scholarly journals EVALUATION OF CARIOGENIC SITUATION IN CHILDREN WITH TYPE 1 DIABETES MELLITUS GIVEN THE MINERALIZING POTENTIAL OF SALIVA AND ENAMEL RESISTANCE

2018 ◽  
Vol 25 (4) ◽  
pp. 22-36
Author(s):  
I. M. BYKOV ◽  
F. N. GILMIYAROVA ◽  
D. A. DOMENYUK ◽  
S. V. DMITRIENKO ◽  
S. O. IVANYUTA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Oral Cavity ◽  
Type 1 Diabetes Mellitus ◽  
Self Regulation ◽  
Dental Status ◽  
Expert Committee ◽  
Healthy Children ◽  
Mineralizing Potential

Aim.This study was conducted to evaluate the caries resistance of hard tooh tissues and the state of the calcium and phosphorus  metabolism in children with type 1 diabetes mellitus given the  mineralizing potential of saliva and antimicrobial protection of the oral cavity.Materials and methods. There was conducted a general clinical, dental, laboratory examination of 127 children with type 1 diabetes  mellitus aged 7 to 12 years with the endocrinopathy experience from eight months to ten years. The obtained data were compared with  the results of the examination of 37 "healthy" and "practically  healthy" children of this age category. When assessing the dental  status of children, were used the hygienic index (Y.A. Fedorov, V.V.  Volodkina, 1970), the CFE/ cf index (WHO Expert Committee, 1962), the simplified hygienic index OHI-S (Green, Vermillion, 1964). The  intensity of the enamel demineralization processes was assessed  using the enamel resistance test (V.R. Okushko, L.I. Kosavera, 1984)  and vital staining (L.A. Aksamit, 1978). The electrometry of  hard tooth tissues was carried out by the electrodiagnostic apparatus "Dent Est" (V.K. Leontiev, G.G. Ivanova, 1985).The  laboratory diagnostics of the salivary indicators included the study of calcium (total, ionized), inorganic phosphorus, alkaline  phosphatase, osteocalcin, parathyroid hormone, 25-hydroxyvitamin D3, lactoferrin. The microcrystallization and  mineralizing potential of saliva were determined according to Leus  P.A. (1997).Results.At the early stages of type 1 diabetes mellitus development children have a compensated and subcompensated form of the  carious process, the increase in the enamel permeability, a slight  predominance of the demineralization processes over the  remineralization processes in solid tooth tissues. It indicates that  self-regulation of the mineral metabolism mechanisms takes place  while maintaining the physiological remineralizing properties of  saliva. At a late stage of type 1 diabetes mellitus development a high intensity and decompensated form of the carious lesions are  established as well as low structural and functional enamel  resistance and pronounced processes of hard tooth tissues  demineralization. The emergence of this complex in children with the experience of endocrinopathy for more than five years indicates the depletion of salivary gland functionality, the disturbance of  mobilization salivary systems in response to the occurrence of the  cariogenic situation in the oral cavity, the change in calcium  homeostasis, the decrease in enamel resistance to organic acids and the absence of saliva crystallization.Conclusion.The growing positive dynamics of index growth in children with long-term type 1 diabetes mellitus, indicating the  deterioration of the dental status, requires adherence to the  principles of rational nutrition, quarterly professional caries preventive measures using modern and effective oral care  products, the introduction of active forms of hygienic training and education taking into account the mineralizing potential of saliva as well as careful monitoring of the acquired manual skills.

Peculiarities of microcirculation in periodont tissues in children of key age groups sufficient type 1 diabetes. Part II

2019 ◽  
Vol 24 (2) ◽  
pp. 108-119 ◽  
Author(s):  
B. N. Davydov ◽  
D. A. Domenyuk ◽  
S. V. Dmitrienko
Keyword(s):  
Diabetes Mellitus ◽  
Blood Flow ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Diabetic Microangiopathy ◽  
Healthy Children ◽  
Doppler Flowmetry

Relevance. Morpho-functional changes in peripheral circulation established in type 1 diabetes mellitus correlate with changes in central hemodynamics, allowing the use of microcirculation indicators as diagnostic and prognostic criteria for assessing the degree of functional vascular disorders. Identifcation of microcirculation features of the blood by the method of laser Doppler flowmetry in children with different experience of type 1 diabetes in key age categories.Materials and methods. The study included 67 children with type 1 diabetes mellitus aged 12-15 years with an experience of the disease from six months to ten years. The comparison group consisted of 38 healthy children. The state of the microvasculature was assessed by laser Doppler flowmetry using a laser analyzer for capillary blood flow LAKK-OP.Results. In children with an experience of type 1 diabetes of less than two years, microcirculation disorders in periodontal tissues correspond to the hyperemic form, accompanied by increased perfusion, a decrease in the amplitude of low-frequency oscillations, increased heart rate, high blood flling, and blood flow bypass. For children with an endocrinopathy experience of more than three years, microcirculation disorders correspond to a stagnant form, combined with a decrease in perfusion due to stagnation of blood in the venular link, endothelial domination with suppression of neurogenic and cardiac fluctuations, low efciency and redistribution of blood flow in favor of the nutritive link.Conclusions. With the increase in experience, the degree of compensation of type 1 diabetes, the progression of diabetic microangiopathy, it is advisable to designate two stages of development of microcirculatory disorders. Early – compensatory with active adaptation, including neurogenic and endothelial regulation mechanisms. Late – decompensation with passive adaptation, supporting the effectiveness of microcirculation due to myogenic control of regulation, shunting and increasing the rate of blood outflow.

Urinary F2-isoprostanes in young healthy children at risk for type 1 diabetes mellitus

2003 ◽  
Vol 35 (6) ◽  
pp. 551-557 ◽  
Author(s):  
Laura D Kauffman ◽  
Ronald J Sokol ◽  
Richard H Jones ◽  
Joseph A Awad ◽  
Marian J Rewers ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
At Risk ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Healthy Children ◽  
Children At Risk

scholarly journals The profile of plasma non-esterified fatty acids in children with different terms of type 1 diabetes mellitus

2016 ◽  
Vol 62 (2) ◽  
pp. 206-211 ◽  
Author(s):  
V.A. Akmurzina ◽  
E.E. Petryairina ◽  
S.V. Saveliev ◽  
A.A. Selishcheva
Keyword(s):  
Diabetes Mellitus ◽  
Fatty Acids ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Plasma Lipids ◽  
Solid Phase ◽  
Fold Increase ◽  
Healthy Children ◽  
Esterified Fatty Acids

Composition and quantitative content of non-esterified fatty acids (NEFA) were investigated in plasma samples of healthy children (12) and children with type 1 diabetes mellitus (DM1) (31) by gas chromatography (GC) after preliminary NEFA solid-phase extraction from plasma lipids. There was a significant (p<0.001) 1.6-fold increase in the total level of NEFA regardless of the disease duration. In the group of DM1 children with the disease period less than 1 year there was an increase in the arachidonic acid (20:4) content (30%) and the oleic acid trans-isomer (18:1) content (82%), and also a decrease in the docosahexaenoic acid (22:6 n3) content (26% ) and the docosapentaenoic acids (22:5 n-6) content (60%). In the group of DM1 children with prolonged course of this disease the altered NEFA levels returned to the normal level

High prevalence of vitamin D deficiency in type 1 diabetes mellitus and healthy children

2008 ◽  
Vol 46 (3) ◽  
pp. 183-189 ◽  
Author(s):  
Abdulbari Bener ◽  
Amer Alsaied ◽  
Mariam Al-Ali ◽  
Aisha Al-Kubaisi ◽  
Basma Basha ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Vitamin D Deficiency ◽  
Healthy Children ◽  
High Prevalence

scholarly journals HLA class II alleles and haplotypes in Lithuanian children with type 1 diabetes and healthy children (HLA and type 1 diabetes)

Medicina ◽  
2010 ◽  
Vol 46 (8) ◽  
pp. 505 ◽  
Author(s):  
Erika Skrodenienė ◽  
Dalia Marčiulionytė ◽  
Žilvinas Padaiga ◽  
Edita Jašinskienė ◽  
Vaiva Sadauskaitė-Kuehne ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Clinical Manifestations ◽  
Class Ii ◽  
Hla Class Ii ◽  
Healthy Children ◽  
Polymerase Chain ◽  
Control Study

Objective. Type 1 diabetes mellitus is a slowly progressive autoimmune disease. The genetic background of type 1 diabetes mellitus is polygenic with the major disease locus located in the human leukocytes antigen (HLA) region. High risk and protective alleles, haplotypes, and genotypes have been determined in Lithuanian children with type 1 diabetes mellitus and healthy children. Material and methods. In this case-control study, 124 children with diabetes (55 males and 69 females; mean age, 9.2±3.9 years) were tested for HLA class II and compared with 78 healthy controls (43 males and 35 females; mean age, 10.8±3.4 years; range, 0–15 years). HLA DRB1, DQA1, and DQB1 alleles were genotyped using a polymerase chain reaction. Results. T1D risk-associated haplotypes (DR4)-DQA1*0301-DQB1*0302, (DR3)- DQA1*0501-DQB1*0201, and (DR1)-DQA1*0101-04-DQB1*0501 were more prevalent among children with diabetes than controls (50.0%, 41.1%, and 37.9% vs. 10.3%, 5.1%, and 24.4%, P<0.001). The haplotypes (DR4)-DQA1*0301-DQB1*0302 and (DR3)-DQA1*0501-DQB1*0201 increased T1D risk by 8.75 and 12.93 times, respectively (P<0.001). Protective haplotypes (DR2)- DQA1*0102-B1*0602, (DR11/12/13)-DQA1*05-DQB1*0301, and (DR13)-DQA1*0103- DQB1*0603 were significantly more prevalent among controls than children with diabetes (25.6%, 33.3%, 19.2% vs. 0%, 3.2%, 0%; P<0.001). These frequencies are quite similar to those from neighbor countries with varying incidence of type 1 diabetes mellitus. Conclusions. HLA class II haplotypes associated with type 1 diabetes mellitus positively or negatively were the same in Lithuanian children as in other European Caucasian populations. Differences in incidence and clinical manifestations of type 1 diabetes might be due to different environmental factors and/or lifestyle.

scholarly journals Characterization of the Oral Microbiome Among Children With Type 1 Diabetes Compared With Healthy Children

2021 ◽  
Vol 12 ◽  
Author(s):  
Moti Moskovitz ◽  
Mira Nassar ◽  
Nadav Moriel ◽  
Avital Cher ◽  
Sarit Faibis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Gut Microbiome ◽  
Species Level ◽  
Oral Microbiome ◽  
Control Group ◽  
Healthy Children ◽  
Diabetes Group

Aim: Current microbiome profiling of type 1 diabetes mellitus (T1D) patients is mostly limited to gut microbiome. We characterized the oral microbiome associated with T1D in children after the onset of the disease and explored its relationship with oral physiological factors and dental status.Methods: This cohort study comprised 37 children aged 5–15 years with T1D and 29 healthy children matched in age and gender. Unstimulated whole saliva was collected from diabetic and non-diabetic children, in the morning after brushing their teeth and a fasting period of at least 1 h before sampling. 16S rRNA gene-based analysis was performed by Powersoil Pro kit by Qiagen and Phusion High-Fidelity PCR Master Mix. Oral physiological and dental parameters studied included decayed, missing, and filled teeth index, salivary flow rate, and salivary pH, glucose, calcium, phosphate, and urea levels.Results: Of the identified 105 different genera and 211 different species, the most abundant genera were Streptococcus, Prevotella, Veillonella, Haemophilus, and Neisseria. Streptococcus was more abundant in T1D children. The diabetes group had 22 taxa at the genus level and 33 taxa at the species level that were not present in the control group and the control group exhibited 6 taxa at the genus level and 9 taxa at the species level that did not exist in the diabetes group. In addition, Catonella, Fusobacterium, and Mogibacterium differed between healthy and T1D subjects. Eight species and eight subspecies were significantly more abundant among healthy children than in T1D children. Porphyromonas and Mogibacterium genera were significantly correlated with salivary parameters. We found similarities between taxa revealed in the present study and those found in gut microbiome in type 1 diabetes mellitus according to gutMDisorder database.Conclusions: Salivary microbiome analysis revealed unique microbial taxa that differed between T1D children and healthy subjects. Several genera found in the saliva of T1D children were associated with gut microbiome in T1D individuals.

Peculiarities of microcirculation in peridont tissues in children of key age groups sufficient type 1 diabetes. Part I

2019 ◽  
Vol 24 (1) ◽  
pp. 4-10
Author(s):  
B. N. Davydov ◽  
D. A. Domenyk ◽  
S. V. Dmitrienko
Keyword(s):  
Diabetes Mellitus ◽  
Blood Flow ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Diabetic Microangiopathy ◽  
Healthy Children ◽  
Doppler Flowmetry

The relevance of the research topic. Morpho-functional changes in peripheral circulation established in type 1 diabetes mellitus correlate with changes in central hemodynamics, allowing the use of microcirculation indicators as diagnostic and prognostic criteria for assessing the degree of functional vascular disorders.Purpose – identifcation of microcirculation features of the blood by the method of laser Doppler flowmetry in children with different experience of type 1 diabetes in key age categories.Methods. The study included 67 children with type 1 diabetes mellitus aged 12-15 years with an experience of the disease from six months to ten years. The comparison group consisted of 38 healthy children. The state of the microvasculature was assessed by laser Doppler flowmetry using a laser analyzer for capillary blood flow LAKK-OP.Results. In children with an experience of type 1 diabetes of less than two years, microcirculation disorders in periodontal tissues correspond to the hyperemic form, accompanied by increased perfusion, a decrease in the amplitude of low-frequency oscillations, increased heart rate, high blood flling, and blood flow bypass. For children with an endocrinopathy experience of more than three years, microcirculation disorders correspond to a stagnant form, combined with a decrease in perfusion due to stagnation of blood in the venular link, endothelial domination with suppression of neurogenic and cardiac fluctuations, low effciency and redistribution of blood flow in favor of the nutritive link.Summary. With the increase in experience, the degree of compensation of type 1 diabetes, the progression of diabetic microangiopathy, it is advisable to designate two stages of development of microcirculatory disorders. Early - compensatory with active adaptation, including neurogenic and endothelial regulation mechanisms. Late - decompensation with passive adaptation, supporting the effectiveness of microcirculation due to myogenic control of regulation, shunting and increasing the rate of blood outflow.

scholarly journals Increased serum soluble leptin receptor levels in children and adolescents with type 1 diabetes mellitus

2004 ◽  
pp. 475-481 ◽  
Author(s):  
J Kratzsch ◽  
A Deimel ◽  
A Galler ◽  
T Kapellen ◽  
A Klinghammer ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Leptin Receptor ◽  
Serum Levels ◽  
Healthy Children ◽  
Duration Of Diabetes ◽  
Soluble Leptin Receptor

OBJECTIVE: We investigated whether or not serum levels of the soluble leptin receptor (sOB-R) and leptin are related to anthropometric and metabolic changes during pubertal development of children and adolescents with type 1 diabetes mellitus. DESIGN AND METHODS: Blood levels of sOB-R, leptin and HbA1C, as well as body-mass index (BMI), diabetes duration and daily insulin doses, were determined in 212 (97 girls; 115 boys) children with type 1 diabetes mellitus and compared with the sOB-R serum levels in 526 healthy children and adolescents. RESULTS: OB-R serum levels and parallel values of the molar ratio between sOB-R and leptin were significantly higher in children with diabetes than in normal children (P<0.05) in almost all investigated Tanner stages. Furthermore, in the entire group of patients, we demonstrated statistically significant correlations (P<0.02) between sOB-R and the duration of diabetes (r=0.30), HbA1c levels (r=0.32) and the insulin dose (r=0.18). Multiple-regression analysis revealed that HbA1c (12.4%), height (7.9%) and duration of diabetes (8.7%) contributed to 29% variance of sOB-R in diabetic children. CONCLUSIONS: Our data suggest that poor glycemic control in diabetes may lead to increased serum levels of sOB-R. This regulation of sOB-R appears to be independent of leptin, but may have an impact on leptin action. The consequently developing molar excess of sOB-R related to leptin could reduce leptin sensitivity and may, therefore, influence leptin-related anthropometric and metabolic abnormalities.

scholarly journals Influence of Type 1 Diabetes Mellitus on the Ocular Biometry of Chinese Children

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Ying Xiao ◽  
Tao Li ◽  
Yan Jia ◽  
Shanshan Wang ◽  
Chenhao Yang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Glycosylated Hemoglobin ◽  
Diabetes Duration ◽  
Control Group ◽  
Healthy Children ◽  
Ocular Biometry ◽  
The Mean

Purpose. To compare ocular biometry between children with type 1 diabetes mellitus (T1DM) and healthy children in China and to determine the correlation of ocular biometry with the glycosylated hemoglobin (HbA1c) level and diabetes duration. Methods. A case-control study was conducted at Children’s Hospital of Fudan University between T1DM children and healthy children. The participants were evaluated for central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), K1 and K2 keratometry, and axial length (AL); also cycloplegic refraction was performed, and spherical equivalent (SE) was acquired. HbA1c levels of the T1DM cases were obtained. Results. Fifty-four eyes of 54 children with T1DM and 53 eyes of 53 healthy children were included. The mean age of T1DM group and control group was 10.59 ± 3.40 years and 9.55 ± 1.89 years, respectively, and the differences between age and gender were not significant (p=0.052, p=0.700). The mean LT in T1DM group (3.49 ± 0.18 mm) was thicker than that in the control group (3.40 ± 0.16 mm) (p=0.018), the mean ACD in T1DM group (3.52 ± 0.26 mm) was shallower than that in the control group (3.72 ± 0.26 mm) (p<0.001), and there were no significant differences of CCT, K1, K2, AL, and SE (p=0.088, p=0.672, p=0.821, p=0.094, and p=0.306, respectively). There was no significant correlation between HbA1c or diabetes duration and ocular biometry. Conclusions. Thicker LT and shallower ACD occurred in T1DM children rather than age-matched and sex-matched healthy children, but the overall refraction was not affected. HbA1c or diabetes duration was not correlated with ocular biometry in T1DM children.

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