Thrombocytopenia and Bleeding in Dengue Fever: A Cross-Sectional Study during a Dengue Outbreak in Burkina Faso

There was no significant increase in platelet count in transfused and not transfused patients, meaning that platelet transfusion had no longer benefit in reduction of clinical or severe bleeding or improvement in platelet count recovery

Download Full-text

Comparison of severity signs between patients with primary and secondary dengue infection during the 2016 Burkina Faso (West Africa) outbreak

10.21203/rs.3.rs-85397/v1 ◽

2020 ◽

Author(s):

Eric Arnaud Diendéré ◽

Apoline Kognimisson Sondo/Ouédraogo ◽

ismael Diallo ◽

Absetou Ky/Ba ◽

Toussaint Rouamba ◽

...

Keyword(s):

Burkina Faso ◽

Dengue Fever ◽

Univariate Analysis ◽

Dengue Infection ◽

Cross Sectional Study ◽

Severe Dengue ◽

Severe Bleeding ◽

Cross Sectional ◽

Binary Dependent Variable ◽

The Relationship

Abstract BackgroundThe factors that expose the severity of dengue are still controversial, particularly the relationship between severe dengue and secondary dengue. More importantly, the severity of dengue infection remains poorly studied in Africa. The objective of this study was to compare severity signs between patients with primary and secondary dengue infection during the 2016 dengue outbreak in Burkina Faso.MethodsThis was a cross-sectional study through a retrospective examination of patient medical records managed in Ouagadougou for dengue fever from 1 January 2015 to 31 December 2017. All health facilities with the capacity to perform dengue diagnosis in Ouagadougou were considered in the survey. Primary dengue was defined as the presence of AgNS1 and/or IgM and secondary dengue as the presence of IgG associated with one of these two markers. Patients with only IgG were excluded. Univariate and multivariable analyzes were performed using a logistic regression with dengue infection (primary or secondary dengue) as the binary dependent variable. The statistical significant level was set at 0.05.Results Of the 811 patients managed for dengue fever during the study period, 418 (51.5%) were male. Thirty-five patients (4.3%) had primary dengue infection (AgNS1 + and / or IgM + with negative IgG) and seven hundred seventy-six (776) patients (95.7%) had secondary dengue infection. 245 patients (30.2%) experienced severe signs. Renal failure (13.1%) was the main sign of severity, followed by severe bleeding (10.6%). In univariate analysis, severe bleeding were associated with primary dengue infection (OR = 2.65, 95%IC: 1.16 -6.03, p = 0.01). Twenty-four deaths (9.8%) were reported during the period. ConclusionSigns of gravity can occur during primary dengue fever. This study highlight the need to conduct more studies on the severity factors of dengue fever.

Download Full-text

The Predictors of the Severity of Dengue Fever: A Cross-Sectional Study in a Tertiary Care Center of Bangladesh

Journal of Dhaka Medical College ◽

10.3329/jdmc.v29i1.51175 ◽

2021 ◽

Vol 29 (1) ◽

pp. 77-82

Author(s):

Mohammad Zaid Hossain ◽

Nusrat Sultana ◽

Afroza Akbar Sweety ◽

Reaz Mahmud ◽

Mohammed Masudul Hassan Khan ◽

...

Keyword(s):

Platelet Count ◽

Dengue Fever ◽

Cross Sectional Study ◽

Severe Dengue ◽

P Value ◽

Sectional Study ◽

Cross Sectional ◽

Medical College ◽

Group I ◽

Study Population

Background: Dengue is an endemic disease for Bangladesh with occasional outbreak. Little is known about the predictors of severe dengue. Methods: This cross sectional study was conducted in the medicine department of Dhaka Medical College from April 2019 to March 2020. Total 199 consecutive patients were enrolled in this study. For the purpose of the analysis, dengue fever was classified as group I and dengue hemorrhagic fever and dengue shock syndrome was classified as group II. Results: The mean (SD) age of the study population was 28.5(12.1) and 87.4% were less than 40 years of age. The male and female ratio was about 3:1. Among the total study population, 149(74.9%) patients had DF, 46 (23.1%) had DHF and only 4 (2%) had DSS on presentation. Baseline demography and clinical presentation did not significantly differ between classical dengue and severe dengue. Previous history of dengue had low association with severity (RR, 95%CI, phi, P value; 1.2, 1.04-1.40, 0.25, 0.001).Most of the laboratory parameters were similar between the groups. The number of platelet count was significantly lower in DHF and DSS [median (IQR) 43500(16500-95250], than DF [median (IQR) 65000(33000-1170000, p-value 0.01] Conclusion: Previous infection with dengue virus and decreasing platelet count are the predictors of the severe dengue. J Dhaka Medical College, Vol. 29, No.1, April, 2020, Page 77-82

Download Full-text

Dengue infection during pregnancy in Burkina Faso: a cross-sectional study

BMC Infectious Diseases ◽

10.1186/s12879-019-4587-x ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Kongnimissom Apoline Sondo ◽

Adama Ouattara ◽

Eric Arnaud Diendéré ◽

Ismaèl Diallo ◽

Jacques Zoungrana ◽

...

Keyword(s):

Burkina Faso ◽

Pregnant Women ◽

Dengue Fever ◽

Neonatal Mortality ◽

Dengue Infection ◽

Rapid Test ◽

Cross Sectional Study ◽

Severe Dengue ◽

Sectional Study ◽

Cross Sectional

Abstract Background Dengue fever is prevalent in the world; in recent years, several outbreaks occurred in West Africa. It affects pregnant women. We aimed to assess the consequences of dengue fever on pregnant women and their fetuses during dengue epidemic in Burkina Faso. Methods We conducted a cross-sectional study from November 1, 2015 to January 31, 2017 in 15 public and private health facilities in Ouagadougou, using secondary data. Immunochromatographic rapid test Duo detecting specific antibodies, immunoglobin M/G and /or dengue non structural antigen1 virus was used to diagnose dengue cases. Results Out of 399 (48%) women registered during the study period, 25 (6%) were pregnant. The average age of pregnant women was 30 years, with 18 and 45 years as extremes. The main symptoms were fever (92%) and headache (92%). Nine patients (36%) had severe dengue characterized by bleeding (16%), neurological symptoms (16%) and acute respiratory distress (8%). Eight (32%) of the 25 women had early miscarriage and 8 (32%) women gave birth to viable fetuses. Among those with viable babies, 5 (20%) presented post-partum hemorrhage and 3 (12%) presented early delivery. The main fetal complications included 3 cases of acute fetal distress (12%). One case of maternal death (4%) and 4 cases of neonatal mortality (44.5%) were notified. Conclusion Dengue fever occurring during pregnancy increases maternal and neonatal mortality. Its severe complications require specific monitoring of pregnant women until delivery.

Download Full-text

Comparison of severity signs between patients with primary and secondary dengue infection during the 2016 Burkina Faso (West Africa) outbreak.

10.21203/rs.3.rs-111786/v1 ◽

2020 ◽

Author(s):

Eric Arnaud Diendéré ◽

Apoline Kognimisson Sondo/Ouédraogo ◽

ismael Diallo ◽

Absetou Ky/Ba ◽

Toussaint Rouamba ◽

...

Keyword(s):

Burkina Faso ◽

Dengue Fever ◽

Univariate Analysis ◽

Dengue Infection ◽

Cross Sectional Study ◽

Severe Dengue ◽

Severe Bleeding ◽

Cross Sectional ◽

Binary Dependent Variable ◽

The Relationship

Abstract Background The factors that expose the severity of dengue are still controversial, particularly the relationship between severe dengue and secondary dengue. More importantly, the severity of dengue infection remains poorly studied in Africa. The objective of this study was to compare severity signs between patients with primary and secondary dengue infection during the 2016 dengue outbreak in Burkina Faso.Methods This was a cross-sectional study through a retrospective examination of patient medical records managed in Ouagadougou for dengue fever from 1 January 2015 to 31 December 2017. All health facilities with the capacity to perform dengue diagnosis in Ouagadougou were considered in the survey. Primary dengue was defined as the presence of AgNS1 and/or IgM and secondary dengue as the presence of IgG associated with one of these two markers. Patients with only IgG were excluded. Univariate and multivariable analyzes were performed using a logistic regression with dengue infection (primary or secondary dengue) as the binary dependent variable. The statistical significant level was set at 0.05.Results Of the 811 patients managed for dengue fever during the study period, 418 (51.5%) were male. Thirty-five patients (4.3%) had primary dengue infection (AgNS1 + and / or IgM + with negative IgG) and seven hundred seventy-six (776) patients (95.7%) had secondary dengue infection. 245 patients (30.2%) experienced severe signs. Renal failure (13.1%) was the main sign of severity, followed by severe bleeding (10.6%). In univariate analysis, severe bleeding were associated with primary dengue infection (OR = 2.65, 95%IC: 1.16 -6.03, p = 0.01). Twenty-four deaths (9.8%) were reported during the period. Conclusion Signs of gravity can occur during primary dengue fever. This study highlight the need to conduct more studies on the severity factors of dengue fever.

Download Full-text

Gender differences in cognitive impairment and mobility disability in old age: A cross-sectional study in Ouagadougou, Burkina Faso

Archives of Gerontology and Geriatrics ◽

10.1016/j.archger.2013.06.007 ◽

2013 ◽

Vol 57 (3) ◽

pp. 311-318 ◽

Cited By ~ 21

Author(s):

Yentéma Onadja ◽

Nicole Atchessi ◽

Bassiahi Abdramane Soura ◽

Clémentine Rossier ◽

Maria-Victoria Zunzunegui

Keyword(s):

Gender Differences ◽

Cognitive Impairment ◽

Burkina Faso ◽

Old Age ◽

Cross Sectional Study ◽

Sectional Study ◽

Mobility Disability ◽

Cross Sectional

Download Full-text

Comparative analysis of the long-term effect of two families of high-flux polysulfone dialysers on platelet count: a retrospective cross-sectional study

Therapeutics and Clinical Risk Management ◽

10.2147/tcrm.s143708 ◽

2017 ◽

Vol Volume 13 ◽

pp. 1415-1422 ◽

Cited By ~ 1

Author(s):

Rosaria Del Giorno ◽

Lorenzo Berwert ◽

Silvio Pianca ◽

Giorgia Bianchi ◽

Olivier Giannini ◽

...

Keyword(s):

Platelet Count ◽

Comparative Analysis ◽

Cross Sectional Study ◽

Term Effect ◽

High Flux ◽

Sectional Study ◽

Cross Sectional ◽

Long Term Effect

Download Full-text

P-035. Behavioral risk factors of cardiovascular diseases in pregnant women. Prevalence and socioeconomic predictors in Burkina Faso: a cross-sectional study

Pregnancy Hypertension ◽

10.1016/j.preghy.2021.07.070 ◽

2021 ◽

Vol 25 ◽

pp. e40

Author(s):

Garanet Franck

Keyword(s):

Risk Factors ◽

Cardiovascular Diseases ◽

Burkina Faso ◽

Pregnant Women ◽

Cross Sectional Study ◽

Behavioral Risk Factors ◽

Behavioral Risk ◽

Sectional Study ◽

Cross Sectional

Download Full-text

Cost of pediatric hospitalizations in Burkina Faso: A cross-sectional study of children aged <5 years enrolled through an acute gastroenteritis surveillance program

Vaccine ◽

10.1016/j.vaccine.2020.08.028 ◽

2020 ◽

Vol 38 (42) ◽

pp. 6517-6523

Author(s):

Negar Aliabadi ◽

Isidore Juste O. Bonkoungou ◽

Talia Pindyck ◽

Moumouni Nikièma ◽

Eyal Leshem ◽

...

Keyword(s):

Burkina Faso ◽

Acute Gastroenteritis ◽

Cross Sectional Study ◽

Surveillance Program ◽

Sectional Study ◽

Cross Sectional

Download Full-text

Comparison of knowledge on stroke for stroke patients and the general population in Burkina Faso: a cross-sectional study

AIMS Public Health ◽

10.3934/publichealth.2020056 ◽

2020 ◽

Vol 7 (4) ◽

pp. 723-735

Author(s):

Christy Pu ◽

◽

Jiun-Yu Guo ◽

Yu-Hua-Yeh ◽

Placide Sankara ◽

...

Keyword(s):

General Population ◽

Burkina Faso ◽

Cross Sectional Study ◽

Sectional Study ◽

Stroke Patients ◽

Cross Sectional

Download Full-text

Platelet count can predict the grade of esophageal varices in cirrhotic patients: a cross-sectional study

F1000Research ◽

10.12688/f1000research.28005.2 ◽

2021 ◽

Vol 10 ◽

pp. 101

Author(s):

Anum Afsar ◽

Muhammad Nadeem ◽

Syed Asim Ali Shah ◽

Huma Hussain ◽

Aysha Rani ◽

...

Keyword(s):

Platelet Count ◽

Negative Correlation ◽

Esophageal Varices ◽

Significant Negative Correlation ◽

Cross Sectional Study ◽

Variceal Hemorrhage ◽

Sectional Study ◽

Cross Sectional ◽

Grade Ii ◽

Cirrhotic Patients

Background: Bleeding from esophageal varices is a life-threatening complication in cirrhosis. Screening endoscopy is recommended in cirrhotic patients to identify patients at risk of variceal hemorrhage, but this is an invasive procedure and has limitations. Therefore, thrombocytopenia has been proposed to predict the existence and grade of esophageal varices. The aim of the current study was to determine a correlation between platelet count and grades of esophageal varices in patients with liver cirrhosis. Methods: This cross-sectional study was conducted at the POF Hospital, Wah Cantt from 1st October, 2017 to 30th May, 2018. Newly diagnosed cases of cirrhosis having varices of any grade on endoscopy were included. Endoscopic findings of patients were standardized using Paquet grading system. On the basis of platelet count, patients were divided into four subgroups. Platelet count groups were correlated with grading of esophageal varices using Spearman rank correlations. Chi Square test was used to see association between the platelet count and grade of esophageal varices. Results: 110 patients were included in the study, 55.5% (n=61) were male. Mean age of the patients was 59.89±9.01 years. Platelet count was <50,000/uL in 35.5% patients, 50,000-99,000/uL in 26.4%, 100,000-150000 in 12.7%, and >150,000/uL in 25.5% patients. Grade I esophageal varices were found in 23.6% of patients, whereas grade II, III and IV were found in 24.5%, 33.6% and 18.2% of patients, respectively. Mean platelet count was 213884.62/mm3 in patients with grade I varices, whereas it was 119518.52/mm3, 58386.49/mm3 and 21600.00/mm3 in patients with grade II, III and IV varices, respectively (p=<0.0001). A significant negative correlation between platelet count and grades of esophageal varices was found (p<0.001). Conclusion: Platelet count can predict the grade of esophageal varices in cirrhotic patients. There is significant negative correlation between platelet count and grades of esophageal varices.

Download Full-text