Sex Therapy

1991 ◽  
Vol 19 (1) ◽  
pp. 131-136 ◽  
Author(s):  
Keith Hawton
Keyword(s):  
Cognitive Processes ◽  
Sex Therapy ◽  
Therapeutic Interventions ◽  
Long Term Results ◽  
Weekly Schedule ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches ◽  
Low Sexual Desire ◽  
Methods Of Treatment

The introduction of sex therapy two decades ago was accompanied by largely uncritical enthusiasm, with the result that too few careful evaluative studies were conducted. Those that were indicated that a weekly or twice weekly schedule of treatment sessions was best and that treatment by individual therapists was as effective as co-therapy. Some of the major prognostic factors and the long-term results of sex therapy have now been elucidated. Low sexual desire has emerged as a problem for which our now traditional methods of treatment are often inadequate and new therapeutic approaches are required. Current efforts to explore the beliefs and cognitive processes associated with erectile dysfunction are proving rewarding and are likely to enrich therapeutic interventions in the future. Attention should now be paid to the beliefs and cognitions associated with other sexual dysfunctions, both male and female.

scholarly journals Progress in Understanding and Treating Parkinson's Disease

1976 ◽  
Vol 3 (2) ◽  
pp. 81-84 ◽  
Author(s):  
André Barbeau
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Long Term Results ◽  
Accelerated Ageing ◽  
Therapeutic Approaches ◽  
Mao B ◽  
New Therapeutic Approaches ◽  
Neuronal Systems

SUMMARY:This review evaluates the long-term results of Levodopa therapy in Parkinson's disease upon quality of life, prolongation of survival and excess mortality. It also focuses on recent and new therapeutic approaches: Levodopa in comhindation with a Dopa-decarboxylase inhibitor or MAO-B inhibitor, dopamine agonists and an active tripeptide: L-prolyl-L-leucylglycine amide (M1F-I). It ends by looking at new avenues of etiological research in Parkinson's disease which may indicate specific accelerated ageing of catecholaminergic (pigmented) neuronal systems.

scholarly journals The Diagnostic and Therapeutic Value of Multimarker Analysis in Heart Failure. An Approach to Biomarker-Targeted Therapy

2020 ◽  
Vol 7 ◽  
Author(s):  
Albert Topf ◽  
Moritz Mirna ◽  
Bernhard Ohnewein ◽  
Peter Jirak ◽  
Kristen Kopp ◽  
...  
Keyword(s):  
Heart Failure ◽  
Morbidity And Mortality ◽  
Therapeutic Interventions ◽  
Stress Axis ◽  
High Morbidity ◽  
Matrix Remodeling ◽  
Therapeutic Approaches ◽  
Therapeutic Setting ◽  
Therapeutic Value

Background: Heart failure is a pathophysiological state, which is still associated with high morbidity and mortality despite established therapies. Diverse well-known biomarkers fail to assess the variety of individual pathophysiology in the context of heart failure.Methods: An analysis of prospective, multimarker-specific therapeutic approaches to heart failure based on studies in current literature was performed. A total of 159 screened publications in the field of biomarkers in heart failure were hand-selected and found to be eligible for this study by a team of experts.Results: Established biomarkers of the inflammatory axis, matrix remodeling, fibrosis and oxidative stress axis, as well as potential therapeutic interventions were investigated. Interaction with end organs, such as cardio-hepatic, cardio-renal and cardio-gastrointestinal interactions show the complexity of the syndrome and could be of further therapeutic value. MicroRNAs are involved in a wide variety of physiologic and pathophysiologic processes in heart failure and could be useful in diagnostic as well as therapeutic setting.Conclusion: Based on our analysis by a biomarker-driven approach in heart failure therapy, patients could be treated more specifically in long term with a consideration of different aspects of heart failure. New studies evaluating a multimarker – based therapeutic approach could lead in a decrease in the morbidity and mortality of heart failure patients.

Results of locally advanced laryngopharyngeal and cervical part of esophagus cancers treatment

2016 ◽  
Vol 21 (3) ◽  
pp. 156-159
Author(s):  
Andrey N. Rudyk ◽  
E. I Sigal ◽  
M. V Burmistrov
Keyword(s):  
High Frequency ◽  
Locally Advanced ◽  
Survival Rates ◽  
Pathological Process ◽  
Chemoradiation Therapy ◽  
Treatment Choice ◽  
Long Term Results ◽  
Surgical Method ◽  
Methods Of Treatment

Issues of locally advanced cancers which involve into the pathological process laryngopharynx and cervical part of esophagus remain to be actual till the present time. Unsatisfactory long-term results lead to the absence of common approaches and clear guidelines on the methods of the treatment choice (radiotherapy, chemoradiation therapy, surgery). Many researchers suppose that the foremost decision is to include surgical component into the treatment schemes of such patients. Main surgical method of the treatment is laryngopharyngectomy or laryngopharyngoesophagectomy. It depends on the extension of cancer. Different kinds of grafts (gastric, jejunal and colon) are used for esophageal reconstrution. The high frequency of complications after surgery, low survival rates are main motives for the search of effective methods of treatment.

scholarly journals A comparative study of the effectiveness and safety of injectable combination therapy of keloid and hypertrophic scars with 5-fluorouracil and betamethasone

2020 ◽  
Vol 23 (6) ◽  
pp. 432-442
Author(s):  
Evgeniya V. Ikonnikova ◽  
Larisa S. Kruglova ◽  
Nataliya E. Manturova ◽  
Marina A. Petrii
Keyword(s):  
Long Term Results ◽  
Intralesional Injection ◽  
Hypertrophic Scars ◽  
Average Decrease ◽  
Group A ◽  
Intralesional Injections ◽  
Group B ◽  
Methods Of Treatment

therapy for their reliable removal. Standard methods of treatment often give unpredictable results, are accompanied by various complications, and require the use of expensive equipment. AIM: To investigate the efficacy and safety of intralesional injection of a combination of 5-fluorouracil (5-FU) and betamethasone for the treatment of keloids and hypertrophic scars. MATERIALS AND METHODS: The study involved 26 patients who were divided into two equal groups. Patients in group A received intralesional injections of betamethasone, and those in group B received 5-FU and betamethasone. Three injections were performed with an interval of 3 weeks. The scars were assessed at the beginning of the treatment, on the 3rd and 6th week during the treatment, and 4 and 16 weeks after the end of the treatment. The dynamics of scar condition was evaluated by the average decrease in the scar height and density, changes in subjective sensations, and the presence or absence of complications. RESULTS: At 4 weeks after the end of the therapy, the total effectiveness of reducing the initial scar height was significantly higher in group B (10 patients; 76.9%) than in group A (6; 46.1%). In the comparison of long-term results at 16 weeks after treatment, 92.3% of the patients from group B and 53.8% of the patients from group A showed cessation of scar growth, flattening and softening, diminished itching and pain, smoothing of the scar contour, and a decrease in the color of the border between the scar and surrounding tissues. CONCLUSIONS: The combination of betamethasone with 5-FU is safer and more effective than monotherapy with betamethasone or 5-FU in the treatment of keloid and hypertrophic scars, with a faster and more pronounced decrease in the height and density of the scar, erythema, and subjective sensations. This mode of therapy is characterized by a low relapse rate with prolonged follow-up. The article is of interest to practicing cosmetologists, dermatologists, and plastic surgeons.

scholarly journals New Therapeutic Approaches for Allergy: A Review of Cell Therapy and Bio- or Nano-Material-Based Strategies

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2149
Author(s):  
Juan L. Paris ◽  
Paz de la Torre ◽  
Ana I. Flores
Keyword(s):  
Cell Therapy ◽  
Treatment Options ◽  
Allergic Diseases ◽  
Immunological Tolerance ◽  
Term Treatment ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches ◽  
Long Term Treatment ◽  
Nano Material

Allergy constitutes a major health issue due to its large prevalence. The established therapeutic approaches (allergen avoidance, antihistamines, and corticosteroids) do not address the underlying causes of the pathology, highlighting the need for other long-term treatment options. Antigen-specific immunotherapy enables the long-term control of allergic diseases by promoting immunological tolerance to the allergen. However, efficacious immunotherapies are not available for all possible allergens, and the risk of undesired reactions during therapy remains a concern, especially in patients with severe allergic reactions. In this context, two types of therapeutic strategies appear especially promising for the future in the context of allergy: cell therapy and bio- or nano-material-based therapy. In this review, the main strategies developed this far in these two types of strategies are discussed, with several examples illustrating the different approaches.

Prospects in treatment of multiple sclerosis: near future

2020 ◽  
Vol 28 (3) ◽  
pp. 377-390
Author(s):  
Gennadii E. Sheiko ◽  
Anna N. Belova ◽  
Maksim N. Kudykin
Keyword(s):  
Multiple Sclerosis ◽  
Modern Science ◽  
Therapeutic Approaches ◽  
New Methods ◽  
New Therapeutic Approaches ◽  
The Central Nervous System ◽  
Unclear Etiology ◽  
Near Future ◽  
The Given ◽  
Methods Of Treatment

Multiple sclerosis (MS) is a widespread dysimmune-neurodegenerative disease of the central nervous system of unclear etiology. Despite significant achievements in the therapy of MS, the level of progressing disability and early mortality remains alarmingly high. The main aim of the given review is to give a detailed description of new promising medical drugs for treatment of MS. In the article the data of preclinical and clinical trials are given, presumptive mechanisms of the medical drugs under development are described. Development of new therapeutic approaches in treatment of MS is of great interest in modern science. The given review highlights new methods of treatment that are now undergoing clinical trialы and will probably come to the clinical practice in the near future.

Liver Transplantation for Hepatitis B Virus Patients: Long-Term Results of Three Therapeutic Approaches

2008 ◽  
Vol 40 (6) ◽  
pp. 1961-1964 ◽  
Author(s):  
A.W. Avolio ◽  
E. Nure ◽  
M. Pompili ◽  
R. Barbarino ◽  
M. Basso ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Long Term Results ◽  
Therapeutic Approaches ◽  
B Virus

Towards new therapeutic approaches for malignant melanoma

2011 ◽  
Vol 13 ◽  
Author(s):  
Ivan Pacheco ◽  
Cristina Buzea ◽  
Victor Tron
Keyword(s):  
Molecular Mechanisms ◽  
Acquired Resistance ◽  
Therapeutic Approaches ◽  
Term Survival ◽  
Therapeutic Modalities ◽  
New Therapeutic Approaches ◽  
Mirna Genes ◽  
Molecular Therapeutics ◽  
Multistep Process

Recent progress in understanding the molecular mechanisms of the initiation and progression of melanoma has created new opportunities for developing novel therapeutic modalities to manage this potentially lethal disease. Although at first glance, melanoma carcinogenesis appears to be a chaotic system, it is indeed, arguably, a deterministic multistep process involving sequential alterations of proto-oncogenes, tumour suppressors and miRNA genes. The scope of this article is to discuss the most recent and significant advances in melanoma molecular therapeutics. It is apparent that using single agents targeting solely individual melanoma pathways might be insufficient for long-term survival. However, the outstanding results on melanoma survival observed with novel selective inhibitors of B-RAF, such as PLX4032 give hope that melanoma can be cured. The fact that melanoma develops acquired resistance to PLX4032 emphasises the importance of simultaneously targeting several pathways. Because the most striking feature of melanoma is its unsurpassed ability to metastasise, it is important to implement newer systems for drug delivery adapted from research on stem cells and nanotechnology.

Penile Fractures: Evaluation, Therapeutic Approaches and Long-Term Results

1996 ◽  
Vol 155 (1) ◽  
pp. 148-149 ◽  
Author(s):  
M.A. Asgari ◽  
S.Y. Hosseini ◽  
M.R. Safarinejad ◽  
B. Samadzadeh ◽  
A.R. Bardideh
Keyword(s):  
Long Term Results ◽  
Therapeutic Approaches
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