MicroVolt Variations of The Human Brain (Quantitative Electroencephalography) Display Differential Torque Effects During West-East versus North-South Orientation in the Geomagnetic Field

2016 ◽  
Vol 12 (2) ◽  
pp. 4255-4259
Author(s):  
Michael A Persinger ◽  
David A Vares ◽  
Paula L Corradini
Keyword(s):  
Human Brain ◽  
Geomagnetic Field ◽  
Neuronal Cell ◽  
Single Subject ◽  
Additional Energy ◽  
Actual Measurement ◽  
Neuronal Processes ◽  
Basic Physics ◽  
Order Of Magnitude ◽  
The Moment

                The human brain was assumed to be an elliptical electric dipole. Repeated quantitative electroencephalographic measurements over several weeks were completed for a single subject who sat in either a magnetic eastward or magnetic southward direction. The predicted potential difference equivalence for the torque while facing perpendicular (west-to-east) to the northward component of the geomagnetic field (relative to facing south) was 4 μV. The actual measurement was 10 μV. The oscillation frequency around the central equilibrium based upon the summed units of neuronal processes within the cerebral cortices for the moment of inertia was 1 to 2 ms which are the boundaries for the action potential of axons and the latencies for diffusion of neurotransmitters. The calculated additional energy available to each neuron within the human cerebrum during the torque condition was ~10-20 J which is the same order of magnitude as the energy associated with action potentials, resting membrane potentials, and ligand-receptor binding. It is also the basic energy at the level of the neuronal cell membrane that originates from gravitational forces upon a single cell and the local expression of the uniaxial magnetic anisotropic constant for ferritin which occurs in the brain. These results indicate that the more complex electrophysiological functions that are strongly correlated with cognitive and related human properties can be described by basic physics and may respond to specific geomagnetic spatial orientation.

scholarly journals Transcribed enhancers in the human brain identify novel disease risk mechanisms

2021 ◽  
Author(s):  
Pengfei Dong ◽  
Gabriel E. Hoffman ◽  
Pasha Apontes ◽  
Jaroslav Bendl ◽  
Samir Rahman ◽  
...  
Keyword(s):  
Human Brain ◽  
Disease Risk ◽  
Association Studies ◽  
Population Level ◽  
Cell Type ◽  
Level Variation ◽  
Functional Interpretation ◽  
Neuropsychiatric Diseases ◽  
Order Of Magnitude ◽  
Cell Type Specific

Enhancer RNAs (eRNAs) constitute an important tissue- and cell-type-specific layer of the regulome. Identification of risk variants for neuropsychiatric diseases within enhancers underscores the importance of understanding the population-level variation of eRNAs in the human brain. We jointly analyzed cell type-specific transcriptome and regulome data to identify 30,795 neuronal and 23,265 non-neuronal eRNAs, expanding the catalog of known human brain eRNAs by an order of magnitude. Examination of the population-level variation of the transcriptome and regulome in 1,382 brain samples identified reproducible changes affecting cis- and trans-co-regulation of eRNA-gene modules in schizophrenia. We show that 13% of schizophrenia heritability is jointly mediated in cis by brain gene and eRNA expression. Inclusion of eRNAs in transcriptome-wide association studies facilitated fine-mapping and functional interpretation of disease loci. Overall, our study characterizes the eRNA-gene regulome and genetic mechanisms in the human cortex in both healthy and disease states.

scholarly journals On the 2PN Periastron Precession of the Double Pulsar PSR J0737–3039A/B

Universe ◽  
2021 ◽  
Vol 7 (11) ◽  
pp. 443
Author(s):  
Lorenzo Iorio
Keyword(s):  
General Relativity ◽  
Present Author ◽  
Moment Of Inertia ◽  
The Other ◽  
Orbital Elements ◽  
Binary Pulsars ◽  
Orbital Phase ◽  
Order Of Magnitude ◽  
General Relativistic ◽  
The Moment

One of the post-Keplerian (PK) parameters determined in timing analyses of several binary pulsars is the fractional periastron advance per orbit kPK. Along with other PK parameters, it is used in testing general relativity once it is translated into the periastron precession ω˙PK. It was recently remarked that the periastron ω of PSR J0737–3039A/B may be used to measure/constrain the moment of inertia of A through the extraction of the general relativistic Lense–Thirring precession ω˙LT,A≃−0.00060∘yr−1 from the experimentally determined periastron rate ω˙obs provided that the other post-Newtonian (PN) contributions to ω˙exp can be accurately modeled. Among them, the 2PN seems to be of the same order of magnitude of ω˙LT,A. An analytical expression of the total 2PN periastron precession ω˙2PN in terms of the osculating Keplerian orbital elements, valid not only for binary pulsars, is provided, thereby elucidating the subtleties implied in correctly calculating it from k1PN+k2PN and correcting some past errors by the present author. The formula for ω˙2PN is demonstrated to be equivalent to that obtainable from k1PN+k2PN by Damour and Schäfer expressed in the Damour–Deruelle (DD) parameterization. ω˙2PN actually depends on the initial orbital phase, hidden in the DD picture, so that −0.00080∘yr−1≤ω˙2PN≤−0.00045∘yr−1. A recently released prediction of ω˙2PN for PSR J0737–3039A/B is discussed.

scholarly journals The Near-Synchronous Polar Candidate V4633 Sgr (Nova Sagittarii 1998)

2004 ◽  
Vol 190 ◽  
pp. 176-177
Author(s):  
Y. Lipkin ◽  
E. M. Leibowitz
Keyword(s):  
Angular Momentum ◽  
Momentum Transfer ◽  
White Dwarf ◽  
Moment Of Inertia ◽  
The Other ◽  
Angular Momentum Transfer ◽  
Classical Nova ◽  
Order Of Magnitude ◽  
Photometric Monitoring ◽  
The Moment

AbstractThe classical nova V4633 Sgr (1998) exhibits two photometric periodicities. The shorter period (P1=3.01 hr) is stable, while the other one, longer by ~2.5%, has decreased monotonically since shortly after the nova eruption, with Ṗ2 ≈ –10−6 (Lipkin et al. 2001).Here we report on results of photometric monitoring of the star in 2001 and 2002. During our observations, the longer period decreased more, and in 2002 it was only 1.8% longer than P1 The decrease rate (Ṗ2) in 2001-2002 was an order of magnitude smaller than in 1998-2000.These new results support the Near-Synchronous Polar classification which was suggested for V4633 Sgr (Lipkin et al. 2001). In this model, the longer period of V4633 Sgr is the spin of the white dwarf, and its variation since 1998 reflects changes in the moment of inertia of the white dwarf, and angular momentum transfer in the system following the nova eruption.

scholarly journals MCT2 is a Major Neuronal Monocarboxylate Transporter in the Adult Mouse Brain

2002 ◽  
Vol 22 (5) ◽  
pp. 586-595 ◽  
Author(s):  
Karin Pierre ◽  
Pierre J. Magistretti ◽  
Luc Pellerin
Keyword(s):  
Mouse Brain ◽  
Adult Mouse ◽  
Monocarboxylate Transporter ◽  
Proteinase K ◽  
Electron Microscopic Level ◽  
Electron Microscopic ◽  
Adult Mouse Brain ◽  
Additional Energy ◽  
Neuronal Processes

Although previous Northern blot and in situ hybridization studies suggested that neurons express the monocarboxylate transporter MCT2, subsequent immunohistochemical analyzes either failed to confirm the presence of this transporter or revealed only a low density of immunolabeled neuronal processes in vivo. The authors report that appropriate section pretreatment (brief warming episode or proteinase K exposure) leads to extensive labeling of the neuropil, which appears as tiny puncta throughout the whole mouse brain. In addition, intense MCT2 immunoreactivity was found in cerebellar Purkinje cell bodies and their processes, on mossy fibers in the cerebellum, and on sensory fibers in the brainstem. Double immunofluorescent labeling with appropriate markers and observation with epifluorescence and confocal microscopy did not show extensive colocalization of MCT2 immunoreactivity with presynaptic or postsynaptic elements, but colocalization could be observed occasionally in the cortex with the postsynaptic density protein PSD95. Observations made at the electron microscopic level in the cortex corroborated these results and showed that MCT2 immunoreactivity was associated with wide membrane segments of neuronal processes. These data provide convincing evidence that MCT2 represents a major neuronal monocarboxylate transporter in the adult mouse brain, and further suggest that mature neurons could use monocarboxylates such as lactate as additional energy substrates.

scholarly journals Was the Devonian geomagnetic field dipolar or multipolar? Palaeointensity studies of Devonian igneous rocks from the Minusa Basin (Siberia) and the Kola Peninsula dykes, Russia

2017 ◽  
Vol 209 (2) ◽  
pp. 1265-1286 ◽  
Author(s):  
V V Shcherbakova ◽  
A J Biggin ◽  
R V Veselovskiy ◽  
A V Shatsillo ◽  
L M A Hawkins ◽  
...  
Keyword(s):  
Kola Peninsula ◽  
Geomagnetic Field ◽  
Mantle Convection ◽  
Geological Time ◽  
Southern Siberia ◽  
Planetary Evolution ◽  
Low Intensity ◽  
Order Of Magnitude ◽  
Earth’S Climate ◽  
The Impact

Abstract Defining variations in the behaviour of the geomagnetic field through geological time is critical to understanding the dynamics of Earth's core and its response to mantle convection and planetary evolution. Furthermore, the question of whether the axial dipole dominance of the recent palaeomagnetic field persists through the whole of Earth's history is fundamental to determining the reliability of palaeogeographic reconstructions and the efficacy of the magnetosphere in shielding Earth from solar wind radiation. Previous palaeomagnetic directional studies have suggested that the palaeofield had a complex configuration in the Devonian period (419–359 Ma). Here we present new high-quality palaeointensity determinations from rocks aged between 408 and 375 Ma from the Minusa Basin (southern Siberia), and the Kola Peninsula that enable the first reliable investigation of the strength of the field during this enigmatic period. Palaeointensity experiments were performed using the thermal Thellier, microwave Thellier and Wilson methods on 165 specimens from 25 sites. Six out of eight successful sites from the Minusa Basin and all four successful sites from the Kola Peninsula produced extremely low palaeointensities (<10 μT). These findings challenge the uniformitarian view of the palaeomagnetic field: field intensities of nearly an order of magnitude lower than Neogene values (except during relatively rare geomagnetic excursions and reversals) together with the widespread appearance of strange directions found in the Devonian suggest that the Earth's field during this time may have had a dominantly multipolar geometry. A persistent, low intensity multipolar magnetic field and associated diminished magnetosphere would increase the impact of solar particles on the Earth's magnetosphere, ionosphere and atmosphere with potential major implications for Earth's climate and biosphere.

scholarly journals Using 10CO2 for Single Subject Characterization of the Stimulus Frequency Dependence in Visual Cortex: A Novel Positron Emission Tomography Tracer for Human Brain Mapping

2001 ◽  
Vol 21 (8) ◽  
pp. 1003-1012 ◽  
Author(s):  
Ian Law ◽  
Mikael Jensen ◽  
Søren Holm ◽  
Robert J. Nickles ◽  
Olaf B. Paulson
Keyword(s):  
Positron Emission Tomography ◽  
Human Brain ◽  
Brain Mapping ◽  
Stimulus Frequency ◽  
Emission Tomography ◽  
Maximal Response ◽  
Single Subject ◽  
Human Brain Mapping ◽  
Pet Tracer ◽  
Positron Emission

Carbon-10–labeled carbon dioxide (10CO2) with a half-life of 19.3 seconds offers almost ideal characteristics as a positron emission tomography (PET) tracer for assessment of the regional cerebral blood flow (rCBF) distribution, enabling multiple independent measurements at short intervals. To appraise the feasibility of 10CO2 for localizing and characterizing human brain function in single subjects, the authors chose a well-characterized activation paradigm. In 6 healthy volunteers, 50 to 64 independent PET scans of the rCBF distribution were acquired while viewing an annular reversing checkerboard presented at 10 reversal frequencies between 0.03 and 30 Hz. Changes in regional cerebral activity as a function of reversal frequency were modeled in every subject using a set of polynomial basis functions, which, as predicted, showed highly significant second or third order relations located in the striatal cortex. Correlation coefficients (R2) ranged from 0.46 to 0.63. The average intersubject maximal response relative to the 0.03 Hz condition was 8.0% ± 1.7% SD occurring at stimulus contrast reversal frequencies between 6 and 15 Hz with an average of 11.8 ± 3.8 (SD) Hz. From the qualitative and quantitative replication of previous results it is concluded that 10CO2 PET is a feasible technique for human brain mapping studies and a great improvement compared with the existing oxygen-15–labeled water (H215 O) PET method, particularly for single subject studies and parametric design.

scholarly journals Investigating The Functional Consequence Of White Matter Damage: An Automatic Pipeline To Create Longitudinal Disconnection Tractograms

2017 ◽  
Author(s):  
Kesshi Marin Jordan ◽  
Anisha Keshavan ◽  
Eduardo Caverzasi ◽  
Joseph Osorio ◽  
Nico Papinutto ◽  
...  
Keyword(s):  
White Matter ◽  
Human Brain ◽  
Large Scale ◽  
Diffusion Imaging ◽  
White Matter Injury ◽  
High Angular Resolution ◽  
Single Subject ◽  
White Matter Damage ◽  
Time Investment ◽  
Manual Intervention

Neurosurgical resection is one of the few opportunities researchers have to image the human brain both prior to and following focal damage. One of the challenges associated with studying brains undergoing surgical resection is that they often do not fit the brain templates most image-processing methodologies are based on, so manual intervention is required to reconcile the pathology and the most extreme cases must be excluded. Manual intervention requires significant time investment and introduces reproducibility concerns. We propose an automatic longitudinal pipeline based on High Angular Resolution Diffusion Imaging acquisitions to facilitate a Pathway Lesion Symptom Mapping analysis relating focal white matter injury to functional deficits. This two-part approach includes (i) automatic segmentation of focal white matter injury from anisotropic power differences, and (ii) modeling disconnection using tractography on the single-subject level, which specifically identifies the disconnections associated with focal white matter damage. The advantages of this approach stem from (1) objective and automatic lesion segmentation and tractogram generation, (2) objective and precise segmentation of affected tissue likely to be associated with damage to long-range white matter pathways (defined by anisotropic power), (3) good performance even in the cases of anatomical distortions by use of nonlinear tensor-based registration in the patient space, which aligns images using white matter contrast. Mapping a system as variable and complex as the human brain requires sample sizes much larger than the current technology can support. This pipeline can be used to execute large-scale, sufficiently powered analyses by meeting the need for an automatic approach to objectively quantify white matter disconnection.

scholarly journals Billions of Human Brains Immersed Within a Shared Geomagnetic Field: Quantitative Solutions and Implications for Future Adaptations

2013 ◽  
Vol 6 (1) ◽  
pp. 8-13 ◽  
Author(s):  
Michael A. Persinger
Keyword(s):  
Cognitive Processes ◽  
Geomagnetic Field ◽  
Protein Sequences ◽  
Genetic Changes ◽  
Magnetic Diffusivity ◽  
Order Of Magnitude ◽  
The Individual ◽  
Human Brains ◽  
With Memory

The implications for adaptation when billions of human cerebrums are considered weak conductors immersed within the same medium, the geomagnetic field, are examined. Quantitative solutions indicated that the intensity of the “transcerebral” field produced from all human brains within the geomagnetic field is the same order of magnitude as the values associated with cognitive processes and altered expressions of proteins within the individual brain. This convergence could meet one of the criteria for a holographic-like phenomenon. The transition from 6 to 8 billion brains would be associated with shared energies within individual cerebral space whose frequencies increase across the visible electromagnetic wavelength from infrared to ultraviolet. Magnetic diffusivity indicates all brains could be influenced within about 10 minutes. Implications for induced ubiquitous genetic changes, shared modifications in protein sequences associated with memory during dream sleep, and limitations upon the proliferation of the species are discussed.

scholarly journals No evidence for entrainment: endogenous gamma oscillations and rhythmic flicker responses coexist in visual cortex

2020 ◽  
Author(s):  
Katharina Duecker ◽  
Tjerk P. Gutteling ◽  
Christoph S. Herrmann ◽  
Ole Jensen
Keyword(s):  
Visual Cortex ◽  
Human Brain ◽  
Visual Stimulation ◽  
Gamma Oscillations ◽  
Photic Stimulation ◽  
Neuronal Populations ◽  
Frequency Entrainment ◽  
Flicker Response ◽  
Neuronal Processes

AbstractMotivated by the plethora of studies associating gamma oscillations (∼30-100 Hz) with various neuronal processes, including inter-regional communication and neuroprotection, we asked if endogenous gamma oscillations in the human brain can be entrained by rhythmic photic stimulation. The photic drive produced a robust Magnetoencephalography (MEG) response in visual cortex up to frequencies of about 80 Hz. Strong, endogenous gamma oscillations were induced using moving grating stimuli as repeatedly shown in previous research. When superimposing the flicker and the gratings, there was no evidence for phase or frequency entrainment of the endogenous gamma oscillations by the photic drive. Rather – as supported by source modelling – our results show that the flicker response and the endogenous gamma oscillations coexist and are generated by different neuronal populations in visual cortex. Our findings challenge the notion that neuronal entrainment by visual stimulation generalises to cortical gamma oscillations.

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