scholarly journals The Correlation Between Asthma Severity and Neutrophil to Lymphocyte Ratio

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Meena Abdul-Sattar Darwesh ◽  
Ibtihal Shukri Abd Alhaleem ◽  
Muhammed Waheeb Salman Al-Obaidy
Keyword(s):  
Clinical Symptoms ◽  
Asthma Severity ◽  
Cross Sectional Study ◽  
Neutrophil To Lymphocyte Ratio ◽  
Healthy Controls ◽  
Cross Sectional ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Asthmatic Patients ◽  
Significant Difference

Background—The prognosis is essential in management and follows up of asthmatic patients. Neutrophil to lymphocyte ratio is considered as the common prognostic marker for many diseases especially the asthma. Aim of study—To assess the relationship between asthma severity and neutrophil to lymphocyte ratio in comparison to healthy controls. Patients and methods—This study is a cross sectional study conducted in Respiratory Consultancy Clinic in Baghdad Teaching Hospital in Medical City during the period from 1st of October, 2018 to 31st of March, 2019 on sample of 50 asthmatic patients and 50 healthy controls. The diagnosis of asthma was confirmed by the supervisor through clinical symptoms, signs, spirometery with reversibility test (according to GINA guideline.). Results—A highly significant difference was observed between asthmatic cases and controls regarding age (p<0.001). A significant association was observed between obesity and asthmatic cases (p=0.001). There was a highly significant association between high neutrophil/lymphocyte ratio and asthmatic cases (p<0.001). The neutrophil/lymphocyte ratio was significantly increased with advanced age, females, severe and uncontrolled asthma. Conclusions—The neutrophil to lymphocyte ratio is useful biomarker in assessment of asthma severity.

The predective role of neutrophils to lymphocytes ratio in bronchial asthma

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Fawzia Hassan Abo Ali ◽  
Sylvia Wefky Abo El Fadle ◽  
HossamMoustafa El Kady ◽  
Nehal Anwar Abdel Maksoud
Keyword(s):  
Bronchial Asthma ◽  
Asthma Severity ◽  
Neutrophil To Lymphocyte Ratio ◽  
Healthy Controls ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Asthmatic Patients ◽  
Significant Difference ◽  
Healthy Control

Abstract Background Neutrophil to lymphocyte ratio is an easy and rapid biomarker measured in peripheral blood, and plays a helpful role in assessing prognosis of bronchial asthma and its severity. Aim To assess NLR levels among atopic asthmatics, non-atopic asthmatics and healthy controls. Patient and methods The study included 120 asthmatic patients and 60 healthy control. Results A highly significant difference was observed between asthmatic patients and healthy controls regarding neutrophil\lymphocyte ratio (p &lt; 0.0001). Conclusion Neutrophil to lymphocyte ratio is useful to assess asthma severity.

scholarly journals Severity-dependent variations of the neutrophil to lymphocyte ratio (NLR) in peripheral vestibular vertigo

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Andi Kurnia Bintang ◽  
Eva Iin Magasingan
Keyword(s):  
Inflammatory Marker ◽  
Cost Effective ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Neutrophil To Lymphocyte Ratio ◽  
University Teaching ◽  
Cross Sectional ◽  
Lymphocyte Ratio ◽  
Significant Difference ◽  
Vestibular Vertigo

Abstract Background Peripheral vestibular vertigo is a common cause of vertigo especially in the elderly. The neutrophil to lymphocyte ratio (NLR) is a rapid and cost-effective inflammatory marker that has been assessed previously in peripheral vestibular disorders. However, its relation to the severity of peripheral vertigo has not been previously investigated. The aim of this study is to assess the levels of NLR in peripheral vestibular vertigo of various severity categories. This was a cross-sectional study at the Wahidin Sudirohusodo Hospital and Hasanuddin University Teaching Hospital in Makassar. The NLR was measured among subjects with periphel vestibular vertigo with severity categorised using the Dizziness Handicap Inventory (DHI) questionnaire. Results A total of 39 participants with peripheral vestibular vertigo were recruited. A statistically significant difference was found (p = 0.002, Kruskal–Wallis ANOVA) between the mean NLR for the mild, moderate, and severe DHI categories were 2.47 ± 1.66, 2.64 ± 0.96, and 5.15 ± 2.59 respectively. Conclusion A significant difference in the NLR was found between the three different vertigo severity groups, wherein NLR values rise with increase in vertigo severity. This warrants further exploration on the role of inflammatory biomarkers in vertigo pathophysiology and clinical assessment.

scholarly journals ANGKA BANDING NETROFIL/LIMFOSIT DI POPULASI DEWASA MUDA

2018 ◽  
Vol 22 (2) ◽  
pp. 105
Author(s):  
Arie Yanti ◽  
Uleng Bahrun ◽  
Mansyur Arif
Keyword(s):  
Adult Population ◽  
Reference Value ◽  
Severe Infection ◽  
Cost Effective ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical Checkup ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Significant Difference

Previous studies have shown that neutrophil/lymphocyte ratio in bacteremia is higher than nonbacteremia, therefore it could beused as a marker to distinguish both conditions in patients with sepsis .Another study on oncology patients in ICU showed a correlationbetween the severity of clinical course and the increase of neutrophil/lymphocyte ratio. In physiological condition, neutrophil/lymphocyteratio <5, while in pathological conditions (severe infection or systemic inflammation) neutrophil/lymphocyte ratio increases >6.Neutrophil/lymphocyte ratio is a sensitive, fast, cost effective and applicable laboratory test for routine use, therefore this test result canbe used as the parameter to assess clinical condition of patients. However, a reference value of neutrophil/lymphocyte ratio has neverbeen defined, especially in Makassar City, South Sulawesi Province. The aim of this study was to know the neutrophil/lymphocyte ratioin a healthy young adult population. A cross sectional study was conducted from March to April 2014, involving residents (specialisticcandidates in Medical Faculty, Hasanuddin University, who underwwent medical checkup and voluntarily joined this study. Samplesconsisted of 198 persons who fulfilled the inclusion criteria with an age range between 24-40 years old, comprising 84 males (42.42%)and 114 females (57.58%). The neutrophil/lymphocyte ratio for all samples was 1.95 (1.15-4.74). Mann Whitney test showed thatthere was no significant difference of neutrophil/lymphocyte ratio between males and females, 1.88 (1.25-4.74) vs 1.95 (1.15-4.12),p=0.65 and neither between the age group 21-30 years old and 31-40 years old, 1.95 (1.21-4.74) vs 1.94 (1.15-4.09), p=0.82.

scholarly journals Choroidal vascularity index in thyroid-associated ophthalmopathy: a cross-sectional study

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Pasquale Loiudice ◽  
Marco Pellegrini ◽  
Michele Marinò ◽  
Barbara Mazzi ◽  
Ilaria Ionni ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Activity Score ◽  
Enhanced Depth Imaging ◽  
Clinical Activity ◽  
Healthy Controls ◽  
Cross Sectional ◽  
Clinical Activity Score ◽  
Significant Difference ◽  
Thyroid Associated Ophthalmopathy ◽  
Imagej Software

Abstract Background Hemodynamic changes have been observed in patients with Graves’ disease. The aim of our study was to evaluate choroidal vascular change using the choroidal vascularity index (CVI) in patients with thyroid-associated ophthalmopathy (TAO). Methods In this cross-sectional observational study, 40 patients affected by TAO were recruited. Forty healthy individuals, matched for age and sex, served as controls. Foveal enhanced-depth imaging optical coherence tomography scans were obtained from all participants. Images were binarized using the ImageJ software and luminal area (LA) and total choroidal area (TCA) were measured. CVI was calculated as the proportion of LA to TCA. The relation between CVI or subfoveal choroidal thickness (SFCT) and clinical activity score, exophthalmometric value, diplopia status, gender, and age was evaluated. Results CVI was significantly higher in patients with TAO (P = 0.004). No significant difference was observed in SFCT (P = 0.200) and TCA (P = 0.153) comparing TAO patients and healthy controls. LA was significantly higher in TAO group (P = 0.045). On multiple regression analysis, CVI was associated with TCA (P = 0.043). No association was found between SFCT or CVI and TCA, clinical activity score, exophthalmometric value, Inami value, diplopia status, gender or age (P > 0.05). Conclusions This is the first study that has demonstrated an increase in CVI in eyes with TAO compared with healthy controls and has assessed its association with clinical features.

scholarly journals Interleukin-37 as an anti-inflammatory cytokine: does its relation to disease activity suggest its potential role in rheumatoid arthritis therapy?

2021 ◽  
Vol 48 (1) ◽  
Author(s):  
Eman A. Baraka ◽  
Mona G. Balata ◽  
Shereen H. Ahmed ◽  
Afaf F. Khamis ◽  
Enas A. Elattar
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Tender Joint ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Significant Difference ◽  
The Mean ◽  
Anti Inflammatory

Abstract Background This study aimed to measure the serum and synovial interleukin (IL)-37 levels in rheumatoid arthritis (RA) patients compared to patients with primary knee osteoarthritis (PKOA) and healthy controls and to detect its relation to RA disease activity. Results This cross-sectional study included 50 RA patients with a mean age of 40.24 ± 8.62 years, 50 patients with PKOA with a mean age of 56.69 ± 4.21, and 40 healthy controls with a mean age of 41.75 ± 7.38 years. The mean serum IL-37 level in the RA patients (382.6 ± 73.97 pg/ml) was statistically significantly (P < 0.001) the highest among the studied groups; however, it showed a non-significant difference between the PKOA patients (70.38 ± 27.49 pg/ml) and the healthy controls (69.97 ± 25.12 pg/ml) (P > 0.94). Both serum and synovial IL-37 levels were significantly positively correlated with disease activity scores (r = 0.92, P< 0.001 and r = 0.85, P < 0.001), tender joint counts (r = 0.83, P < 0.001 and r = 0.82, P < 0.001 ), swollen joint counts (r = 0.72, P < 0.001 and r = 0.60, P < 0.001), visual analog scale (r = 0.82, P < 0.001 and r = 0.82, P < 0.001), erythrocyte sedimentation rate (r = 0.75, P < 0.001 and r = 0.65, P < 0.001), and C-reactive protein (r = 0.93, P < 0.001 and r = 0.79, P < 0.001), respectively. Conclusion Serum and synovial IL-37 were significantly elevated in the RA patients, and they were closely correlated. Being less invasive, the serum IL-37 could be a marker of disease activity and could reflect the effective disease control by drugs. Having an anti-inflammatory effect could not suggest IL-37 as the key player to control inflammation alone, but its combination with other anti-proinflammatory cytokines could be investigated.

Low Level of Serum Sclerostin in Adult Patients with Tumor-induced Osteomalacia Comparing with X-linked Hypophosphatemia

2021 ◽  
Author(s):  
Xiaolin Ni ◽  
Qi Zhang ◽  
Xiang Li ◽  
Qianqian Pang ◽  
Yiyi Gong ◽  
...  
Keyword(s):  
Bone Mass ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Cross Sectional ◽  
Significant Difference ◽  
Healthy Control ◽  
Premenopausal Patients ◽  
Male Patients ◽  
Sclerostin Level ◽  
Sclerostin Antibody

Abstract Context Sclerostin is an inhibitor of Wnt-β-catenin signaling to regulate bone formation. Circulating sclerostin levels were reported to be elevated in patients with X-linked hypophosphatemia (XLH), and sclerostin antibody (Scl-Ab) has been shown to increase bone mass and normalize circulating phosphate levels in Hyp mice. However, circulating sclerostin level in acquired hypophosphatemic patients with tumor-induced osteomalacia (TIO) remains rare reported. Objectives This study was designed to evaluate serum sclerostin levels in TIO patients comparing them with age-, sex- matched healthy controls and XLH patients, and analyze correlation of circulating sclerostin with BMD and laboratory parameters. Design, Setting and Participants 190 individuals including 83 adult TIO patients, 83 adult healthy controls and 24 adult XLH patients were enrolled in this cross-sectional study. Main outcome measures Serum sclerostin levels were determined in TIO patients, healthy controls and XLH patients. Results TIO patients (43 male and 40 female) aged 44.3 ± 8.7 (mean ± SD) years had lower levels of circulating sclerostin than healthy controls (94.2 ± 45.8 vs 108.4 ± 42.3 pg/mL, p = 0.01) with adjustment for age, gender, BMI and diabetes rate. Sclerostin levels were positively associated with age (r = 0.238, p = 0.030). Male patients had higher sclerostin level than female patients (104.7 ± 47.3 vs 83.0 ± 41.8 pg/mL, p = 0.014) and postmenopausal patients had higher tendency of sclerostin level than premenopausal patients (98.4 ± 48.8 vs 71.6 ± 32.3 ng/ml, p = 0.05). Sclerostin levels were positively associated with BMD of L1-4 (r = 0.255, p = 0.028), femoral neck (r = 0.242, p = 0.039) and serum calcium (r = 0.231, p = 0.043). TIO subgroup patients (n=24, 35.9 ± 7.3 years old) comparing with age-, sex-matched adult XLH patients and healthy controls revealed significant difference of sclerostin levels (XLH, TIO and healthy control were 132.0 ± 68.8, 68.4 ± 31.3 and 98.6 ± 41.1 pg/mL, respectively, p &lt; 0.001). Conclusions Circulating sclerostin levels were decreased in TIO patients but increased in XLH patients, which might be result of histological abnormality and bone mass.

scholarly journals A Cross-Sectional Study of Neutrophil-to-Lymphocyte Ratio in Diagnosing Acute Appendicitis in Hospital Melaka

2019 ◽  
Vol 26 (6) ◽  
pp. 55-66
Author(s):  
Khairol Ashraf Ahmad ◽  
◽  
Noorharisman Ideris ◽  
Syed Hassan Syed Abd Aziz ◽  
◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Cross Sectional Study ◽  
Neutrophil To Lymphocyte Ratio ◽  
Sectional Study ◽  
Cross Sectional ◽  
Lymphocyte Ratio

scholarly journals Associations between the Neutrophil-to-Lymphocyte Ratio and Diabetic Complications in Adults with Diabetes: A Cross-Sectional Study

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Heng Wan ◽  
Yuying Wang ◽  
Sijie Fang ◽  
Yi Chen ◽  
Wen Zhang ◽  
...  
Keyword(s):  
Diabetic Complications ◽  
Large Population ◽  
Cross Sectional Study ◽  
Cerebrovascular Diseases ◽  
Neutrophil To Lymphocyte Ratio ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Lymphocyte Ratio ◽  
Urine Albumin ◽  
Laboratory Index

Objective. The neutrophil-to-lymphocyte ratio (NLR) is an inexpensive and easily measurable laboratory index indicating systemic inflammation, while the application of many other inflammatory markers has been limited in daily clinical practice. However, large population studies about investigating the associations of the NLR level with diabetic complications including cardiovascular and cerebrovascular diseases (CVD), diabetic kidney disease (DKD), and diabetic retinopathy (DR) in the same population were limited. The aim of our study is to evaluate the associations between the NLR level and the prevalence of CVD, DKD, and DR in adults with diabetes simultaneously. Methods. A cross-sectional survey of 4,813 diabetic adults was conducted in seven communities in China. Persons underwent several medical examinations, including the measurement of anthropometric factors, blood pressure, routinely analyzed leukocyte characteristics, glucose, lipid profiles, urine albumin/creatinine ratio, and fundus photographs. Results. Compared with the first quartile of the NLR level, the odds of having CVD was significantly increased by 21% for participants in the highest quartile (OR 1.21; 95% CI 1.00, 1.47) (P for trend<0.05). Similarly, the prevalence of DKD among participants in the highest quartile of the NLR level was significantly increased by 150% (OR 2.50; 95% CI 1.95, 3.19) (P for trend<0.05). However, no association was found between the NLR level and the prevalence of DR (P for trend>0.05). These associations were all fully adjusted. Conclusions. A higher NLR level was associated with an increased prevalence of CVD and DKD, other than DR, in diabetic adults.

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