scholarly journals Estimation of Endothelin-1 and Vitamin D Levels in Patients with Some Renal disease

2019 ◽  
Vol 24 (7) ◽  
pp. 1
Author(s):  
Ihsan Maher Abdul Amir ◽  
Moafaq Mutlak Zeidan
Keyword(s):  
Vitamin D ◽  
Renal Disease ◽  
General Hospital ◽  
Chronic Renal Disease ◽  
Public Health Problem ◽  
Control Group ◽  
Cross Sectional ◽  
Endothelin 1 ◽  
Number Of Patients ◽  
Vitamin D Levels

Chronic renal disease is a worldwide public health problem with an increasing incidence, prevalence, poor outcomes, and high cost. A cross-sectional study was carried out in balad city from 10th of November 2018 to 15th of March 2019. The number of patients under  study were 60 patients with renal disease (30 acute renal disease and 30 chronic renal disease under hemodialysis). Their ages were between (20-75) years. Patients with acute renal disease were admitted to Balad general hospital and patients with chronic renal disease who admitted to Salahaddin general hospital for hemodialysis. The study included 30 apparently healthy subject as control group. The results showed that the highest mean level of endothelin-1 was found in patients with chronic renal disease (13.15±7.81)pg/ml followed by patients with acute renal disease (1.78±1.49) pg/ml compared with  the control group (0.41±0.31) pg/ml. These result were significant higher (P< 0.01). The results  showed that the lowest mean level of vitamin D was found in patients with chronic renal disease (14.45±5.92) ng/ml followed by patients with acute renal disease (23.49±13.14) ng/ml compared with the control group (24.02 ±8.22) ng/ml. The results were significant higher than control (P≤0.01). The study showed that patients with acute renal disease were distributed equally to male and female (1:1) while 56.67% of patients with chronic renal disease were males. The conclute from this study that the endothelin elevated in chronic renal disease patients and vitamin D was reduced.    http://dx.doi.org/10.25130/tjps.24.2019.121

Association of Vitamin D Status With Liver and Kidney Disease: A Systematic Review of Clinical Trials, and Cross-Sectional and Cohort Studies

2019 ◽  
pp. 1-13 ◽  
Author(s):  
Seyed Mostafa Parizadeh ◽  
Majid Rezayi ◽  
Reza Jafarzadeh-Esfehani ◽  
Amir Avan ◽  
Hamideh Ghazizadeh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Kidney Disease ◽  
Renal Disease ◽  
Cohort Studies ◽  
Cochrane Library ◽  
Major Public Health Problem ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Beneficial Effects ◽  
Vitamin D Levels

Abstract. Background: Vitamin D deficiency (VDD) is a major public health problem. There are few comprehensive systematic reviews about the relationship between Vitamin D status and liver and renal disease in Iran. Methods: We systemically searched the following databases: Web of Science; PubMed; Cochrane Library; Scopus; Science Direct; Google Scholar and two Iranian databases (Scientific Information Database (SID) and IranMedex) up until November 2017 to identify all randomized control trials (RCTs), case control, cross-sectional and cohort studies investigating the association between vitamin D and any form of liver or kidney disease. Results: Vitamin D insufficiency, or deficiency (VDD), is highly prevalent in Iran, reports varying between 44.4% in Isfahan to 98% in Gorgan. There is also a high prevalence of VDD among patients with liver or kidney disease, and the administration of vitamin D supplements may have beneficial effects on lipid profile, blood glucose, liver function and fatty liver disease, and bone health. Low serum vitamin D levels are related with abnormalities in these laboratory and clinical parameters. Conclusion: VDD is prevalent in patients with chronic liver or renal disease in Iran. There appear to be several beneficial effects of vitamin D supplementation in vitamin D deficient patients with liver or kidney disease.

scholarly journals P0299EVALUATION OF THE CORRELATION BETWEEN VITAMIN D LEVELS AND THROMBOCYTE MARKERS IN PATIENTS WITH DİALYSİS, CHRONIC RENAL DISEASE AND RENAL TRANSPLANTATION PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
KÖNÜL AHMEDOVA ◽  
Garip SAHIN ◽  
Cengiz Bal ◽  
Rüya Mutluay
Keyword(s):  
Vitamin D ◽  
Renal Transplantation ◽  
Renal Disease ◽  
Negative Correlation ◽  
Chronic Renal Disease ◽  
Significant Negative Correlation ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Before And After ◽  
Grade 3

Abstract Background and Aims 25(OH)D3 levels are known to be lower in patients with chronic renal disease (CRD). Vitamin D supplementation has been shown to have beneficial effects on mortality in these patients. In our study, we have evaluated the pleiotropic effect of vitamin D on thrombocyte markers, which is known very little by most. Method The main thrombocyte function markers (MPV, PDW and PCT) were obtained in patients which underwent dialysis, renal transplantation and patients with grade 3-4 CRD before and after vitamin D supplementation. 40 healthy individuals were chosen as control group and 24 patients underwent renal transplantation, 25 patients underwent dialysis for at least 3 months, 32 patients were diagnosed as Grade 3-4 CRD. All of the patients above had 25(OH)D3 levels &lt;20ng/mL (&lt;50nmol/L). Thrombocyte markers were evaluated before and after vitamin D supplementation (which was given 50.000 IU orally once a week for 8 weeks). Results Statistically no significant difference were found between MPV values in- and across- group comparison before and after vitamin D supplementation. After the correlation analyses were reviewed, statistically significant negative correlation was found (r=-0,422 p&lt;0.05) between ΔMPV and ΔVitamin D in renal transplantation group. Also statistically significant positive correlation was found between ΔPDW and ΔVitamin D. In the control group with healty participants, a statistically significant negative correlation was found (r=-0,493 p&lt;0.05) between ΔVitamin D and ΔThrombocyte count. In the dialysis group a statistically significant negative correlation was found (r=-0,422 p&lt;0.05) between ΔVitamin D and ΔMPV. Conclusion A significant correlation was found particularly between Vitamin D and MPV in dialysis and renal transplantation patients. In order to prevent cardiovascular events due to thrombosis caused by Vitamin D deficiency which increases MPV, it has been thought that Vitamin D supplementation and antiaggregant therapy might be beneficial.

scholarly journals The Restoration of Vitamin D Levels Slows the Progression of Renal Ischemic Injury in Rats Previously Deficient in Vitamin D

2021 ◽  
Vol 8 ◽  
Author(s):  
Michele Santiago dos Santos ◽  
Daniele Canale ◽  
Desiree Rita Denelle Bernardo ◽  
Maria Heloisa Massola Shimizu ◽  
Antonio Carlos Seguro ◽  
...  
Keyword(s):  
Vitamin D ◽  
Renal Function ◽  
Renal Disease ◽  
Disease Progression ◽  
Ischemia Reperfusion ◽  
Kidney Injury ◽  
Public Health Problem ◽  
Standard Diet ◽  
Renal Disease Progression ◽  
Vitamin D Levels

Chronic kidney disease (CKD) remains a global public health problem. The initial damage after ischemia/reperfusion (I/R) injury plays an important role in the pathogenesis of acute kidney injury (AKI) and predisposition to CKD. Several studies have been showing that nontraditional risk factors such as AKI and hypovitaminosis D could also be involved in CKD progression. Vitamin D deficiency (VDD) is associated with hemodynamic changes, activation of inflammatory pathways and renal disease progression (RDP) following I/R-AKI. Strategies for prevention and/or slowing RDP have been determined and the sufficiency of vitamin D has been emerging as a renoprotective factor in many diseases. Therefore, we investigated the effect of the restoration of vitamin D levels in the progression of I/R injury (IRI) in rats previously deficient in vitamin D. On day 30, male Wistar rats were submitted to bilateral 45 min IRI and divided into three groups: IRI, standard diet for 120 days; VDD+IRI, vitamin D-free diet for 120 days; and VDD+IRI+R, vitamin D-free diet in the first 30 days and just after I/R, we reintroduced the standard diet in the last 90 days. After the 120-day protocol, VDD+IRI+R rats presented an improvement in the renal function and renal protein handling followed by a smaller fractional interstitial area. Furthermore, those animals exhibited a reestablishment regarding the hemodynamic parameters and plasma levels of aldosterone, urea and PTH. In addition, the restoration of vitamin D levels reestablished the amount of MCP1 and the renal expressions of CD68+ and CD3+ cells in the VDD+IRI+R rats. Also, VDD+IRI+R rats showed a restoration regarding the amount of collagen type III and renal expressions of fibronectin, vimentin and α-SMA. Such changes were also accompanied by a reestablishment on the renal expression of VDR, Klotho, JG12, and TGF-β1. Our findings indicate that the restoration of vitamin D levels not only improved the renal function and hemodynamics but also reduced the inflammation and fibrosis lesions observed in I/R-AKI associated with VDD. Thus, monitoring of vitamin D status as well as its replacement in the early stages of kidney injury may be a therapeutic alternative in the mitigation of renal disease progression.

Evaluation of vitamin D levels in patients with primary hypothyroidism: A cross-sectional study

2021 ◽  
Vol 8 (3) ◽  
pp. 193-197
Author(s):  
Minakshi Kumari ◽  
Rajiv Kumar Mahli ◽  
Sunil Kumar Verma ◽  
Vinod Kumar
Keyword(s):  
Vitamin D ◽  
Cross Sectional Study ◽  
Primary Hypothyroidism ◽  
Control Group ◽  
Thyroid Peroxidase ◽  
Sectional Study ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
Lower Vitamin ◽  
Hypothyroid Patients

Vitamin D deficiency (VDD) and hypothyroidism have been linked in research with inconsistent outcomes. Because of the controversy surrounding these two disorders and their relatively high incidence, we undertook a case-control research comparing the prevalence of VDD in hypothyroid patients (both TPO-Ab positive and negative) to euthyroid controls. This is a cross-sectional study with a single centre. Adults (aged 18 and above) of both sexes with primary hypothyroidism (TSH &#62;5.1 mIU/L) were included (n = 165), as were age and sex matched euthyroid (TSH 5 mIU/ml) controls (n = 165) from the outpatients' department. Biochemical parameters like Thyroid stimulating hormone (TSH), free T4 (fT4), 25 hydroxy vitamin D (Vit D) and thyroid peroxidase antibody (TPO-Ab) were tested in both the groups.The study involved 330 patients, with 165 (mean age 46± 15 years) having primary hypothyroidism (3 having subclinical hypothyroidism) and 165 (mean age 45± 17 years) being euthyroid controls. VDD was seen in 96 percent of hypothyroid patients compared to 90 percent in the control group. The hypothyroid group had a significantly lower mean Vitamin D level than the euthyroid group (12.03± 8.6 SD vs. 17.49± 11.89 SD [ng/ml]; P= 0.001). TPO-Ab was found in two-thirds of the hypothyroid group (110/165). The mean Vitamin D level in the TPO-Ab positive hypothyroid group was 10.4± 7.2 ng/ml, compared to 15.3± 10.3 ng/ml in the TPO-Ab negative group (P = 0.004). With increased TPO-Ab titers, there was a downward trend in Vitamin D levels. A direct association between Vitamin D levels and TPO-Ab, on the other hand, did not reveal any relevance. Patients with hypothyroidism had considerably lower vitamin D levels than euthyroid controls. TPO-Ab positive individuals had lower vitamin D levels than TPO-Ab negative patients.

scholarly journals P007: Association between serum biomarkers and frailty level in seniors with minor injurys

CJEM ◽  
2016 ◽  
Vol 18 (S1) ◽  
pp. S80-S81
Author(s):  
N. Allain-Boulé ◽  
J. Lebon ◽  
M. Sirois ◽  
M. Aubertin-Leheudre ◽  
M. Émond
Keyword(s):  
Vitamin D ◽  
Thyroid Stimulating Hormone ◽  
Serum Biomarkers ◽  
Sexual Hormones ◽  
Clinical Frailty Scale ◽  
Cross Sectional ◽  
Number Of Patients ◽  
Vitamin D Levels ◽  
Minor Injuries ◽  
Age And Sex

Introduction: Frailty is associated with mobility & physical impairment in seniors with minor injuries. Serum biomarkers have also been suggested as potential markers of these impairments in clinical studies. No study has examined if serum biomarkers could contribute to the diagnosis of frailty in seniors with minor injuries. Objectives: To explore the association between several serum biomarkers (Ferritin, Creatinine, Vitamin D, Albumin, Glucose, Estradiol, Testosterone, Thyroid Stimulating Hormone (TSH), Insulin-Growth Factor (IGF-1) C-reactive protein (CRP)) and frailty level in seniors treated in emergency department (ED) for minor injuries. Methods: Cross-sectional study within the larger CETI cohort. It includes 142 seniors discharged home from 4 EDs after treatment of minor injuries. Their frailty status was measured by the Canadian Study of Health & Aging-Clinical Frailty Scale (CSHA-CFS). Biomarkers were obtained from blood samples. Pearson’s correlations (r) were performed to examine the relation between serum biomarkers and frailty levels. Partial correlation controlled for age and sex, were also performed. Results: Due to inclusion criteria, no patient was severely frail. Overall, these preliminary analyses seem to indicate that robust patients tended to have lower Glucose & Vitamin D levels (-0.264 ≤ r ≤ -0.230; p < 0.05), higher Estradiol (r = 0,230; p < 0.05) & Testosterone (r = 0,295; p < 0.05), while prefrail/frail patients tended to have higher Glucose & Vitamin D levels (0,235 ≤ r ≤ 0,238; p < 0.05), lower Estradiol levels (r = -0,235; p < 0.05) & more elevated Ferritin levels. Due to the small number of patients, controlling for age and sex lead to non-significant results of the most associations. Conclusion: Pre-frail/frail seniors presenting to EDs with minor injuries tend to have higher Ferritin, Glucose & Vitamin D levels as well as lower sexual hormones levels than robust individuals. Larger samples are needed in order to elucidate which biomarkers could be most useful to identify frail seniors needing clinical attention and to assess a possible association with mobility impairments in this population.

scholarly journals SERUM VITAMIN D LEVEL IN TYPE 2 DIABETIC PATIENTS

2018 ◽  
Vol 21 (05) ◽  
pp. 992-997
Author(s):  
Imran Ali Shaikh ◽  
Naila Masood ◽  
Shazia Memon
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Control Group ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Type 2 Diabetic

Objective: To find out serum vitamin D levels in type 2 DM patients in Hyderabad.Design: Cross sectional study. Setting: Private clinics, OPDs of government hospitals likeQasimabad, Latifabad and Pretabad. Duration: January to July 2013. Patients and Methods:Total 550 patients were selected, 450 patients (250 males and 200 females) taken from differentOPDs of Hyderabad and towns or Tehsils with diagnosis of type 2 Diabetes mellitus andanother 100 patients were taken as control (60 males and 40 females). The mean age was45.6 years. The written consent was obtained and demographic features were noted, 3cc ofblood was taken for estimation of vitamin D levels. The level of vitamin D was done on anElectrochemiluminescence Immuno Assay (ECLIA) at Diagnostic & Research laboratory LiaquatUniversity of Medical &Health sciences (LUMHS) Jamshoro, Sind. Results and Observations:Out of 550, 450 diabetic subjects tested for vitamin D, females were 44.4%and 55.5% weremales. The deficiency was seen in 33.7% patients (p <0.04) and Vitamin D insufficiency wasobserved in20% in both sex. In control group, the deficiency was observed in 23% in femalesand 20% in males while insufficiency noted in 5% in both sex. Conclusions: The study showedsignificant decreased levels of vitamin D in type 2 Diabetic subjects than normal individuals. Thevitamin D deficiency increased considerably in females with diabetes type 2.

scholarly journals Investigation of Vitamin D Deficiency in 
Pre-School Children During Summer Season

2021 ◽  
Vol 10 (1) ◽  
pp. 21-27
Author(s):  
Esra Ulgen Temel ◽  
Kenan Kocabay ◽  
Aybars Ozkan
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Public Health Problem ◽  
Summer Season ◽  
Important Public Health Problem ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

Aim: Vitamin D deficiency is an important public health problem, especially affecting children. The aim of our study is to evaluate the serum 25 (OH) vitamin D levels of children during the summer and to determine some features such as exposure to the sun, oral vitamin D supplementation, and to examine the parameters that affect serum vitamin D levels. Methods: In our study, children aged between 12 and 83 months were included. A questionnaire was answered by families. In this cross-sectional study, serum 25 (OH) vitamin D levels of children and biochemical parameters were examined. Results: The mean serum 25 (OH) vitamin D level was 27.0±12.4 ng/ml. Vitamin D deficiency was found 17%, and vitamin D insufficiency was 6%. The children that taking daycare indoors and body mass index <5th percentile had lower serum 25 (OH) vitamin D levels. Children between the ages of 12- 36 months and children with chronic diseases were found to have a shorter time to benefit from sunlight. Conclusion: The rate of vitamin D deficiency and insufficiency (<20 ng/ml) in children were found at 23% in summer season. Families and caregivers should be informed about vitamin D and should be aware of safe sun exposure. Keywords: Vitamin D, sunlight, summer, children, vitamin D deficiency

scholarly journals Clinical Evaluation of Significance of 25(Oh)D (Vitamin D) Status in Swine Flu (H1N1)

2020 ◽  
Vol 6 (2) ◽  
pp. 1-17
Author(s):  
Bal Kishan Gupta ◽  
Kashish Narula ◽  
Makhan Lal Saini ◽  
Rakesh Kumar Baberwal ◽  
Jigyasa Gupta
Keyword(s):  
Vitamin D ◽  
Hospital Stay ◽  
Winter Season ◽  
Public Health Problem ◽  
Severity Of Illness ◽  
Mean Value ◽  
Swine Flu ◽  
Control Group ◽  
High Morbidity ◽  
Cross Sectional

Background Since swine flu has been declared pandemic in 2009 it has become a major challenging public-health problem associated with high morbidity and mortality. 25(OH)D deficiency is also pandemic and has been reported to be clinically correlated with decreased immunity and respiratory infections. The possible role of vitamin D in infections is implied from its impact on the innate and adaptive immune responses. This study is planned to evaluate clinical significance of 25(OH)D status on course and outcome in hospitalized cases of swine flu and to compare it with normal healthy subjects living in the same vicinity to evaluate if vitamin D is having any protective effect. Material & Methods Present prospective cross-sectional study was conducted on 79 RT-PCR confirmed cases of swine flu admitted during recent epidemic. All patients were evaluated thoroughly by clinical history physical examination and laboratory investigations as per Performa and followed-up during hospital stay. 25-hydroxyvitamin D (25(OH)D) estimation was done by electro-chemiluminescent Assay in all the cases and it was also done in 36 normal healthy family members of study patients living in the same vicinity (control group). Results High prevalence (70.9%) of low (≤30ng/ml) status of 25(OH)D was observed in cases of swine flu as compared to control group. 25(OH)D status was associated with severity of illness. Mean value of 25(OH)D in mechanically ventilated patients was 9.81±6.43 while it was 22.76±11.35 ng/ml in patients who do not required ventilation (p<0.05). Mean 25(OH)D level in patients who stayed in hospital for <5 days was 28.60±8.79 ng/ml, 24.18±11.67 for 6-10 days and 8.23±2.12 for >10 days (p<0.01). Mean value of 25(OH)D in patients who died was 9.59±5.90 ng/ml as compared to 23.13±11.62 ng/ml who survived (p<0.01). Conclusion Our study suggests that 25(OH)D may have preventive role for swine flu infection. Low level of 25(OH)D is associated with high morbidity in terms of increase requirement for mechanical ventilation, multiorgan dysfunction and long duration of hospital stay. 25(OH)D deficiency is associated with high mortality in swine flu. 25(OH)D status should be given due consideration in high risk patients especially during winter season.

scholarly journals Vitamin D Status and Associated Factors in Neonates in a Resource Constrained Setting

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Khadija Murtaza Bhimji ◽  
Helga Naburi ◽  
Said Aboud ◽  
Karim Manji
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Associated Factors ◽  
Tertiary Care ◽  
Public Health Problem ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
Infant Birth

Vitamin D deficiency (VDD) is emerging as a serious public health problem globally; however due to lack of resources, vitamin D levels are not routinely measured among neonates. The study was conducted to determine vitamin D levels in neonates and factors associated with the same. A cross-sectional study was conducted among neonates admitted at neonatal ward of a tertiary care hospital. Means and proportions were calculated from summarized data in frequency tables. Chi square test was used to determine association between vitamin D and various associated factors such as sex, infant birth weight, gestation age, parity of the mother, maternal age, and HIV status of the mother. A total of 170 neonates were studied, out of which 80% had vitamin D deficiency. Neonates born to HIV-infected mothers were significantly less likely to have vitamin D deficiency (OR 0.21, 95% CI 0.06 – 0.77, p = 0.009). Subgroup analysis revealed the association to be stronger in terms neonates (p = 0.005). The association was not observed among preterm newborns. The prevalence of vitamin D deficiency in neonates was observed to be very high and needs more attention.

scholarly journals Vitamin D status in exclusively breast-fed infants and their mothers

2018 ◽  
Vol 5 (5) ◽  
pp. 1966
Author(s):  
Vignesh Kumaran C. R. ◽  
Sundari S. ◽  
Shanthi Ramesh
Keyword(s):  
Vitamin D ◽  
Public Awareness ◽  
Public Health Problem ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
Tropical Country ◽  
Cross Sectional ◽  
Breastfed Infants ◽  
Young Infants ◽  
Vitamin D Levels

Background: India, despite being a tropical country has widespread vitamin D deficiency across all age groups. Present study was conducted to estimate the prevalence of subclinical hypovitaminosis D in exclusively breastfed infants and their mothers and also to study the correlation between the Vitamin D levels of these infants and their mothers.Methods: This cross-sectional study was conducted in 37 exclusively breastfed infants aged 6 months and below and their mothers.  Under strict aseptic precautions 2 ml of blood was taken from each infant and mother and serum levels of 25(OH) D levels were measured by the direct ELISA method. Statistical analysis was done by using chi-square test, one-way ANOVA f-test and student independent t-test.Results: In present study, authors found that 78.3% of the mothers were Vitamin D deficient and 21.7% of the mothers were Vitamin D insufficient. Among the infants, authors found that 91.9% of the infants were Vitamin D deficient and 8.1% of the infants were Vitamin D insufficient. The association between dietary pattern and socio-economic class and mean maternal vitamin D levels was found to be statistically significant (p <0.05).Conclusions: There is a high prevalence of hypovitaminosis D amongst exclusively breastfed infants and their mothers. Hence, public awareness needs to be created regarding the benefits of sunlight exposure. Vitamin D fortification of food products and routine Vitamin D supplementation program for antenatal and lactating mothers and their young infants may be able to address this emerging public health problem in our country.

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