Monge ◽  
Jesús Pla
Keyword(s):  
Mammalian Cells ◽  
Genetic Manipulation ◽  
Pathogenic Fungi ◽  
Biological Research ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches ◽  
Short Palindromic Repeat ◽  
Future Outcomes ◽  
Near Future ◽  
Genome Manipulation

Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-Cas systems have emerged as a powerful tool for genome manipulation. Class 2 type II CRISPR/ CAS9 is so far the most studied system and has been implemented in many biological systems such as mammalian cells, plants, fungi and bacteria. Fungi are important causes of human diseases worldwide. Genetic manipulation of pathogenic fungi is critical to develop new therapeutic approaches and novel antifungals. We will review here the progress done with CRISPR/ CAS9 systems in human pathogenic fungi, with emphasis in Candida albicans and the main modifications that have improved their usefulness in biological research. We finally discuss possible future outcomes and applications to the developed in a near future.

Sex Therapy

1991 ◽  
Vol 19 (1) ◽  
pp. 131-136 ◽  
Author(s):  
Keith Hawton
Keyword(s):  
Cognitive Processes ◽  
Sex Therapy ◽  
Therapeutic Interventions ◽  
Long Term Results ◽  
Weekly Schedule ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches ◽  
Low Sexual Desire ◽  
Methods Of Treatment

The introduction of sex therapy two decades ago was accompanied by largely uncritical enthusiasm, with the result that too few careful evaluative studies were conducted. Those that were indicated that a weekly or twice weekly schedule of treatment sessions was best and that treatment by individual therapists was as effective as co-therapy. Some of the major prognostic factors and the long-term results of sex therapy have now been elucidated. Low sexual desire has emerged as a problem for which our now traditional methods of treatment are often inadequate and new therapeutic approaches are required. Current efforts to explore the beliefs and cognitive processes associated with erectile dysfunction are proving rewarding and are likely to enrich therapeutic interventions in the future. Attention should now be paid to the beliefs and cognitions associated with other sexual dysfunctions, both male and female.

scholarly journals Neuroprotective activity of orexin system in ischemic stroke

2018 ◽  
Vol 17 (2) ◽  
pp. 4-11
Author(s):  
I. A. Filchenko ◽  
Yu. V. Sviryaev ◽  
T. D. Vlasov
Keyword(s):  
Ischemic Stroke ◽  
Brain Damage ◽  
Neuroprotective Activity ◽  
Therapeutic Approaches ◽  
Common Features ◽  
Protective Potential ◽  
New Methods ◽  
New Therapeutic Approaches ◽  
The Common

The protective potential of orexin system is a field of interest in the search of the new methods to diminish brain damage in ischemic stroke. The cytoprotective potential of orexins in hypoxic damage is associated with their antioxidant, anti-inflammatory and anti-apoptotic properties and with their ability to activate proliferation and normalize metabolism. Even though today little is known about the role of orexins in memory and pain in ischemic stroke, the common features of the pathogenesis of these disruptions and the mechanisms of orexin-associated protection could suggest the opportunity to use of orexins for correction of these complications following ischemic stroke. Further studies of the orexin-associated neuroprotection could become the further step on the way to the new therapeutic approaches in ischemic stroke.

Multiple sclerosis-modifying therapies: view in the future

2021 ◽  
Vol LII (3) ◽  
pp. 41-54
Author(s):  
Anna N. Belova ◽  
Gennadij E. Sheiko ◽  
Evgeniya M. Belova
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Trial ◽  
Mechanisms Of Action ◽  
Disease Modifying Therapies ◽  
The World ◽  
The Central Nervous System ◽  
The Russian Federation ◽  
Disease Modifying ◽  
Favorable Safety ◽  
Near Future

Multiple sclerosis is a chronic disabling disease of the central nervous system, afflicting mainly young people. The efforts of investigators around the world are aimed at creating highly effective disease-modifying therapies that have a favorable safety and tolerance profile. The review briefly lists the disease-modifying therapies currently registered in the Russian Federation. Information is provided on the international clinical trial phases II and III of disease-modifying therapies, international nonproprietary products and/or active substance molecules, intended mechanisms of action and indicators of their effectiveness and safety. The article describes disease-modifying therapies that have been approved by the FDA and that may be available for Russian neurologists in the near future for the treatment of multiple sclerosis. The treatment possibilities of drugs used in Russia for other indications than multiple sclerosis are discussed.

Neuromyelitis Optica

2013 ◽  
Author(s):  
Aaron E. Miller ◽  
Teresa M. DeAngelis
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Neuromyelitis Optica ◽  
Autoimmune Disorder ◽  
Therapeutic Approaches ◽  
New Concepts ◽  
The Central Nervous System ◽  
Spectrum Disorders

Neuromyelitis optica (NMO), a chronic inflammatory, demyelinating autoimmune disorder of the central nervous system with a predilection for the optic nerves and spinal cord, has long been confused with classical multiple sclerosis. In this chapter, we review the important clinical and radiographic distinctions of NMO and NMO spectrum disorders, and summarize promising new concepts in pathophysiology and therapeutic approaches.

Rabies

2017 ◽  
Author(s):  
Alan C. Jackson
Keyword(s):  
Central Nervous System ◽  
Clinical Course ◽  
Multiple Organ ◽  
Medical Complications ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches ◽  
Acute Viral Infection ◽  
The Central Nervous System ◽  
Animal Bites ◽  
Rabies Pathogenesis

Rabies is an acute viral infection involving the central nervous system with distinctive clinical features reflecting early brainstem involvement, including hydrophobia. This infection is usually transmitted by animal bites, typically from dogs or wildlife, including bats. There is a progressive clinical course to coma and the disease is virtually always fatal. When rabies is treated aggressively there are usually multiple medical complications, including multiple organ failure. Therapeutic attempts have been disappointing and new approaches need to be taken in the future. An improved understanding of rabies pathogenesis might lead to important insights into the development of new therapeutic approaches.

scholarly journals New Insights into the Role of Oxidative Stress Mechanisms in the Pathophysiology and Treatment of Multiple Sclerosis

2016 ◽  
Vol 2016 ◽  
pp. 1-18 ◽  
Author(s):  
Bożena Adamczyk ◽  
Monika Adamczyk-Sowa
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Chronic Phase ◽  
Current Treatment ◽  
New Drugs ◽  
Inflammatory Processes ◽  
The Central Nervous System ◽  
The Brain ◽  
Methods Of Treatment

Multiple sclerosis (MS) is a multifactorial disease of the central nervous system (CNS) characterized by an inflammatory process and demyelination. The etiology of the disease is still not fully understood. Therefore, finding new etiological factors is of such crucial importance. It is suspected that the development of MS may be affected by oxidative stress (OS). In the acute phase OS initiates inflammatory processes and in the chronic phase it sustains neurodegeneration. Redox processes in MS are associated with mitochondrial dysfunction, dysregulation of axonal bioenergetics, iron accumulation in the brain, impaired oxidant/antioxidant balance, and OS memory. The present paper is a review of the current literature about the role of OS in MS and it focuses on all major aspects. The article explains the mechanisms of OS, reports unique biomarkers with regard to their clinical significance, and presents a poorly understood relationship between OS and neurodegeneration. It also provides novel methods of treatment, including the use of antioxidants and the role of antioxidants in neuroprotection. Furthermore, adding new drugs in the treatment of relapse may be useful. The article considers the significance of OS in the current treatment of MS patients.

scholarly journals Therapeutic Targeting of Immune Cell Autophagy in Multiple Sclerosis: Russian Roulette or Silver Bullet?

2021 ◽  
Vol 12 ◽  
Author(s):  
Guan Yang ◽  
Luc Van Kaer
Keyword(s):  
Multiple Sclerosis ◽  
Immune Cell ◽  
Inflammatory Diseases ◽  
Chronic Inflammatory Disease ◽  
Nerve Fibers ◽  
Therapeutic Approaches ◽  
Autoimmune Encephalomyelitis ◽  
Autoimmune And Inflammatory Diseases ◽  
The Central Nervous System

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) in which the immune system damages the protective insulation surrounding nerve fibers that project from neurons. The pathological hallmark of MS is multiple areas of myelin loss accompanied by inflammation within the CNS, resulting in loss of cognitive function that ultimately leads to paralysis. Recent studies in MS have focused on autophagy, a cellular self-eating process, as a potential target for MS treatment. Here, we review the contribution of immune cell autophagy to the pathogenesis of experimental autoimmune encephalomyelitis (EAE), the prototypic animal model of MS. A better understanding of the role of autophagy in different immune cells to EAE might inform the development of novel therapeutic approaches in MS and other autoimmune and inflammatory diseases.

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