EFFECT OF NASAL MICROBIOTA ON THE LEVEL OF TOTAL IMMUNOGLOBULIN E IN BLOOD SERUM OF CHILDREN WITH BRONCHIAL ASTHMA

2020 ◽  
Vol 99 (2) ◽  
pp. 56-63
Author(s):  
M.I. Efimova ◽  
◽  
S.V. Krasilnikova ◽  
D.Yu. Ovsyannikov ◽  
T.I. Eliseeva ◽  
...  
Keyword(s):  
Blood Serum ◽  
Bronchial Asthma ◽  
Immunoglobulin E ◽  
Nasal Microbiota ◽  
Total Immunoglobulin

Correlation between Total Serum Immunoglobulin E (IgE) and Absolute Eosinophil Count (AEC) in Allergic Diseases In Children

2020 ◽  
Vol 7 (1) ◽  
pp. 5-9
Author(s):  
Dr. Mayank Surana ◽  
Dr. Vineeta Pande ◽  
Dr. Sharad Agarkhedkar ◽  
Dr. Ajit Teegala
Keyword(s):  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Eosinophil Count ◽  
Immunoglobulin E ◽  
Allergic Diseases ◽  
Total Ige ◽  
Serum Ige ◽  
Absolute Eosinophil Count ◽  
Serum Total Ige ◽  
Total Immunoglobulin

Allergy, is a clinical expression of soluble factors like IgE, histamine or eosinophils found in serum or plasma of such patients. The products that are responsible for allergy are called as Allergens. Allergens normally induce IgE production which leads to type 1 hypersensitivity response on subsequent exposure to the same allergen. The target organs are mostly nose, lung, skin and gastrointestinal tract. Atopy is also considered as a triad of Atopic dermatitis, allergic rhinitis and bronchial asthma. Raised serum IgE and AEC are proven indicators of allergic phenomenon. Various studies show relationship between serum Immunoglobulin E level and total eosinophil count in population suffering from allergic diseases. Serum total Immunoglobulin E, total eosinophil count and specific IgE are all helpful for the diagnosis and treatment of allergic diseases. Objectives: 1.To Evaluate Serum Total IgE level in Children with allergic diseases.2. To Evaluate Absolute Eosinophil Count (AEC) in children with allergic diseases.3. To Correlate Serum Total Immunoglobulin E Level and Absolute Eosinophil Count (AEC) with allergic diseases. Methodology: Cross sectional study with 100 children in the age group 2-12 years with nasopharyngeal allergies (like bronchial asthma and atopic rhinitis) and skin allergies (like atopic dermatitis, urticaria) ,eye allergies were enrolled and serum IgE levels and AEC levels was done. Results: In present study Absolute eosinophil count was raised in 58% of cases Serum IgE was raised in 54% of cases. In present study, of 58% cases with raised Absolute eosinophil count 81% (47 cases) showed raised serum IgE levels. Conclusion: Absolute eosinophil count and serum Total IgE has been considered as a significant marker of allergic state and can be used as a marker of allergic response in atopic individuals. Raised serum IgE and AEC are more in nasobronchial allergy as compare to other systemic allergies. The elevated level of serum Total IgE and Absolute Eosinophil Count both shows Significant Correlation thus can be considered as a dependable laboratory investigation in diagnosing and categorizing allergic diseases.

Bronchial asthma: lack of relationships between allergic factors, illness severity and psychosocial variables in adult patients attending an asthma clinic

1984 ◽  
Vol 14 (4) ◽  
pp. 847-852 ◽  
Author(s):  
Bruce J. Spittle ◽  
Malcolm R. Sears
Keyword(s):  
Bronchial Asthma ◽  
Social Factors ◽  
Immunoglobulin E ◽  
Illness Severity ◽  
Adult Patients ◽  
Psychosocial Variables ◽  
Psychosomatic Disorder ◽  
Serum Ige ◽  
Total Immunoglobulin

SynopsisThe relationships between illness severity, allergy as indicated by serum total immunoglobulin E, and various psychological and social factors were studied in 66 adult asthmatics. No substantial relationships were found between these factors. An earlier onset of illness before 3 years was associated with a higher serum IgE. These results do not support the commonly held concept that asthma is a ‘psychosomatic’ disorder.

scholarly journals Prevalence of bronchial asthma in young people living in industrial city

2014 ◽  
Vol 95 (4) ◽  
pp. 548-552
Author(s):  
I A Zakharova
Keyword(s):  
Body Mass Index ◽  
Young People ◽  
Body Mass ◽  
Bronchial Asthma ◽  
Immunoglobulin E ◽  
Expected Value ◽  
Newly Diagnosed ◽  
Industrial City ◽  
True Prevalence ◽  
Total Immunoglobulin

Aim. To reveal the true prevalence of asthma in young people living in a large industrial city. Methods. 1518 young persons aged 18-44 years (males - 698, females - 820, mean age 30.34±5.7 years) who attended outpatient clinics of the Clinical Hospital №4 of Chelyabinsk (12.9% of the total population served by the hospital) were randomly picked out. Respondents surveys were conducted, the determination of total immunoglobulin E levels were measured, patients underwent spirometry and were consulted by pulmonologist. Results. Diagnosis of bronchial asthma has been previously confirmed in 2.8% of patients, while in accordance with the Global Initiative for Asthma (GINA) criteria (2013), the true prevalence is 7.8%. In patients with newly diagnosed bronchial asthma body mass index was 26.32±6.3 kg/m2 compared to 24.53±4.9 kg/m2 in patients without asthma; level of total immunoglobulin E was 259.6±16.5 ME/ml vs 47.8±12,6 ME/ml respectively. Not only a decrease in spirometric indices of respiratory function (forced expiratory volume in 1st second (FEV1) was 69.2±8.1% of the expected value vs 105.6±9.1% in the group of healthy individuals, FEV1/FVC (forced vital capacity) ratio - 75.62±13.7% vs 84.2±12.9% respectively), but also a significant increase in total lung capacity (up to 94.5±18,8% of the expected value compared to 78.1±14.1% in the group of healthy subjects) and the residual lung volume (up to 102.2±14.5% vs 79.5±5.9% respectively), was registered in newly diagnosed patients with bronchial asthma indicating pathological process in the small airways, even in patients with small term of the disease. Conclusion. The incidence of bronchial asthma is more than 3 times higher than the official statistics report; in individuals with newly diagnosed bronchial asthma higher body mass index and total immunoglobulin E levels were registered in comparison with the general population.

MYCOPLASMA AND CHLAMYDIA AS ETHIOLOGICAL FACTORS OF BRONCHIAL ASTHMA IN TERMS OF ETHNOGENESIS

2013 ◽  
Vol 68 (7) ◽  
pp. 57-60
Author(s):  
O. A. Sharavii ◽  
S. V. Smirnova
Keyword(s):  
Immune Response ◽  
Chlamydia Trachomatis ◽  
Blood Serum ◽  
Bronchial Asthma ◽  
Mycoplasma Hominis ◽  
Acute Stage ◽  
Control Group ◽  
Clinical Markers ◽  
Chlamydophila Psittaci ◽  
Asthma Patients

 Aim. The study of the prevalence and clinical peculiarities of Mycoplasmosis and Chlamydiosis in patients with different pathogenic forms of bronchial asthma (BA) taking into account ethnicity of a patient. Subjects and Methods. The research covered 239 subjects – both the Europeoids and the Mongoloids in the city of Krasnoyarsk and the town of Kyzyl, all of them being BA patients of different stages, including acute stage and practically healthy. We had determined antigens Mycoplasma pneumoniae, Mycoplasma hominis, Chlamydophila pneumoniae, Chlamydophila psittaci and Chlamydia trachomatis in smears of mucosa of pharynx and antibodies to these antigens in peripheral blood serum. Results.  We found high frequency of Mycoplasmosis and Chlamydiosis in the inhabitants of Eastern Siberia, BA patients with different pathogenic forms as compared to control group. We had determined ethnic peculiarities of specific immune response: IgM to М. pneumoniae was revealed in the Europoids more frequently than in the Mongoloids, but IgM to С. pneumoniae and to C. trachomatis, C. trachomatis antigens had been revealed more often in the Mongoloids than in the Europoids. We accepted as clinical equivalents of Mycoplasmosis and Chlamydiosis diagnostics the following signs: temperature around 37C (subfebrile temperature), non-intensive but stable coughing with scanty mucous and muco-purulent sputum, dyspnea of mixed character. Conclusions. Mycoplasma and Chlamydia are meaningful etiologic factors of bronchial asthma. We have found the peculiarities of immune response depending on ethnicity of a patient (ethnic belonging). Clinical markers of Mycoplasmosis and Chlamydiosis should be taken into account in bronchial asthma in order to provide diagnostics timely as well as eradication of infection agents. Because of insufficient knowledge of problem of bronchial asthma related to contamination with Мycoplasma and Chlamydia we put the goal to study the frequency of Mycoplasmosis and Chlamydiosis occurrence in bronchial asthma patients and determine the characteristics clinical course of diseases. We defined antigens Мycoplasma pneumoniae, Мycoplasma hominis, Chlamydophila pneumoniaе, Chlamydophila psittaci, Chlamydia trachomatis in smears of oropharynx mucosa and antibodies to them in blood serum. 

Creatinuria and Dynamics of Calcium Metabolism in Children in the Phase of Exacerbation of Bronchial Asthma

2020 ◽  
Vol 16 (1) ◽  
pp. 28-33
Author(s):  
Vitalii B. Kaliberdenko ◽  
Shanmugaraj Kulanthaivel ◽  
Michael V. Shterenshis ◽  
Olga Y. Poleshchuk ◽  
Kadri Mametov ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Blood Serum ◽  
Bronchial Asthma ◽  
Picric Acid ◽  
Colorimetric Method ◽  
Cellular Level ◽  
Creatine Kinase Activity ◽  
Biological Medium ◽  
Creatinine Concentration ◽  
Test Kit

: Bronchial asthma is one of the most common and severe diseases among children. The phenomenon of creatinuria (CU) in patients with bronchial asthma (BA) has been acknowledged for a relatively long time. Aims: The Aim of the research is to study the level of creatinuria, creatinemia, creatine kinase activity, and the concentration of calcium in biological medium (blood, saliva, urine) in children suffering from an intermittent and persistent form of asthma during the period of exacerbation. Material and methods:: The research consists of 102 children with asthma who were treated in inpatient department in Simferopol Clinic. The intermittent course of asthma was recorded in 49 children and a persistent course of asthma was recorded in 53 children. The subject of study was blood serum and daily urine of observed patients. The level of calcium in the biological medium was studied using the "Filisit" test kit (Dnipro) and the activity of the creatine kinase by test set "Lahma". The levels of creatine and creatinine were determined using a colorimetric method based on a color reaction with picric acid. Results and conclusion: : The analysis testifies that creatinuria in children with persistent BA is caused by the disorder of the phosphorylation process rather than the disorder of creatinin rephosphorylation synthesis, that is testified by the normal creatinine level. In children with persistent BA, there is а decrease of creatinine concentration in the blood serum and urine during the exacerbation period and early post exacerbation period. The low activity of creatinine kinase at the background of creatinine elimination is typical for the children in the phase of exacerbation of persistent form of BA, though its level remains to be sufficient for the synthesis of the necessary amount of creatinine phosphate. Conclusion: The processes of creatinuria and calciuria in children suffering from a persistent form of BA are interdependent, that is testified by the data of correlative analysis. In connection with this, it is possible to consider the change of calcium homeostasis in the pathogenesis of the disease as one of the causes of distributing the creatinine metabolism on the cellular level.

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