scholarly journals Association of Serum Urotensin-II Levels with Insulin Resistance and Endothelin-I in Type-II Diabetes Mellitus Patients

2021 ◽  
pp. 2514-2525
Author(s):  
Sara M. Khidhir ◽  
Almas MR Mahmud ◽  
Ismail M. Maulood
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Cyclic Peptide ◽  
Fasting Blood Glucose ◽  
Type Ii Diabetes Mellitus ◽  
Model Assessment ◽  
Urotensin Ii ◽  
Patients With Diabetes ◽  
Homeostatic Model Assessment ◽  
Positive Correlations

     Urotensin-II (UII), a pluripotent vasoactive cyclic peptide, exhibits the progression of cardiovascular diseases and the glucose metabolic disorder of insulin resistance. Type 2 Diabetes Mellitus (T2DM) is entirely associated with insulin resistance. This study aimed to demonstrate the association of UII with insulin resistance in diabetic and non-diabetic subjects. A total of 73 male and female subjects aged 40-60 years were recruited in this case-control study. They included 35 non- diabetic subjects with a body mass index of (BMI) ≤ 25 and 38 patients with Diabetes Mellitus and BMI ≥ 25. UII levels were assessed beside other vasoactive and clinical parameters.     The results revealed that patients with T2DM had elevated UII and Endothelin-I (ET-I) levels, along with positive correlations with the insulin-resistance marker of Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), blood pressure (BP), fasting blood glucose (FBG), hemoglobin A1c (HbA1C), and asymmetric dimethylarginine (ADMA). Results from stepwise multiple regressions indicated that UII correlated positively with the increases in the levels of serum cholesterol, ET-I, urea, ADMA, and FBG. This study concludes that the increase in UII level has a positive relation with insulin-resistance and the increase in ET-I level. However, UII could inhibit glucose-induced insulin secretion and, hence, can be utilized as a marker for T2DM and its complications through inflammatory microangiopathy.

scholarly journals Effects of Namya Kanom Jeen powder extract on hypoglycemic and anti-oxidant properties in Alloxan-induced diabetic rats

2018 ◽  
Vol 1 (8) ◽  
pp. 86
Author(s):  
Preeya Dat-arun ◽  
Rattana Leelawattana ◽  
Pavinee Chinachoti
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Blood Glucose ◽  
Water Extract ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Water Soluble ◽  
Model Assessment ◽  
Homeostatic Model Assessment ◽  
Anti Oxidant

Background: Diabetes mellitus (DM) is a major health care problem worldwide.  Major intervention control of DM is by using medical treatments and dietetic therapy.  Spices and herbs have been known to have anti-oxidant, anti-inflammation and anti-diabetic properties. Southern Thai foods known to contain phytochemicals in large amount, have been demonstrated to exhibit such properties and Namya Kanom Jeen (NKJ), a Southern Thai soup, shown to be most promising.  Here, we studied the effect of NKJ water extracts on hypoglycemic and anti-oxidant properties in Alloxan-induced diabetic rats.Methods: This study aimed to assess the effect of NKJ water extract on blood glucose, insulin, malondialdehyde (MDA), homeostatic model assessment of insulin resistance (HOMA-IR) and high sensitive C-reactive protein (hs-CRP) levels in Alloxan-induced diabetic (DM) rats for 3 weeks.Results: In Alloxan-induced diabetic rats, the NKJ water soluble extracts at 200, 1,000 and 2,000 mg/kg body weight doses (n=7) significantly lowered blood glucose, insulin, MDA, HOMA-IR levels compared to diabetic control (Metformin, p < 0.05). Conclusion: In summary, feeding of NKJ aqueous extract effectively lowered baseline blood glucose, insulin, MDA and HOMA-IR in diabetic rats.Keywords: Diabetes mellitus; Anti-oxidant; Glycemic; Insulin resistance; HOMA-IR, Namya Kanom Jeen powder 

scholarly journals Effects of green coffee extract on fasting blood glucose, insulin concentration and homeostatic model assessment of insulin resistance (HOMA-IR): a systematic review and meta-analysis of interventional studies

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Omid Nikpayam ◽  
Marziyeh Najafi ◽  
Samad Ghaffari ◽  
Mohammad Asghari Jafarabadi ◽  
Golbon Sohrab ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Glucose ◽  
Meta Analysis ◽  
Fasting Blood Glucose ◽  
Experimental Studies ◽  
Current Evidence ◽  
Model Assessment ◽  
Green Coffee ◽  
Homeostatic Model Assessment ◽  
Homeostatic Model

Abstract Many studies have investigated the relationship between coffee and diabetes. Evaluation of the current evidence on the effect of coffee intake on diabetes is critical. Therefore, we aimed to investigate the potential association between green coffee extract (GCE) and fasting blood glucose (FBG), insulin and homeostatic model assessment of insulin resistance (HOMA-IR) by pooling together the results from clinical trials. PubMed, Scopus and Google Scholar were searched for experimental studies which have been published up to December 2018. Randomized controlled trials (RCTs) that investigated the effect of GCE supplementation on FBG, insulin and HOMA-IR in adults were included for final analysis. A total of six articles were included in the meta-analysis. Results revealed that GCE supplementation reduced FBG level (SMD: −0.32, 95% CI − 0.59 to − 0.05, P = 0.02) but had no effect on insulin levels (SMD: −0.22, 95% CI −0.53 to 0.09, P = 0.159). Although analysis showed that GCE supplementation cannot change the HOMA-IR status (SMD: −0.30, 95% CI −0.73 to 0.13, P = 0.172), after stratified studies by GCE dosage (< 400 mg/day versus > 400 mg/day) there was a significant decrease in HOMA-IR status in a dose greater than 400 mg. These findings suggest that GCE intake might be associated with FBG improvement.

scholarly journals IMPORTANCE OF FASTING INSULIN LEVELS IN INSULIN RESISTANCE AND DIABETES MELLITUS (HOMEOSTATIC MODEL ASSESSMENT)

2016 ◽  
Vol 5 (90) ◽  
pp. 6685-6688
Author(s):  
Irfan Ahamed H B ◽  
Aniruddha Udupa K ◽  
Mohammed Ismail ◽  
Syed Aman Jagirdar ◽  
Naveen Sagar H M
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Insulin Levels ◽  
Homeostatic Model Assessment ◽  
Homeostatic Model

Association of visceral adiposity index with insulin resistance in adults with diabetes mellitus

2020 ◽  
Vol 14 (1) ◽  
pp. 5-12
Author(s):  
Sultana Parveen ◽  
Tohfa E Ayub ◽  
Tahniyah Haq ◽  
Nazmun Nahar ◽  
Naureen Manbub ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Adult Population ◽  
Fasting Blood Glucose ◽  
Visceral Adiposity ◽  
High Rate ◽  
Visceral Adiposity Index ◽  
Model Assessment ◽  
Anthropometric Parameters ◽  
Adiposity Index

Background and objectives: Visceral adiposity is linked to excess morbidity and mortality and positively correlates with the risk of insulin resistance, type-2 diabetes mellitus, cardiovascular disease and premature death. The study was conducted to find out the relationship between visceral adiposity index (VAI) and homeostatic model assessment insulin resistance (HOMA-IR) in diabetes mellitus (DM). Materials and methods: This cross sectional study was carried out on adult population with and without DM. Waist circumference (WC) and body mass index (BMI) were measured. BMI of 25-29.9 kg/m2 and ≥30 kg/m2 was defined as overweight and obese respectively. HOMA-IR method was used to calculate insulin resistance (IR). Standard formula using BMI, WC, triglyceride (TG) and high density lipoprotein cholesterol (HDL-c) was used to calculate VAI. Blood was analyzed for fasting blood glucose (FBS), TG, HDL-c and insulin level. Results: A total of 439 individuals were included in the study of which 269 had DM and 170 were healthy volunteers and the mean age was 41.47±6.82 and 36.16±7.44 years respectively. Compared to healthy controls, a greater number of diabetics had high VAI (86.5% vs. 98.9%) and high IR (43.5% vs. 85.1%). We found the highest sensitivity and specificity at a cut-off of 2.23 of VAI while at 3.65 had the highest specificity. Insulin resistance was observed significantly higher in those with diabetes compared to control, both in case of normal and high VAI at all cut-offs of VAI. Among anthropometric parameters (WC, BMI and VAI), VAI had positive (r=0.21, p<0.001) correlation with HOMA-IR than WC (r=0.10, p=0.043). Visceral fat was linearly related with insulin resistance (ß=0.18, p<0.001). Area under the curve (AUC) (0.66) showed that VAI can discriminate HOMA-IR. Conclusion: There was a high rate of raised VAI in cases with DM. VAI had positive association with HOMA-IR in diabetes mellitus. Although weak, there was an acceptable discrimination between them. Ibrahim Med. Coll. J. 2020; 14(1): 5-12

Sarkopenie im Kontext von Insulinresistenz und Diabetes mellitus im Alter – Daten aus der Berliner Altersstudie II

2020 ◽  
Vol 15 (05) ◽  
pp. 400-408
Author(s):  
Dominik Spira ◽  
Nikolaus Buchmann ◽  
Knut Mai ◽  
Thomas Bobbert ◽  
Joachim Spranger ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Body Mass Index ◽  
Body Mass ◽  
Diabetes Mellitus Typ 2 ◽  
Körperliches Training ◽  
Model Assessment ◽  
Homeostatic Model Assessment ◽  
Homeostatic Model ◽  
Negative Effekte

Zusammenfassung Hintergrund Diabetes mellitus Typ 2 (T2DM) und Sarkopenie nehmen mit steigendem Alter in ihrer Prävalenz zu und können langfristig betrachtet jeweils zu erheblichen gesundheitlichen und funktionellen Einschränkungen führen. Während eine zunehmende Insulinresistenz bei abnehmender Muskelmasse plausibel erscheint, sind umgekehrt auch glukotoxische negative Effekte auf die Skelettmuskulatur im Sinne einer sekundären Sarkopenie denkbar. Ziel dieser Arbeit war es, den Zusammenhang zwischen Sarkopenie, Insulinresistenz und T2DM bei älteren Menschen zu untersuchen. Methoden Untersucht wurden 1555 Probanden der Berliner Altersstudie II (BASE-II) mit einem durchschnittlichen Alter von 68 ± 4 Jahren. Die Diagnose T2DM wurde basierend auf der Anamnese sowie oralem Glukosetoleranztest und HbA1c-Wert nach ADA-Kriterien gestellt und die Insulinresistenz wurde via Homeostatic Model Assessment for Insulin resistance (HOMA-IR) und Insulinsensitivitätsindex nach Matsuda (ISI) eingeschätzt. Die appendikuläre Skelettmuskelmasse (ALM) wurde mittels Dual-Röntgen-Absorptiometrie (DXA) und eine Sarkopenie mithilfe der anhand des Body-Mass-Index (BMI) korrigierten Muskelmasse (ALM/BMI) nach den Cut-off-Werten des FNIH Sarcopenia Project bestimmt. Gruppenvergleiche wurden mittels Kruskal-Wallis-Test berechnet, und der Zusammenhang zwischen Diabetes mellitus und Sarkopenie bzw. ALM und Insulinresistenz wurde mittels geeigneter Regressionsmodelle überprüft. Ergebnisse 25,2 % der insgesamt 160 Probanden mit T2DM hatten bereits eine Sarkopenie. Sarkopenisch-adipöse Probanden wiesen im Vergleich zu nur adipösen, nur sarkopenen oder weder adipösen noch sarkopenen Probanden im Median einen niedrigeren ISI und einen höheren HOMA-IR auf (jeweils p < 0,001). T2DM zeigte sich unabhängig assoziiert mit Sarkopenie (OR 3,293, 95 %-KI 1,984–5,466, p < 0,001), während nach Ausschluss bekannter Diabetiker eine höhere ALM mit einem höheren ISI (B 0,229, 95 %-KI 0,119–0,338; p < 0,001), nicht jedoch niedrigerem HOMA-IR (B –0,017, 95 %-KI –0,089–0,055; p = 0,640) einherging. Diskussion Sarkopenie ist sowohl mit Insulinresistenz als auch T2DM assoziiert. Die Frage bzgl. der Kausalität ist aufgrund des querschnittlichen Designs der Studie nicht zu beantworten, jedoch sollte eine mögliche Rolle des T2DM als sekundäre Sarkopenieursache berücksichtigt und weiter untersucht werden. Im Hinblick auf mögliche Folgen erscheinen die Identifizierung von Risikopatienten mit kombiniertem Auftreten von Sarkopenie und Insulinresistenz und die Evaluation basaler präventiver Maßnahmen wie gezieltes körperliches Training und angepasste Ernährung ein weiterführendes sinnvolles Ziel.

scholarly journals In -Vivo Anti-Diabetic Activity of Hydro-Ethanolic Seed Extract of Syzygium Cumini (L.)

2021 ◽  
Vol 14 (1) ◽  
pp. 241-247
Author(s):  
Meharban Asanaliyar ◽  
Pratibha Nadig
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Blood Glucose ◽  
Beta Cell Function ◽  
Cell Function ◽  
Fasting Blood Glucose ◽  
Seed Extract ◽  
Model Assessment ◽  
Syzygium Cumini ◽  
Homeostasis Model Assessment

Introduction: Diabetes mellitus continues to be a major health problem in India and across the world. Over centuries, numerous herbal extracts have been used in the Indian traditional medicine to control elevated blood sugar levels in patients with diabetes. Different aqueous and organic extracts of Syzygium cumini (L.) Skeels have found widespread use owing to their anti-diabetic activity. A systematic study was undertaken to characterise and evaluate the effects of a hydro-ethanolic seed extract (SCE) of Syzygium cumini in a rodent model of experimental type 2 diabetes mellitus. Methods: An established model of diabetes mellitus with a combination of streptozotocin and high fat diet (over 12 weeks) in adult male Wistar albino rats, was used in this study. The onset of diabetes mellitus in rats was confirmed with a fasting blood glucose (FBG) of >200 mg/dl. The diabetic rats were allocated into five experimental groups and treated as follows: with vehicle alone, pioglitazone (10 mg/kg), 100mg/kg or 200mg/kg or 400 mg/kg of SCE, respectively for 21 days. The pre and post treatment levels of fasting blood glucose, insulin and lipids were measured from serum obtained from the various treatment groups. In order to measure insulin resistance, a homeostasis model assessment of insulin resistance (HOMA IR) and for measuring the beta cell function a homeostasis model assessment were employed. The results obtained from these studies were analysed using the Analysis of variance (ANOVA) method. Results: Our study demonstrates the SCE preparation to induce a statistically significant dose-dependent reduction in FBG, serum lipid levels and HOMA IR with a concomitant increase in the serum insulin levels and HOMA B. Conclusions: Wistar rats dosed with SCE at 100 and 200 mg/kg body weight demonstrated statistically significant anti-diabetic activity by virtue of improving the pancreatic beta cell function and reduction in insulin resistance.

scholarly journals Adipokines Vaspin and Visfatin in Obese Children

2015 ◽  
Vol 3 (4) ◽  
pp. 563-566 ◽  
Author(s):  
Hassan M. Salama ◽  
Ashraf Galal ◽  
Ayat A. Motawie ◽  
Ashraf F. Kamel ◽  
Doaa M. Ibrahim ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Waist Circumference ◽  
Serum Insulin ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Assessment Method ◽  
Model Assessment ◽  
Obese Children ◽  
Significant Elevation ◽  
Positive Correlations

BACKGROUND: Adipokines provides new insights about the physiology, pathology and treatment of obesity.AIM: We investigated the association between serum vaspin and serum visfatin concentrations with obesity in Egyptian children.MATERIAL AND METHODS: Twenty two obese children with body mass index (BMI) above 95th percentile; 11 males and 11 females were included in this study. Their mean age was 9.18 ± 2.8 years. After general clinical examination, fasting blood glucose, triglycerides, total cholesterol and high density lipoprotein cholesterol were measured in cases and controls (n=11). Fasting insulin, vaspin and visfatin were detected using ELIZA. Insulin resistance was estimated by Homeostasis model assessment method (HOMA-IR).RESULTS: Blood pressure, in both systolic and diastolic measurements was elevated significantly in obese children. Significant elevation of serum insulin and insulin resistance (HOMA/IR) were observed in obese children too. Vaspin and visfatin showed significant elevation in obese children than controls. Significant positive correlations were detected between visfatin and BMI, waist circumference, hip circumference and HOMA/IR. We found that Vaspin and visfatin are higher in obese children.CONCLUSION: Visfatin but not vaspin correlates positively with waist circumference and HOMA/IR in obese children.

scholarly journals Sex-dependent association between erythrocyte n-3 PUFA and type 2 diabetes in older overweight people

2016 ◽  
Vol 115 (8) ◽  
pp. 1379-1386 ◽  
Author(s):  
Kylie A. Abbott ◽  
Martin Veysey ◽  
Mark Lucock ◽  
Suzanne Niblett ◽  
Katrina King ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Model Assessment ◽  
Dietary Interventions ◽  
Overweight Women ◽  
Overweight People ◽  
Homeostatic Model Assessment

AbstractThe association between n-3 PUFA intake and type 2 diabetes (T2D) is unclear, and studies relating objective biomarkers of n-3 PUFA consumption to diabetic status remain limited. The aim of this study was to determine whether erythrocyte n-3 PUFA levels (n-3 index; n-3I) are associated with T2D in a cohort of older adults (n 608). To achieve this, the n-3I (erythrocyte %EPA+%DHA) was determined by GC and associated with fasting blood glucose; HbA1c; and plasma insulin. Insulin resistance (IR) was assessed using the homeostatic model assessment of insulin resistance (HOMA--IR). OR for T2D were calculated for each quartile of n-3I. In all, eighty-two type 2 diabetic (46·3 % female; 76·7 (sd 5·9) years) and 466 non-diabetic (57·9 % female; 77·8 (sd 7·1) years) individuals were included in the analysis. In overweight/obese (BMI≥27 kg/m2), the prevalence of T2D decreased across ascending n-3I quartiles: 1·0 (reference), 0·82 (95 % CI 0·31, 2·18), 0·56 (95 % CI 0·21, 1·52) and 0·22 (95 % CI 0·06, 0·82) (Ptrend=0·015). A similar but non-significant trend was seen in overweight men. After adjusting for BMI, no associations were found between n-3I and fasting blood glucose, HbA1c, insulin or HOMA-IR. In conclusion, higher erythrocyte n-3 PUFA status may be protective against the development of T2D in overweight women. Further research is warranted to determine whether dietary interventions that improve n-3 PUFA status can improve measures of IR, and to further elucidate sex-dependent differences.

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