FEATURES OF THE EFFECT OF VARIOUS FORMS OF VITAMIN D ON THE BONE AND JOINT SYSTEM

Vitamin D takes part into the metabolism of the bone tissue, regulating the processes of mineralization and remodeling. There are a lot of data on uses of using of vitamin D in patients of trauma and orthopedic profile, but opinions about the method of taking, dosage, effectiveness differ greatly and requires more in-depth research.The objectiveof this study was to review and analyze of actual clinical and experimental researches related to the influence of metabolites of vitamin D in the endoprosthesis of large joints, among the available sources of medical database of PubMed, Cohraine, e-Library.The results of most studies of local and systemic use of metabolites of vitamin D led to the conclusion about the beneficial effects of these compounds on bone regeneration in traumatology and orthopedics. However, further researches are required to clearly identify the clinical application of these approaches.We supposed that the following factors considered for long-term work: assessment of long-term effect and usage of standardized doses, learning new derivatives of vitamin D, synergy in the combinations of vitamin D preparations, pharmacokinetics of vitamin D preparations and polymorphisms of genes associated with vitamin D, genes influencing the life activity of bone and assessment of the effect of concomitant disease, systemic pathological processes on related of vitamin D metabolism, and bone restoration. We are also define the simultaneous corrections of vitamin D levels as an important component of the compensation of bone disorders in trauma and orthopedic patients.

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Long term effect on trabecular bone score but not BMD is preserved in GH-deficient adults only when sufficient vitamin D levels are maintained

Endocrine Abstracts ◽

10.1530/endoabs.70.aep170 ◽

2020 ◽

Author(s):

Martin Kužma ◽

Juraj Smaha ◽

Daša Stojkovičová ◽

Peter Jackuliak ◽

Zdenko Killinger ◽

...

Keyword(s):

Vitamin D ◽

Trabecular Bone ◽

Trabecular Bone Score ◽

Term Effect ◽

Long Term Effect ◽

Vitamin D Levels ◽

Sufficient Vitamin

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Association of Vitamin D Status With Liver and Kidney Disease: A Systematic Review of Clinical Trials, and Cross-Sectional and Cohort Studies

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000540 ◽

2019 ◽

pp. 1-13 ◽

Cited By ~ 2

Author(s):

Seyed Mostafa Parizadeh ◽

Majid Rezayi ◽

Reza Jafarzadeh-Esfehani ◽

Amir Avan ◽

Hamideh Ghazizadeh ◽

...

Keyword(s):

Vitamin D ◽

Kidney Disease ◽

Renal Disease ◽

Cohort Studies ◽

Cochrane Library ◽

Major Public Health Problem ◽

Vitamin D Status ◽

Cross Sectional ◽

Beneficial Effects ◽

Vitamin D Levels

Abstract. Background: Vitamin D deficiency (VDD) is a major public health problem. There are few comprehensive systematic reviews about the relationship between Vitamin D status and liver and renal disease in Iran. Methods: We systemically searched the following databases: Web of Science; PubMed; Cochrane Library; Scopus; Science Direct; Google Scholar and two Iranian databases (Scientific Information Database (SID) and IranMedex) up until November 2017 to identify all randomized control trials (RCTs), case control, cross-sectional and cohort studies investigating the association between vitamin D and any form of liver or kidney disease. Results: Vitamin D insufficiency, or deficiency (VDD), is highly prevalent in Iran, reports varying between 44.4% in Isfahan to 98% in Gorgan. There is also a high prevalence of VDD among patients with liver or kidney disease, and the administration of vitamin D supplements may have beneficial effects on lipid profile, blood glucose, liver function and fatty liver disease, and bone health. Low serum vitamin D levels are related with abnormalities in these laboratory and clinical parameters. Conclusion: VDD is prevalent in patients with chronic liver or renal disease in Iran. There appear to be several beneficial effects of vitamin D supplementation in vitamin D deficient patients with liver or kidney disease.

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Decline in serum 25-OH vitamin D levels in HIV/hepatitis B virus (HBV) co-infected patients after long term antiretroviral therapy

Antiviral Therapy ◽

10.3851/imp2673 ◽

2013 ◽

Vol 19 (1) ◽

pp. 41-49 ◽

Cited By ~ 4

Author(s):

Anchalee Avihingsanon ◽

◽

Tanakorn Apornpong ◽

Reshmie A Ramautarsing ◽

Sasiwimol Ubolyam ◽

...

Keyword(s):

Vitamin D ◽

Hepatitis B Virus ◽

Antiretroviral Therapy ◽

Hepatitis B ◽

Vitamin D Levels ◽

B Virus ◽

25 Oh Vitamin D

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The Long-Term Effect of Vitamin D Supplementation on Quality of Life in Persistent (Perennial) Allergic Rhinitis Patients

Indian Journal of Otolaryngology and Head & Neck Surgery ◽

10.1007/s12070-021-02938-6 ◽

2021 ◽

Author(s):

Prazwal Shrestha ◽

Jasmine Kaur ◽

Yeshdeep Gupta ◽

Hitesh Verma

Keyword(s):

Quality Of Life ◽

Vitamin D ◽

Allergic Rhinitis ◽

Vitamin D Supplementation ◽

Term Effect ◽

Perennial Allergic Rhinitis ◽

Long Term Effect

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Efeitos de longo prazo do treinamento resistido na pressão arterial: uma revisão sistemática

Brazilian Journal of Kinanthropometry and Human Performance ◽

10.5007/1980-0037.2017v19n6p730 ◽

2017 ◽

Vol 19 (6) ◽

pp. 730-742

Author(s):

Paulo Eduardo Carnaval Pereira da Rocha ◽

Vladimir Schuindt da Silva ◽

Luiz Antonio Bastos Camacho ◽

Ana Glória Godoi Vasconcelos

Keyword(s):

Resistance Training ◽

Aerobic Exercise ◽

Training Model ◽

Training Models ◽

Beneficial Effects ◽

Long Term Effect ◽

Traditional Resistance Training ◽

Load Intensity ◽

Meta Analyses

Studies assessed the beneficial effects of aerobic exercise on blood pressure (BP); however, few studies have evaluated the effects of long-term resistance training on variations of this response. The aim of the study was to verify through a systematic review, the long-term effect of resistance training on BP. Searches were made on Medline through Pubmed, Science Direct, Scopus, Web of Science and Lilacs databases. Overall, 751 articles were found, of which 22 were further analyzed. The analysis followed the PRISMA checklist (Statement for Reporting Systematic Reviews and Meta-Analyses of Studies) and was divided according to two resistance training models: traditional resistance training (TRT), resistance training alone; or combined resistance training (CRT), resistance training associated with aerobic exercise. Greater BP reductions occurred for CRT compared to TRT. However, further studies are needed to better explicit the resistance training variables (number of exercises, repetitions, number of sets, intervals, speed of execution and load intensity), in order to identify the best training model and improve the methodological quality of experiments in an attempt to reduce the risk of bias.

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Evaluation of Vitamin D Metabolism in Patients with Type 1 Diabetes Mellitus in the Setting of Cholecalciferol Treatment

Nutrients ◽

10.3390/nu12123873 ◽

2020 ◽

Vol 12 (12) ◽

pp. 3873

Author(s):

Alexandra Povaliaeva ◽

Ekaterina Pigarova ◽

Artem Zhukov ◽

Viktor Bogdanov ◽

Larisa Dzeranova ◽

...

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Controlled Study ◽

Affinity Constant ◽

Vitamin D Metabolites ◽

Vitamin D Metabolism ◽

Vitamin D Levels

In this prospective controlled study, we examined 25 adults with adequately controlled (HbA1c level < 8.0%) type 1 diabetes mellitus (T1DM) and 49 conditionally healthy adults, intending to reveal the diversity of vitamin D metabolism in the setting of cholecalciferol intake at a therapeutic dose. All patients received a single dose (150,000 IU) of cholecalciferol aqueous solution orally. Laboratory assessments including serum vitamin D metabolites (25(OH)D3, 25(OH)D2, 1,25(OH)2D3, 3-epi-25(OH)D3 and 24,25(OH)2D3), free 25(OH)D, vitamin D-binding protein (DBP) and parathyroid hormone (PTH) as well as serum and urine biochemical parameters were performed before the intake and on Days 1, 3 and 7 after the administration. The studied groups had no significant differences in baseline parameters except that the patients with diabetes showed higher baseline levels of free 25(OH)D (p < 0.05). They also lacked a correlation between the measured and calculated free 25(OH)D in contrast to the patients from the control group (r = 0.41, p > 0.05 vs. r = 0.88, p < 0.05), possibly due to the glycosylation of binding proteins, which affects the affinity constant for 25(OH)D. The elevation of vitamin D levels after the administration of cholecalciferol was comparable in both groups, with slightly higher 25(OH)D3 levels observed in the diabetes group throughout the study since Day 1 (p < 0.05). Overall, our data indicate that in patients with adequately controlled T1DM 25(OH)D3 levels and the therapeutic response to cholecalciferol is similar to that in healthy individuals.

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Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458509355069 ◽

2009 ◽

Vol 16 (2) ◽

pp. 133-138 ◽

Cited By ~ 88

Author(s):

K. Claire Simon ◽

Kassandra L Munger ◽

Xing Yang ◽

Alberto Ascherio

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Conditional Logistic Regression ◽

Dietary Vitamin ◽

Environment Interaction ◽

Nucleotide Polymorphisms ◽

Vitamin D Metabolism ◽

Logistic Regression Models ◽

Gene Environment ◽

Vitamin D Levels

The extent to which potential genetic determinants of vitamin D levels may be related to multiple sclerosis (MS) risk has not been thoroughly explored. The objective of this study was to determine whether polymorphisms in VDR, CYP27B1, CYP24A1, CYP2R1 and DBP are associated with the risk of MS and whether these variants may modify associations between environmental or dietary vitamin D on MS risk. A nested case-control study was conducted in two, large cohorts of US nurses, including 214 MS cases and 428 age-matched controls. Conditional logistic regression models were used to calculate relative risks (RR) and 95% confidence intervals (CIs) and to assess the significance of gene—environment interactions. No associations were observed for any of the single-nucleotide polymorphisms (SNPs) in VDR, CYP27B1, CYP24A1, CYP2R1 or DBP (p > 0.05 for all). The authors did observe an interaction (p = 0.04) between dietary intake of vitamin D and the vitamin D receptor FokI polymorphism on MS risk. The protective effect of increasing vitamin D was evident only in individuals with the ‘ff ’ genotype (RR = 0.2, 95% CI: 0.06, 0.78; p = 0.02 for 400 IU/day increase). It was concluded that this does not support a role for the selected SNPs involved in vitamin D metabolism in the etiology of MS. The finding of a marginally significant gene—environment interaction requires replication in larger datasets, but suggests future genetic studies may benefit from considering relevant environmental context.

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P431 Vitamin D binding protein in the limelight: IBD-related inflammation and circulating levels of vitamin D binding protein, total, free and bioavailable 25-hydroxyvitamin D

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjz203.560 ◽

2020 ◽

Vol 14 (Supplement_1) ◽

pp. S393-S393

Author(s):

A Aksan ◽

K Böttger ◽

N Hein ◽

Y Caicedo-Zea ◽

I Diehl ◽

...

Keyword(s):

Vitamin D ◽

Binding Protein ◽

Transferrin Saturation ◽

Simultaneous Detection ◽

Full Blood Count ◽

Vitamin D Binding Protein ◽

Vitamin D Metabolism ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D

Abstract Background Vitamin D deficiency occurs frequently in patients with Crohn’s disease (CD) and ulcerative colitis (UC). While recent cohort studies support an association of vitamin D with important clinical parameters and outcomes in IBD, the complex interplay of inflammation with vitamin D metabolism in IBD poses a viscious circle. We sought to further illucidate the relation between inflammation and different vitamin D parameters. To the best our knowledge, this was the first study to focus on the relationship between vitamin D binding protein (VDBP), circulating total, free, and bioavailable 25-hydroxyvitamin D (25(OH)D), and inflammation, in adult IBD patients. Methods This was a comparative, single-centred, cross-sectional study in patients with IBD aged 18–65 years. Full blood count, transferrin, albumin and hsCRP were determined by standard methods. The presence/absence of inflammation was assessed based on serum hsCRP levels (cutoff <5mg/l). VDBP levels were determined by ELISA, and 25(OH)D by LCMS. Free and bioavailable vitamin D levels were calculated using the validated formula. IBM SPSS version 25.0 was used for statistical analysis. Results In total, 129 subjects with IBD (70 male/59 female; 82 CD/47 UC; mean age 41.7 ± 12.6 years) were enrolled. Of these, 38/129 had inflammation (19 m/19 f; 26 CD/12 UC; 39.6 ± 12.9 years) while 91/129 had no inflammation (40 m/51 f; 56 CD/35 UC; 42.5 ± 12.5 years). Subjects with disease activity had significantly higher leukocyte, erythrocyte sedimentation rate (ESR) and hsCRP, but lower transferrin, transferrin saturation (TSAT) and albumin levels than those without inflammation (p < 0.05). Average serum levels of 25(OH)D (24.6[6.8–54.8] vs. 26.4[5.0–74.4]ng/ml), free 25(OH)D (5.9[1.3–13.3] vs. 1.0[1.0–21.4]ng/ml) and bioavailable 25(OH)D(2.3 [0.1–4.7] vs. 2.4[0.5–19.5]ng/ml) were similar in patients with vs. without inflammation (p > 0.05). However, VDBP levels were significantly higher in inflammatory conditions (359.6[252.2–530.6] mg/l vs. 327.4[183.5–560.3]mg/l; p < 0.05) and showed a positive correlation with CRP levels (0.293, p < 0.001). Ratio of free/total 25(OH)D correlated negatively with CRP levels (−0.282, p = 0.002). Conclusion High levels of circulating VDBP were associated with inflammatory activity. Moreover, free/total 25(OH)D ratio was inversely associated with inflammation. Other vitamin D parameters including total, free and bioavailable 25(OH)D showed no association with inflammation. These findings suggest that VDBP may play a bigger role than thought as a modulator of vitamin D and inflammation, and that simultaneous detection and investigation of plasma VDBP may provide additional insights into this complex interaction.

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Potential Beneficial Effects of Vitamin D in Coronary Artery Disease

Nutrients ◽

10.3390/nu12010099 ◽

2019 ◽

Vol 12 (1) ◽

pp. 99 ◽

Cited By ~ 2

Author(s):

Christian Legarth ◽

Daniela Grimm ◽

Marcus Krüger ◽

Manfred Infanger ◽

Markus Wehland

Keyword(s):

Coronary Artery Disease ◽

Vitamin D ◽

Coronary Artery ◽

Vitamin D Supplementation ◽

Diabetic Patients ◽

Inverse Association ◽

Bone Homeostasis ◽

Beneficial Effects ◽

Vitamin D Levels ◽

Artery Disease

Vitamin D plays a pivotal role in bone homeostasis and calcium metabolism. However, recent research has indicated additional beneficial effects of vitamin D on the cardiovascular system. This review aims to elucidate if vitamin D can be used as an add-on treatment in coronary artery disease (CAD). Large-scale epidemiological studies have found a significant inverse association between serum 25(OH)-vitamin D levels and the prevalence of essential hypertension. Likewise, epidemiological data have suggested plasma levels of vitamin D to be inversely correlated to cardiac injury after acute myocardial infarction (MI). Remarkably, in vitro trials have showed that vitamin D can actively suppress the intracellular NF-κB pathway to decrease CAD progression. This is suggested as a mechanistic link to explain how vitamin D may decrease vascular inflammation and atherosclerosis. A review of randomized controlled trials with vitamin D supplementation showed ambiguous results. This may partly be explained by heterogeneous study groups. It is suggested that subgroups of diabetic patients may benefit more from vitamin D supplementation. Moreover, some studies have indicated that calcitriol rather than cholecalciferol exerts more potent beneficial effects on atherosclerosis and CAD. Therefore, further studies are required to clarify these assumptions.

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