scholarly journals Clinicopathological Evaluation of Eyelid and Conjunctival Lesions in Patients of Farshchian Hospital in Hamadan

2018 ◽  
Vol 3 (3) ◽  
pp. 120
Author(s):  
Fateme Eslami ◽  
Hamidreza Ghasemibasir
Keyword(s):  
Clinical Diagnosis ◽  
Malignant Tumors ◽  
Histopathological Examination ◽  
Age Groups ◽  
Final Diagnosis ◽  
Histological Diagnosis ◽  
Bulbar Conjunctiva ◽  
Benign Lesions ◽  
Cross Sectional ◽  
Clinical Appearance

Introduction: The lesions of the eyelid and conjunctiva are benign and malignant. The ratio of benign lesions is more than the malignant, increases with age, and are easily diagnosed clinically. However, in some cases, the clinical diagnosis of malignant tumors is impossible, necessitating the final diagnosis by histopathological examination. The incidence of benign and malignant tumors differs between countries according to the genetics of the racial population or environmental factors.Materials and methods: This cross-sectional descriptive study was conducted on 424 patients with eyelid and conjunctival lesions from the Farshchian Hospital of Hamadan between 2010–2014. The final pathological report, clinical diagnosis, demographic variables including age and gender, site of lesions, and clinical appearance were extracted from medical records.Results: The lesions consisted of 159 (37.5%) eyelid and 265 (62.5%) conjunctival lesions. The predominant location was bulbar conjunctiva (35.1%), and the least was external canthus (1.7%). The most frequent lesion based on clinical diagnosis was pterygium (51.7%), and the least frequent was sebaceous glands carcinoma. The most frequent lesion based on histological diagnosis was pterygium (52.5%), and the least frequent was xanthelasma. In this study, the concordance between clinical and histological diagnosis was 90.3% that indicated the physician’s accurate diagnosis.Conclusion: According to this study, the frequency of eyelid and conjunctival lesion was similar in males and females. The prevalence of lesions in >60-year-olds is more common than that in other age groups. The benign lesions of eyelids and conjunctiva are common than malignant lesions. Despite high clinicopathological concordance, the physician should always consider the rare cases, and the pathological diagnosis must be considered for all specimens.

scholarly journals The Frequency and Causes of Subepidermal Gaps or Blisters and the Compliance Rate Between Clinical Diagnosis and Pathology Reports from 2015 to 2019

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Abbas Darjani ◽  
Hojat Eftekhari ◽  
Seyedeh Rojin Amini Rad ◽  
Narges Alizadeh ◽  
Rana Rafiee ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Skin Diseases ◽  
Histopathological Examination ◽  
Compliance Rate ◽  
Clinical Manifestations ◽  
Final Diagnosis ◽  
Direct Immunofluorescence ◽  
Diagnostic Challenge ◽  
Cross Sectional ◽  
Pathology Reports

Background: Skin diseases are the fourth most common cause of human illness, and blisters with different clinical manifestations make a diagnostic challenge. Objectives: This study aimed to evaluate the frequency and causes of subepidermal gaps or blisters, as well as the compliance rate between the initial and final clinical diagnoses based on pathology reports. Methods: In this cross-sectional study, pathology reports of subepidermal blisters or gaps were evaluated in the patients referred to the Razi Laboratory of Rasht from 2015 to 2019. The samples were examined by a pathologist after hematoxylin and eosin staining. The reports included demographic information, clinical differential diagnoses, final diagnosis, direct immunofluorescence findings, and salt split results. Finally, the compliance rate of clinical diagnosis with pathology reports was determined. Results: A total of 183 pathology reports were evaluated, 170 of which contained the final diagnosis. Females were more frequently affected by the disease, and pemphigoid bolus and lichen planus were the most prevalent final diagnoses. The compliance rate between the initial and final diagnoses was 94%. About 37.2% of the reports lacked direct immunofluorescence (DIF) and salt split, and only 42.6% of the samples had undergone DIF examination, while 20.2% had both DIF and salt split. There was no significant association between the compliance rate of the final diagnosis with age, sex, and undergoing diagnostic tests. Conclusions: A high incidence of subepidermal gaps or blisters was seen in middle-aged individuals and females. The compliance rate of the initial clinical diagnosis with the final diagnosis based on pathological reports was high. Our findings emphasize the importance of histopathological examination and the complementary role of direct immunofluorescence and salt split in diagnosis.

scholarly journals Solitary Schwannoma on the Hypothenar Region of the Hand: A Literature Review

2020 ◽  
Vol 5 (10) ◽  
pp. 449-452
Author(s):  
Kastanis G ◽  
Kapsetakis P ◽  
Magarakis G ◽  
Bachlitzanaki M ◽  
Christoforidis C ◽  
...  
Keyword(s):  
Literature Review ◽  
Clinical Diagnosis ◽  
Peripheral Nerves ◽  
Histopathological Examination ◽  
Final Diagnosis ◽  
Benign Tumors ◽  
Rare Manifestation ◽  
Histopathological Evidence ◽  
Volar Surface

Schwannomas or neurilemmomas are the most common benign tumors of the neural sheaths of the peripheral nerves. Incidence of these tumors in the hand accounts to 0.8-2%. The majority of them appear as an isolated grown mass along the route of the nerves. Peripheral nerves benign tumors present many difficulties concerning the clinical diagnosis and only histopathological evidence provides the final diagnosis. In this case study, we present a 45 year old man with a grown asymptomatic mass on the volar surface of right hand (hypothenar) remained for two years and impinging the skin of the hand only the last months. Initial MRI results diagnosed the mass as gaglion cyst. Histopathological examination revealed a schwannoma. We present this case as a rare manifestation of a schwannoma in hypothenar area of the hand. A literature review of diagnoses and therapeutic management is also presented.

scholarly journals A study of gastrointestinal tumors at kathmandu medical college teaching hospital

2018 ◽  
Vol 8 (1) ◽  
pp. 1285-1288
Author(s):  
Sailesh Bahadur Pradhan ◽  
Binita Pradhan ◽  
Sailuja Maharjan ◽  
Prabin Bikram Thapa
Keyword(s):  
Gastrointestinal Tract ◽  
Teaching Hospital ◽  
Histopathological Examination ◽  
Benign Lesion ◽  
Malignant Lesion ◽  
College Teaching ◽  
Age Group ◽  
Benign Lesions ◽  
Cross Sectional ◽  
Medical College

Background: Gastrointestinal tract tumour is responsible for more cancers and death than any other cancers.  The tumour in GIT include the tumour of the Oral cavity, Esophagus, Stomach, Colon, Rectum, Liver, Gallbladder, Pancreas and Biliary tree.Materials and methods: A cross sectional study was carried out among all the gastrointestinal tract tumours specimens received for histopathological examination in between January 2016 to June 2017 in Department of Pathology, Kathmandu Medical College Teaching Hospital. All tumors diagnosed either benign or malignant were included in this study. Ethical clearance was obtained from the Institutional Review Committee in KMCTH.Results: Colorectum was found to be the most commonly involved site for malignant lesion comprising 40.2% among all malignant lesions followed by stomach comprising 28.6%. Malignancy was found to be more prevalent among male with M:F ratio of 1.6:1 in colorectal region and 1.4:1 in stomach cancers. Regarding benign lesions (polyps), rectum was found to be the commonest site (57.5%), followed by colon (20.0%) and stomach, the least common site.Malignant lesions were more common among the age group of 51-60 years (37.66%) with 70.13% above 50 years. Benign lesions were also found to be the most common above 50 years comprising 40.0 percent.Conclusion: Rectum & colon was found to be the most commonly involved site for both malignant and benign lesion. Malignancy is more prevalent among male and common above 50 years of age. However, malignant cases noted in the adult age group are a matter of great concern.

scholarly journals Hepatocellular Carcinoma Is the Most Frequent Final Diagnosis of Focal Liver Lesions Identified in a Cross-Sectional Evaluation of Patients with Chronic Liver Disease in Saudi Arabia

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Adnan Agha ◽  
Manuele Furnari ◽  
Rafaat Morched Chakik ◽  
Mamdouh M. Abdulhadi Ali ◽  
Dib Alsaudi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Odds Ratio ◽  
Final Diagnosis ◽  
Liver Lesion ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Benign Lesions ◽  
Cross Sectional

Background. Hepatocellular carcinoma (HCC) is a frequent diagnosis in patients with chronic liver disease (CLD) and a newly identified liver lesion, although benign diseases may also be responsible for this finding. Objective. To evaluate the characteristics of focal liver lesions in a population of patients with CLD not under surveillance for HCC in the Middle East. Methods. We performed a cross-sectional study evaluating 77 patients with CLD and a focal liver lesion identified during ultrasonography. Patients’ characteristics were analyzed on the basis of the final diagnosis (HCC versus benign lesions). Results. The most frequent diagnosis was HCC (64.9%). These patients were older (median age 64 versus 55 years, P=0.003) and cirrhotics (80.0% versus 51.9%, P=0.018), with multinodular lesions (58.0% versus 29.6%, P=0.031) and portal vein thrombosis (24.0% versus 0%, P=0.001) compared to patients with benign lesions. Prevalence of elevated alpha-fetoprotein (>10 ng/mL) was similar in both groups (80.0% versus 88.9%, P=0.198). Cirrhosis (odds ratio: 3.283) and multinodularity (odds ratio: 2.898) were independently associated with HCC. Conclusions. HCC is the most common diagnosis in Middle-Eastern patients with CLD and a liver lesion identified outside HCC surveillance programs, especially in cirrhotic patients. In these patients, elevated alpha-fetoprotein does not differentiate HCC from benign lesions.

scholarly journals Histopathological Evaluation of Lymph Node Biopsies: A Hospital Based Study

2012 ◽  
Vol 2 (1) ◽  
pp. 8-14
Author(s):  
Md Atiqur Rahman ◽  
Md Mamun Ali Biswas ◽  
Syeda Tasfia Siddika ◽  
Abdul Mannan Sikder
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Hodgkin Lymphoma ◽  
Histopathological Examination ◽  
Age Groups ◽  
The Body ◽  
Cross Sectional ◽  
Cervical Lymph Nodes ◽  
Female Ratio ◽  
Histopathological Evaluation

Background: Lymphadenopathy is a common manifestation of a large variety of disorders,both benign and malignant. It is essential to define the pattern of disorders presenting primarily as lymph node enlargement in a particular environment. Histopathological examination of the lymph node biopsies is a gold standard test in the distinction between reactive and malignant lymphoid proliferations as well as for detailed subtyping oflymphomas. We designed this study in our population for histopathological evaluation of lymph nodes that might be helpful for clinical management of these lesions. Objective: Histopathological evaluation of lymphadenopathy from excised specimen, in relation to ageand sex of the patients, and distribution of the lymph nodes. Materials and Methods: It was a retrospective cross sectional study conducted in the department of Pathology, Enam MedicalCollege & Hospital, Savar, Dhaka during the period from January 2006 to December 2010. Lymph node biopsies of all patients of both sexes and all age groups were included.Metastatic lymph nodes associated with evidence of primaries elsewhere in the body were excluded from the study. Total 191 lymph node biopsies were selected for histopathological evaluation. Among these 90 (47.12%) were from males and 101 (52.88%) were from females with male to female ratio being 1:2.1. The age of the patients ranged from 2 to 85 years with a mean age of 35.73 ± 18 years. Results: Cervical lymph nodes were the most common (56%) biopsied group. Of the 191 cases 59 cases (30.89%) were reactive lymphadenitis, 64 cases (33.5%) were tuberculosis, 2 cases (1.05%) were non-caseous granuloma, 11 cases (5.76%) were Hodgkin lymphoma, 22 cases (11.52%) were non-Hodgkin lymphoma, 24 cases (12.57%) were metastatic neoplasm and 9 cases (4.7%) were other lesions.Conclusion: Tuberculosis was the most common cause of lymphadenopathy, followed by reactive lymphadenitis and the cervical group of lymph nodes was most frequently affected. DOI: http://dx.doi.org/10.3329/jemc.v2i1.11915 J Enam Med Col 2012; 2(1):8 -14

scholarly journals Frequency of Ovarian Tumors According to WHO Histological Classification and Their Association to Age at Diagnosis

2017 ◽  
Vol 23 (2) ◽  
Author(s):  
Muhammad Arif Khan ◽  
Saira Afzal ◽  
Hassan Saeed ◽  
Hnia Usman ◽  
Rooqash Ali ◽  
...  
Keyword(s):  
Ovarian Neoplasms ◽  
Malignant Tumors ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Ovarian Tumors ◽  
Age At Diagnosis ◽  
Surface Epithelium ◽  
Histological Classification ◽  
Cross Sectional ◽  
Neoplastic Lesions

Ovarian tumors, or ovarian neoplasms, are benign or malignant tumors arising from the ovaries. They may arise from any of the three components of ovary i.e. surface epithelium, germ cells and the stroma of the ovary including sex cords. Tumors in the ovary can also be secondary or metastatic tumors.Objective:  To determine the frequency of Ovarian Tumors according to WHO Histological classification and their relation to age at diagnosis in almost one year.Methods:  A cross-sectional study was carried out, that included all the consecutive cases of ovarian neoplasms diagnosed at the Pathology department of a public sector university in Lahore from 1 January 2015 to 13 February 2016.Results:  In 95 female patients diagnosed with ovarian tumors, the mean age was found to be 29.58 ±11.493 with a range of 3-65 years. Tumors were most common between the ages of 15 to 30 years. The highest rates of malignancy were in the 0-15 and 45-60 age groups (Figure 1). About 78.9% of the tumors (75/95) were benign, 1.1% (1/95) were borderline and 20% (19/95) were malignant (Figure 3), 72.6% (69/95) were epithelial tumors, 23.2% (22/95) were germ cell and 4.2% (4/95) were sex cord stromal tumors (Figure 4). Among the 95 cases, serous tumors were the most common (49.5%), followed by mucinous (16.8%) and teratomas (15.8%).Conclusion:  According to our study, ovarian tumors were common between the age of 15 to 29 years. Benign neoplastic lesions were more common than malignant neoplastic lesions. The frequency of malignant and benign ovarian neoplasms found in our research differed from other studies conducted in Pakistan. There is a significant association of ovarian tumors in age less than 30 year as compared to older age groups (P < 0.001).

scholarly journals Epidemiology of Primary Malignant Bone Tumors in Isfahan Province, Iran

2019 ◽  
Vol 6 (4) ◽  
pp. 7-12
Author(s):  
Hossein Akbari Aghdam ◽  
◽  
Azin Mohammad-Salehi ◽  
Hamed i Zandi-esfahan ◽  
Mohsen Heidari ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Malignant Tumors ◽  
Age Groups ◽  
Soft Tissue Tumors ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Isfahan Province ◽  
Medical Centers ◽  
Study Results ◽  
Epidemiological Characteristics

Background: Primary malignant tumors, including rare tumors of the skeleton, are of concern. However, the unpredictable prognosis, morbidity, and mortality of these tumors have raised them as one of the health problems. Objectives: This study was designed to evaluate the epidemiological characteristics of these tumors in Isfahan province, Iran. Methods: In this cross-sectional study, 489 patients with malignant bone and soft tissue tumors were enrolled from 2006 to 2016. Their data were available in Isfahan medical centers, and their diagnostic biopsies from their hospitals’ records were examined. The data were statistically analyzed using SPSS. Results: The most common tumors were in the descending order: Osteosarcoma (15.1%), Ewing sarcoma (13.7%), chondrosarcoma (13.1%), fibrosarcoma and neurofibrosarcoma (10.8%), malignant fibrous histiocytoma (7.8%), synovial sarcoma (6.7%), liposarcoma (6.5%), dermatofibrosarcoma (3.3%), rhabdomyosarcoma (3.1%), and leiomyosarcoma (3.1%). Other sarcomas comprised 16.8%. The highest prevalence of tumors was in Isfahan city. Conclusion: This study was conducted for the first time in Isfahan Province to evaluate the epidemiological characteristics of malignant bone and soft tissue tumors. Our study results were similar to most studies conducted in different regions of the world. Considering the relatively high prevalence of malignant bone and soft tissue tumors in lower age groups, we recommend further studies in this area to manage this problem.

scholarly journals Study on morphological changes in the gall bladder mucosa associated with cholelithiasis.

2020 ◽  
Vol 27 (08) ◽  
pp. 1753-1762
Author(s):  
Shamshad Bano ◽  
Lal Bakhsh ◽  
Gulshad Wagan ◽  
Asad Ali Zardari ◽  
Mohammad Anwar Bangulzai ◽  
...  
Keyword(s):  
Gall Bladder ◽  
Histopathological Examination ◽  
Morphological Changes ◽  
Age Groups ◽  
Morphological Type ◽  
The Body ◽  
P Value ◽  
Bladder Mucosa ◽  
Cross Sectional ◽  
Gallbladder Mucosa

Cholelithiasis is known to produce diverse histopathological changes in the gallbladder mucosa. Objectives: To observe the morphological changes in the gall bladder mucosa associated with cholelithiasis. Study Design: Descriptive Cross Sectional study. Setting: Department of Anatomy, Jamshoro with collaboration of Department of Pathology, LUMHS, Jamshoro. Period: April 2016 to October 2016. Material and Methods: All the cases after diagnosis of cholelithiasis with all age groups (20 to 50 years) in male and female were included. Gallstones were assessed for various parameters, i.e., number, size, and morphological type. Gallbladder mucosa was subjected to histopathological examination. Sections of the body, the fundus and the bottom of the gallbladder were drawn. 01 cm of the body, the body, and the bottom of the gallbladder were drawn from the funduse and prepared for histological research. Data was statistically analyzed by SPSS (Statistical Package of Social Sciences) version 22.0. Results: Total 87 cases were selected and average age of 49.95±6.14 years of male was seen in a gall bladder width and length in the gallbladder and gallbladder length in both sex of P-value 0.07 while male of female average were 41.30añ6.62, age range from 30 to 52 years. Sixty-seven (77.0%) cases had multiple stones. 29 (33.3 percent) patients had congested the serological layer, while 58 (66.7 percent) were usually impacted. Mucosa hemorrhagic in 22(25.3%) cases, atrophic in 51(58.6%) cases and nodular in 4(4.6%) cases. 36(41.4%) gall bladders reported normal results, 41(47.1%), 1(1.1%), and 3(3.4%) were identified with Fibrosis, and 2(2.3%) are found with Fibrosis. Many cases were linked to fibrosis, dysplasia, and hyperplasia, compared to single calculus (P value 0.048). There was no substantial difference between normal and thickened gall bladders in the microscopic tests (P value 0.26). Fibrosis, dysprasia and hyperplasia are correlated mainly with internal mucus detections (P value 0.002). Hemorrhagic mucous membranes are found mainly. Conclusion: Hemorrhagic and fibrotic changes were the most common mucosal findings, and significantly associated with multiple cholelithiasis.

scholarly journals Simple vs ugly adnexal lesions: is ultrasonography alone good enough?

2019 ◽  
Vol 7 (8) ◽  
pp. 3020
Author(s):  
Rahul Dev Chauhan ◽  
Yashvir Mathur
Keyword(s):  
Histopathological Examination ◽  
Imaging Modality ◽  
Cross Sectional Study ◽  
Colour Doppler ◽  
Benign Lesions ◽  
Cross Sectional ◽  
Adnexal Masses ◽  
Cross Sectional Imaging ◽  
Ovarian Masses

Background: Ultrasound (USG) is easily available and effective imaging modality for adnexal lesions. A simple looking lesion on ultrasound is usually benign and an ugly looking adnexal lesion is either benign or malignant. This study aims to evaluate the varied appearance of simple and ugly benign adnexal lesions on USG and to find out any additional role of colour Doppler in such suspected benign lesions. The confirmation of diagnosis was done either by follow up appearance of lesions on USG or by histopathological evaluation.Methods: A total of 55 consecutive female patients with age between 18 to 50 years were enrolled in this prospective cross sectional study. USG and colour Doppler for all the lesions were done. The patients found to have malignant lesions on histopathological examination, were later excluded from the analysis. Follow up USG was done for all the cases. Those cases wherein there was no resolution of lesions even after 08 weeks, were given an option to undergo laparoscopy as next management step.Results: Out of 50 benign adnexal masses, 88% masses were ovarian in origin and 12% were tubal masses. Ovarian masses included hemorrhagic cysts, endometriosis, simple cysts, serous cystadenomas and ovarian dermoid. All extra-ovarian masses were hydrosalpinx. Colour Doppler did not add any additional finding. Some of the patients underwent diagnostic laparoscopy followed by excision of masses in majority of them.Conclusions: Benign adnexal lesions can have varied appearance ranging from simple to ugly on USG. Ultrasonographic features of benign lesions on USG can be appreciated very well even without further use of colour Doppler or cross sectional imaging. Follow up USG remains key modality for benign adnexal masses in absence of MRI.

scholarly journals Histopathological diagnosis of ovarian mass

2018 ◽  
Vol 8 (1) ◽  
pp. 1261-1264
Author(s):  
Shahali Shadab ◽  
Tadayon Tadayon
Keyword(s):  
Malignant Tumors ◽  
Histopathological Examination ◽  
Age Groups ◽  
Germ Cell Tumors ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Benign Tumors ◽  
Histopathological Diagnosis ◽  
Hospital Data ◽  
Ovarian Masses

Background:  Ovarian cysts are common forms of gynecological problems that can be range from physiological cysts to highly aggressive neoplastic lesions. The purpose of this study was to investigate prevalence and frequency of different histopathological patterns of ovarian lesions and their correlation with various parameters in Ahvaz, Iran.Materials and Methods: This is the retrospective study of patients with the ovarian masses at Ahvaz Imam Khomeini Hospital from 2010 - 2015. The relevant clinical details about the patient were retrieved from hospital data. Clinical characteristics of patients such as patient's age, presenting signs and symptoms, histopathological diagnosis, mass type, mass subtype, size of cysts and ovary which is involved were noted. Results: Two hundred sixty seven specimens of ovarian tumor obtained for histopathological examination. Of these, 163(61.0%) were tumor like, 96(36.0%) were benign tumor and 8(3.0%) were malignant. The most common tumor like conditions was Corpus luteum cyst (43.4% cases), among benign and malignant tumors, mature cystic teratoma (17.2% of total) and Epithelial tumors (n=4) were most common. There is a statistically significant positive relation between age and various ovarian masses. (P= 0.002). Histopathological diagnosis wasn't correlated with ovarian involvement.Conclusion: Benign tumors are more common than malignant tumors in all age groups. Germ cell tumors followed by surface epithelial cell tumors are the commonest tumor. Mature cystic teratoma was the most common tumor. Unilaterality is more frequently seen in ovarian tumors and various tumors are seen in various age groups.

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