scholarly journals Adverse drug reactions in hospitalized colombian children

2016 ◽  
pp. 142-147 ◽  
Author(s):  
Roxana De las salas ◽  
Daniela Díaz Agudelo ◽  
Francisco Javier Burgos Flórez ◽  
Claudia Vaca ◽  
Dolores Vanessa Serrano Meriño
Keyword(s):  
Cohort Study ◽  
Adverse Drug Reactions ◽  
Drug Safety ◽  
Safety Data ◽  
Incidence Density ◽  
Hospitalized Children ◽  
Drug Reactions ◽  
Additional Burden ◽  
Male Patients ◽  
Systemic Antibiotics

Introduction: The occurrence of adverse drug reactions is an important issue due to the lack of drug safety data in children. Objective: To describe the Adverse Drug Reactions in inpatient children under 6 years of age in two general pediatrics wards located in Barranquilla, Colombia. Methods: A prospective cohort study based on intensive pharmacovigilance was conducted during six months in order to monitor the emergence of Adverse Drug Reactions in inpatients children under 6 years of age with at least one medication prescribed. The study was conducted in two pediatric wards of two hospitals located in Barranquilla, Colombia. Naranjo´s Algorithm was used to evaluate imputability, the modified Hartwig and Siegel assessment scale to establish severity and the Schumock and Thornton criteria to determine preventability. Results: Of a total of 772 monitored patients, 156 Adverse Drug Reactions were detected on 147 children. The cumulative incidence of Adverse Drug Reactions was 19.0% (147/772); the incidence density was 37.6 Adverse Drug Reactions per 1,000 patients-days (147/3,913). The frequency was higher in children under 2 years of age (12.7%). Emergence of Adverse Drug Reactions was higher in male patients (RR= 1.66; 95% CI= 1.22 to 2.22, p= 0.001) and in those who used systemic antibiotics (RR= 1.82; 95% CI= 1.17 to 2.82, p= 0.005). Conclusions: Adverse Drug Reactions are common among hospitalized children and represent an additional burden of morbidity and risk, particularly in those who used several medicines, including antibiotics.

scholarly journals Adverse drug reactions in hospitalized paediatric patients in a tertiary care center in Kerala, India

2018 ◽  
Vol 7 (10) ◽  
pp. 1998
Author(s):  
Shiva Murthy N. ◽  
Praveen V. Jose ◽  
Basalingappa S. ◽  
Safeera K. Ali ◽  
Mabel Elizabeth V. K.
Keyword(s):  
Drug Safety ◽  
Care Center ◽  
Tertiary Care ◽  
Safety Information ◽  
Tertiary Care Center ◽  
Paediatric Patients ◽  
Additional Burden ◽  
Male Patients ◽  
Systemic Antibiotics ◽  
Drug Safety Information

Background: Drug safety information about children is scarcely available. This study aims to describe the ADRs in hospitalized paediatric patients under 12 years of age in paediatrics wards of DM WIMS Hospital, Wayanad, Kerala, a tertiary care center in southern part of India.Methods: A retrospective study based on data collected as per the ongoing pharmacovigilance program of India (PvPI) was conducted for twelve months period in order to study the ADRs in hospitalized paediatric patients under 12 years of age with at least one medication prescribed. The study was conducted in paediatrics wards of DM WIMS Hospital, Wayanad. WHO-UMC scale and Naranjo´s Algorithm was used to evaluate causality, the modified Hartwig and Siegel assessment scale was used to establish severity and the Schumock and Thornton criteria was used to determine preventability.Results: Forty-two children (42) who experienced 55 ADRs were included in the study. The frequency was higher in children under 1 year of age (47.62%). Emergence of ADRs was higher in male patients (59.52%), in those used three or more medicines together (71.43%) and in those with systemic antibiotics (58.18%).Conclusions: Being the first study from Kerala in paediatric patients, it is an important contribution to drug safety profile in children from this region of India. ADRs frequency and other descriptive characteristics are provided for the enrolled children under 12 years of age. ADRs are an additional burden of morbidity and risk, particularly in those who used several medicines, including antibiotics.

Causality and avoidability of adverse drug reactions of antibiotics in hospitalized children: a cohort study

2021 ◽  
Author(s):  
Sheila Feitosa Ramos ◽  
Fernando de Castro Araújo-Neto ◽  
Giulyane Targino Aires-Moreno ◽  
Dyego Carlos Souza Anacleto de Araújo ◽  
Elisângela da Costa Lima ◽  
...  
Keyword(s):  
Cohort Study ◽  
Adverse Drug Reactions ◽  
Hospitalized Children ◽  
Drug Reactions

METHODOLOGIES FOR ASSESSING DRUG SAFETY, EFFECTIVENESS AND ADVERSE DRUG REACTIONS

2018 ◽  
Vol 20 (3) ◽  
pp. 112-117
Author(s):  
O.I. Slyusar ◽  
◽  
A.B. Kachalov ◽  
M.V. Ryzhkova ◽  
I.В. Slyusar ◽  
...  
Keyword(s):  
Adverse Drug Reactions ◽  
Drug Safety ◽  
Drug Reactions ◽  
Safety Effectiveness

scholarly journals Operation Save the World from Adverse Drug Reactions: findings from a drug safety surveillance programme in Nigeria

2019 ◽  
Vol 7 ◽  
pp. S46 ◽  
Author(s):  
Yohanna Kambai Avong ◽  
Bolajoko Jatau ◽  
Gbenga Ayodele Kayode ◽  
Blessing Ukpabi ◽  
Eunice Bosede Avong ◽  
...  
Keyword(s):  
Adverse Drug Reactions ◽  
Drug Safety ◽  
Drug Reactions ◽  
Surveillance Programme ◽  
Safety Surveillance ◽  
Drug Safety Surveillance ◽  
The World

scholarly journals Body Weight as a Determining Factor in the Predominance of Adverse Drug Reactions Induced by Fixed-Dose Adalimumab Injections in Female Patients in a Korean Hospital Setting

2020 ◽  
Vol 9 (2) ◽  
pp. 461
Author(s):  
Kwi Suk Kim ◽  
Young Hee Choi ◽  
Aree Moon ◽  
Sang Geon Kim
Keyword(s):  
Body Weight ◽  
Adverse Drug Reactions ◽  
Laboratory Data ◽  
Fixed Dose ◽  
Drug Reactions ◽  
Female Patients ◽  
Adalimumab Therapy ◽  
Male Patients ◽  
The Impact ◽  
Determining Factor

Adalimumab is used at 40-mg dose to treat systemic inflammatory diseases. Given the impact of adverse drug reactions (ADRs), which particularly result in the discontinuation of adalimumab therapy in female patients, this study examined whether sex affects the frequency and type of ADRs induced by adalimumab. In this study, the prescription records and laboratory data of patients aged ≥19 years who had been admitted to the Seoul National University Hospital (SNUH) and prescribed adalimumab were analyzed using an electronic medical record database. The analysis revealed that female patients more frequently experienced adalimumab-induced ADRs compared with male patients (63.2% vs. 52.2%). The incidence of ADRs was significantly higher in female patients with ankylosing spondylitis or rheumatoid arthritis than in male patients with similar conditions (81.5% vs. 60.7% or 64.4% vs. 50.0%, respectively). The median body weight (BW) was lower in female patients than in male patients (54.0 vs. 66.0 kg). Moreover, the incidence of ADRs in patients with a BW of <54.0 kg (i.e., the median female BW) was higher than for those with a BW of ≥54.0 kg, in both males and females. Our results suggested that the predominance of ADRs induced by adalimumab in females was because of their relatively lower BW. This suggests the importance of BW as a determining factor in sex disparity of ADR occurrences.

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