scholarly journals Pubertal growth in normal Thai children: a longitudinal study

2010 ◽  
Vol 4 (5) ◽  
pp. 793-795
Author(s):  
Suttipong Wacharasindhu ◽  
Vichit Supornsilchai ◽  
Suphab Aroonparkmongkol ◽  
Thaninee Sahakitrungrueng
Keyword(s):  
Longitudinal Study ◽  
Growth Parameters ◽  
Longitudinal Growth ◽  
Compensatory Mechanism ◽  
Growth Data ◽  
Clinical Practices ◽  
Normal Children ◽  
Pubertal Onset ◽  
Pubertal Growth ◽  
Height Gain

Abstract Background: Pubertal growth data in Thai children has been reported as cross-sectional studies. There is no longitudinal study in Thai children. Objective: Investigate the longitudinal growth data in normal Thai children including the relationship between age at pubertal onset and other growth parameters. Material and method: Eighty-eight normal children (44 boys, 44 girls) were longitudinally assessed for the growth and puberty until they reached their final adult height. Pubertal staging was assessed by the Tanner method. Results: Mean age of pubertal onset was 10.2 ± 1.2 years for girls and 12.2 ± 1.0 years for boys. Total pubertal height gain was 18.3 ± 4.0 cm for girls and 22.3 ± 4.4 cm for boys. Total pubertal height gain had a negative correlation with age at pubertal onset for girls, but not for boys. Conclusion: The onset of puberty was not much changed from previous studies. Girls with early puberty had a higher pubertal height gain. This might be due to a compensatory mechanism. These longitudinal growth data can be used as a reference in clinical practices for Thai children.

A longitudinal study of total and free thyroid hormones and thyroxinebinding globulin during normal puberty

1990 ◽  
Vol 123 (3) ◽  
pp. 305-310 ◽  
Author(s):  
David B. Dunger ◽  
Janet A. Perkins ◽  
Terence P. Jowett ◽  
Philip R. Edwards ◽  
Leslie A. Cox ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Thyroid Hormones ◽  
Normal Children ◽  
Thyroxine Binding Globulin ◽  
Free Thyroid Hormones ◽  
Pubertal Growth ◽  
Normal Ranges ◽  
Stage 4 ◽  
Puberty Stages ◽  
Males And Females

Abstract. Thyroid hormones are essential for normal pubertal growth, yet the changes in total and, especially, free thyroid hormones and thyroxine-binding globulin during puberty have not been adequately defined. Serum from 39 normal children (20 girls, 19 boys) between the ages of 10 and 15 years were assayed for total T4, free T4, free T3 and thyroxine-binding globulin at 6-monthly intervals; the free hormone assays were valid, non-analogue methodologies. In the girls, free T4 levels fell from 15.7±0.6 pmol/l at 10 years to 13.0±0.6 (p<0.001) at 12.5 years before rising to 15.9±0.7 at 15 years; this nadir occurred at puberty stages 3-4. Changes in total T4 followed a similar pattern with a slight delay in the nadir (13 years, puberty stage 4). In the boys, free T4 fell from 16.3±0.6 pmol/l at 10 years to 14.3±0.3 at 13.5 years, then rising to 15.4±0.5 at 15 years; the nadir again occurred at puberty stages 3-4. The corresponding nadir in total T4 which occurred at puberty stages 4-5 was not apparent by age analysis. Thyroxine-binding globulin concentrations remained unchanged in the girls, but fell slightly in the boys during later puberty. Free T3 concentrations in the girls showed a progressive fall after 12.5 years which was significant by the age of 14 when most had been in puberty stage 5 for more than 1 year. The boys showed no change of free T3 concentration throughout the study. These data demonstrate important differences in the levels of free thyroid hormones in males and females during puberty. Normal ranges for girls and boys between the ages of 9.5 and 15.5 years are presented.

scholarly journals Adult Height after Growth Hormone Treatment at Pubertal Onset in Short Adolescents Born Small for Gestational Age: Results from a Belgian Registry-Based Study

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
M. Thomas ◽  
D. Beckers ◽  
C. Brachet ◽  
H. Dotremont ◽  
M.-C. Lebrethon ◽  
...  
Keyword(s):  
Adult Height ◽  
Hormone Treatment ◽  
Growth Data ◽  
Gh Therapy ◽  
Gh Treatment ◽  
Pubertal Stage ◽  
Pubertal Onset ◽  
Total Height ◽  
Height Gain ◽  
Lower Height

Objectives. Information on the efficacy of GH treatment in short SGA children starting their treatment in adolescence is limited. Therefore, adult height (AH), total height gain, and pubertal height gain were evaluated in short SGA children who started GH treatment at pubertal onset. Patient and Methods. Growth data of 47 short SGA adolescents (22 boys) who started GH treatment at pubertal onset (PUB group) were compared with results from 27 short SGA patients (11 boys) who started GH therapy at least 1 year before pubertal onset (PrePUB group). Results. The PUB group achieved a mean (±SD) total height gain of 0.8 ± 0.7 SDS and an AH of −2.5 ± 0.7 SDS after 4.1 ± 1.1 years of GH treatment with a dosage of 41.8 ± 8.4 μg/kg/day. These results were comparable with those in the PrePUB group, which was treated for a longer duration (5.8 ± 2.1 years), resulting in a total height gain of 1.1 ± 0.7 SDS and an AH of −2.1 ± 1.0 SDS. Multiple regression analysis showed a significantly lower height gain in pubertal patients, females, and patients weighing less at start of GH treatment. An AH above −2 SDS and above the parent-specific lower limit of height was, respectively, reached in 28% and 70% of PUB and 44% and 67% of PrePUB patients (NS). AH SDS was positively correlated with the height SDS at start of GH. Conclusions. Short SGA adolescents starting GH therapy at an early pubertal stage have a modest and variable height gain. A normal AH can be expected in one third of the patients, especially in those with a smaller height deficit at onset of GH treatment.

scholarly journals Serum Amino Acid Profiles in Childhood Predict Triglyceride Level in Adulthood: A 7-Year Longitudinal Study in Girls

2016 ◽  
Vol 101 (5) ◽  
pp. 2047-2055 ◽  
Author(s):  
Petri Wiklund ◽  
Xiaobo Zhang ◽  
Xiao Tan ◽  
Sirkka Keinänen-Kiukaanniemi ◽  
Markku Alen ◽  
...  
Keyword(s):  
Amino Acids ◽  
Longitudinal Study ◽  
Amino Acid ◽  
High Risk ◽  
Triglyceride Level ◽  
Early Adulthood ◽  
Health Science ◽  
Model Assessment ◽  
Pubertal Growth ◽  
Amino Acid Profiles

AbstractContext:Branched-chain and aromatic amino acids are associated with high risk of developing dyslipidemia and type II diabetes in adults.Objective:This study aimed to examine whether serum amino acid profiles associate with triglyceride concentrations during pubertal growth and predict hypertriglyceridemia in early adulthood.Design:This was a 7.5-year longitudinal study.Setting:The study was conducted at the Health Science Laboratory, University of Jyväskylä.Participants:A total of 396 nondiabetic Finnish girls aged 11.2 ± 0.8 years at the baseline participated in the study.Main Outcome Measures:Body composition was assessed by dual-energy x-ray absorptiometry; serum concentrations of glucose, insulin, and triglyceride by enzymatic photometric methods; and amino acids by nuclear magnetic resonance spectroscopy.Results:Serum leucine and isoleucine correlated significantly with future triglyceride, independent of baseline triglyceride level (P &lt; .05 for all). In early adulthood (at the age of 18 years), these amino acids were significantly associated with hypertriglyceridemia, whereas fat mass and homeostasis model assessment of insulin resistance were not. Leucine was the strongest determinant discriminating subjects with hypertriglyceridemia from those with normal triglyceride level (area under the curve, 0.822; 95% confidence interval, 0.740–0.903; P = .000001).Conclusions:Serum leucine and isoleucine were associated with future serum triglyceride levels in girls during pubertal growth and predicted hypertriglyceridemia in early adulthood. Therefore, these amino acid indices may serve as biomarkers to identify individuals at high risk for developing hypertriglyceridemia and cardiovascular disease later in life. Further studies are needed to elucidate the role these amino acids play in the lipid metabolism.

Effect of 3-Month Lysine Supplementation on Growth and Muscle Function Parameters in Pre-pubertal Indian Girls

2018 ◽  
Vol 55 (4) ◽  
pp. 423
Author(s):  
Sejil T. Verghese ◽  
Maria Pauline ◽  
Arun Das ◽  
Anura V. Kurpad
Keyword(s):  
Muscle Strength ◽  
Growth Parameters ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Dominant Hand ◽  
Indian Children ◽  
Significant Difference ◽  
Height Gain ◽  
Hand Dynamometer

Lysine is the limiting amino acid in the predominantly cereal and legume based typical Indian diet and its supplementation has been shown to positively affect muscle strength in short term adult and animal models; but similar studies are lacking in children. This study looked at the effect of a 3-month lysine and iron intervention on muscle strength and growth parameters in prepubertal Indian girls. The study was a randomized controlled trial conducted in 40 normal Indian girls in the 9-10 yrs age group. The control group received only iron (6.25mg) supplementation, while the intervention group received both iron and lysine supplementation that increased the lysine intake to 50mg/kg/day. Muscle strength was estimated in both upper limbs with a hand dynamometer and muscle endurance was estimated in the non-dominant hand. Height and weight were recorded to assess growth. A significant difference was seen in the increase in the non-dominant hand grip strength between the groups (intervention: 1.4 vs control: 0.2 kg, p=0.042) at the end of the study. There was a trend of increased height gain (about 25%) and weight gain (about 50%) in the intervention group compared to control group. Lysine supplementation for 3 months increased non-dominant forearm muscle strength in Indian children.

The impact of random-effect misspecification on percentile estimation for longitudinal growth data

2012 ◽  
Vol 31 (28) ◽  
pp. 3708-3718 ◽  
Author(s):  
Kyeongmi Cheon ◽  
Paul S. Albert ◽  
Zhiwei Zhang
Keyword(s):  
Random Effect ◽  
Longitudinal Growth ◽  
Growth Data ◽  
Percentile Estimation ◽  
The Impact

scholarly journals Multilevel growth curve models that incorporate a random coefficient model for the level 1 variance function

2017 ◽  
Vol 27 (11) ◽  
pp. 3478-3491 ◽  
Author(s):  
Harvey Goldstein ◽  
George Leckie ◽  
Christopher Charlton ◽  
Kate Tilling ◽  
William J Browne
Keyword(s):  
Random Effects ◽  
Repeated Measures ◽  
Random Effect ◽  
Growth Function ◽  
Individual Variability ◽  
Growth Patterns ◽  
Variance Function ◽  
Longitudinal Growth ◽  
Growth Data ◽  
The Mean

Aim To present a flexible model for repeated measures longitudinal growth data within individuals that allows trends over time to incorporate individual-specific random effects. These may reflect the timing of growth events and characterise within-individual variability which can be modelled as a function of age. Subjects and methods A Bayesian model is developed that includes random effects for the mean growth function, an individual age-alignment random effect and random effects for the within-individual variance function. This model is applied to data on boys’ heights from the Edinburgh longitudinal growth study and to repeated weight measurements of a sample of pregnant women in the Avon Longitudinal Study of Parents and Children cohort. Results The mean age at which the growth curves for individual boys are aligned is 11.4 years, corresponding to the mean ‘take off’ age for pubertal growth. The within-individual variance (standard deviation) is found to decrease from 0.24 cm2 (0.50 cm) at 9 years for the ‘average’ boy to 0.07 cm2 (0.25 cm) at 16 years. Change in weight during pregnancy can be characterised by regression splines with random effects that include a large woman-specific random effect for the within-individual variation, which is also correlated with overall weight and weight gain. Conclusions The proposed model provides a useful extension to existing approaches, allowing considerable flexibility in describing within- and between-individual differences in growth patterns.

scholarly journals Hybrid Poplar Genotype Affects Attack Incidence by the Poplar-and-Willow Borer (Cryptorhynchus lapathi)

2003 ◽  
Vol 18 (4) ◽  
pp. 276-280 ◽  
Author(s):  
J.D. Johnson ◽  
K.R. Johnson
Keyword(s):  
Pacific Northwest ◽  
Arid Regions ◽  
Growth Parameters ◽  
Wood Quality ◽  
Hybrid Poplar ◽  
Stem Volume ◽  
Growth Data ◽  
Cascade Mountains ◽  
Poplar Plantations ◽  
Lombardy Poplar

Abstract Increasing incidence of the poplar-and-willow borer (Cryptorhynchus lapathi) in Pacific Northwest hybrid poplar plantations has resulted in reduced wood quality and stem breakage. Three replicated, 5-yr-old clone trials established in the vicinity of Pullman, WA were rated for host attack preference. Attacks by C. lapathi were found to be significant for plantation, clone, and the clone by plantation interaction. Attack rating among clones was affected by genotype. Those clones possessing P. nigra parentage, including Lombardy poplar, OP-367, and PC-6, showed significantly lower attacks across all plantations. Within the P. trichocarpa × P. deltoides (TD) hybrids, both 58-280 and 50-194 consistently exhibited lower attacks compared to the remaining four TD hybrids. Plantation, clone, and the plantation by clone interaction affected tree growth parameters significantly. Mean clone stem volume across sites from largest to smallest was: 49-177, OP-367, 50-197, 52-225, PC-6, 50-194, 58-280, 15-29, and Lombardy poplar. Attempts to correlate attack rating with any parameter of tree size were unsuccessful. Combining growth data and attack rating, OP-367 would be recommended for planting in arid regions east of the Cascade Mountains, followed by PC-6, 50-194 and 58-280. Future hybrid poplar breeding for this region should consider P. nigra as a parent. West. J. Appl. For. 18(4):276–280.

Genetics of pre-pubertal growth: A longitudinal study of Japanese twins

2011 ◽  
Vol 38 (5) ◽  
pp. 608-614 ◽  
Author(s):  
Karri Silventoinen ◽  
Jaakko Kaprio ◽  
Yoshie Yokoyama
Keyword(s):  
Longitudinal Study ◽  
Pubertal Growth
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