scholarly journals ACE gene I/D polymorphism and arterial hypertension in patients with COPD

Pneumologia ◽  
2019 ◽  
Vol 68 (3) ◽  
pp. 114-119
Author(s):  
Mariya Marushchak ◽  
Khrystyna Maksiv ◽  
Inna Krynytska
Keyword(s):  
Arterial Hypertension ◽  
Polymerase Chain Reaction Amplification ◽  
Control Group ◽  
Chronic Obstructive ◽  
Gene Encoding ◽  
Obstructive Pulmonary Disease ◽  
Ace Gene ◽  
Increased Risk ◽  
Hardy Weinberg Equilibrium ◽  
Group 2

Abstract Background Cardiovascular diseases (CVDs) are common in people with chronic obstructive pulmonary disease (COPD), and their presence is associated with an increased risk for hospitalization, longer length of stay and all-cause and CVD-related mortality. We assessed the role of angiotensin-converting enzyme (ACE) gene polymorphism in the occurrence of arterial hypertension (AH) in patients with COPD. Methods The study group consisted of 96 patients. Group 1 had 25 individuals with COPD, Group 2 had 23 individuals with AH and Group 3 had 28 individuals with COPD and AH. The control group consisted of 20 healthy subjects. I/D genotypes of ACE were determined by polymerase chain reaction amplification. Results The frequency distribution of polymorphic genotypes of the gene encoding ACE and assessment of compliance with the Hardy-Weinberg population equilibrium were carried out in groups of patients with COPD, AH and COPD + AH combination. The frequencies of the genotype responsible for I/D polymorphism of the ACE gene in the control and experimental groups were not found to deviate significantly from the Hardy–Weinberg equilibrium. The results of the study have not demonstrated any significant impact of alleles of ACE genes or ACE genes on occurrence of diseases such as COPD, AH and combinations thereof. However, analysis of odds ratio has demonstrated that the presence of the D allele of the ACE gene may increase the risk for occurrence of the COPD + AH (OR = 1.26). Conclusion The data obtained in the study allow suggesting that the presence of D allele of the ACE gene may increase the risk for AH in patients with COPD.

scholarly journals ACE gene I/D polymorphism and arterial hypertension in patients with COPD

Pneumologia ◽  
2019 ◽  
Vol 68 (3) ◽  
pp. 114-119 ◽  
Author(s):  
Mariya Marushchak ◽  
Khrystyna Maksiv ◽  
Inna Krynytska
Keyword(s):  
Arterial Hypertension ◽  
Polymerase Chain Reaction Amplification ◽  
Control Group ◽  
Chronic Obstructive ◽  
Gene Encoding ◽  
Obstructive Pulmonary Disease ◽  
Ace Gene ◽  
Increased Risk ◽  
Hardy Weinberg Equilibrium ◽  
Group 2

Abstract Background Cardiovascular diseases (CVDs) are common in people with chronic obstructive pulmonary disease (COPD), and their presence is associated with an increased risk for hospitalization, longer length of stay and all-cause and CVD-related mortality. We assessed the role of angiotensin-converting enzyme (ACE) gene polymorphism in the occurrence of arterial hypertension (AH) in patients with COPD. Methods The study group consisted of 96 patients. Group 1 had 25 individuals with COPD, Group 2 had 23 individuals with AH and Group 3 had 28 individuals with COPD and AH. The control group consisted of 20 healthy subjects. I/D genotypes of ACE were determined by polymerase chain reaction amplification. Results The frequency distribution of polymorphic genotypes of the gene encoding ACE and assessment of compliance with the Hardy-Weinberg population equilibrium were carried out in groups of patients with COPD, AH and COPD + AH combination. The frequencies of the genotype responsible for I/D polymorphism of the ACE gene in the control and experimental groups were not found to deviate significantly from the Hardy–Weinberg equilibrium. The results of the study have not demonstrated any significant impact of alleles of ACE genes or ACE genes on occurrence of diseases such as COPD, AH and combinations thereof. However, analysis of odds ratio has demonstrated that the presence of the D allele of the ACE gene may increase the risk for occurrence of the COPD + AH (OR = 1.26). Conclusion The data obtained in the study allow suggesting that the presence of D allele of the ACE gene may increase the risk for AH in patients with COPD.

scholarly journals Association between arterial hypertension and chronic obstructive pulmonary disease: role of AGT gene polymorphism

Pneumologia ◽  
2020 ◽  
Vol 68 (4) ◽  
pp. 174-182
Author(s):  
Mariya Marushchak ◽  
Khrystyna Maksiv ◽  
Inna Krynytska ◽  
Kateryna Kozak
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Gene Polymorphism ◽  
Arterial Hypertension ◽  
Pulmonary Disease ◽  
Polymerase Chain Reaction Amplification ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Agt Gene

AbstractBackgroundChronic obstructive pulmonary disease (COPD) continues to cause a heavy health and economic burden in the Europe and around the world. Arterial hypertension (AH) is considered as one of the principal COPD-associated comorbidi-ties. However, no data for association between gene polymorphism and AH in patients with COPD in Ukraine have ever been internationally published. We assessed the genotype and allele frequencies of angiotensinogen (AGT) M235T polymorphisms in patients with COPD and comorbid AH.MethodsThe study group consisted of 96 patients: Group 1 (25 individuals with COPD), Group 2 (23 individuals with AH) and Group 3 (28 individuals with COPD and AH). The control group consisted of 20 healthy subjects. M/T genotypes of AGT were determined by polymerase chain reaction amplification.ResultsThe results of the study have not demonstrated any significant impact of alleles of AGT genes on the occurrence of diseases such as COPD, AH and combinations thereof. However, analysis of odds ratio has demonstrated the presence of a trend towards a protective role of the M allele of the AGT gene concerning occurrence of COPD, AH and their combinations. At the same time, the presence of the T allele of the AGT gene may increase the risk for occurrence of the above-mentioned diseases.ConclusionsThe study that we have conducted suggests that the presence of T allele of the AGT gene at position 235 of the peptide chain both in homozygous and heterozygous states may increase the risk for AH in patients with COPD.

scholarly journals The role of insertion-deletion polymorphism of the ACE gene in development of arterial hypertension in patients with chronic obstructive pulmonary disease

2020 ◽  
Vol 19 (3) ◽  
pp. 543-551
Author(s):  
Mariya Marushchak ◽  
Khrystyna Maksiv ◽  
Inna Krynytska ◽  
Mariya Koval
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Arterial Hypertension ◽  
Pulmonary Disease ◽  
Control Group ◽  
Chronic Obstructive ◽  
Deletion Polymorphism ◽  
Obstructive Pulmonary Disease ◽  
Ace Gene ◽  
Ace Activity

Objective. This study aims to establish the role of insertion-deletion polymorphism of the angiotensin-converting enzyme gene in development of arterial hypertension in patients with chronic obstructive pulmonary disease. Materials and Methods: The study group consisted of 96 patients: Group 1 (25 individuals with COPD), Group 2 (23 individuals with AH), Group 3 (28 individuals with COPD and AH). The control group consisted of the 20 healthy subjects. I/D genotypes of ACE were determined by polymerase chain reaction (PCR) amplification. Plasma ACE activity was determined photometrically by a commercially available kit. Results and Discussion: The distribution of polymorphic variants of the ACE gene among COPD-only patients genotype spreading was close to the data obtained in controls. In hypertensive patients, there were fewer ID heterozygotes and more ІІ homozygotes compared to controls. In the COPD+AH category of patients, II genotype was predominant in 7.1% subjects, DD genotype was predominant in 10.0% subjects and the proportion of ID heterozygotes was 17.1% lower compared to controls. The II genotype had a positive relationship with patient age and a negative relationship with body weights and respiratory rates of COPD+AH patients. The ID genotype was associated with increased respiratory rates; however, its correlation with the duration of the disease was negative. Conclusion: The data obtained in the study allow suggesting that polymorphism of the ACE gene doesn’t relate to development of AH in patients with COPD. The highest activity of ACE was found in patients with combination of COPD and AH; maximum findings of ACE activity were seen in patients with DD genotype. Bangladesh Journal of Medical Science Vol.19(3) 2020 p.543-551

scholarly journals AGT M235T Polymorphism and Arterial Hypertension in Patients with Chronic Obstructive Pulmonary Disease

2021 ◽  
Vol 46 (3) ◽  
pp. 176-183
Author(s):  
Mariya Marushchak ◽  
Khrystyna Maksiv ◽  
Inna Krynytska
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Arterial Hypertension ◽  
Pulmonary Disease ◽  
Polymerase Chain Reaction Amplification ◽  
Protective Role ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Agt Gene

Background: Chronic obstructive pulmonary disease (COPD) represents an important public health challenge. It is a major cause of chronic morbidity and mortality throughout the world. Arterial hypertension (AH) is considered one of the principal COPD-associated comorbidities. Objective: The study was aimed to assess the role of angiotensinogen (AGT) gene polymorphism in occurrence of AH in patients with COPD. Methods: The study was conducted among 96 patients of them, Group 1 (25 individuals with COPD), Group 2 (23 individuals with AH), Group 3 (28 individuals with COPD and AH). The control group consisted of the 20 healthy subjects. I/D genotypes of AGT were determined by polymerase chain reaction amplification. Plasma AGT activity was determined photometrically by a commercially available kit. Results: The results of the study have not demonstrated any significant impact of alleles of AGT genes on occurrence of such disease as COPD, AH and combinations thereof. However, analysis of odds ratio has demonstrated the presence of a trend towards a protective role of the M allele of the AGT gene concerning occurrence of COPD, AH and their combinations (OR=0.90, OR=0.71 and OR=0.56, respectively). At the same time, the presence of the T allele of the AGT gene may increase the risk for occurrence of the above mentioned disease (OR=1.11, OR=1.4 and OR=1.79, respectively). Conclusion: The study suggests that the presence of Т allele of the AGT gene at position 235 of the peptide chain both in homozygous and heterozygous state may increase the risk for AH in patients with COPD. Bangladesh Med Res Counc Bull 2020; 46(3): 176-183

scholarly journals THE EFFECT OF TRACHEAL DIVERTICULUM AND CHRONIC OSTRUCTIVE LUNG DISEASE ON CHEST ANTHROPOMETRY

2021 ◽  
Author(s):  
Mine ARGALI DENIZ ◽  
Hilal ER ULUBABA ◽  
M. Furkan ARPACI ◽  
Fatih CAVUS ◽  
Gokhan DEMIRTAS ◽  
...  
Keyword(s):  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Group 4 ◽  
Tracheal Diverticulum ◽  
Copd Patients ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Objective: In this study, the effect of tracheal diverticula (TD) on chest anthropometry and its relation with chronic obstructive pulmonary disease (COPD) was evaluated. Method: Between January 2019 and March 2020, 995 patients who underwent chest CT were retrospectively analyzed and TD was detected in 31 cases. Group 1 is only TD, Group 2 is TD + COPD, Group 3 is only COPD, Group 4 is defined as control group. We measured the localization, size, the distance to carina and vocal cord of TDs. In all groups chest diameters at T4 and T9 levels were measured as transverse and vertical plans. Results: TDs detected mostly at the T2 and T3 levels. In Group 1 and Group 2, there was a statistically significant difference the distance to TD of vocal chords. A statistically significant difference was found between Group 1 and Group 3 only in the vertical diameter at the T4 and T9 levels. Conclusion: We observed that COPD effect TD location and also TD had opposite effect on anteroposteriorly increasing chest parameters in COPD. Precence of TD is essential on COPD patients about thorax anthropometry. Keywords: Tracheal diverticulum; antropometry; radiology; COPD; chest diameter

scholarly journals Predictive Factors for the Effect of Treatment by Noninvasive Ventilation in Patients with Respiratory Failure as a Result of Acute Exacerbation of the Chronic Obstructive Pulmonary Disease

2015 ◽  
Vol 3 (4) ◽  
pp. 655-660 ◽  
Author(s):  
Sava Pejkovska ◽  
Biserka Jovkovska Kaeva ◽  
Zlatica Goseva ◽  
Zoran Arsovski ◽  
Jelena Jovanovska Janeva ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Upper Airway ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Failure Group ◽  
Copd Patients ◽  
Arterial Ph ◽  
Increased Risk ◽  
Group 2

BACKGROUND: Noninvasive mechanical ventilation (NIV) applies ventilator support through the patient’s upper airway using a mask.AIM: The aim of the study is to define factors that will point out an increased risk of NIV failure in patients with exacerbation of Chronic Obstructive Pulmonary Disease (COPD).PATIENTS AND METHODS: Patients over the age of 40, treated with NIV, were prospectively recruited. After data processing, the patients were divided into two groups: 1) successful NIV treatment group; 2) failed NIV treatment group.RESULTS: On admission arterial pH and Glasgow coma scale (GCS) levels were lower (pH: p < 0.05, GCS: p < 0.05), and Acute Physiology and Chronic Health Evaluation II (APACHE) score and PaCO2 were higher (p < 0.05) in the NIV failure group. Arterial pH was lower (p < 0.05) and PaCO2 and respiratory rate were higher (p < 0.05) after 1h, and arterial pH was lower (p < 0.05) and PaCO2 (p < 0.05), respiratory and heart rate were higher (p < 0.05) after 4h in the NIV failure group.CONCLUSION: Measurement and monitoring of certain parameters may be of value in terms of predicting the effectiveness of NIV treatment.

scholarly journals Role of signal-averaged electrocardiography and ventricular late potentials in patients with chronic obstructive pulmonary disease

2015 ◽  
Vol 53 (2) ◽  
pp. 133-139 ◽  
Author(s):  
C.A. Buzea ◽  
G.A. Dan ◽  
Anca Rodica Dan ◽  
Caterina Delcea ◽  
M.I. Balea ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Ventricular Arrhythmias ◽  
Control Group ◽  
Chronic Obstructive ◽  
Late Potentials ◽  
Obstructive Pulmonary Disease ◽  
Ventricular Late Potentials ◽  
Copd Patients ◽  
Increased Risk

Abstract Patients with chronic obstructive pulmonary disease (COPD) have an increased risk for cardiac arrhythmias. Ventricular late potentials (VLP) on signal-averaged electrocardiography (SAECG) are associated with an increased risk for malignant ventricular arrhythmias. Our aim is to investigate the modifications of SAECG parameters and the presence of VLP as possible indicators of proarrhythmic substrate in patients with COPD. We prospectively enrolled 41 consecutive patients in the COPD group and 63 patients without any history of pulmonary disease, matched for age and hypertension history, in the control group. Pulmonary function tests, arterial blood gases, echocardiography, 24-hour Holter monitoring and SAECG were performed. We measured total filtered QRS duration (QRSf), duration of high frequency, low-amplitude signals < 40 V (HFLA40), and root mean square voltage in the last 40 ms (RMS40). VLP were considered if at least two of these parameters were abnormal. Results. We did not register any significant differences in QRSf, HFLA40 or RMS40 between the two groups. In the COPD group there was a non-significant higher percentage of patients with VLP in comparison with the control group. In the COPD patients we registered a significantly higher number of isolated premature ventricular beats and of combined complex ventricular arrhythmias, consisting of polymorphic PVC, couplets, triplets or nonsustained ventricular tachycardias. None of these arrhythmic parameters correlated with SAECG variables or with the presence of VLP. Conclusion. In COPD patients parameters measured on signal-averaged electrocardiography and ventricular late potentials analysis have little value in risk stratification for ventricular arrhythmias.

scholarly journals How to improve the effectiveness of combination therapy of arterial hypertension in patients with concomitant chronic obstructive pulmonary disease?

2020 ◽  
Vol 4 (7) ◽  
pp. 418-424
Author(s):  
N.Yu. Grigorieva ◽  
◽  
M.O. Samolyuk ◽  
T.V. Sheshina ◽  
N.B. Koroleva ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Lipid Peroxidation ◽  
Arterial Hypertension ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Number Of Patients ◽  
Group 2 ◽  
Azilsartan Medoxomil ◽  
Group 1

Aim: to conduct a comparative assessment of the hypotensive effect, as well as the effect on endothelial function, oxidative stress, and pulmonary artery pressure of chlorthalidone and hydrochlorothiazide as part of combined antihypertensive therapy in patients with arterial hypertension (AH) in combination with chronic obstructive pulmonary disease (COPD).Patients and Methods: the prospective study included 66 patients divided into two groups. As the main antihypertensive therapy, group 1 was prescribed with a combination of azilsartan medoxomil 40 mg and chlortalidone 12.5 mg as a fixed combination of Edarbi® CLO. Group 2 received a free combination of azilsartan medoxomil 40 mg (Edarbi®) and hydrochlorothiazide 12.5 mg. All patients underwent 24-hour blood pressure monitoring: (ABPM), echodopplercardiography, endothelium-dependent vasodilation, lipid peroxidation (LPO), nitric oxide metabolites, and endothelin-1 levels at baseline and after 6 months of treatment. Results: target blood pressure values (<130/80 mm Hg) were achieved in 91% of patients in group 1, and 51.5% in group 2 after 1 month of the study. After 6 months of treatment, all patients in both groups reached the target BP values, but in group 2, the dose of hydrochlorothiazide had to be increased to 25 mg. According to the ABPM data, after 6 months of treatment, group 1 showed a decrease in the morning surge in SBP by 7.0±2.1% and DBP by 10±7.3%. There was also an increase in the number of patients with the daily profile of «dipper» type to 78.8%. In group 2, there was a decrease in the morning surge in SBP by 6.3±5.9% and DBP by 4.8±4.6% after 6 months of treatment. There was an increase in the number of patients with the daily profile of «dipper» type to 36.4%. After 6 months of treatment, there was more pronounced improvement in laboratory parameters of group 1 characterizing endothelial dysfunction and oxidative stress. Statistically significant results were obtained for conjugated trienes, NO2, S, Imax, and endothelin-1 when comparing groups 1 and 2.Conclusion: treatment of AH in patients with concomitant COPD in the form of a fixed combination of azilsartan medoxomil and chlorthalidone versus free combination of azilsartan medoxomil with hydrochlorothiazide has a more pronounced antihypertensive effect, positively affecting the daily BP profile, pulmonary artery pressure, endothelial function and lipid peroxidation processes after 6 months of treatment.KEYWORDS: arterial hypertension, chronic obstructive pulmonary disease, endothelial dysfunction, lipid peroxidation, azilsartan medoxomil, chlorthalidone.FOR CITATION: Grigorieva N.Yu., Samolyuk M.O., Sheshina T.V. et al. How to improve the effectiveness of combination therapy of arterial hypertension in patients with concomitant chronic obstructive pulmonary disease? Russian Medical Inquiry. 2020;4(7):418–424. DOI: 10.32364/2587-6821-2020-4-7-418-424.

scholarly journals Effects of Diabetes on pulmonary function tests in COPD Patient

2021 ◽  
pp. 48-51
Author(s):  
Bantupalli Suranjan ◽  
Atluri Deekshit ◽  
Bala Yaswanth Kumar S ◽  
Mano Ranjitha Pulivarthi
Keyword(s):  
Inflammatory Responses ◽  
Pulmonary Function Tests ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Increased Risk ◽  
Study Results ◽  
Lung Dysfunction ◽  
Patients With Diabetes ◽  
Group 2

COPD (chronic obstructive pulmonary disease) is a condition caused by abnormalities in the inflammatory responses of the lungs to irritable particles or gases. This is an irreversible condition that progresses in later years.Diabetes patients have an increased risk of developing abnormal lung functioning and also in conditions of COPD it even worsens the condition, up to 1.6-16% of the COPD population were affected due to diabetes mellitus.Many studies also suggest that the lungs are a target organ in diabetes and glycemic exposure may be a causation factor for reduced lung function. Systemic inflammation, hypoxemia, oxidative stress, altered gas exchange, and changes in lung tissues were the major impacts on the respiratory system which were induced by hypoglycemia. In this study, we aimed to assess the lung functioning in COPD patients with diabetes by performing the pulmonary functions test like spirometry by obtaining the values of FVC, FEV1, FEV/FVC, and PEF thereby analyzing the level of lung dysfunction that has been done. Patients were includes of both genders and were divided into two groups depending on their disease group 1 includes COPD and group 2 includes COPD with DM considering twenty members in each group. Our study results show that diabetes worsens the lung functioning in COPD than it already is, it may also cause respiratory collapse if untreated.

scholarly journals Features of Changes of Vascular Age and Cardiovascular Risk Level in Patients with Arterial Hypertension and Comorbid Chronic Obstructive Pulmonary Disease

2021 ◽  
pp. 48-52
Author(s):  
Iryna Vysochyna ◽  
Tetiana Burtniak ◽  
Valerii Potabashniy
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Cardiovascular Risk ◽  
Arterial Hypertension ◽  
Pulmonary Disease ◽  
Risk Level ◽  
Control Group ◽  
Chronic Obstructive ◽  
Additional Risk Factor ◽  
Obstructive Pulmonary Disease ◽  
Vascular Age

The objective: Evaluate changes in vascular age and cardiovascular risk level with reference to the severity of chronic obstructive pulmonary disease (COPD) in patients with arterial hypertension (AH) and COPD. Materials and methods. The study included 120 patients with hypertension stage II, grade 2, 3 and 3 in combination with COPD grade II–III and clinical groups A, B, C, D (group 1), 30 patients with AH without COPD (group 2), 30 patients with COPD without AH (group 3) and 30 healthy individuals (control group) representative by age and sex. Results. In the group of patients with AH and comorbid COPD, more than 50% of patients corresponded to moderate CVR, more than a third to high CVR, and a very high risk was found in isolated cases. The analysis of the obtained data revealed a significant increase in vascular age relative to chronological in groups 1, 2 and 3, but in control group there was only a tendency to ahead of vascular age (p>0.05). The diagnostic value of indicators for determining the exacerbation of COPD in patients with hypertension and comorbid COPD was determined using ROC analysis, which showed the presence of prognostic value for the following factors: age (AUC 0.50; CI 0.41–0.59), pack-years (AUC 0.60; CI0.51–0.69), duration of COPD (AUC 0.60; CI 0.51–0.69). Conclusion. The GP of the family medicine must evaluate the CVR on the SCORE scale as a screening technique. In the presence of comorbid COPD, the factor of disease duration becomes significant, which is an additional risk factor and affects the severity of CVR. Regardless of the comorbid pathology of AH and COPD, patients have a discrepancy between vascular and chronological age, which is a predictor of cardiovascular disease.

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