Anti-diabetic and hepato-renal protective potential of hydroalcoholic extract of Teucrium polium in alloxan-induced diabetic rats

2022 ◽  
Author(s):  
Ali Nouri ◽  
Hossein Amini-Khoei ◽  
Mahmoud Rafieian-Kopaei ◽  
Mohammad Rahimi-Madiseh
Keyword(s):  
Diabetic Rats ◽  
Hydroalcoholic Extract ◽  
Protective Potential ◽  
Teucrium Polium

scholarly journals GLUCOSE HOMEOSTATIC AND PANCREAS PROTECTIVE POTENTIAL OF TECOMELLA UNDULATA ROOT EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC RATS .

2017 ◽  
Vol 10 (6) ◽  
pp. 292
Author(s):  
Kanwar Lal ◽  
Ashok Purohit ◽  
Heera Ram
Keyword(s):  
Hematological Parameters ◽  
Ethanolic Extract ◽  
Serum Biochemistry ◽  
Diabetic Rats ◽  
The Body ◽  
Root Extract ◽  
Standard Drug ◽  
Protective Potential ◽  
Normal Ranges ◽  
Tecomella Undulata

Objective: The study was aimed to evaluate glucose homeostatic and pancreas protective potential of Tecomella undulata root extract in streptozotocin induced diabetic rats.Methods: The ethanolic root extract was prepared by following standard soxhlation methods. The experimental design was divided in to control and treated groups for 28 days of comparative experimental schedule. The body and organ weights, serum biochemistry, histo-pathology, hematology and toxicity profiles were assayed by following standard methods and protocols.Results: The treatment of ethanolic extract of root of T. undulata was significantly (p ≤ 0.001) reduced glucose levels at 7day, 14day, 21day and 28 days in comparison to standard drug of metformin. Correspondingly, lipid profile i.e. total cholesterol, HDL, VLDL, LDL and triglyceride were also altered significantly. Whereas, body and organs weight and hematological parameters were not shown significant changes. Subsequently, toxicity profile i.e. hepatic and renal parameters were remained under normal ranges. Corresponding, the treatment of ethanolic root extract caused normalcy of histoarchitecture of pancreas in comparison to standard drugs.Conclusion: The results of study illustrated that Tecomella undulata root extract possessing particular kind of phytocompounds which caused glucose homeostatic and pancreas protective potential in diabetic rats.

The Effect of Hydroalcoholic Extract of Ferulago angulata on Liver Function Parameters and Antioxidant Status in Alloxan-Induced Diabetic Rats

2017 ◽  
Vol 20 (2) ◽  
pp. 1-9 ◽  
Author(s):  
Seyedeh-Fatemeh Mousavi-Ezmareh ◽  
Mohammad Mazani ◽  
Esfandiar Heidarian ◽  
Reza Alipanah Moghadam ◽  
Mahmoud Rafieian-kopaei ◽  
...  
Keyword(s):  
Liver Function ◽  
Antioxidant Status ◽  
Diabetic Rats ◽  
Hydroalcoholic Extract

scholarly journals The Protective Effect of Marigold Hydroalcoholic Extract in STZ-Induced Diabetic Rats: Evaluation of Cardiac and Pancreatic Biomarkers in the Serum

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Esmaeel Ebrahimi ◽  
Saeed Shirali ◽  
Rahman Talaei
Keyword(s):  
Diabetes Mellitus ◽  
Protective Effect ◽  
Antioxidant Property ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Dependent Manner ◽  
Hydroalcoholic Extract ◽  
Diabetic Control Group ◽  
Male Wistar Rats

Diabetes mellitus is the most common endocrine disorder worldwide and it is usually along with complications such as retinopathy, neuropathy, nephropathy, and cardiovascular disease. The prevalence of diabetes is increasing and its treatment has created concerns in society. The use of herbal medicine can be helpful in the management of diabetes mellitus. The aim of this study was to investigate the protective effect of marigold hydroalcoholic extract under diabetes condition. A total of 36 male Wistar rats were randomly divided into four groups: normal control group, diabetic control group, and groups treated with 250 or 500 mg/kg hydroalcoholic extract of marigold flower during four weeks. At the end of the study, the rats were anesthetized with ketamine/xylazine, and sampling was performed through cardiac puncture. The results showed that treatment with marigold improved body weight. In addition, we determined that marigold normalized the level of CK-MB, total CK, amylase, and lipase in a dose-dependent manner. Probably these effects resulted from antioxidant property of marigold; thus we suggest that marigold flower can be useful for reduction of diabetes complication.

scholarly journals Evaluation of Antidiabetic and Antihyperlipidemic Effects of Peganum harmala Seeds in Diabetic Rats

Cholesterol ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Gholamreza Komeili ◽  
Mohammad Hashemi ◽  
Mohsen Bameri-Niafar
Keyword(s):  
Total Cholesterol ◽  
Glycosylated Hemoglobin ◽  
Diabetic Rats ◽  
Male Rats ◽  
Peganum Harmala ◽  
Hydroalcoholic Extract ◽  
End Of Treatment ◽  
Total Antioxidant ◽  
Treatment Of Diabetes ◽  
Different Doses

The present study was carried out to investigate the antidiabetic and antihyperlipidemic properties of hydroalcoholic extract of Peganum harmala in streptozotocin-induced diabetic male rats. In an experimental study, 64 normal Wistar albino male rats (200–230 g) were randomly divided into 8 groups. Control and diabetic rats were treated with normal saline and three different doses (30, 60, and 120 mg/kg) of hydroalcoholic extract of Peganum harmala seeds for 4 weeks orally. At the end of treatment, blood samples were taken and glucose, triglycerides, total cholesterol, LDL-c, HDL-c, malondialdehyde (MDA), total antioxidant capacity (TCA), ALT, AST, GGT, bilirubin, and glycosylated hemoglobin (HbA1C) were determined. STZ-induced diabetic rats showed significant changes in the values of glucose, triglycerides, total cholesterol, LDL-c, MDA, TAC, ALT, AST, GGT, bilirubin, and HbA1C in comparison with normal rats. Administration of the extract to diabetic rats resulted in a remarkable decrease in glucose, lipid profiles, MDA, ALT, AST, GGT, bilirubin, and HbA1C levels and increase in TAC relative to diabetic group. The results of this study indicated that hydroalcoholic extract of Peganum harmala seeds possesses antidiabetic and hypolipidemic activities and could be useful in treatment of diabetes.

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