Vitamin D, parathyroid hormone and risk factors for coronary artery disease in an elderly Chinese population

Background: Cardiovascular disease (CVD) is the leading cause of death in the developed world. The present study was conducted to assess correlation of plasma 25-Hydroxy-Vitamin D level with angiographic severity in coronary artery disease. Subjects and Methods: The present study was conducted on 120 patients of CAD. Group I were cases and group II were control. Hypertension, type II diabetes mellitus status, smoking etc. was recorded. 2 ml of blood sample was taken from all patients and measurement of 25(OH) vit D levels was performed. Results: The mean BMI in group I was 24.6 kg/m2 and 24.8 kg/m2 in group II, smoking habit was seen in 78 in group I and 34 in group II, hypertension was seen in 65 in group I and 26 in group II, diabetes was seen in 52 in group I and 30 in group II, alcoholism in 36 in group I and 10 in group II, dyslipidemia was seen in 48 in group I and 15 in group II. The mean 25 (OH) vitamin D in group I was 15.1 ng/ml and 19.6 ng/ml in group. The difference was significant (P< 0.05). Maximum dyslipidemia (80.5%) patients had low vitamin D level followed by DM, smoking, BMI, alcoholism and alcoholism. There was no correlation between risk factors and vitamin D deficiency (P> 0.05). Conclusion: Authors found that in cases, vitamin D level was lowered as compared to control, however, there was no correlation between risk factors and CAD.

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Evaluation of Serum 25 Hydroxy Vitamin D level in acute myocardial infarction patients in a tertiary care hospital

Asian Journal of Medical Sciences ◽

10.3126/ajms.v7i6.15699 ◽

2016 ◽

Vol 7 (6) ◽

pp. 11-15 ◽

Cited By ~ 1

Author(s):

Debapriya Rath ◽

Rachita Nanda ◽

Pramila Kumari Mishra ◽

Pradeep Kumar Patra

Keyword(s):

Risk Factors ◽

Myocardial Infarction ◽

Coronary Artery Disease ◽

Acute Myocardial Infarction ◽

Vitamin D ◽

Coronary Artery ◽

Serum Vitamin ◽

Coronary Risk Factors ◽

Serum Vitamin D ◽

Artery Disease

Background: Coronary artery disease is the leading cause of death worldwide with acute myocardial infarction being the most severe manifestation. Recent evidences have linked vitamin D in the pathogenesis of the coronary risk factors like diabetes, hypertension, obesity and smoking.Aims and Objectives: The present study was undertaken with an aim to look for the vitamin D status of the AMI patients and its relation if any with the above mentioned risk factors.Material and Methods: One hundred acute myocardial infarction patients along with one hundred age and sex matched healthy controls were included in the study and the serum 25 (OH) D was estimated in both the groups.Results: Serum 25 (OH) Vit D level was found to be lower in cases (19.6±6.85 ng/ml) than in controls (27.5±6.23 ng/ml) (p<0.001).The decreased vitamin D level was associated with the incidence of AMI after adjusting for other risk factors. The serum vitamin D level was significantly decreased in the patients having risk factors among the AMI group.Conclusion: The present study showed a significantly low serum vitamin D in AMI patients . Given the therapeutic safety and inexpensiveness of vitamin D, further studies may be undertaken to look for the effect of its supplementation on coronary artery disease. Asian Journal of Medical Sciences Vol.7(6) 2016 11-15

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Low Vitamin D and High Parathyroid Hormone Levels Are Associated with Left Ventricular Dysfunction but Not with Increased Aortic Stiffness in Patients Undergoing Cardiac Catheterization for Coronary Artery Disease.

Journal of Cardiac Failure ◽

10.1016/j.cardfail.2010.06.107 ◽

2010 ◽

Vol 16 (8) ◽

pp. S32

Author(s):

Hidekatsu Fukuta ◽

Nobuyuki Ohte ◽

Kazuaki Wakami ◽

Toshihiko Goto ◽

Seiji Mukai ◽

...

Keyword(s):

Coronary Artery Disease ◽

Vitamin D ◽

Parathyroid Hormone ◽

Coronary Artery ◽

Cardiac Catheterization ◽

Left Ventricular Dysfunction ◽

Aortic Stiffness ◽

Ventricular Dysfunction ◽

Left Ventricular ◽

Artery Disease

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A study of association of vitamin D deficiency and coronary artery disease

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20171557 ◽

2017 ◽

Vol 5 (5) ◽

pp. 1765

Author(s):

Manoj Kumar ◽

Granth Kumar ◽

Vijay K. Verma ◽

Manish Gupta ◽

Rajesh K. Gautam

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Vitamin D ◽

Coronary Artery ◽

Vitamin D Deficiency ◽

Independent Predictor ◽

Developed Countries ◽

Blood Cholesterol ◽

Control Group ◽

Artery Disease

Background: Recently vitamin D has received great interests for its multiple effects on inflammatory system and potential role in atherothrombosis. Coronary artery disease (CAD) is one of the common causes of death and disability in developed countries. Experimental evidence points to the involvement of multiple factors in coronary plaque formation, including vitamin D. The study aimed to examine the association of coronary artery disease with vitamin D level.Methods: 140 patients of CAD (coronary artery disease) and 101 age and sex matched control were enrolled in the study and 25-hyroxyvitamin D (25(OH)D) concentration was measured. All participants were evaluated for presence of conventional risk factors for coronary artery disease. Association of vitamin D level was established after adjusting other risk factors using logistic regression analysis.Results: In our study vitamin D level is significantly lower in patient group (CAD patients) compared with control group (18.2±10.9 vs 28.8±21ng/mL). Vitamin D deficiency was present in 81.4% patient in CAD patients whereas 57.7% in control group. Vitamin D deficiency was found to be an independent predictor of CAD after adjusting effect of other risk factors like hypertension, diabetes, smoking, obesity, high blood cholesterol and level of physical activity with adjusted odds ratio (95% confidence interval) 2.695 (1.148-6.330).Conclusions: In present study patients of coronary artery disease had significantly low level of vitamin D as compared to individual without coronary artery disease. Vitamin D deficiency was found to be an independent predictor of CAD after adjusting other risk factors emphasizing that vitamin D can be a potential risk factor for development of coronary artery disease.

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Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease

Clinical Science ◽

10.1042/cs20190999 ◽

2019 ◽

Vol 133 (22) ◽

pp. 2283-2299

Author(s):

Apabrita Ayan Das ◽

Devasmita Chakravarty ◽

Debmalya Bhunia ◽

Surajit Ghosh ◽

Prakash C. Mandal ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Chronic Inflammation ◽

Ex Vivo ◽

Human Subjects ◽

Critical Role ◽

Atherosclerotic Cardiovascular Disease ◽

Tnf Α ◽

Artery Disease

Abstract The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic inflammation. Yet, no information is available about the involvement of sTLT1 in atherosclerotic cardiovascular disease. Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)−/− mice. Plasma level of sTLT1 was found to be significantly (P<0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI) to activate spleen tyrosine kinase (SYK)-mediated downstream MAP kinase signalling cascade to activate nuclear factor-κ B (NF-kB). Activation of NF-kB induces secretion of tumour necrosis factor-α (TNF-α) from macrophage cells that plays pivotal role in governing the persistence of chronic inflammation. Atherosclerotic apoE−/− mice also showed high levels of sTLT1 and TNF-α in nearly occluded aortic stage indicating the contribution of sTLT1 in inflammation. Our results clearly demonstrate that sTLT1 is clinically related to the risk factors of CAD. We also showed that binding of sTLT1 with macrophage membrane receptor, FcɣR1 initiates inflammatory signals in macrophages suggesting its critical role in thrombus development and atherosclerosis.

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