scholarly journals Possibilities of photodynamic therapy in the treatment of malignant tumors of the oral cavity

2021 ◽  
Vol 10 (3) ◽  
pp. 32-38
Author(s):  
Y. A. Panaseykin ◽  
E. V. Filonenko ◽  
F. E. Sevrukov ◽  
V. V. Polkin ◽  
P. A. Isaev ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Oral Cavity ◽  
Oral Mucosa ◽  
Surface Defects ◽  
Radiation Treatment ◽  
Malignant Tumors ◽  
Survival Rates ◽  
Functional Results ◽  
Malignant Neoplasms ◽  
Common Disease

Oral mucosa cancer is a common disease with relatively low survival rates. The standard for the treatment of malignant neoplasms (MNO) of the oral mucosa is the surgical method, chemotherapy and / or radiation therapy. With the introduction of modern protocols and the improvement of current treatment methods, the increase in survival is insignificant due to the development of local and distant relapses, the appearance of simultaneous tumors of the oral cavity. Cosmetic and functional results in patients who have undergone complex treatment for oral cancer are often unsatisfactory. There is an obvious need to develop new approaches to treating patients with cancer of the oral mucosa. Photodynamic therapy (PDT) has similar properties. With the development of endoscopic and fiber-optic equipment, the fields of PDT application have significantly expanded. Foci in the oral cavity and oropharynx became available for PDT. The early stages of oral mucosal cancer are optimal for PDT because large surface defects can be treated with minimal complications. Preservation of subepithelial and collagen structures, which is typical for PDT, promotes healing without the formation of scar processes, thereby achieving an ideal cosmetic and functional effect. The use of PDT in the treatment of oral cavity cancer is not limited only to the initial stages in an independent version. It is possible to use PDT in combination with surgical and radiation treatment. In case of massive tumor processes, PDT is used for palliative purposes. The influence of the adaptive immune response under the influence of PDT is being studied.

scholarly journals THE DYNAMICS OF THE DETECTION OF MALIGNANT TUMORS OF THE LIPS AND ORAL MUCOSA IN THE MOSCOW REGION

2019 ◽  
Vol 23 (1) ◽  
pp. 32-34
Author(s):  
Irina A. Kryazhinova ◽  
V. V Sadovsky ◽  
E. E Olesov ◽  
E. V Glazkova ◽  
P. V Kashchenko ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Oral Mucosa ◽  
Annual Report ◽  
Malignant Tumors ◽  
Moscow Region ◽  
Malignant Neoplasms ◽  
First Year ◽  
Oncology Research ◽  
Fourth Patient ◽  
Research Institute

The analysis of the prevalence of malignant neoplasms (EIT) on the lips and oral cavity according to the annual report on Russia prepared by the Moscow Oncology research Institute named after P. A. Herzen and the Moscow regional oncologic dispensary. The dynamics of the analysis was carried out for 2011 - 2017 years. The detectability of the lip and oral cavity ZNO in the Moscow region is significant. The incidence of malignant tumors of the oral cavity is more pronounced in comparison with the ZNO lips. The extent of the EIT I-II degree are more characteristic of ZNO lips, and for TESTING of the oral cavity II-III degree. Mortality during the first year after diagnosis was established in every fourth patient with oral HEAT. The prevalence of lip ZNO for the period from 2011 to 2017 decreases, and the ZNO of the oral cavity increases.

scholarly journals REVIEW OF THE CURRENT STATE OF THE PROBLEM OF PRIMARY DETECTION OF MALIGNANT TUMORS OF THE CAVITY

2019 ◽  
Vol 15 (2) ◽  
pp. 50-55
Author(s):  
Наталья Нуриева ◽  
Natal'ya Nurieva ◽  
Александр Гузь ◽  
Aleksandr Guz ◽  
Александр Захаров ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Head And Neck ◽  
Malignant Tumors ◽  
Malignant Neoplasm ◽  
Diagnostic Procedures ◽  
Primary Diagnosis ◽  
Malignant Neoplasms ◽  
Dental Rehabilitation ◽  
Late Treatment ◽  
Clinically Significant

Subject: malignant neoplasms of the oral cavity, primary detectability, appeal to specialists, terms of treatment before hospitalization. Objective: based on a five-year analysis of the medical records of patients with a verified diagnosis of malignant neoplasm of the oral cavity, to identify significant criteria for primary diagnosis, doctors of the first contact, including non-cancer profile. Methodology. Malignant neoplasms occupy one of the leading places among all medical and social problems. This is due to a number of reasons, among which are particularly high rates of morbidity and mortality, late treatment of patients and frequent disability. the Purpose of early detection of malignant tumors of the oral cavity is to increase the effectiveness and radicality of treatment, increase the possibility of dental rehabilitation, reduction of disability. To write this article, we conducted a five-year analysis of the primary detection of malignant tumors of the oral cavity in 76 patients hospitalized for treatment in the head and neck Department of the Chelyabinsk district Oncology center. All patients with histologically confirmed diagnosis. Everyone needs specialized anti-tumor treatment. In addition to standard diagnostic procedures, all patients were surveyed on the issues of primary complaints and appeals to medical specialists. Results. On the example of the received questionnaires as well as the standard medical examinations conducted upon admission to the head and neck Department, the trends of the primary referral of patients to primary contact doctors, the terms of treatment before referral to a specialized oncological institution, the stage of the process and the presence of metastasis of the primary focus during treatment, the presence of aggravating factors are analyzed. Conclusions. The results for the five-year period in patients with primary malignant neoplasm of the oral cavity were evaluated, practical recommendations on clinically significant symptoms of malignant tumors of the oral cavity, orientation on the timing of observation were given.

scholarly journals Тhe effect of cancer patients’ positioning accuracy during radiation therapy sessions using medical linear electron accelerators on the parameters of their individual 3D dose distribution

Doklady BGUIR ◽  
2020 ◽  
Vol 18 (7) ◽  
pp. 31-39
Author(s):  
M. N. Piatkevich ◽  
E. V. Titovich ◽  
G. V. Belkov
Keyword(s):  
Radiation Therapy ◽  
Radiation Treatment ◽  
Malignant Tumors ◽  
Rapid Development ◽  
Treatment Session ◽  
Malignant Neoplasms ◽  
Horizontal Position ◽  
Individual Dose ◽  
Dose Distributions ◽  
The Impact

Due to the rapid development and further improvement of radiation treatment technologies oncologists have an opportunity to precisely deliver individual dose distributions to the tumor, minimizing the doses obtained by critical organs and healthy structures. For the correct and successful application of these complex methods of radiation therapy, it was necessary to enforce the requirements for the technical and dosimetric parameters of the radiotherapy equipment. The purpose of the research is to determine the magnitude of the possible error for patients’ positioning during their radiotherapy treatments using medical linear accelerators by modeling the impact of the patient’s body on the treatment couch. To determine the values of a possible error, the authors have considered the design and characteristics of a typical treatment couch, developed a model of the “average” patient’s body (phantom), which allowed changing the load to the treatment couch with a step of 1 kg. The position parameters of treatment couches were determined for the main types of localization of radiation therapy for malignant tumors: head and neck tumors, breast tumors and pelvic tumors. Numerical values of the treatment coach deviations from prescribed horizontal position were experimentally established for a load from 40 to 180 kg for a treatment couch used at the N.N. Alexandrov National Cancer Centre of Belarus. Based on the obtained experimental data, the necessity to correct the patient's treatment conditions at the stage of treatment planning were confirmed in order to ensure the delivery accuracy of individual dose distributions as required by the radiation therapy protocols. Authors stated that an analysis of the dependence of the deviations in the dose delivered to the patients on the deviation of the radiotherapy table from its horizontal position should be carried out for each radiotherapy table used in clinical practice. The development and implementation of a mechanism that will allow considering this information when choosing the parameters of the patient’s treatment session and prescribing the dose for any localization of malignant neoplasms is needed.

scholarly journals Photodynamic therapy of cancer of large duodenal papilla and extrahepatic bile ducts

2020 ◽  
Vol 9 (2) ◽  
pp. 18-28
Author(s):  
E. F. Stranadko ◽  
A. V. Baranov ◽  
V. A. Duvansky ◽  
A. I. Lobakov ◽  
V. A. Morokhotov ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Bile Ducts ◽  
Malignant Tumors ◽  
Control Group ◽  
Malignant Neoplasms ◽  
Duodenal Papilla ◽  
Risk Of Death ◽  
Photodynamic Therapy Of Cancer ◽  
Bile Drainage ◽  
Extrahepatic Bile Ducts

The problem of treating patients with malignant neoplasms of the extrahepatic bile ducts and the large duodenal papilla remains relevant due to the growing incidence, high mortality, and a pronounced decrease in the quality of life of patients, despite the radical surgery. The purpose of this study was to evaluate the effectiveness of photodynamic therapy (PDT) in inoperable patients with malignant tumors of these localizations.The study is based on the treatment of 79 patients with adenocarcinoma of large duodenal papilla and extrahepatic bile ducts. 29 patients received palliative bile drainage operations with PDT. 50 patients in the control group only had palliative bile drainage operations. Patients in the study group received from 1 to 3 PDT courses in a year. In total, 29 patients received 52 PDT courses. The tolerance to the method and the life expectancy of patients were evaluated. The median survival of patients who underwent PDT was 18 months (11–60 months); in the control group – 11.5 months. PDT, in combination with bile drainage operation, is an effective method for the treatment of inoperable patients with malignant neoplasms of the extrahepatic bile ducts and the large duodenal papilla in the absence of severe complications and with easy tolerance to therapy by patients. For the treatment and prolongation of life of patients whose radical surgical treatment is associated with a high risk of death, PDT seems to be the best treatment option. Results of PDT treatment for cancer of this localization are comparable with the results of radical surgeries and exceed those for palliative surgeries.

scholarly journals IMMUNE EFFECTS OF STEREOTACTIC ABLATIVE RADIATION THERAPY IN PATIENTS WITH MALIGNANT TUMORS: LITERATURE REVIEW

2020 ◽  
Vol 19 (5) ◽  
pp. 108-113
Author(s):  
A. Yu. Zozulya ◽  
I. A. Baldueva ◽  
S. N. Novikov
Keyword(s):  
Radiation Therapy ◽  
Cancer Patients ◽  
Radiation Treatment ◽  
Malignant Tumors ◽  
Survival Rates ◽  
Systemic Effect ◽  
Stereotactic Ablative Radiotherapy ◽  
Systematic Analysis ◽  
Combined Use ◽  
Abscopal Effects

The purpose of the study was to conduct a systematic analysis of the data available in the modern literature on the systemic (abscopal) effects in radiation therapy, which are mediated by immunological phenomena.Material and Methods.A structured search for articles published in peer-reviewed journals between January 2000 and February 2019 was conducted using MEDLINE database. The review included data from registered clinical trials at Clinicaltrials.gov, showing the results of the combined use of immunotherapy and radiation therapy.Results. There is an opinion that the systemic effect of radiotherapy is mediated by immunological phenomena. In connection with the recent data, there is a growing interest in the combined use of immunotherapy with radiation therapy in order to increase the efficacy of systemic therapy. However, the incidence of abscopal effects after standard radiation treatment is very low. In this regard, stereotactic ablative radiotherapy, due to its high immunogenic potential, low toxicity and short duration of the treatment, is apparently an attractive partner for immunotherapy in patients with metastatic disease.Conclusion. In view of the variety of the immunological effects of radiotherapy, further studies of the effect of radiation therapy on the immune system of cancer patients are needed, and the use of various combinations of immunotherapy and radiation therapy should be continued. All this, ultimately, will help improve the survival rates of cancer patients. 

136 THE PHOTODYNAMIC THERAPY OF MALIGNANT NEOPLASMS OF ORAL CAVITY AND LIPS

2008 ◽  
Vol 5 ◽  
pp. S45
Author(s):  
A.M. Shubina ◽  
M.A. Kaplan ◽  
V.N. Kapinus ◽  
I.S. Spichenkova ◽  
V.V. Polkin
Keyword(s):  
Photodynamic Therapy ◽  
Oral Cavity ◽  
Malignant Neoplasms

scholarly journals IMPACT OF POLYCHEMOTHERAPY ON THE ORAL SOFT TISSUES IN CHILDREN WITH MALIGNANT ABDOMINAL TUMORS

2019 ◽  
Vol 72 (5) ◽  
pp. 978-982
Author(s):  
Yuliia V. Popelo ◽  
Pavlo I. Tkachenko ◽  
Serhii O. Bilokon
Keyword(s):  
Oral Cavity ◽  
Soft Tissues ◽  
Malignant Tumors ◽  
Dental Health ◽  
Abdominal Cavity ◽  
Scientific Work ◽  
Malignant Neoplasms ◽  
Cytotoxic Effects ◽  
Abdominal Tumors ◽  
Number Of Cells

Introduction: According to modern standards of treatment of malignant neoplasms conducting polychemotherapy requires up to 90% of cancer patients. However, in addition to the expected cytotoxic effects, it is accompanied by disorders in dental health in the vast majority of patients. The aim: To study the effect of cytostatics on soft tissues of the oral cavity in children with malignant tumors of the abdominal cavity. Materials and methods: Material for writing this scientific work served as a synthesis of results for 25 people aged 7 to 15 years with malignant tumors of the abdominal cavity, in which a comprehensive oral examination was performed to determine the manifestations of dental toxicity cytostatics. Results: At the end of the first course of chemotherapy, all patients had dry redness of the lips, 20 - (80,0%) with eruptions, in 18 - (20,0%) erosion. The Green-Vermillion, PMA, and PBI indices grew by 1,8; 7 and 3,3 times respectively. In cytograms with buccal epithelium an increase in the number of cells of polymorphic sizes and forms with signs of gidropic dystrophy was found. The nuclear-cytoplasmic ratio decreased by 1,4 times compared with the primary examination. Conclusions: This situation creates the preconditions for the development of inflammatory process in the tissues of the oral cavity and requires the use in this category of patients of a substantiated pathogenetic correction of existing disorders.

RECONSTRUCTIVE PLASTIC SURGERY IN TREATMENT OF PATIENTS WITH MALIGNANT TUMORS OF THE ORAL CAVITY

2018 ◽  
Vol 64 (5) ◽  
pp. 602-606
Author(s):  
Denis Kulbakin ◽  
Yevgeniy Choynzonov ◽  
Marat Mukhamedov ◽  
Yevgeniy Garbukov ◽  
Ruslan Vasilev ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Reconstructive Surgery ◽  
Malignant Tumors ◽  
Previous Treatment ◽  
Functional Results ◽  
Maxillofacial Region ◽  
Reconstructive Operations ◽  
The Face ◽  
Reconstructive Plastic Surgery ◽  
Reconstructive Plastic

Introduction: Currently the problems of treating patients with advanced carcinomas of the oral cavity, and especially the reconstructive surgery for this causes, are very relevant. Materials and methods: We analyzed 127 reconstructive operations performed for patients with oral cancer. We used free (90 cases - 71%) and pedicle (37 cases - 29%) flaps for the reconstruction. Results: Good functional results were achieved in most cases (85%). Adequate mobility of the tongue was restored by using skin-fascial flaps. In cases of reconstruction of the maxillofacial region (mandible and maxilla) with the use of bone flaps it was possible to restore the continuity of mandible and maxilla, the natural contour of the face and the opening of the mouth. Conclusions: To achieve good functional and cosmetic results as well as to reduce postoperative complications of reconstructive surgery in patients with oral cavity tumors an adequate reconstructive material should be selected depending on the prevalence of the tumor process, the volume of reconstruction and previous treatment.

scholarly journals Primary screening of substances-photosensibilizers of the bacteriochlorin range for photodynamic therapy of malignant neoplasms

2018 ◽  
Vol 64 (3) ◽  
pp. 283-289 ◽  
Author(s):  
E.A. Plotnikova ◽  
M.A. Grin ◽  
P.V. Ostroverkhov ◽  
I.V. Pantushenko ◽  
R.I. Yakubovskaya ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Malignant Tumors ◽  
Light Exposure ◽  
Spectral Characteristics ◽  
Red Light ◽  
Wavelength Region ◽  
Biological Properties ◽  
Malignant Neoplasms ◽  
Long Wavelength ◽  
Primary Screening

This paper presents a primary screening of bacteriochlorin-type compounds with aminoamide, propyl and carbohydrate substituents aimed for development a new generation photosensitizers (PS) for photodynamic therapy of malignant tumors. Absorption and fluorescence spectral characteristics of the compounds, their storage stability in solutions under dark conditions and light exposure, photo-induced and dark cytotoxicity against human HEp2 tumor cells have been studied. It has been shown that the dyes with aminoamide substituents have an absorbtion maximum at 754±2 nm in the long wavelength region and they are not stable during storage (the specific fluorescence intensity decreased by 33-56% during 24 hours). The long wavelength region absorption of the propyl and carbohydrate substituted compounds varied in the range 780-831 nm, they were stable in solutions during storage and under light irradiation. Except the dye with a carbohydrate residue in the exocycle E, all PS exhibited the high photo-induced activity and low level of the dark cytotoxicity. The highest photo-induced cytotoxicity was observed for compounds with aminoamide substituents inthe macrocyclic ring (IC 50 values ranged from 17 nM to49 nM after 2 hour incubation with PS followed by exposure to the 10 J/cm 2 dose of red light). Taking into account the totality of the physico-chemical and biological properties, as well as manufacturability of production, O-propyloxime-N-propoxybacteriopurinimide methyl ester was chosen as the most promising candidate compound for further investigations.

scholarly journals Epidemiology of oral mucosal lesions in Slovenia

2018 ◽  
Vol 52 (3) ◽  
pp. 263-266 ◽  
Author(s):  
Andrej Aleksander Kansky ◽  
Vojko Didanovic ◽  
Tadej Dovsak ◽  
Bozana Loncar Brzak ◽  
Ivica Pelivan ◽  
...  
Keyword(s):  
Oral Health ◽  
Oral Cavity ◽  
Oral Mucosa ◽  
Malignant Tumors ◽  
Epidemiological Data ◽  
Denture Stomatitis ◽  
Linea Alba ◽  
Screening Programs ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions

Abstract Background Among the diseases of oral mucosa, malignant tumors are the most dangerous, but not the most common lesions that might appear in the oral cavity. Since most of the studies are focused on the detection of cancer in the oral cavity, we were interested in detecting the frequency of benign changes of the oral mucosa in Slovene population. Oral mucosal lesions are important pointer of oral health and quality of life, especially in elderly. The prevalence of oral mucosal lesions, together with information on the risk habits associated with oral health, such as tobacco and alcohol use, can help in planning future oral health studies and screening programs. Patients and methods Survey upon oral mucosal lesions was conducted during the national project for oral cancer screening in spring 2017 in the Slovenia in which more than 50% of dentists participated and 2395 patients (904 men and 1491 women) were included. Results Clinical examination, which was conducted according to the WHO standards revealed that 645 patients (27%) had oral mucosal lesions. The ten most common oral lesions detected were fibroma, gingivitis, Fordyce spots, white coated tongue, cheek biting, linea alba, denture stomatitis, geographic tongue, recurrent aphthous ulcerations and lichen planus. Conclusions Overall, these epidemiological data suggest need for specific health policies for prevention, diagnosis and treatment of oral mucosal lesions.

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