scholarly journals Clinical Evaluation of Significance of 25(Oh)D (Vitamin D) Status in Swine Flu (H1N1)

2020 ◽  
Vol 6 (2) ◽  
pp. 1-17
Author(s):  
Bal Kishan Gupta ◽  
Kashish Narula ◽  
Makhan Lal Saini ◽  
Rakesh Kumar Baberwal ◽  
Jigyasa Gupta
Keyword(s):  
Vitamin D ◽  
Hospital Stay ◽  
Winter Season ◽  
Public Health Problem ◽  
Severity Of Illness ◽  
Mean Value ◽  
Swine Flu ◽  
Control Group ◽  
High Morbidity ◽  
Cross Sectional

Background Since swine flu has been declared pandemic in 2009 it has become a major challenging public-health problem associated with high morbidity and mortality. 25(OH)D deficiency is also pandemic and has been reported to be clinically correlated with decreased immunity and respiratory infections. The possible role of vitamin D in infections is implied from its impact on the innate and adaptive immune responses. This study is planned to evaluate clinical significance of 25(OH)D status on course and outcome in hospitalized cases of swine flu and to compare it with normal healthy subjects living in the same vicinity to evaluate if vitamin D is having any protective effect. Material & Methods Present prospective cross-sectional study was conducted on 79 RT-PCR confirmed cases of swine flu admitted during recent epidemic. All patients were evaluated thoroughly by clinical history physical examination and laboratory investigations as per Performa and followed-up during hospital stay. 25-hydroxyvitamin D (25(OH)D) estimation was done by electro-chemiluminescent Assay in all the cases and it was also done in 36 normal healthy family members of study patients living in the same vicinity (control group). Results High prevalence (70.9%) of low (≤30ng/ml) status of 25(OH)D was observed in cases of swine flu as compared to control group. 25(OH)D status was associated with severity of illness. Mean value of 25(OH)D in mechanically ventilated patients was 9.81±6.43 while it was 22.76±11.35 ng/ml in patients who do not required ventilation (p<0.05). Mean 25(OH)D level in patients who stayed in hospital for <5 days was 28.60±8.79 ng/ml, 24.18±11.67 for 6-10 days and 8.23±2.12 for >10 days (p<0.01). Mean value of 25(OH)D in patients who died was 9.59±5.90 ng/ml as compared to 23.13±11.62 ng/ml who survived (p<0.01). Conclusion Our study suggests that 25(OH)D may have preventive role for swine flu infection. Low level of 25(OH)D is associated with high morbidity in terms of increase requirement for mechanical ventilation, multiorgan dysfunction and long duration of hospital stay. 25(OH)D deficiency is associated with high mortality in swine flu. 25(OH)D status should be given due consideration in high risk patients especially during winter season.

scholarly journals Estimation of Endothelin-1 and Vitamin D Levels in Patients with Some Renal disease

2019 ◽  
Vol 24 (7) ◽  
pp. 1
Author(s):  
Ihsan Maher Abdul Amir ◽  
Moafaq Mutlak Zeidan
Keyword(s):  
Vitamin D ◽  
Renal Disease ◽  
General Hospital ◽  
Chronic Renal Disease ◽  
Public Health Problem ◽  
Control Group ◽  
Cross Sectional ◽  
Endothelin 1 ◽  
Number Of Patients ◽  
Vitamin D Levels

Chronic renal disease is a worldwide public health problem with an increasing incidence, prevalence, poor outcomes, and high cost. A cross-sectional study was carried out in balad city from 10th of November 2018 to 15th of March 2019. The number of patients under  study were 60 patients with renal disease (30 acute renal disease and 30 chronic renal disease under hemodialysis). Their ages were between (20-75) years. Patients with acute renal disease were admitted to Balad general hospital and patients with chronic renal disease who admitted to Salahaddin general hospital for hemodialysis. The study included 30 apparently healthy subject as control group. The results showed that the highest mean level of endothelin-1 was found in patients with chronic renal disease (13.15±7.81)pg/ml followed by patients with acute renal disease (1.78±1.49) pg/ml compared with  the control group (0.41±0.31) pg/ml. These result were significant higher (P< 0.01). The results  showed that the lowest mean level of vitamin D was found in patients with chronic renal disease (14.45±5.92) ng/ml followed by patients with acute renal disease (23.49±13.14) ng/ml compared with the control group (24.02 ±8.22) ng/ml. The results were significant higher than control (P≤0.01). The study showed that patients with acute renal disease were distributed equally to male and female (1:1) while 56.67% of patients with chronic renal disease were males. The conclute from this study that the endothelin elevated in chronic renal disease patients and vitamin D was reduced.    http://dx.doi.org/10.25130/tjps.24.2019.121

scholarly journals Maternal Vitamin D Levels in Gestation - An Observational Cross Sectional Study in the Rural Population of South India

2019 ◽  
Vol 4 (08) ◽  
Author(s):  
Julie Christy Amalraj ◽  
Andal . ◽  
Perumal Saraswathi ◽  
Swayam Jothi Dorairaj ◽  
Dr. G. Sumathy
Keyword(s):  
Vitamin D ◽  
South India ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Mean Value ◽  
Control Group ◽  
Age Group ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
The Mean

Background:Vitamin D* called the sunshine vitamin is essential throughout life. Pregnancy is an altered physiological state in women, which requires proper nourishment. During gestation, this vitamin also plays an important role in development of the fetus. Objective:To observe the serum vitamin D (25diohydroxycholicalciferol) levels and serum calcium levels in the maternal blood during the three trimesters. Design: Observational Cross sectional study. Study population: Rural Mothers from Kancheepuram District, Tamil Nadu South India. We used 50 antenatal blood samples as experimental group and 15 as control group. The age group included 20-40 years. Blood samples were collected from 50 antenatal mothers between 20 – 40 years age group, from Obstetrics and Gynecology OPD for their routine antenatal check-ups, after getting duly signed informed consent. Control group had 15 women in the same age group not pregnant. Results: The results were tabulated. The mean value of 25dihydroxy vitamin D was observed very low than normal levels in all the three trimesters. The mean value of serum vitamin D in first trimester was 50.87 ng/ml, mean value of serum vitamin D in second trimester was 54.05.ng/ml, and mean third trimester vitamin D was 61.24ng/ml which was well below the optimum level of 100ng/ml. Conclusion: The vitamin D deficiency with normal level maintenance of serum calcium shows the compensatory mechanism that involves the normal calcium level maintence with resorption of bones by the osteoclastic actions to correct the deficit. If the deficiency is left untreated it may lead to faster osteoporosis in the mother. *25 dihydroxycholicalciferol

scholarly journals Opportunistic Infections and Associated Factors among HIV/AIDS Patients taking Ante-Retroviral Therapy at Selected Hospitals in Sidama Zone, Southern Ethiopia: A facility-based cross-sectional study

2019 ◽  
Author(s):  
Demelash Wachamo ◽  
Fisseha Bonja
Keyword(s):  
Associated Factors ◽  
Opportunistic Infections ◽  
Public Health Problem ◽  
Cross Sectional Study ◽  
High Morbidity ◽  
Major Public Health Problem ◽  
Sectional Study ◽  
Aids Patients ◽  
Cross Sectional ◽  
Hiv Aids

Abstract Background Opportunistic infections are late complications of HIV infection is the depletion of the immune system. It is a major public health problem and high morbidity AIDS patients die of AIDS-related infections in developing countries like Ethiopia. Identification of opportunistic infections (OIs) is important to develop a specific intervention. Therefore, this study aimed to assess the burden and associated factors of opportunistic infections.Method A facility-based cross-sectional study was conducted on 420 randomly selected HIV/AIDS patients taking anti-retroviral therapy. Data was collected from selected hospitals in Sidama Zone based on population proportion to size. Data was collected by a pre-tested questionnaire and a pre-tested checklist from the medical records of patients. Data entry and analyzed for descriptive and logistic regression models by SPSS v.23. The result declared as statistically significant at p < 0.05.Result The magnitude of opportunistic infections was 39.6%. Major identified OIs was oral candidacies 23.2%, recurrent bacterial pneumonia 21.5%, Herpes zoster 6.3%, and Pulmonary Tuberculosis 6.0%.The magnitude of opportunistic associated with; older age [AOR=2.69, 95% CI: 1.33-5.43], No formal education [AOR=3.12, 95% CI: 1.06-9.25], Low monthly income [AOR=2.27, 95%CI:1.35-3.83], initial CD4 count less than 200 cells/mm3 [AOR=1.91, 95% CI:1.05-3.46), WHO clinical stage II [AOR=2.43, 95% CI:1.34-4.42] and stage III and IV [AOR=4.27, 95% CI: 2.12-8.59], had no extra medicine additional to ART (prophylaxis) had [AOR= 5.91, 95% CI: 3.31-10.56], who interrupt ART medicines [AOR=2.03, 95% CI: 1.09- 3.80] and Khat chewing [AOR=5.48, 95% CI: 2.32-12.96] when compared to their counterparts.Conclusions The overall magnitude of opportunistic infections was high when compared with other studies. Health officials and clinicians need to give attention on the strengthening of the provision if ART with prophylaxis on early-stage and adhrerence, implementation of the TB/HIV collaboration activity, and early initiation of ART to reduce opportunistic infections.

scholarly journals Vitamin D Deficiency and Associated Risk Factors in Women from Riyadh, Saudi Arabia

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Nora A. AlFaris ◽  
Nora M. AlKehayez ◽  
Fatema I. AlMushawah ◽  
AbdulRhman N. AlNaeem ◽  
Nadia D. AlAmri ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Saudi Arabia ◽  
Vitamin D Deficiency ◽  
Public Awareness ◽  
Public Health Problem ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Associated Risk Factors

AbstractVitamin D deficiency is an epidemic public health problem worldwide. It is common in the Middle East and is more severe in women. This cross-sectional study was conducted to assess vitamin D deficiency and associated risk factors in women living in Riyadh, Saudi Arabia. Serum 25-hydroxyvitamin D (25(OH)D) was measured in 166 women aged 30–65 years. Socio-demographic, lifestyle and health status characteristics, as well as intake of selected dietary supplements, were collected. Weight and height were measured. Vitamin D deficiency (25(OH)D < 20 ng/mL) was reported in 60.2% of participants. Mean of serum 25(OH)D was 20.7 ng/mL. Older age and taking the supplements of vitamin D, multi-vitamins or calcium were identified as factors that associated with a lower risk of hypovitaminosis D. A national strategy is needed to control a hypovitaminosis D crisis in Saudi Arabia. This could be accomplished by raising public awareness regarding vitamin D, regulating and enhancing vitamin D fortification and supplementation and screening vitamin D status among women at high risk.

scholarly journals The Effect of Sugar Apple (Annona squamosa L.) Seeds Solution as an Insecticide Against Mortality of Aedes aegypti Mosquito with Liquid Electric Method

2018 ◽  
Vol 9 (2) ◽  
pp. 200
Author(s):  
Amalinda Mega Novasari ◽  
Retno Sasongkowati
Keyword(s):  
Aedes Aegypti ◽  
Public Health Problem ◽  
Hemorrhagic Fever ◽  
Cross Sectional Study ◽  
Primary Data ◽  
Control Group ◽  
Annona Squamosa ◽  
Control Group Design ◽  
Cross Sectional ◽  
Apple Seeds

Dengue hemorrhagic fever is a public health problem in Indonesia that the number of DHF cases has been increased. Morbidity number of DHF per 100,000 population at 2011 was 26.67 became 34.3 in 2012. The control of DHF has been attempted, but a lot of synthetic insecticide used has been negatively affected to environment. So, it need the insecticide alternative. The aim of study was to identify the effect of solvent sugar apple (Annona squamosa L.) seeds to the death of Aedes aegypti mosquitoes by electric liquid method. Type of this research was experimental with cross sectional study design as well as the post test only control group design. The study was conducted from February to July 2013 in the Laboratory of Entomology of the Provincial Health Office of East Java. The population of this research was the Aedes aegypti with 560 sample of mosquitoes were divided into five treatments and four repetitions for each treatment. The collection of quantitative data drawn from primary data through observation by calculating the death of Aedes aegypti of each the sugar apple seeds concentration of 10%, 20%, 30%, 40% and 50% for 24 hours. The results showed that the concentration of 50% solvent of sugar apple seeds provide the greatest effect in causing the death of Aedes aegypti mosquitoes as many as 36 died after exposure. It can be concluded that there are effected by giving solvent of sugar apple (Annona squamosa L.) seeds to the death of Aedes aegypti mosquitoes by electric liquid method.

scholarly journals Gambaran Pengetahuan Klinisi Ruang Rawat Intensif mengenai Ventilator Associated Pneumonia (VAP) Bundle di Ruang Rawat Intensif RSUP Dr. Hasan Sadikin Bandung

2017 ◽  
Vol 5 (2) ◽  
pp. 85
Author(s):  
M. Fajar Sadli ◽  
Doddy Tavianto ◽  
Ike Sri Redjeki
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Intensive Therapy ◽  
Educational Status ◽  
Mean Value ◽  
High Morbidity ◽  
Ventilator Associated Pneumonia ◽  
Cross Sectional ◽  
Level Of Knowledge ◽  
Vap Bundle

Ventilator associated pneumonia (VAP) merupakan infeksi yang terjadi pada pasien yang terintubasi ≥48 jam di ruang rawat intensif. Penanganan VAP merupakan tantangan utama akibat morbiditas dan mortalitas yang tinggi.Ventilator associated pneumonia bundle (VAPb) telah terbukti dapat menurunkan angka kejadian VAP sehingga pengetahuan dokter dan perawat mengenai VAPb menentukan keberhasilan pencegahan VAP di ruang rawat intensif. Tujuan penelitian ini mengetahui pengetahuan dokter dan perawat mengenai VAPb di ruang rawat intensif RSUP Dr. Hasan Sadikin Bandung. Data diambil dari bulan November–Desember 2016. Penelitian deskriptif dengan desain potong lintang ini menggambarkan pengetahuan mengenai VAPb dari dokter residen Departemen Anestesi dan Terapi Intensif dan perawat di ruang rawat intensif RSUP Dr. Hasan Sadikin Bandung. Responden terdiri atas 79 dokter dan 88 perawat. Tingkat pengetahuan VAPb diuji menggunakan 20 pertanyaan kuesioner. Responden perawat terbanyak berjenis kelamin perempuan (74%), berusia ≥30 tahun (92%), status pendidikan diploma III (65%), lama kerja >5 tahun (76%), dan bekerja di Intensive Care Unit (ICU) (32%). Responden dokter terbanyak berjenis kelamin laki-laki (71%), berusia ≥30 tahun (83%), dan telah menyelesaikan stase ICU (61%). Simpulan, nilai kuesioner perawat dan dokter rata-rata berturut-turut 73,63 dan 73,16. Kata kunci: Klinisi ruang rawat intensif, tingkat pengetahuan, ventilator associated pneumonoia bundle Description of Intensive Care Clinician Knowledge about Ventilator Associated Pneumonia (VAP) Bundle in the Intensive Care Unit of  Dr. Hasan Sadikin Hospital BandungVentilator associated pneumonia (VAP) is an infection that occurs in patients who are intubated ≥48 hours in intensive care. Management VAP is a major challenge due to the high morbidity and mortality. Ventilator associated pneumonia bundle (VAPb) has been shown to reduce the incidence of VAP, so knowledge of doctors and nurses about VAPb determine the success of preventing VAP in intensive care. This study aims to know the description of intensive care clinician knowledge about ventilator associated pneumonia bundle in the intensive care of Dr. Hasan Sadikin General Hospital Bandung. Data were collected from November–December 2016. Descriptive study with cross-sectional design depicts VAPb knowledge of resident physicians Department of Anesthesia and Intensive Therapy and nurses in the Intensive Care Department of Dr. Hasan Sadikin Hospital. Respondents consisted of 79 doctors and 88 nurses. The level of knowledge VAPb tested using a 20 question questionnaire. Most nurse respondents were female (74%), aged ≥30 years (92%), educational status diploma III (65%), length of employment >5 years (76%), and work in Intensive Care Unit (ICU) (32%). Most physician respondents were male sex (71%), aged ≥30 years (83%), and had completed stase ICU (61%). In conclution, the mean value of the questionnaire nurses and doctors respectively 73.63 and 73.16. Key words: Intensive care clinician, level of knowledge, ventilator associated pneumonoia bundle

scholarly journals Anti-chikungunya virus seroprevalence in Indigenous groups in the São Francisco Valley, Brazil

2021 ◽  
Vol 15 (6) ◽  
pp. e0009468
Author(s):  
Jandir Mendonça Nicacio ◽  
Ricardo Khouri ◽  
Antônio Marconi Leandro da Silva ◽  
Manoel Barral-Netto ◽  
João Augusto Costa Lima ◽  
...  
Keyword(s):  
Chikungunya Virus ◽  
Public Health Problem ◽  
Epidemiological Data ◽  
Indigenous Populations ◽  
High Rate ◽  
Vulnerable Groups ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Cross Sectional ◽  
Epidemiological Profile

Background Chikungunya fever (CHIKF) is a serious public health problem with a high rate of infection and chronic disabling manifestations that has affected more than 2 million people worldwide since 2005. In spite of this, epidemiological data on vulnerable groups such as Indigenous people are scarce, making it difficult to implement public policies in order to prevent this disease and assist these populations. Objective To describe the serological and epidemiological profile of chikungunya virus (CHIKV) in two Indigenous populations in Northeast Brazil, as well as in an urbanized control community, and to explore associations between CHIKV and anthropometric variables in these populations. Methodology/Principal findings This is a cross-sectional ancillary study of the Project of Atherosclerosis among Indigenous Populations (PAI) that included people 30 to 70 years old, recruited from two Indigenous tribes (the less urbanized Fulni-ô and the more urbanized Truká people) and an urbanized non-Indigenous control group from the same area. Subjects underwent clinical evaluation and were tested for anti-CHIKV IgG by enzyme-linked immunosorbent assay. Serological profile was described according to ethnicity, sex, and age. The study population included 433 individuals distributed as follows: 109 (25·2%) Truká, 272 (62·8%) Fulni-ô, and 52 (12%) from the non-Indigenous urbanized control group. Overall prevalence of CHIKV IgG in the study sample was 49.9% (216; 95% CI: 45·1–54·7). When the sample was stratified, positive CHIKV IgG was distributed as follows: no individuals in the Truká group, 78·3% (213/272; 95% CI: 72·9–83·1) in the Fulni-ô group, and 5.8% (3/52; 95% CI: 1.21–16) in the control group. Conclusions/Significance Positive tests for CHIKV showed a very high prevalence in a traditional Indigenous population, in contrast to the absence of anti-CHIKV serology in the Truká people, who are more urbanized with respect to physical landscape, socio-cultural, and historical aspects, as well as a low prevalence in the non-Indigenous control group, although all groups are located in the same area.

scholarly journals Geographic and Seasonal Variation of Vitamin D: A Retrospective Study in Two Centers of Nepal

2020 ◽  
Vol 18 (1) ◽  
pp. 103-107
Author(s):  
Arun Sedhain ◽  
Gandhi R Bhattarai ◽  
Sanjaya Raya Yadav ◽  
Bhupendra Raj Pandey ◽  
Thakur Prasad Pant
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Winter Season ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Age Group ◽  
Cross Sectional ◽  
Study Results ◽  
The Status

Background: Vitamin D deficiency is a common problem in many countries throughout the world. This study aimed at understanding the status of vitamin D deficiency in relation to age, gender, geography and season among relatively bigger numbers of population residing in central and western regions of Nepal.Methods: This retrospective cross-sectional study was carried out by reviewing the records of vitamin D tests in two centers of Nepal- namely united reference laboratories at Pokhara and Chitwan Medical College at Chitwan. A total of 3320 individuals who were tested for clinical suspicion of vitamin D deficiency over a period of one year were included in the study. Results: Mean vitamin D level was 18.7 ng/mL. Majority of subjects tested for vitamin D were females (71.36 %) with female to male ratio of 2.49:1. Hypovitaminosis D (? 30 ng/mL) was found in 84.5% subjects and was moderate to severely deficit (<10 ng/mL) in 25.9% of subjects. Status of hypovitaminosis D was found to be less in ?50 years (79.9%) than the younger subjects (89.9% in ?18 years and 87.0% in 19-49 years age group). Vitamin D deficiency was found lower in hills districts (80.8% vs 89.7% in the plains), which was found to be more pronounced during winter through summer seasons as compared to fall season.Conclusions: Population residing in plain areas and summer, spring and winter season are found to have increased problem of Hypovitaminosis D. It is also found to be common among younger children and female of reproductive age group. We have also found out the increased problem of hypovitaminosis D among population residing in the plain areas than in the hills especially in the summer, spring and winter season.Keywords: Geographic variation; hypovitaminosis D; Nepal

scholarly journals Gangguan Kepadatan Tulang pada Orang Dewasa di Daerah Urban dan Rural

2014 ◽  
pp. 272
Author(s):  
Sarah Mardiyah ◽  
Ratu Ayu Dewi Sartika
Keyword(s):  
Public Health ◽  
Vitamin D ◽  
Bone Density ◽  
Rural Area ◽  
Protein Intake ◽  
Public Health Problem ◽  
Related Factor ◽  
Major Public Health Problem ◽  
Cross Sectional ◽  
Adult Bone

Gangguan kepadatan tulang atau osteoporosis dan osteopenia merupakan masalah kesehatan masyarakat utama yang disebabkan oleh banyak faktor. Tujuan dari penelitian ini adalah mengetahui berbagai faktor yang berhubungan dengan gangguan kepadatan tulang pada kelompok usia dewasa di daerah urban dan rural terpilih di Provinsi Jawa Barat tahun 2012. Desain penelitian yang digunakan adalah potong lintang dengan sampel 142 responden. Penelitian dilakukan pada bulan Mei - Juni 2012 di Pesona Khayangan, Kecamatan Sukmajaya, Kota Depok, sebagai daerah urban dan Desa Pabuaran, Kecamatan Gunung Sindur, Kabupaten Bogor sebagai daerah rural. Prevalensi gangguan kepadatan tulang dalam penelitian ini adalah sekitar 31,7% (4,2% osteoporosis dan 27,5% osteopenia). Analisis multivariat menemukan responden yang mempunyai indeks massa tubuh (IMT) < 23,49 kg/m2 berisiko mengalami gangguan kepadatan tulang 5,5 kali lebih tinggi daripada responden dengan IMT > 27,36 kg/m2. Responden yang mempunyai IMT 23,49 _ 27,36 kg/m2 berisiko mengalami gangguan kepadatan tulang 2,2 kali lebih tinggi daripada responden yang mempunyai IMT > 27,36 kg/m2 setelah dikontrol variabel usia, asupan vitamin D, dan asupan protein. Pada penelitian ini, IMT merupakan faktor yang paling berhubungan dengan gangguan kepadatan tulang setelah dikontrol variabel usia, asupan vitamin D, dan asupan protein. Semakin rendah IMT,maka semakin tinggi risiko gangguan kepadatan tulang.Bone density disorder (osteoporosis and osteopenia) is a major public health problem caused by multifactor. The purpose of this study was to find out factors related to adult bone density disorder in the selected urban and rural area, West Java Province, 2012. It used cross-sectional method and the samples were 142 respondents. The data was taken from 2012 May to June in Pesona Khayangan, Kecamatan Sukmajaya, Kota Depok as the urban area and Desa Pabuaran, Kecamatan Gunung Sindur, Kabupaten Bogor as the rural area. Prevalence of bone density disorder in this study was 31.7% (4.2% osteoporosis and 27.5% osteopenia). Multivariate analysis verified that respondent with body mass index (BMI) < 23.49 kg/m2 will 5.5 times higher to have bone density disorder than respondent with BMI > 27.36 kg/m2. Respondent with BMI 23.49 _ 27.36 kg/m2 will 2.2 times higher to have bone density disorder than respondent with BMI > 27.36 kg/m2 after controlled by age, vitamin D and protein intake variable. In this study, BMI is the most related factor of bone density disorder after controlled by age, vitamin D and protein intake variable. The lower BMI, the higher risk of bone density disorder.      

scholarly journals Vitamin D Status and Parathyroid Hormone Levels in Girls With Central Precocious Puberty

2021 ◽  
Author(s):  
Teodoro Durá-Travé ◽  
Fidel Gallinas-Victoriano ◽  
Lotfi Ahmed-Mohamed ◽  
Paula Moreno-González ◽  
María Urretavizcaya-Martinez ◽  
...  
Keyword(s):  
Vitamin D ◽  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Hypovitaminosis D ◽  
Bone Age ◽  
Control Group ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Endocrine Society ◽  
Prepubertal Girls

Abstract The objective of this study was to analyze the vitamin D status and PTH levels in 6- to 8-years-old girls with central precocious puberty. A cross-sectional clinical and blood testing (calcium, phosphorus, 25(OH)D and PTH) were carried out in 78 girls with central precocious puberty (CPP group), aged 6.1-7.9 years. A control group was recruited (157 prepubertal girls, aged 6.1-8.2 years). The criteria of the US Endocrine Society were used for the definition of hypovitaminosis D. There were no significant differences in the vitamin D status between both groups. There were not significant differences in 25(OH)D levels between CPP (25.4±8.6 ng/mL) and control groups (28.2±7.4 ng/mL). In contrast, in CPP group PHT levels (44.8±16.3 pg/mL) were higher (p < 0.05) with respect to control group (31.0±11.9 ng/mL). In CPP group there was positive correlation (p < 0.05) between PTH levels and growth rate, bone age, basal estradiol, basal FSH, basal LH and LH peak. Conclusion: Vitamin D status in 6- to 8-years-old girls with CPP is similar to that in prepubertal girls. PTH levels were significantly higher in girls with CPP, and could be considered as a pubertal characteristic and, in this case, of pubertal precocity.

Sign in / Sign up

Export Citation Format

Share Document