scholarly journals The Effect of Vitamin D3 Supplementation of Biomarkers of Oxidative Stress and Glycemic Status in Adults with Type 2 Diabetes

2018 ◽  
Author(s):  
Sahar Ajabshir
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Vitamin D3 ◽  
Glycemic Status ◽  
Vitamin D3 Supplementation ◽  
Biomarkers Of Oxidative Stress

Curcumin supplementation improves biomarkers of oxidative stress and inflammation in conditions of obesity, type 2 diabetes and NAFLD: Updating the status of clinical evidence

2021 ◽  
Author(s):  
Kabelo Mokgalaboni ◽  
Yonela Ntamo ◽  
Khanyisani Ziqubu ◽  
Tawanda M Nyambuya ◽  
Bongani Nkambule ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Liver Disease ◽  
Fatty Liver Disease ◽  
Clinical Evidence ◽  
Metabolic Complications ◽  
Nonalcoholic Fatty Liver ◽  
The Status ◽  
Biomarkers Of Oxidative Stress

Oxidative stress and inflammation remain the major complications implicated in the development and progression of metabolic complications, including obesity, type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD). In...

scholarly journals Patients with type 2 diabetes have reduced levels of plasma vitamin D3 and are well correlated with the oxidative stress parameters

2016 ◽  
Vol 7 (3) ◽  
pp. 35-40 ◽  
Author(s):  
Pinaki Saha ◽  
Sayantan Dasgupta ◽  
Santanu Sen ◽  
Arun Kumar ◽  
Utpal Kumar Biswas
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Vitamin D3 ◽  
Significant Positive Correlation ◽  
Antioxidant Defense ◽  
Significant Negative Correlation ◽  
Plasma Vitamin ◽  
Total Oxidative Stress ◽  
Type 2 Diabetic

Background: Diabetes has emerged as an epidemic in this country as well as worldwide. Increased oxidative stress and decreased antioxidant defense are established etiological factors of this multifactorial disease. Some of the recent studies reported deficiency of vitamin-D3 in type-2 diabetic patients. Aims and Objectives: This study was aimed to estimate the total oxidative stress (TOS), the total antioxidant defense (TAD) and the plasma 25-hydroxy vitamin D3 levels in patients of type-2 diabetes patients with an objective to elucidate if there is any significant correlation between the TOS, TAD and vitamin D3 levels.Materials and Methods: The study was conducted in forty patients recently diagnosed type-2 diabetic and the findings were compared with age/sex matched healthy controls. Total oxidative stress and TAD values was estimated by two simple colorimetric tests developed and standardized in our laboratory, plasma 25-hydroxy vitamin D3 by standardized ELISA method.Results  and Discussion: The levels of vitamin D3 in patients was found to be 50.17 ± 15.85ng/ml which was significantly decreased (P<0.001) when compared to healthy control group (75.42 ± 9.59 ng/ml). The plasma vitamin D3 levels show a significant positive correlation (r=0.564, P<0.001) with the TAD values and a significant negative correlation (r=-0.561, P<0.001) with the TOS values in the study subjects. There is significant positive correlation of 25-OH vitamin-D3 with antioxidant defense and significant negative correlation with oxidative stress observed in the current study, and the levels of vitamin D3 were significantly decreased in type-2 diabetes when compared to the healthy controls.Conclusion: The type-2 diabetes patients are usually associated with vitamin D3 deficiency which is significantly correlated with the oxidative stress conditions in this group of patients.Asian Journal of Medical Sciences Vol. 7(3) 2016 35-40

scholarly journals Exploring the effect of vitamin D3 supplementation on surrogate biomarkers of cholesterol absorption and endogenous synthesis in patients with type 2 diabetes—randomized controlled trial

2020 ◽  
Vol 112 (3) ◽  
pp. 538-547
Author(s):  
Huicui Meng ◽  
Nirupa R Matthan ◽  
Edith Angellotti ◽  
Anastassios G Pittas ◽  
Alice H Lichtenstein
Keyword(s):  
Type 2 Diabetes ◽  
Serum Cholesterol ◽  
Vitamin D3 ◽  
Cholesterol Synthesis ◽  
Cholesterol Absorption ◽  
Cholesterol Lowering ◽  
Ancillary Study ◽  
Vitamin D3 Supplementation ◽  
Endogenous Synthesis

ABSTRACT Background Inverse associations have been reported between serum 25-hydroxyvitamin D [25(OH)D] and circulating cholesterol concentrations in observational studies. Postulated mechanisms include reduced bioavailability of intestinal cholesterol and alterations in endogenous cholesterol synthesis. Objective To explore the effect of daily supplementation with 4000 IU/d vitamin D3 for 24 wk on surrogate biomarkers of cholesterol absorption (campesterol and β-sitosterol) and endogenous synthesis (lathosterol and desmosterol). Methods Ancillary study of The Vitamin D for Established Type 2 Diabetes (DDM2) trial. Patients with established type 2 diabetes (N = 127, 25–75 y, BMI 23–42 kg/m2) were randomly assigned to receive either 4000 IU vitamin D3 or placebo daily for 24 wk. Of participants without changes in cholesterol-lowering medications (n = 114), plasma surrogate cholesterol absorption and endogenous synthesis biomarker concentrations were measured and merged with available measures of serum LDL cholesterol and HDL cholesterol concentrations. Results At week 24, vitamin D3 supplementation significantly increased 25(OH)D concentrations (+21.5 ± 13.4 ng/mL) but not insulin secretion rates (primary outcome of the parent study) as reported previously. In this ancillary study there was no significant effect of vitamin D3 supplementation on serum cholesterol profile or surrogate biomarkers of cholesterol absorption and endogenous synthesis. Compared with participants not treated with cholesterol-lowering medications, those who were treated exhibited a greater reduction in plasma campesterol concentrations in the vitamin D3 but not placebo group (P-interaction = 0.011). Analyzing the data on the basis of cholesterol absorption status (hypo- versus hyperabsorbers) or cholesterol synthesis status (hypo- versus hypersynthesizers) did not alter these results. Conclusions Vitamin D3 supplementation for 24 wk had no significant effect on surrogate biomarkers of cholesterol absorption or endogenous synthesis, consistent with the lack of effect on serum cholesterol profile. Vitamin D3 supplementation resulted in greater reduction in campesterol concentrations in participants not using compared with those using cholesterol-lowering medications. Further studies are required. This trial was registered at clinicaltrials.gov as NCT01736865.

scholarly journals Physical Exercise and Redox Balance in Type 2 Diabetics: Effects of Moderate Training on Biomarkers of Oxidative Stress and DNA Damage Evaluated through Comet Assay

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Monica Pittaluga ◽  
Antonio Sgadari ◽  
Ivan Dimauro ◽  
Barbara Tavazzi ◽  
Paolo Parisi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Dna Damage ◽  
Ascorbic Acid ◽  
Exercise Training ◽  
Comet Assay ◽  
Redox Homeostasis ◽  
Diabetic Patients ◽  
Biomarkers Of Oxidative Stress

Objective.Hyperglycemia leads to increased production of reactive oxygen species (ROS) in type 2 diabetes, which reduces cellular antioxidant defenses and induces DNA lesions. The aim of this study was to investigate the effects on redox homeostasis and DNA oxidative damage of exercise training in patients with type 2 diabetes compared with nondiabetic individuals.Methods and Results.12 sedentary type 2 diabetic males (62.1 ± 4.3 yrs) and 12 sedentary healthy males (61.7 ± 3.9 yrs) were exposed to 4-month moderate training, 3 times per week, to evaluate the effect on plasma biomarkers of oxidative stress malondialdehyde and antioxidant status (GSSG, GSH/GSSG, and ascorbic acid) as well as basal and H2O2-induced DNA damage trough alkaline comet assay in peripheral blood lymphocytes. After training, glutathione and ascorbic acid levels increased in both groups, but only in diabetics the malondialdehyde as well as the DNA damage decreased.Conclusion.Our study demonstrates for the first time that moderate exercise training is not only effective in improving the redox homeostasis, through an increase of the endogenous antioxidant defences in healthy as well as in diabetic patients, but also, specifically in diabetic patients, effective in lowering the susceptibility to oxidative DNA damage and the lipid peroxidation levels.

scholarly journals Vitamin D3 supplementation decreases a unique circulating monocyte cholesterol pool in patients with type 2 diabetes

2018 ◽  
Vol 177 ◽  
pp. 187-192 ◽  
Author(s):  
Amy E. Riek ◽  
Jisu Oh ◽  
Isra Darwech ◽  
Veronica Worthy ◽  
Xiaobo Lin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D3 ◽  
Vitamin D3 Supplementation
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