scholarly journals Development of coated beads for oral controlled delivery of cefaclor: In vitro evaluation

2013 ◽  
Vol 63 (1) ◽  
pp. 31-44 ◽  
Author(s):  
Bazigha K. Abdul ◽  
Sahar A. Fahmy
Keyword(s):  
Antimicrobial Activity ◽  
Controlled Release ◽  
Dosage Form ◽  
Size Range ◽  
Alginate Beads ◽  
Controlled Delivery ◽  
Peg 400 ◽  
Maximum Value ◽  
Plasma Profile

The aim of the present study was to develop and characterize coated chitosan-alginate beads containing cefaclor as a controlled release delivery system. Coated cefaclor beads were prepared by solvent evaporation techniques. Beads were found to be intact and spherical in shape. Their size range was 1.05 to 2.06. The loading efficiency showed maximum value when the concentration of cefaclor, chitosan and PEG 400 was 10 % (m/V), 0.5 % (m/V) and 2 % (V/V), respectively. Best retardation of cefaclor release from chitosan-alginate beads was achieved by coating with 15 % of shellac in formula F19. A significant antimicrobial activity (p < 0.05) against Staphylococcus aureus and Klebsiella pneumoniae was observed for formula F19 compared to the standard antibiotic disc. Furthermore, the simulated plasma profile showed the superiority of F19 in sustaining drug release for more than 12 h. Therefore, shellac coated chitosan-alginate beads could be considered a successful controlled release oral cefaclor dosage form.

scholarly journals Fabrication and In Vitro Evaluation of pH-Sensitive Polymeric Hydrogels as Controlled Release Carriers

Gels ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 110
Author(s):  
Muhammad Suhail ◽  
Chih-Wun Fang ◽  
Arshad Khan ◽  
Muhammad Usman Minhas ◽  
Pao-Chu Wu
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Acrylic Acid ◽  
Chondroitin Sulfate ◽  
Diclofenac Sodium ◽  
Research Work ◽  
Controlled Delivery ◽  
Scanning Calorimetry ◽  
Release Studies

The purpose of the current investigation was to develop chondroitin sulfate/carbopol-co-poly(acrylic acid) (CS/CBP-co-PAA) hydrogels for controlled delivery of diclofenac sodium (DS). Different concentrations of polymers chondroitin sulfate (CS), carbopol 934 (CBP), and monomer acrylic acid (AA) were cross-linked by ethylene glycol dimethylacrylate (EGDMA) in the presence of ammonium peroxodisulfate (APS) (initiator). The fabricated hydrogels were characterized for further experiments. Characterizations such as Scanning electron microscopy (SEM), Thermogravimetric analysis (TGA), Differential scanning calorimetry (DSC), Powder X-ray diffractometry (PXRD), and Fourier transform infrared spectroscopy (FTIR) were conducted to understand the surface morphology, thermodynamic stability, crystallinity of the drug, ingredients, and developed hydrogels. The swelling and drug release studies were conducted at two different pH mediums (pH 1.2 and 7.4), and pH-dependent swelling and drug release was shown due to the presence of functional groups of both polymers and monomers; hence, greater swelling and drug release was observed at the higher pH (pH 7.4). The percent drug release of the developed system and commercially available product cataflam was compared and high controlled release of the drug from the developed system was observed at both low and high pH. The mechanism of drug release from the hydrogels followed Korsmeyer–Peppas model. Conclusively, the current research work demonstrated that the prepared hydrogel could be considered as a suitable candidate for controlled delivery of diclofenac sodium.

The choice of excipients in the development of a soft dosage form of phleboprotective action containing a micronized flavonoid fraction

2021 ◽  
pp. 25-30
Author(s):  
Viktoriya Konstantinovna Maltseva ◽  
Eleonora Fedorovna Stepanova ◽  
Evgeniya Olegovna Kulichenko ◽  
Marina Sergeevna Makieva
Keyword(s):  
21St Century ◽  
Active Ingredient ◽  
Dosage Form ◽  
Sedentary Lifestyle ◽  
Varicose Veins ◽  
Semipermeable Membrane ◽  
Peg 400 ◽  
Flavonoid Fraction ◽  
Final Composition

Varicose veins are called one of the diseases of the 21st century, caused by a sedentary lifestyle and genetics. The purpose of this study was the development of ointment compositions containing the micronized flavonoid fraction and the study of the degree of release of the micronized fraction by the flavonoid from the ointment compositions with penetrating components. With the obtained ointment compositions, a complex of biopharmaceutical studies in vitro was carried out: release from ointment compositions by diffusion into a gelatin gel and dialysis through a semipermeable membrane, while the quality indicators of the ointment compositions were established. The conducted in vitro biopharmaceutical studies helped to determine the final composition of the ointment in relation to the auxiliary composition: active ingredient — 2%, PEG 1500:PEG 400 (7:3), propylene glycol — 1%.

scholarly journals FABRICATION AND EVALUATION OF ORAL CONTROLLED RELEASE OF MUCOADHESIVE ALGINATE MICROBEADS CONTAINING FLUVASTATIN SODIUM

2019 ◽  
pp. 101-112
Author(s):  
VENKATA RAMANA REDDY K ◽  
NAGABHUSHANAM MV
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Transport Mechanism ◽  
Entrapment Efficiency ◽  
Alginate Beads ◽  
Polymer Mixture ◽  
Infrared Spectroscopic Study ◽  
Alginate Concentration ◽  
Curing Agents

Objective: The aim of this study is to prepare oral controlled release (CR) of mucoadhesive alginate microbeads encapsulating fluvastatin by gastroretention technology. Methods: The mucoadhesive microbeads containing fluvastatin were produced using emulsification internal gelation technique. The effect of different variables such as sodium alginate concentration and its combination with other hydrophilic polymers, and the effect of various curing agents on particle size, entrapment efficiency, and in vitro studies were evaluated. Results: There was no marked change in drug entrapment efficiency, and dissolution studies occur during the stability studies of fluvastatin. The in vitro results give data that improvement in the CR of the drug from microbeads compared with marketed tablet. Hence, in this regard, to minimize the frequency of drug administration to reduce side effects. The optimum condition for the preparation of stable alginate beads and produce CR manner was occurred at a higher concentration of combined polymer mixture in equal ratios, i.e., 3% w/v. Infrared spectroscopic study (Fourier transform infrared) confirmed the no incompatibility between drug and other excipients. X-ray diffraction study and differential scanning calorimetry were provided evidence that successful entrapment of drug into the alginates microbeads and drug converted into amorphous nature. The efficiency of mucoadhesion strength of microbeads was determined by wash-off study. Conclusion: The kinetic modeling of the release data indicates drug release from the microbeads follow anomalous transport mechanism and super Case-II transport mechanism. Drug release is a function of pH dependent and controlled drug release depends on type and concentration of polymer blend and curing agents. The release kinetics of drug from the alginate beads followed zero order.

Once‐a‐Day Controlled‐Release Dosage form of Divalproex Sodium I: Formulation Design and in Vitro/in Vivo Investigations

2003 ◽  
Vol 92 (6) ◽  
pp. 1166-1173 ◽  
Author(s):  
Yihong Qiu ◽  
Howard S. Cheskin ◽  
Kevin R. Engh ◽  
Richard P. Poska
Keyword(s):  
Controlled Release ◽  
Dosage Form ◽  
Divalproex Sodium ◽  
Formulation Design

scholarly journals Preparation and Evaluation of Release Formulation of γ-Oryzanol/Algae Oil Self-Emulsified with Alginate Beads

Marine Drugs ◽  
2019 ◽  
Vol 17 (3) ◽  
pp. 156 ◽  
Author(s):  
Kai-Min Yang ◽  
Po-Yuan Chiang
Keyword(s):  
In Vitro Release ◽  
Bimodal Distribution ◽  
Alginate Beads ◽  
Controlled Delivery ◽  
Simulated Intestinal Fluid ◽  
Release Formulation ◽  
Emulsion Droplets ◽  
Algae Oil ◽  
Preparation And Evaluation

Self-emulsion improves solubility and bioavailability for γ-oryzanol/algae oil, and alginate beads can be used as controlled release carriers. In this study, self-emulsified alginate beads (SEABs) were prepared with different weight ratios of self-emulsion treatment (5%, 10%, 15%, 20%, and 30%) with alginate. We found that the microstructure with a surfactant of SEABs had a different appearance with alginate-based beads. The encapsulation of γ-oryzanol corresponded with the self-emulsion/alginate ratio, which was 98.93~60.20% with a different formulation of SEABs. During in vitro release, SEABs had the gastric protection of γ-oryzanol/algae oil, because γ-oryzanol and emulsion were not released in the simulated stomach fluid. When the SEABs were transferred to a simulation of the small intestine, they quickly began to swell and dissolve, releasing a higher content of the emulsion. We observed that the emulsion that formed had a bimodal distribution in the simulated intestinal fluid as a result of the hydrogel and emulsion droplets, leading to the formation of large aggregates. These results suggested that γ-oryzanol encapsulation within alginate beads via emulsification combined with gelation can serve as an effective controlled delivery system.

Surface modified titania nanotubes containing anti-bacterial drugs for controlled delivery nanosystems with high bioactivity

2014 ◽  
Vol 2 (48) ◽  
pp. 8616-8625 ◽  
Author(s):  
Peilin Huang ◽  
Jingnan Wang ◽  
Shuting Lai ◽  
Fang Liu ◽  
Nan Ni ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Controlled Delivery ◽  
Titania Nanotubes ◽  
Surface Modified

Drug delivery nanosystems have been designed as Enro-NH2-TNTs and Enro-SH-TNTs with high bioactivity and excellent in vitro and in vivo controlled release.

Once‐a‐Day Controlled‐Release Dosage Form of Divalproex Sodium II: Development of a Predictive In Vitro Drug Release Method

2003 ◽  
Vol 92 (11) ◽  
pp. 2317-2325 ◽  
Author(s):  
Yihong Qiu ◽  
J. Garren ◽  
E. Samara ◽  
G. Cao ◽  
C. Abraham ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Dosage Form ◽  
Divalproex Sodium ◽  
In Vitro Drug Release ◽  
Release Method
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