scholarly journals Interdigital Tinea: The Forerunner of Infectious Eczematoid Dermatitis

2020 ◽  
Vol 4 (4) ◽  
pp. 353-356
Author(s):  
Kyle R Bhatia ◽  
Robert T Brodell ◽  
Ashish C Bhatia ◽  
Chelsea S Mockbee
Keyword(s):  
Immune Response ◽  
Hypersensitivity Reaction ◽  
Primary Infection ◽  
Tinea Pedis ◽  
Acute Onset ◽  
Common Presentation ◽  
Streptococcal Species ◽  
Purulent Drainage ◽  
Source Management ◽  
Infectious Source

Infectious eczematoid dermatitis (IED) is defined as an acute, eczematous eruption that occurs secondary to autosensitization to purulent drainage from a primary infected site. The condition is believed to develop when bacterial products, most often the result of Staphylococcal or Streptococcal species, act as haptens and stimulate an immune response. IED typically manifests as a plaque with associated vesicles and pustules surrounding drainage from a central infectious source, or as oozing, erythema, crusting, and scaling spreading peripherally from a central infectious source. Management of IED includes both targeting the causative primary infection and suppressing the immune response producing a hypersensitivity reaction. This report details two cases. Case 1 describes a common presentation of tinea pedis. Case 2 is that of a 28 year-old-male who presented with an acute onset tender, pruritic, weeping rash after wearing boots for two straight days, and who was subsequently diagnosed and treated for IED.

scholarly journals Seropositivity to Nucleoprotein to detect SARS-CoV-2 infections: a tool to detect breakthrough infections after COVID-19 vaccination

2021 ◽  
Author(s):  
Lotus Leonie van den Hoogen ◽  
Gaby Smits ◽  
Cheyenne CE van Hagen ◽  
Denise Wong ◽  
Eric RA Vos ◽  
...  
Keyword(s):  
Immune Response ◽  
Primary Infection ◽  
Spike Protein ◽  
Multiplex Immunoassay ◽  
Specific Immunoglobulin ◽  
Vaccination History ◽  
Specific Igg ◽  
Exposure History ◽  
Asymptomatic Individuals ◽  
Roll Out

Background With COVID-19 vaccine roll-out ongoing in many countries globally, monitoring of breakthrough infections is of great importance. Antibodies persist in the blood after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Since COVID-19 vaccines induce immune response to the Spike protein of the virus, which is the main serosurveillance target to date, alternative targets should be explored to distinguish infection from vaccination. Methods Multiplex immunoassay data from 1,513 SARS-CoV-2 RT-qPCR-tested individuals (352 positive and 1,161 negative) with a primary infection and no vaccination history were used to determine the accuracy of Nucleoprotein-specific immunoglobulin G (IgG) in detecting past SARS-CoV-2 infection. We also described Spike S1 and Nucleoprotein-specific IgG responses in 230 COVID-19 vaccinated individuals (Pfizer/BioNTech). Results The sensitivity of Nucleoprotein seropositivity was 85% (95% confidence interval: 80-90%) for mild COVID-19 in the first two months following symptom onset. Sensitivity was lower in asymptomatic individuals (67%, 50-81%). Participants who had experienced a SARS-CoV-2 infection up to 11 months preceding vaccination, as assessed by Spike S1 seropositivity or RT-qPCR, produced 2.7-fold higher median levels of IgG to Spike S1 ≥14 days after the first dose as compared to those unexposed to SARS-CoV-2 at ≥7 days after the second dose (p=0.011). Nucleoprotein-specific IgG concentrations were not affected by vaccination in naïve participants. Conclusions Serological responses to Nucleoprotein may prove helpful in identifying SARS-CoV-2 infections after vaccination. Furthermore, it can help interpret IgG to Spike S1 after COVID-19 vaccination as particularly high responses shortly after vaccination could be explained by prior exposure history.

scholarly journals Robust SARS-CoV-2-specific T-cell immunity is maintained at 6 months following primary infection

2020 ◽  
Author(s):  
Jianmin Zuo ◽  
Alex Dowell ◽  
Hayden Pearce ◽  
Kriti Verma ◽  
Heather Long ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Immune Responses ◽  
Antibody Level ◽  
Primary Infection ◽  
Natural Infection ◽  
T Cell Responses ◽  
Symptomatic Infection ◽  
Cell Responses ◽  
Cell Immunity

Abstract The immune response to SARS-CoV-2 is critical in both controlling primary infection and preventing re-infection. However, there is concern that immune responses following natural infection may not be sustained and that this may predispose to recurrent infection. We analysed the magnitude and phenotype of the SARS-CoV-2 cellular immune response in 100 donors at six months following primary infection and related this to the profile of antibody level against spike, nucleoprotein and RBD over the previous six months. T-cell immune responses to SARS-CoV-2 were present by ELISPOT or ICS analysis in all donors and are characterised by predominant CD4+ T cell responses with strong IL-2 cytokine expression. Median T-cell responses were 50% higher in donors who had experienced an initial symptomatic infection indicating that the severity of primary infection establishes a ‘setpoint’ for cellular immunity that lasts for at least 6 months. The T-cell responses to both spike and nucleoprotein/membrane proteins were strongly correlated with the peak antibody level against each protein. The rate of decline in antibody level varied between individuals and higher levels of nucleoprotein-specific T cells were associated with preservation of NP-specific antibody level although no such correlation was observed in relation to spike-specific responses. In conclusion, our data are reassuring that functional SARS-CoV-2-specific T-cell responses are retained at six months following infection although the magnitude of this response is related to the clinical features of primary infection.

Fluctuations in rat liver alanine-amino-transferase activity during experimental nippostrongylosis

Parasitology ◽  
1989 ◽  
Vol 98 (2) ◽  
pp. 301-306
Author(s):  
Lucy J. Robertson
Keyword(s):  
Immune Response ◽  
Primary Infection ◽  
Parasitic Infection ◽  
Transferase Activity ◽  
Nippostrongylus Brasiliensis ◽  
Alanine Amino Transferase ◽  
A Value ◽  
Gluconeogenic Enzyme ◽  
Alt Activity

SUMMARYThe activity of the gluconeogenic enzyme, alanine-amino-transferase (ALT), in a preparation from the liver of rats was studied by means of an in vitro assay throughout the course of a primary infection of Nippostrongylus brasiliensis, established by a subcutaneous injection of approximately 4000 3rd-stage larvae. The activity was measured on days 1–14 p.i. in both uninfected and infected rats and a marked pattern in the enzyme's activity was observed. In infected rats, the activity increased from 1·46±0·19 U/g liver on day 1 p.i. to a peak on day 4 p.i. of 10·75±1·62 U/g liver, then decreased to a trough of 0·44±0·18 U/g liver on day 10 p.i. before returning to original levels by day 14 p.i., by which time the infection had been largely eliminated. In uninfected rats the activity of the liver enzyme remained constant throughout this period with a value of 2·54±0·12 U/g liver. The activity of the enzyme in vitro was found to be related to the size of the inoculum on days 4 and 10 p.i. It was proposed that these observations could be due to either (1) a direct effect of the parasite, or (2) a consequence of the host immune response to the infection. In order to investigate the second proposition more fully, liver ALT activity was investigated by in vitro assay on selected days p.i. in rats experiencing a secondary N. brasiliensis infection. In these rats the liver ALT activity was observed to reach a peak on day 2 p.i., with an activity of 3·87 ± 0-28 U/g liver, and a trough on day 4 p.i. with an activity of 0·11 ±0·03 U/g liver, returning to similar levels to those measured in uninfected rats by day 7 p.i. When serum prepared from rats having secondary N. brasiliensis infections collected on day 4 p.i. was added to the assay, a reduction in the activity of liver ALT activity from both the infected and uninfected rats was measured by in vitro assay. The results are discussed in relation to protein metabolism and gluconeogenesis in rats infected with N. brasiliensis, and also in relation to the host’s immune response to the parasitic infection.

Sepsis

2018 ◽  
Author(s):  
Graham Cooke
Keyword(s):  
Immune Response ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Primary Infection ◽  
Clinical Manifestations ◽  
Host Immune Response ◽  
Organ Damage ◽  
Clinical Syndrome ◽  
Systemic Inflammatory Response ◽  
Physiological Status

Sepsis is a clinical syndrome defined by the presence of both infection and a systemic inflammatory response with or without organ damage. The pathogenesis of sepsis is complex and may differ according to the infecting microbe, the site of primary infection, and the host’s immunological and physiological status prior to infection. The term ‘systemic inflammatory response syndrome’ refers to the clinical manifestations of a dysregulated host immune response, while ‘bacteraemia’, in contrast, refers to the presence of viable organisms that can be cultured from blood.

scholarly journals The Immune Response toHaemophilus ducreyiResembles a Delayed‐Type Hypersensitivity Reaction throughout Experimental Infection of Human Subjects

1998 ◽  
Vol 178 (6) ◽  
pp. 1688-1697 ◽  
Author(s):  
Katherine L. Palmer ◽  
Carol T. Schnizlein‐Bick ◽  
Attilio Orazi ◽  
Karla John ◽  
Cheng‐Yen Chen ◽  
...  
Keyword(s):  
Immune Response ◽  
Hypersensitivity Reaction ◽  
Experimental Infection ◽  
Human Subjects ◽  
Delayed Type Hypersensitivity

A Primary Infection Model for HIV and Immune response with Two Discrete Time Delays

2010 ◽  
Vol 18 (4) ◽  
pp. 385-399 ◽  
Author(s):  
Prashant K. Srivastava ◽  
M. Banerjee ◽  
Peeyush Chandra
Keyword(s):  
Immune Response ◽  
Discrete Time ◽  
Primary Infection ◽  
Time Delays ◽  
Infection Model

scholarly journals The Importance and Challenges of Identifying SARS-CoV-2 Reinfections

2020 ◽  
Author(s):  
Ahmed Babiker ◽  
Charles Marvil ◽  
Jesse J. Waggoner ◽  
Matthew Collins ◽  
Anne Piantadosi
Keyword(s):  
Immune Response ◽  
Viral Genome ◽  
Primary Infection ◽  
Genomic Data ◽  
Medical Community ◽  
Immune Protection ◽  
Key Factors ◽  
Clinical Laboratories ◽  
Strength And Durability ◽  
Total Immunoglobulin

Reports of SARS-CoV-2 reinfection have raised important questions about the strength and durability of the immune response to primary infection, which are key factors in predicting the course of the pandemic. Identifying reinfection requires detecting the virus at two different time points and using viral genomic data to distinguish reinfection from persistent viral carriage. This process is hindered by challenges of logistics and capacity, such as banking samples from primary infection and performing viral genome sequencing. These challenges may help to explain why very few cases have been described to date. In addition, reinfection may be a rare phenomenon, but detailed prospective studies are needed to rigorously assess its frequency. To provide context for future investigations of SARS-CoV-2 reinfection, we review 16 cases that have been published to date or are available in pre-print. Reinfection occurred across demographic spectra and in patients whose initial infections were both asymptomatic/mild and moderate/severe. For cases in which severity could be compared between episodes, half of reinfections were less severe, raising the possibility of partial immune protection. Although many patients had a positive total immunoglobulin or IgG result at the time of reinfection, very little examination of their immune response was performed. Further work is needed to elucidate the frequency, determinants, and consequences of SARS-CoV-2 reinfection. Establishing the necessary frameworks for surveillance and investigation will rely heavily on clinical laboratories and clinical investigators, and we propose several considerations to guide the medical community in identifying and characterizing SARS-CoV-2 reinfections.

Homotypic immune response to primary infection with rotavirus serotype G1

1995 ◽  
Vol 47 (4) ◽  
pp. 404-409 ◽  
Author(s):  
A. M. Rojas ◽  
Y. Boher ◽  
M. J. Guntinas ◽  
I. Pérez-Schael
Keyword(s):  
Immune Response ◽  
Primary Infection

BCG masking phenomena might depend on the species of Mycobacterium

2021 ◽  
Author(s):  
Joana Korablioviene ◽  
Mykolas Mauricas ◽  
Irena Dumalakiene ◽  
Saulius Caplinskas ◽  
Rita Viliene ◽  
...  
Keyword(s):  
Immune Response ◽  
Antibody Response ◽  
Hypersensitivity Reaction ◽  
Mycobacterium Bovis ◽  
Mycobacterial Infection ◽  
Cross Reactivity ◽  
Primary Immunization ◽  
Wild Type ◽  
Increased Risk ◽  
Infection Susceptibility

AbstractThis study investigated BCG masking dependency on the species of Mycobacterium through the immune response to the mycobacterial region of deletion 1 (RD-1) associated growth affecting proteins (GEP).To evaluate the effects of GEP, 8-week old female BALB/c mice were immunized with either the wild type Mycobacterium bovis (MBGEP) or the ATCC Mycobacterium avium subsp. avium (MAGEP) strain and then subjected to further exposure with Mycobacterium terrae or M. avium sub. avium. Mice immunized with MAGEP and those mice further exposed to M. avium subsp. avium had increased granulocytes (GRA) and monocytes to lymphocytes rate (MLR) compared to control mice. Immunization of mice with GEP induced an antibody response one month after primary immunization, as observed by cross-reactivity. Our findings suggest that MAGEP is related to a latent hypersensitivity reaction and an increased risk of mycobacterial infection susceptibility. According to the results of the present study, previous sensitization with NTM antigens results in varying immune reactions after contact with different NTM argued that masking phenomena may be dependent on the species of Mycobacterium.

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